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Stock-Based Compensation (Tables)
 3 Months Ended
Mar. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Valuation Assumptions The fair value of each option award is estimated on the date of grant using the Black-Scholes option-pricing formula that uses assumptions noted in the following table. Expected volatilities and risk-free interest rates are based upon the expected life of the grant.
Three Months Ended March 31,
Assumptions20212020
Expected dividends— — 
Risk-free rate0.19% - 0.22%0.85%-1.60%
Expected volatility165.43% - 166.02%78.56% - 79.58%
Expected term (in years)3.2 - 3.3 years3.2 - 3.3 years
Schedule of Stock Option Activity
A summary of option activity under the 1999 Director Stock Option Plan, 2009 Equity Incentive Plan, and the 2016 Equity Incentive Plan as of March 31, 2021 and changes during the period are presented below:

Number of
Options
Weighted Average
Exercise Price
Outstanding as of January 1, 2021507,295 $18.31 
Issued1,754,120 0.82 
Exercised— — 
Forfeited(2,932)13.41 
Expired(29,836)28.41 
Outstanding as of March 31, 2021
2,228,647 $4.42 
Exercisable as of March 31, 2021
239,453 $31.05 
Schedule of Stock Options Outstanding and Exercisable
The following tables summarize information regarding options outstanding and exercisable at March 31, 2021:
 
Outstanding:
Stock
Options		Weighted
Average		Weighted
Average
Remaining
Range of Exercise PricesOutstandingExercise PriceContractual Life
$0.00 - $7.802,052,118 $1.22 9.69
$7.81 - $15.049,974 10.27 6.25
$15.1 - $55.060,950 26.47 6.83
$55.1 - $106.765,605 79.29 4.78
Total2,228,647 $4.42 9.39

Exercisable: 
Range of Exercise PricesStock Options ExercisableWeighted Average Exercise Price
$0.00 - $7.8076,652 $4.40 
$7.81 - $15.046,852 10.36
$15.1 - $55.050,344 28.01
$55.1 - $106.765,605 79.29
Total239,453 $31.05 
Schedule of Nonvested Restricted Stock Units Activity The following table summarizes the number of unvested RSUs and their weighted average exercise price for the three months ended March 31, 2021.
Number of RSUsWeighted Average Grant Date Fair Value
Non-vested balance at January 1, 202123,686 $2.59 
Changes during the period:
Shares granted1,379,465 0.82 
Shares vested(181)35.30 
Shares forfeited— — 
Non-vested balance at March 31, 2021
1,402,970 $0.85 

•Represents shares granted not accounted for under the 2016 plan.