UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: November 21, 2008 12:00 P.M.
Form: S-4
CIK: 0000356830
Company Name: OSCIENT PHARMACEUTICALS CORP
File Number: 333-153394
CIK: 0001443593
Company Name: Guardian II Acquisition CORP
File Number: 333-153394-01