November 1, 2006


Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549


ATTN:    Mr. Mark Cowan
         Document Control - EDGAR

                  RE:  RiverSource Variable Portfolio - Investment Series, Inc.
                            RiverSource Variable Portfolio - Emerging Markets
                                         Fund
                            RiverSource Variable Portfolio - Growth Fund
                            RiverSource Variable Portfolio - International
                                         Opportunity Fund
                            RiverSource Variable Portfolio - Large Cap Equity
                                         Fund
                            RiverSource Variable Portfolio - Large Cap Value
                                         Fund
                            RiverSource Variable Portfolio - Mid Cap Growth Fund
                            RiverSource Variable Portfolio - Mid Cap Value Fund
                            RiverSource Variable Portfolio - S&P 500 Index Fund
                            RiverSource Variable Portfolio - Small Cap Advantage
                                         Fund

                  Post-Effective Amendment No. 59
                  File No. 2-73115/811-3218

Dear Mr. Cowan:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, please
accept this letter as certification that the prospectus and Statement of
Additional Information for the above-referenced Funds do not differ from that
contained in Registrant's Post-Effective Amendment No. 59 (Amendment). This
Amendment was filed electronically on October 26, 2006.

If you have any questions regarding this filing, please contact either Anna
Butskaya at (612) 671-4993 or me at (612) 671-4321.

Sincerely,


/s/ Christopher O. Petersen
- ---------------------------
    Christopher O. Petersen
    Vice President and Group Counsel
    Ameriprise Financial, Inc.