Prospectus Filed pursuant to Rule 424(b)(3) Registration No. 333-265209

 Tenax Therapeutics, Inc.

21,192,054 Shares of Common Stock

This prospectus relates to the resale of up to 21,192,054 shares of our common stock, $0.0001 par value per share, from time to time in one or more offerings by the selling stockholder named herein and any additional selling stockholders who will be identified in one or more prospectus supplements.

The 21,192,054 shares offered hereby are issuable upon exercise of the Pre-Funded Warrants and Series E Warrants sold in the private placement described under “Summary — Recent Developments — Private Placement of Warrants” in this prospectus.

We will not receive any proceeds from the resale of the shares of our common stock offered hereby, although we will receive the exercise price of any exercised warrants paid to us by the selling stockholder, which will be used for working capital and general corporate purposes.

Our common stock is traded on the Nasdaq Capital Market and is quoted under the symbol TENX. On May 24, 2022, the last reported sale price of our common stock was $0.5886 per share.

The selling stockholder may offer all or part of the shares registered hereby for resale from time to time directly to purchasers, through agents selected by the selling stockholder, or to or through underwriters or dealers, at either prevailing market prices or at privately negotiated prices. If agents, underwriters or dealers are used in the sale of the shares by the selling stockholder, such agents, underwriters or dealers will be named and their compensation described in any applicable prospectus supplement.

Investing in our securities involves a high degree of risk. You should review carefully the risks and uncertainties described under the heading “Risk Factors” on page 10 of this prospectus and the documents that are incorporated by reference into this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is June 3, 2022

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TABLE OF CONTENTS

About this Prospectus	3
Special Note Regarding Forward-Looking Statements	4
Summary	5
Risk Factors	9
Use of Proceeds	10
Selling Stockholder	11
Plan of Distribution	13
Legal Matters	14
Experts	14
Where You Can Find Additional Information	14
Incorporation of Certain Information by Reference	14

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ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission, or the SEC, utilizing a “shelf” registration process. Under this process, the selling stockholder may from time to time, in one or more offerings, sell the shares of common stock described in this prospectus.

A prospectus supplement may also add, update, or change the information contained or incorporated in this prospectus. Any prospectus supplement will supersede this prospectus to the extent it contains information that is different from, or that conflicts with, the information contained or incorporated in this prospectus. The registration statement we filed with the SEC includes exhibits that provide more detail of the matters discussed in this prospectus. You should read and consider all information contained in this prospectus and the related registration statement and exhibits filed with the SEC and any accompanying prospectus supplement in making your investment decision. You should also read and consider the information contained in the documents identified under the headings “Where You Can Find Additional Information” and “Incorporation of Certain Information by Reference” in this prospectus.

You should rely only on the information contained or incorporated by reference in this prospectus and in any prospectus supplement. We have not authorized any dealer, salesman, or other person to give any information or to make any representation other than those contained or incorporated by reference in this prospectus. The selling stockholder is offering to sell and seeking offers to buy the common stock only in jurisdictions where offers and sales are permitted. You should assume that the information appearing in this prospectus is accurate only as of the date of this prospectus, and that any information incorporated by reference is accurate only as of the date of the document incorporated by reference, unless we indicate otherwise. Our business, financial condition, results of operations, and prospects may have changed since those dates.

When we refer to “Tenax Therapeutics,” “the Company,” “we,” “our,” and “us” in this prospectus, we mean Tenax Therapeutics, Inc., a Delaware corporation, unless otherwise specified. References to our “common stock” refer to the common stock, par value $0.0001 per share, of Tenax Therapeutics, Inc.

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SPECIAL NOTE REGARDING FORWARD LOOKING STATEMENTS

Information set forth in this prospectus and the information incorporated by reference may contain various “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act. All information relative to future development of and markets for our products and trends in and anticipated levels of and needs with respect to revenue, cash, gross margins, and expenses, as well as other statements containing words such as “believe,” “project,” “may,” “will,” “anticipate,” “target,” “plan,” “estimate,” “expect,” and “intend” and other similar expressions constitute forward-looking statements. These forward-looking statements are subject to risks related to our financial position and need for additional capital, our business strategy and operations, drug development and commercialization, our industry, our dependence on third parties, intellectual property, ownership of our common stock, and other risks and uncertainties, both known and unknown, and actual results may differ materially from those contained in the forward-looking statements. Examples of risks and uncertainties that could cause actual results to differ materially from historical performance and any forward-looking statements include, but are not limited to, the risks described under the heading “Risk Factors” on page 10 of this prospectus, in our most recent Annual Report on Form 10-K, and subsequent reports filed with the SEC. Given these risks, uncertainties, and other factors, you should not place undue reliance on these forward-looking statements. Also, these forward-looking statements represent our estimates and assumptions only as of the date such forward-looking statements are made. You should read carefully this prospectus and the information incorporated by reference completely and with the understanding that our actual future results may be materially different from what we expect. We hereby qualify all of our forward-looking statements by these cautionary statements. Except as required by law, we assume no obligation to update these forward-looking statements publicly or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future.

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SUMMARY

This summary is not complete and does not contain all of the information you should consider before investing in the securities offered by this prospectus. You should read this summary together with the entire prospectus, including our financial statements, the notes to those financial statements, and the other documents identified under the headings “Where You Can Find More Information” and “Incorporation of Certain Information by Reference” in this prospectus before making an investment decision. See the Risk Factors section of this prospectus on page 8 for a discussion of the risks involved in investing in our securities.

Overview

Tenax Therapeutics was originally formed as a New Jersey corporation in 1967 under the name Rudmer, David & Associates, Inc., and subsequently changed its name to Synthetic Blood International, Inc. Effective June 30, 2008, we changed the domiciliary state of the corporation to Delaware and changed the Company name to Oxygen Biotherapeutics, Inc. On September 19, 2014, we changed the Company name to Tenax Therapeutics, Inc.

On November 13, 2013, we acquired a license granting Life Newco, our wholly-owned subsidiary, an exclusive, sublicensable right to develop and commercialize pharmaceutical products containing levosimendan, 2.5 mg/ml concentrate for solution for infusion / 5ml vial in the United States and Canada. On October 9, 2020 and January 25, 2022, we entered into amendments to the license to include two product dose forms containing levosimendan, in capsule and solid dosage form, and a subcutaneously administered product containing levosimendan, subject to specified limitations.

On January 15, 2021, we acquired 100% of the equity of PHPrecisionMed Inc., a Delaware corporation, or PHPM, with PHPM surviving as our wholly-owned subsidiary. As a result of the merger, we plan to develop and commercialize pharmaceutical products containing imatinib for the treatment of pulmonary arterial hypertension, or PAH.

The address of the principal executive offices of Tenax Therapeutics is ONE Copley Parkway, Suite 490, Morrisville, North Carolina 27560 and telephone number is (919) 855-2100.

Strategy

Our principal business objective is to identify, develop, and commercialize late-stage pharmaceutical therapeutic products for serious cardiovascular and pulmonary diseases with high unmet medical need. The key elements of our business strategy are outlined below.

·	Efficiently conduct clinical development to establish clinical proof of principle in new indications, refine formulation, and commence Phase 3 testing of our current product candidates.
	Levosimendan and imatinib have been approved and prescribed globally for more than 20 years, but we believe their mechanisms of action have not been fully exploited, despite promising evidence they may significantly improve the lives of patients with pulmonary hypertension. We are conducting clinical development with the intent to establish proof of beneficial activity in cardiopulmonary diseases in which these therapeutics would be expected to have benefit for patients with diseases for which either no pharmaceutical therapies are approved at all, or in the case of PAH, where numerous expensive therapies generally offer a modest reduction of symptoms. Our focus is primarily on designing and executing formulation improvements, protecting these innovations with patents and other forms of exclusivity, and employing innovative clinical trial science to establish a robust foundation for subsequent development, product approval, and commercialization.
·	Efficiently explore new high-potential therapeutic applications, in particular where expedited regulatory pathways are available, leveraging third-party research collaborations and our results from related areas.
	Levosimendan has shown promise in multiple disease areas in its two decades of use following its approval. In order to achieve our objectives of developing these medicines for new groups of patients, we have established collaborative research relationships with investigators from leading research and clinical institutions, and our strategic partners. Additionally, we believe we will be able to leverage clinical safety data and preclinical results from some programs to support accelerated clinical development efforts in other areas, saving substantial development time and resources compared to traditional drug development.

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·	Continue to expand our intellectual property portfolio.
	Our intellectual property, and the confidentiality of all our company information, is important to our business and we take significant steps to protect its value. We have ongoing research and development efforts, both through internal activities and through collaborative research activities with others, which aim to develop new intellectual property and enable us to file patent applications that cover new applications of our existing technologies, alone or in combination with existing therapies, as well as other product candidates.
·	Enter into licensing or product co-development arrangements.
	In addition to our internal development efforts, an important part of our product development strategy is to work with collaborators and partners to accelerate product development, maintain our low development and business operations costs, and broaden our commercialization capabilities globally.

As we focus on the development of our existing product candidates, we also continue to position ourselves to execute upon licensing and other partnering opportunities. To do so, we will need to continue to maintain our strategic direction, manage and deploy our available cash efficiently and strengthen our collaborative research development and partner relationships.

On January 4, 2022, the Company was issued US Pat. No. 11,213,524, entitled PHARMACEUTICAL COMPOSITIONS FOR SUBCUTANEOUS ADMINISTRATION OF LEVOSIMENDAN, which is directed towards the use of levosimendan via subcutaneous administration for treating a subject having a health condition of any kind, such as heart failure, pulmonary hypertension including PH-HFpEF, chronic kidney disease, stroke, or other health conditions. The patent is expected to expire no earlier than 2039, exclusive of any possible extensions. The Company also has a PCT international application pending, with a U.S. counterpart already under examination, that describes and claims methods of treating the Company’s first intended clinical indication, PH-HFpEF, by providing levosimendan by any route of administration.

Recent Developments

Private Placement of Warrants

On May 17, 2022, Tenax entered into a securities purchase agreement (the “Purchase Agreement”) with Armistice Capital Master Fund, Ltd. (the “Investor”) pursuant to which the Company agreed to sell and issue to the Investor 10,596,027 units (“Units”) in a private placement at a purchase price of $0.755 per Unit (the “Private Placement”). Each Unit consisted of one unregistered pre-funded warrant to purchase one share of common stock, par value $0.0001 (collectively the “Pre-Funded Warrants”) and one unregistered warrant to purchase one share of common stock (collectively the “Series E Warrants” and together with the Pre-Funded Warrants, the “Warrants”). In the aggregate, 21,192,054 shares of the Company’s common stock are underlying the Warrants (the “Warrant Shares”). The aggregate gross proceeds to the Company of the Private Placement were approximately $8.0 million.

Each Pre-Funded Warrant has an exercise price of $0.0001 per share of common stock, is immediately exercisable, may be exercised at any time until exercised in full and is subject to customary adjustments. Each Series E Warrant has an exercise price of $0.63 per share of common stock, is immediately exercisable, will expire five and one-half years from the date of issuance and is subject to customary adjustments. The Warrants may not be exercised if the aggregate number of shares of the Company’s common stock beneficially owned by the holder (together with its affiliates) would exceed 9.99% of the Company’s outstanding common stock immediately after exercise. However, the holder may increase (upon 61 days’ prior notice from the holder to the Company) or decrease such percentage, provided that in no event such percentage exceeds 9.99%.

Also on May 17, 2022, and in connection with the Private Placement, the Company entered into a registration rights agreement (the “Registration Rights Agreement”) with the Investor, pursuant to which the Company agreed to register for resale the Warrant Shares within 120 days following the date of the Registration Rights Agreement.

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Under certain circumstances, including, but not limited to, (i) if the registration statement is not filed by the earlier of 45 days after the date of the Registration Rights Agreement (ii) if the registration statement has not been declared effective (A) by the 120th day after the date of the Registration Rights Agreement (or, in the event of a “full review” by the Securities and Exchange Commission (the “SEC”), the 150th day after the date of the Registration Rights Agreement) or (B) within five trading days following the date the Company is notified by the SEC that the registration statement will not be reviewed or is no longer subject to further review and comments then the Company has agreed to pay the Investor, as partial liquidated damages, an amount equal to 1.0% of the Investor’s aggregate subscription amount paid pursuant to the Purchase Agreement.

In connection with the Private Placement, the Company entered into a warrant amendment agreement (the “Warrant Amendment Agreement”) with the Investor pursuant to which the Company agreed to amend certain previously issued warrants held by the Investor, as follows:

i.	the warrants issued on July 8, 2021 to purchase 4,773,269 shares of common stock at an exercise price of $1.97 per share, were amended by reducing the existing exercise price to $0.63 and extending the termination date of the warrant to January 8, 2029;
ii.	the Series B warrants issued on July 8, 2020 to purchase 3,175,924 shares of common stock at an exercise price of $0.903 per share, were amended by extending the termination date of the warrant to January 8, 2028;
iii.	the Series C warrants issued on July 8, 2020 to purchase 4,607,692 shares of common stock at an exercise price of $0.903 per share, were amended by extending the termination date of the warrant to January 8, 2028;
iv.	the warrants issued on March 13, 2020 to purchase 2,360,313 shares of common stock at an exercise price of $1.04 per share, were amended by reducing the existing exercise price to $0.63 and extending the termination date of the warrant to September 15, 2027; and
v.	the Series 2 warrants issued on December 11, 2018 to purchase 2,072,538 shares of common stock at an exercise price of $1.93 per share, were amended by reducing the existing exercise price to $0.63Price and extending the termination date of the warrant to December 11, 2025.

All of the warrants and pre-funded warrants held by the Investor are subject to beneficial ownership limitations (9.99% for all pre-funded warrants and either 4.99% or 9.99%, as set forth in each respective warrant) that prohibit the Investor from exercising any portion of any warrant to the extent that, following such exercise, the Investor’s ownership of the Company’s common stock would exceed the relevant beneficial ownership limitation.  The beneficial ownership limitations, taken as a whole, cap the Investor’s ownership in the Company’s common stock at 9.99% of the Company’s outstanding shares, other than to the extent the Investor were to acquire additional shares on the open market.

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The Offering

This prospectus relates to the resale by the selling stockholder named herein and any additional selling stockholders who will be identified in one or more prospectus supplements of up to 21,192,054 shares of our common stock issuable upon exercise of: (i) the Series E Warrants to purchase 10,596,027 shares of common stock with an exercise price of $0.63 per share that expires on November 19, 2027 and (ii) the Pre-Funded Warrants to purchase 10,596,027 shares of common stock with an exercise price of $0.0001 per share.

Common stock offered by us in this offering:	We are not selling any shares of common stock pursuant to this prospectus.
Common stock offered by selling stockholder:	21,192,054 shares
Common stock outstanding before this offering:(1)	25,206,914 shares
Common stock outstanding after this offering:	46,398,968 shares
Use of proceeds:	We will not receive any proceeds from the sale of our shares of common stock by the selling stockholder, although we will receive proceeds from the exercise price of any Warrants exercised on a cash basis. We intend to use those proceeds, if any, for working capital and general corporate purposes.
Risk factors:	Investing in our common stock involves a high degree of risk. See “Risk Factors” and other information contained in this prospectus or otherwise incorporated by reference before deciding to invest in shares of our common stock.
Nasdaq Capital Market symbol:	Our common stock is listed on the Nasdaq Capital Market under the symbol “TENX”.

(1) Unless otherwise indicated, all references in this prospectus to the number of shares of our common stock to be outstanding after this offering is based on 25,206,914 shares outstanding as of May 19, 2022 and excludes:

· 699,470 shares are reserved for issuance upon exercise of outstanding options issued under the Company’s stock option plans;

· 600,000 shares are reserved for issuance upon exercise of outstanding options issued pursuant to the employment inducement award exemption provided by Nasdaq Listing Rule 5635(c)(4);

· 52,154,095 shares are reserved for issuance upon exercise of outstanding warrants to purchase common stock; and

· 210 shares of convertible preferred stock, convertible into 210 shares of common stock.

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RISK FACTORS

An investment in any securities offered pursuant to this prospectus and any applicable prospectus supplement is speculative and involves a high degree of risk. You should carefully consider the risk factors incorporated by reference from our most recent Annual Report on Form 10-K, and all other information contained or incorporated by reference into this prospectus, as updated by our subsequent filings under the Exchange Act, and the risk factors and other information contained in any applicable prospectus supplement, before acquiring any of such securities. If any of the risks actually occur, our business, results of operations, financial condition, and prospects could be materially adversely affected, the trading price of our common stock could decline significantly, and you might lose all or part of your investment. You should also refer to our financial statements and the notes to those statements, which are incorporated by reference into this prospectus.

Sales of shares of our common stock by the selling stockholder may cause our stock price to decline.

As of May 19, 2022, we had 25,206,914 shares of common stock outstanding. Sales of substantial amounts of our shares of common stock in the public market by the selling stockholder, or the perception that those sales may occur, could cause the market price of shares of our common stock to decline and impair our ability to raise capital through the sale of additional shares of our common stock.

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USE OF PROCEEDS

We will not receive any proceeds from the sale of common stock by the selling stockholder. To the extent we receive proceeds from the exercise of warrants held by the selling stockholder, we will use those proceeds for working capital and other general corporate purposes.

We may receive up to a total of $6,676,566.61 in gross proceeds if all of the Warrants are exercised hereunder for cash. However, as we are unable to predict the timing or amount of potential exercises of the Warrants, we have not allocated any proceeds of such exercises to any particular purpose. Accordingly, all such proceeds are allocated to working capital. Pursuant to conditions set forth in the Warrants, the Warrants are exercisable under certain circumstances on a cashless basis, and should a selling stockholder elect to exercise on a cashless basis we will not receive any proceeds from the sale of common stock issued upon the cashless exercise of the Warrants.

The selling stockholder will pay any underwriting discounts and commissions and expenses they incur for brokerage, accounting, tax, or legal services, or any other expenses they incur in disposing of their shares. We will incur certain expenses in connection with the registration with the SEC of the shares of our common stock to be sold by the selling stockholder.

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SELLING STOCKHOLDER

The common stock being offered by the selling stockholder are those issuable to the selling stockholder upon exercise of the Warrants. For additional information regarding the issuances of those Warrants, see “Summary — Recent Developments — Private Placement of Warrants” above. We are registering the shares of common stock underlying the Warrants in order to permit the selling stockholder to offer such shares for resale from time to time.

Except as described herein, the selling stockholder has not had any material relationship with us within the past three years. Armistice Capital, LLC (“Armistice”) is a significant indirect beneficial owner of the Company’s equity securities, which securities are directly held by the selling stockholder named herein, Armistice Capital Master Fund Ltd. (the “Master Fund”). In the last three years, Master Fund has participated in offerings of the Company’s securities, as described under “Summary — Recent Developments — Private Placement of Warrants” in this prospectus, as well as (i) in July 2021, the Company issued and sold to Master Fund 4,773,269 units, each unit consisting of one unregistered pre-funded warrant to purchase one share of common stock and one unregistered warrant to purchase one share of common stock, in a private placement at a purchase price of $2.095 per unit, for an aggregate purchase price of approximately $10.0 million; (ii) in July 2020, the Company issued and sold to the Master Fund an aggregate of 2,523,622 shares of common stock, 5,260,005 pre-funded warrants to purchase one share of common stock and 7,783,616 warrants to purchase one share of common stock, for an aggregate purchase price of approximately $8.0 million; and (iii) in March 2020, the Company issued and sold to the Master Fund an aggregate of 750,000 shares of common stock, 1,610,313 pre-funded warrants to purchase one share of common stock and 2,360,313 warrants to purchase one share of common stock, for an aggregate purchase price of approximately $2.75 million. Additionally, Keith Maher is a managing director of Armistice and a member of the Company’s board of directors and Steven Boyd is the managing member of Armistice, a director of the Master Fund, and a member of the Company’s board, and may be deemed to have indirect beneficial ownership of the Company’s equity securities that are directly held by the Master Fund.

The table below lists the selling stockholder and other information regarding the beneficial ownership of the shares of common stock by the selling stockholder. The second column lists the number of shares of common stock beneficially owned by the selling stockholder, based on its ownership of the shares of common stock, warrants and pre-funded warrants, as of May 19, 2022, assuming exercise of the warrants and pre-funded warrants held by the selling stockholder on that date, without regard to any beneficial ownership limitations on exercises (such beneficial ownership limitations are described further below).

The third column lists the shares of common stock being offered by this prospectus by the selling stockholder.

In accordance with the terms of the Registration Rights Agreement with the selling stockholder, this prospectus generally covers the resale of the maximum number of shares of common stock issuable upon exercise of the Warrants, determined as if the Warrants were exercised in full as of the trading day immediately preceding the date this registration statement was initially filed with the SEC, each as of the trading day immediately preceding the applicable date of determination and all subject to adjustment as provided in the Registration Rights Agreement, without regard to any limitations on the exercise of the Warrants. The fourth and fifth columns assume the sale of all of the shares offered by the selling stockholder pursuant to this prospectus, and assume the exercise of the warrants and pre-funded warrants held by the selling stockholder on that date, without regard to any beneficial ownership limitations on exercises (such beneficial ownership limitations are described further below).

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Under the terms of the Warrants, the selling stockholder may not exercise the Warrants to the extent such exercise would cause such selling stockholder, together with its affiliates and attribution parties, to beneficially own a number of shares of common stock which would exceed 9.99% of our then-outstanding common stock following such exercise, excluding for purposes of such determination shares of common stock issuable upon exercise of the Warrants which have not been exercised. The numbers of shares in the columns below do not reflect this limitation. The selling stockholder may sell all, some or none of its shares in this offering. See “Plan of Distribution”.

Additionally, all of the other warrants and pre-funded warrants held by the Master Fund are also subject to beneficial ownership limitations (9.99% for all pre-funded warrants and either 4.99% or 9.99%, as set forth in each respective warrant) that prohibit the Master Fund from exercising any portion of any warrant to the extent that, following such exercise, the Master Fund’s ownership of the Company’s common stock would exceed the relevant beneficial ownership limitation.  The beneficial ownership limitations, taken as a whole, cap the Master Fund’s ownership in the Company’s common stock at 9.99% of the Company’s outstanding shares, other than to the extent the Master Fund were to acquire additional shares on the open market.

Name of Selling Security Holder	Number of shares of Common Stock Beneficially Owned Prior to Closing		Maximum Number of Shares of Common Stock to be Sold Pursuant to this Prospectus		Number of Shares of Common Stock Owned After Offering		Percentage of Common Stock Beneficially Owned After Offering (1)
Armistice Capital Master Fund, Ltd. (2)		50,235,059		21,192,054		29,043,005		39.56	%

(1)

Based upon 25,206,914 shares of common stock outstanding on May 19, 2022. The number and percentage of shares beneficially owned is determined in accordance with Rule 13d-3 of the Exchange Act and the information is not necessarily indicative of beneficial ownership for any other purpose. Under such rule, beneficial ownership includes any shares as to which the person has sole or shared voting power or investment power and also any shares that the person has the right to acquire within 60 days of May 19, 2022 through the exercise of any stock options, warrants or other rights or the conversion of preferred stock. Any shares that a person has the right to acquire within 60 days are deemed to be outstanding for the purpose of computing the percentage ownership of such person but are not deemed outstanding for the purpose of computing the percentage ownership of any other person.

(2)

Master Fund and Steven Boyd share voting and dispositive power over 2,019,995 shares, 20,629,301 shares exercisable under pre-funded warrants and 27,585,763 shares issuable upon the exercise of warrants. Steven Boyd disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. All of the warrants and pre-funded warrants held by the Master Fund are subject to beneficial ownership limitations (9.99% for all pre-funded warrants and either 4.99% or 9.99%, as set forth in each respective warrant) that prohibit the Master Fund from exercising any portion of any warrant to the extent that, following such exercise, the Master Fund’s ownership of the Company’s common stock would exceed the relevant beneficial ownership limitation.  The beneficial ownership limitations, taken as a whole, cap the Master Fund’s ownership in the Company’s common stock at 9.99% of the Company’s outstanding shares, other than to the extent the Master Fund were to acquire additional shares on the open market. Consequently, the selling stockholder is not able to exercise all of its warrants and pre-funded warrants due to the aforementioned beneficial ownership limitations, which are not reflected in the table above.

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PLAN OF DISTRIBUTION

The selling stockholder of the securities and any of its pledgees, assignees and successors-in-interest (the “selling stockholders”) may, from time to time, sell any or all of their securities covered hereby on The Nasdaq Stock Market LLC or any other stock exchange, market or trading facility on which the securities are traded or in private transactions. These sales may be at fixed or negotiated prices. A selling stockholder may use any one or more of the following methods when selling securities:

· ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;

· block trades in which the broker-dealer will attempt to sell the securities as agent but may position and resell a portion of the block as principal to facilitate the transaction;

· purchases by a broker-dealer as principal and resale by the broker-dealer for its account;

· an exchange distribution in accordance with the rules of the applicable exchange;

· privately negotiated transactions;

· settlement of short sales;

· in transactions through broker-dealers that agree with the selling stockholders to sell a specified number of such securities at a stipulated price per security;

· through the writing or settlement of options or other hedging transactions, whether through an options exchange or otherwise;

· a combination of any such methods of sale; or

· any other method permitted pursuant to applicable law.

The selling stockholders may also sell securities under Rule 144 or any other exemption from registration under the Securities Act, if available, rather than under this prospectus.

Broker-dealers engaged by the selling stockholders may arrange for other brokers-dealers to participate in sales. Broker-dealers may receive commissions or discounts from the selling stockholders (or, if any broker-dealer acts as agent for the purchaser of securities, from the purchaser) in amounts to be negotiated, but, except as set forth in a supplement to this prospectus, in the case of an agency transaction not in excess of a customary brokerage commission in compliance with FINRA Rule 2121; and in the case of a principal transaction a markup or markdown in compliance with FINRA Rule 2121.

In connection with the sale of the securities or interests therein, the selling stockholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the securities in the course of hedging the positions they assume. The selling stockholders may also sell securities short and deliver these securities to close out their short positions, or loan or pledge the securities to broker-dealers that in turn may sell these securities. The selling stockholders may also enter into option or other transactions with broker-dealers or other financial institutions or create one or more derivative securities which require the delivery to such broker-dealer or other financial institution of securities offered by this prospectus, which securities such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction).

The selling stockholders and any broker-dealers or agents that are involved in selling the securities may be deemed to be “underwriters” within the meaning of the Securities Act in connection with such sales. In such event, any commissions received by such broker-dealers or agents and any profit on the resale of the securities purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. Each selling stockholder has informed us that it does not have any written or oral agreement or understanding, directly or indirectly, with any person to distribute the securities.

We are required to pay certain fees and expenses incurred by us incident to the registration of the securities. We have agreed to indemnify the selling stockholders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act.

We agreed to keep this prospectus effective until the earlier of (i) the date on which the securities may be resold by the selling stockholders without registration and without regard to any volume or manner-of-sale limitations by reason of Rule 144, without the requirement for the Company to be in compliance with the current public information requirement under Rule 144 under the Securities Act or any other rule of similar effect or (ii) all of the securities have been sold pursuant to this prospectus or Rule 144 under the Securities Act or any other rule of similar effect. The resale securities will be sold only through registered or licensed brokers or dealers if required under applicable state securities laws. In addition, in certain states, the resale securities covered hereby may not be sold unless they have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement is available and is complied with.

                Under applicable rules and regulations under the Exchange Act, any person engaged in the distribution of the resale securities may not simultaneously engage in market making activities with respect to the common stock for the applicable restricted period, as defined in Regulation M, prior to the commencement of the distribution. In addition, the selling stockholders will be subject to applicable provisions of the Exchange Act and the rules and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of the common stock by the selling stockholders or any other person. We will make copies of this prospectus available to the selling stockholders and have informed them of the need to deliver a copy of this prospectus to each purchaser at or prior to the time of the sale (including by compliance with Rule 172 under the Securities Act).

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LEGAL MATTERS

The validity of our securities issuable hereunder and certain other legal matters have been passed upon for us by Wyrick Robbins Yates & Ponton LLP, Raleigh, North Carolina.

EXPERTS

The consolidated financial statements of Tenax Therapeutics, Inc. and Subsidiaries as of December 31, 2021 and 2020, and for each of the years in the two-year period ended December 31, 2021, included in our Annual Report on Form 10-K, have been incorporated by reference herein in reliance upon the report of Cherry Bekaert LLP, independent registered public accounting firm, incorporated by reference herein, and upon the authority of said firm as experts in accounting in auditing. The report contains an explanatory paragraph regarding our ability to continue as a going concern.

WHERE YOU CAN FIND ADDITIONAL INFORMATION

We file annual reports, quarterly reports, current reports, and proxy and information statements and other information with the SEC. Copies of reports and other information from us are available on the SEC’s website at http://www.sec.gov. Such filings are also available at our website at http://www.tenaxthera.com. Our website and the information contained therein or connected thereto are not part of this prospectus.

INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

The SEC allows us to “incorporate by reference” in this prospectus the information we file with the SEC, which means that we can disclose important information to you by referring you to those documents. The following documents filed with the SEC are hereby incorporated by reference in this prospectus:

· our Annual Report on Form 10-K for the year ended December 31, 2021, filed with the SEC on March 29, 2022;

· the information specifically incorporated by reference into our Annual Report on Form 10-K from our Definitive Proxy Statement on Schedule 14A, filed with the SEC on April 28, 2022;

· our Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2022, filed with the SEC on May 16, 2022;

· our Current Reports on Form 8-K filed with the SEC on January 5, 2022, January 12, 2022, January 24, 2022, January 28, 2022, January 31, 2022, February 18, 2022, March 24, 2022, May 20, 2022, May 23, 2022; and

· the description of our common stock contained in Exhibit 4.14 to our Annual Report on Form 10-K for the year ended December 31, 2021, filed with the SEC on March 29, 2022, including any amendments or reports filed for the purpose of updating such description.

In addition, all documents we subsequently filed pursuant to Sections 13(a), 13(c), 14, and 15(d) of the Exchange Act, including prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold and also between the date of the registration statement that contains this prospectus and prior to effectiveness of such registration statement, shall be deemed to be incorporated by reference in this prospectus and to be a part hereof from the date of filing of such documents. However, any documents or portions thereof, whether specifically listed above or filed in the future, that are not deemed “filed” with the SEC, including without limitation any information furnished pursuant to Item 2.02 or 7.01 of Form 8-K or certain exhibits furnished pursuant to Item 9.01 of Form 8-K, shall not be deemed to be incorporated by reference in this prospectus.

Any statement contained herein or in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained herein or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus.

We will furnish without charge to you, upon written or oral request, a copy of any or all of the documents incorporated by reference herein, other than exhibits to such documents that are not specifically incorporated by reference therein. All requests should be sent to our Corporate Secretary by e-mail at Secretary@tenaxthera.com, by mail addressed to Tenax Therapeutics, Inc., Attn: Corporate Secretary, ONE Copley Parkway, Suite 490, Morrisville, North Carolina 27560, or by telephone at (919) 855-2100.

Copies of the documents incorporated by reference may also be found on our website at http://www.tenaxthera.com.

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21,192,054 Shares of Common Stock

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PROSPECTUS

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