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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 YCqurYySnJj2AhnaDy/Pig==

<SEC-DOCUMENT>0001209191-04-005406.txt : 20040129
<SEC-HEADER>0001209191-04-005406.hdr.sgml : 20040129
<ACCEPTANCE-DATETIME>20040129144411
ACCESSION NUMBER:		0001209191-04-005406
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031231
FILED AS OF DATE:		20040129

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SMITH EDGAR ASHLEY
		CENTRAL INDEX KEY:			0001269034

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-31564
		FILM NUMBER:		04551948

	BUSINESS ADDRESS:	
		STREET 1:		700 GEMINI
		STREET 2:		SUITE 100
		CITY:			HOUSTON
		STATE:			TX
		ZIP:			77058
		BUSINESS PHONE:		2814883883

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ISOLAGEN INC
		CENTRAL INDEX KEY:			0000357097
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				870458888
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2500 WILCREST
		STREET 2:		5TH FLOOR
		CITY:			HOUSTON
		STATE:			TX
		ZIP:			77042
		BUSINESS PHONE:		713-780-4754

	MAIL ADDRESS:	
		STREET 1:		2500 WILCREST
		STREET 2:		5TH FLOOR
		CITY:			HOUSTON
		STATE:			TX
		ZIP:			77042

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMERICAN FINANCIAL HOLDING INC /DE
		DATE OF NAME CHANGE:	19960330

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMERICAN FINANCIAL HOLDING INC /CO
		DATE OF NAME CHANGE:	19921008

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	VIDTOR COMMUNICATIONS INC
		DATE OF NAME CHANGE:	19920721
</SEC-HEADER>
<DOCUMENT>
<TYPE>5
<SEQUENCE>1
<FILENAME>boh12032_9eas.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0201</schemaVersion>

    <documentType>5</documentType>

    <periodOfReport>2003-12-31</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0000357097</issuerCik>
        <issuerName>ISOLAGEN INC</issuerName>
        <issuerTradingSymbol>ILE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001269034</rptOwnerCik>
            <rptOwnerName>SMITH EDGAR ASHLEY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2500 WILCREST, 5TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>HOUSTON</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>77042</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Non Qualified Stock Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>6.00</value>
            </conversionOrExercisePrice>
            <transactionCoding></transactionCoding>
            <exerciseDate>
                <value>2003-11-01</value>
            </exerciseDate>
            <expirationDate>
                <value>2011-07-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>100000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">40,000 of these options vest on November 1, 2003; 30,000 of these options vest on November 1, 2004; and 30,000 of these options vest on November 1, 2005</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Edgar Ashley Smith</signatureName>
        <signatureDate>2004-01-22</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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