-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 yiepqG5W7zZ0zcyHVm1MdQ==

<SEC-DOCUMENT>0000905148-08-005250.txt : 20081217
<SEC-HEADER>0000905148-08-005250.hdr.sgml : 20081217
<ACCEPTANCE-DATETIME>20081217184035
ACCESSION NUMBER:		0000905148-08-005250
CONFORMED SUBMISSION TYPE:	3/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081125
FILED AS OF DATE:		20081217
DATE AS OF CHANGE:		20081217

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OSCIENT PHARMACEUTICALS CORP
		CENTRAL INDEX KEY:			0000356830
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				042297484
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1000 WINTER STREET
		STREET 2:		SUITE 2200
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		7813982300

	MAIL ADDRESS:	
		STREET 1:		1000 WINTER STREET
		STREET 2:		SUITE 2200
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GENOME THERAPEUTICS CORP
		DATE OF NAME CHANGE:	19941215

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	COLLABORATIVE RESEARCH INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Michael Kao
		CENTRAL INDEX KEY:			0001452251

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-10824
		FILM NUMBER:		081256039

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		818-883-8270

	MAIL ADDRESS:	
		STREET 1:		21700 OXNARD STREET
		STREET 2:		SUITE 1520
		CITY:			WOODLAND HILLS
		STATE:			CA
		ZIP:			91367-7584

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			AKANTHOS ARBITRAGE MASTER FUND LP
		CENTRAL INDEX KEY:			0001218962

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-10824
		FILM NUMBER:		081256040

	BUSINESS ADDRESS:	
		STREET 1:		C/O HUNTLAW CORP SERVICES LTD
		STREET 2:		PO BOX 1350GT 75 FORT ST.
		CITY:			GEORGE TOWN GRAND CAYMAN
		STATE:			C8
		ZIP:			91367-7584
		BUSINESS PHONE:		8184565220

	MAIL ADDRESS:	
		STREET 1:		C/O APPLEBY TRUST (CAYMAN) LTD.
		STREET 2:		CLIFTON HOUSE,75 FORT ST., P.O. BOX 1350
		CITY:			GRAND CAYMAN KY1-1108
		STATE:			E9
		ZIP:			00000

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			AKANTHOS CAPITAL MANAGEMENT LLC
		CENTRAL INDEX KEY:			0001218957

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-10824
		FILM NUMBER:		081256041

	BUSINESS ADDRESS:	
		STREET 1:		21700 OXNARD ST
		STREET 2:		SUITE 1520
		CITY:			WOODLAND HILLS
		STATE:			CA
		ZIP:			91367-7584
		BUSINESS PHONE:		8188838270

	MAIL ADDRESS:	
		STREET 1:		21700 OXNARD ST
		STREET 2:		SUITE 1520
		CITY:			WOODLAND HILLS
		STATE:			CA
		ZIP:			91367-7584
</SEC-HEADER>
<DOCUMENT>
<TYPE>3/A
<SEQUENCE>1
<FILENAME>efc8-1667_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2008-11-25</periodOfReport>

    <dateOfOriginalSubmission>2008-12-15</dateOfOriginalSubmission>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000356830</issuerCik>
        <issuerName>OSCIENT PHARMACEUTICALS CORP</issuerName>
        <issuerTradingSymbol>OSCI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001218957</rptOwnerCik>
            <rptOwnerName>AKANTHOS CAPITAL MANAGEMENT LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>21700 OXNARD STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1520</rptOwnerStreet2>
            <rptOwnerCity>WOODLAND HILLS</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>91367-7584</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001218962</rptOwnerCik>
            <rptOwnerName>AKANTHOS ARBITRAGE MASTER FUND LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O APPLEBY TRUST (CAYMAN) LTD.</rptOwnerStreet1>
            <rptOwnerStreet2>CLIFTON HOUSE, 75 FORT ST., PO BOX 1350</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-1108</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001452251</rptOwnerCik>
            <rptOwnerName>Michael Kao</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>21700 OXNARD STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1520</rptOwnerStreet2>
            <rptOwnerCity>WOODLAND HILLS</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>91367-7584</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>COMMON STOCK</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1790000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>12.50% CONVERTIBLE GUARANTEED SENIOR NOTES DUE 2011</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F4"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F3"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>COMMON STOCK</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>6509091</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>SEE FOOTNOTES</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This statement is filed by and on behalf of each of Akanthos Capital Management, LLC (&quot;ACM&quot;), Akanthos Arbitrage Master
 Fund,  L.P. (&quot;AAMF&quot;) and Michael Kao (Mr. &quot;Kao&quot;).  ACM acts as the investment adviser and general partner to, and manages
 investment and trading accounts of, other persons, including AAMF.  ACM may be deemed, through investment advisory contracts
 or otherwise, to
beneficially own securities owned by other persons, including AAMF.  Mr. Kao is the Manager of ACM and may be deemed to
 beneficially own securities owned by ACM. These shares of the issuer's common stock, par value
$.10 per share (&quot;Shares&quot;) are held for the account of AAMF.  Reporting persons hold approximately 8,299,091 Shares of the
issuer, consisting of: (A) 1,790,000 Shares; and (B) 7,160,000 units 12.50% Convertible Guaranteed Senior Notes due 2011
(the &quot;Notes&quot;), convertible at $1.10 per share into 6,509,091 Shares.</footnote>
        <footnote id="F2">Reporting persons exceeded the 10% threshold due to an exchange offer (the &quot;Exchange&quot;) made by the issuer in which AAMF
participated.  As per the information provided by the issuer in its Prospectus dated November 24, 2008, prior to the
Exchange, on November 3, 2008, the issuer had 14,256,628 Shares outstanding.  As per the information provided by the
issuer in its Form 8-K dated November 24, 2008, 21,310,549 were issued in the Exchange. Therefore, we understand that
the outstanding Shares of the issuer total 35,567,177.</footnote>
        <footnote id="F3">The Notes are immediately convertible into Shares. The Notes mature on January 15, 2011, unless earlier converted or
 repurchased.</footnote>
        <footnote id="F4">The initial conversion rate of the Notes is 909.0909 Shares per $1,000 principal amount of Notes (equal to a conversion price
 of approximately $1.10 per Share).</footnote>
        <footnote id="F5">The original Form 3 filed by AAMF and ACM on December 15, 2008 is being amended hereby to include Mr. Kao as a reporting
 person.  With respect to AAMF and ACM, the holdings information included herein is not new or revised, but is being reported
 again so that the information on all reporting persons' filings will be the same.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>By:  /s/ Michael Kao, Manager of Akanthos Capital Management, LLC, general partner to Akanthos Arbitrage Master Fund, L.P.</signatureName>
        <signatureDate>2008-12-15</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By:  /s/ Michael Kao, Manager of Akanthos Capital Management, LLC</signatureName>
        <signatureDate>2008-12-15</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By:  /s/ Michael Kao, an individual</signatureName>
        <signatureDate>2008-12-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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