Registration No. 2-75276

File No. 811-3346

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

FORM N-1A

REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933	x
Pre-Effective Amendment No. ____	o
Post-Effective Amendment No. 52	x

and/or

REGISTRATION STATEMENT UNDER THE INVESTMENT COMPANY ACT OF 1940	x
Amendment No. 53	x

OPPENHEIMER SERIES FUND, INC.

_____________________________________________________________

(Exact Name of Registrant as Specified in Charter)

6803 South Tucson Way, Centennial, Colorado 80112-3924

_____________________________________________________________

(Address of Principal Executive Offices) (Zip Code)

(303) 768-3200

_____________________________________________________________

(Registrant’s Telephone Number, including Area Code)

Arthur S. Gabinet, Esq.

OppenheimerFunds, Inc.

Two World Financial Center, 225 Liberty Street,
New York, NY 10281

_____________________________________________________________

(Name and Address of Agent for Service)

It is proposed that this filing will become effective (check appropriate box):

x immediately upon filing pursuant to paragraph (b)

o on ______________ pursuant to paragraph (b)

o 60 days after filing pursuant to paragraph (a)(1)

o on ______________ pursuant to paragraph (a)(1)

o 75 days after filing pursuant to paragraph (a)(2)

o on ______________ pursuant to paragraph (a)(2) of Rule 485.

If appropriate, check the following box:

o This post-effective amendment designates a new effective date for a previously filed post-effective amendment.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933 and the Investment Company Act of 1940, the Registrant certifies that it meets all the requirements for effectiveness of this Registration Statement pursuant to Rule 485(b) under the Securities Act of 1933 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York and State of New York on the 14^th day of March, 2011.

OPPENHEIMER SERIES FUND, INC.
By:	/s/ William F. Glavin, Jr.*
	William F. Glavin, Jr.*, President and Principal Executive Officer

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities on the dates indicated:

Signatures	Title	Date
Brian F. Wruble*	Chairman of the Board of Directors	March 14, 2011
Brian F. Wruble
William F. Glavin, Jr.*	President and Principal Executive Officer	March 14, 2011
William F. Glavin, Jr.
Brian W. Wixted*	Treasurer, Principal Financial & Accounting Officer	March 14, 2011
Brian W. Wixted
David K. Downes*	Director	March 14, 2011
David K. Downes
Matthew P. Fink*	Director	March 14, 2011
Matthew P. Fink
Phillip A. Griffiths*	Director	March 14, 2011
Phillip A. Griffiths
Mary F. Miller*	Director	March 14, 2011
Mary F. Miller
Joel W. Motley*	Director	March 14, 2011
Joel W. Motley
Mary Ann Tynan*	Director	March 14, 2011
Mary Ann Tynan
Joseph M. Wikler*	Director	March 14, 2011
Joseph M. Wikler
Peter I. Wold*	Director	March 14, 2011
Peter I. Wold

*By:	/s/ Mitchell J. Lindauer
	Mitchell J. Lindauer, Attorney-in-Fact

EXHIBIT INDEX

Exhibit No.	Description
Ex-101.INS	XBRL Instance Document
Ex-101.SCH	XBRL Taxonomy Extension Schema Document
Ex-101.CAL	XBRL Taxonomy Extension Calculation Linkbase Document
Ex-101.DEF	XBRL Taxonomy Extension Definition Linkbase
Ex-101.LAB	XBRL Taxonomy Extension Labels Linkbase
Ex-101.PRE	XBRL Taxonomy Extension Presentation Linkbase Document

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