Common Stocks - 99.5%
|
|||
Shares
|
Value ($)
|
||
Biotechnology - 22.4%
|
|||
Biotechnology - 22.4%
|
|||
Acelyrin, Inc.
|
180,373
|
743,137
|
|
Alnylam Pharmaceuticals, Inc. (a)
|
14,671
|
2,177,617
|
|
Annexon, Inc. (a)
|
291,889
|
1,409,824
|
|
Arcellx, Inc. (a)
|
41,100
|
2,137,200
|
|
Arcus Biosciences, Inc. (a)
|
318,000
|
4,792,260
|
|
ArriVent Biopharma, Inc.
|
151,600
|
2,942,556
|
|
Ascendis Pharma A/S sponsored ADR (a)
|
36,100
|
4,877,110
|
|
Avidity Biosciences, Inc. (a)
|
641,700
|
17,236,062
|
|
Beam Therapeutics, Inc. (a)
|
177,800
|
4,235,196
|
|
Biogen, Inc. (a)
|
77,100
|
17,342,874
|
|
bluebird bio, Inc. (a)(b)
|
2,226,000
|
2,010,968
|
|
Blueprint Medicines Corp. (a)
|
244,600
|
25,819,976
|
|
CRISPR Therapeutics AG (a)(b)
|
53,000
|
2,848,220
|
|
Cytokinetics, Inc. (a)
|
23,100
|
1,120,581
|
|
Dyne Therapeutics, Inc. (a)
|
984,300
|
31,379,484
|
|
Galapagos NV sponsored ADR (a)
|
36,900
|
1,026,558
|
|
Generation Bio Co. (a)(b)
|
715,276
|
2,274,578
|
|
Gilead Sciences, Inc.
|
607,800
|
39,063,306
|
|
Insmed, Inc. (a)
|
200,000
|
11,010,000
|
|
Intellia Therapeutics, Inc. (a)
|
133,200
|
2,847,816
|
|
Leap Therapeutics, Inc. warrants 1/31/26 (a)
|
60,600
|
70
|
|
Legend Biotech Corp. ADR (a)
|
877,500
|
35,108,775
|
|
Merus BV (a)
|
108,000
|
5,749,920
|
|
Moderna, Inc. (a)
|
350,100
|
49,906,755
|
|
Monte Rosa Therapeutics, Inc. (a)
|
796,400
|
3,281,168
|
|
NewAmsterdam Pharma Co. NV (a)(b)
|
243,700
|
4,569,375
|
|
Prothena Corp. PLC (a)
|
75,800
|
1,577,398
|
|
PTC Therapeutics, Inc. (a)
|
260,900
|
9,486,324
|
|
Sarepta Therapeutics, Inc. (a)
|
244,500
|
31,750,770
|
|
Spyre Therapeutics, Inc. (a)
|
148,742
|
5,198,533
|
|
Xenon Pharmaceuticals, Inc. (a)
|
226,000
|
8,603,820
|
|
332,528,231
|
|||
Consumer Staples Distribution & Retail - 0.0%
|
|||
Drug Retail - 0.0%
|
|||
MedAvail Holdings, Inc. (a)
|
66
|
0
|
|
Health Care Equipment & Supplies - 1.5%
|
|||
Health Care Equipment - 1.5%
|
|||
Inspire Medical Systems, Inc. (a)
|
39,600
|
6,288,084
|
|
Ion Beam Applications SA (b)
|
350,600
|
5,498,495
|
|
Nyxoah SA (a)(b)
|
298,200
|
2,783,538
|
|
Nyxoah SA (a)
|
140,500
|
1,322,105
|
|
Pulmonx Corp. (a)
|
864,000
|
6,264,000
|
|
22,156,222
|
|||
Health Care Providers & Services - 0.4%
|
|||
Health Care Services - 0.4%
|
|||
agilon health, Inc. (a)
|
875,942
|
5,518,435
|
|
Life Sciences Tools & Services - 1.4%
|
|||
Life Sciences Tools & Services - 1.4%
|
|||
Gerresheimer AG
|
177,200
|
20,298,506
|
|
Pharmaceuticals - 73.8%
|
|||
Pharmaceuticals - 73.8%
|
|||
Agomab Therapeutics SA warrants 10/10/33 (a)(c)(d)
|
10
|
0
|
|
Arvinas Holding Co. LLC (a)
|
26,300
|
871,582
|
|
AstraZeneca PLC sponsored ADR
|
1,712,100
|
133,578,042
|
|
Axsome Therapeutics, Inc. (a)
|
58,400
|
4,288,312
|
|
Bristol-Myers Squibb Co.
|
744,500
|
30,591,505
|
|
Catalent, Inc. (a)
|
228,900
|
12,312,531
|
|
Edgewise Therapeutics, Inc. (a)
|
436,300
|
7,473,819
|
|
Elanco Animal Health, Inc. (a)
|
773,000
|
13,666,640
|
|
Eli Lilly & Co.
|
429,661
|
352,468,107
|
|
Fulcrum Therapeutics, Inc. (a)(b)
|
683,600
|
5,366,260
|
|
Galderma Group AG
|
92,240
|
7,527,253
|
|
GSK PLC sponsored ADR
|
1,595,860
|
71,446,652
|
|
Harmony Biosciences Holdings, Inc. (a)(b)
|
130,677
|
3,841,904
|
|
Indivior PLC (a)
|
320,600
|
5,936,451
|
|
Merck & Co., Inc.
|
557,136
|
69,942,853
|
|
Merck KGaA
|
146,300
|
26,590,050
|
|
Novo Nordisk A/S Series B sponsored ADR
|
1,603,900
|
216,975,592
|
|
Royalty Pharma PLC
|
1,192,000
|
32,672,720
|
|
Sandoz Group AG ADR (b)
|
4,979
|
176,705
|
|
Structure Therapeutics, Inc. ADR (a)
|
54,000
|
1,846,800
|
|
UCB SA
|
474,700
|
66,586,533
|
|
Zoetis, Inc. Class A
|
172,100
|
29,181,276
|
|
1,093,341,587
|
|||
TOTAL COMMON STOCKS
(Cost $1,006,403,666)
|
1,473,842,981
|
||
Convertible Preferred Stocks - 0.4%
|
|||
Shares
|
Value ($)
|
||
Biotechnology - 0.1%
|
|||
Biotechnology - 0.1%
|
|||
Castle Creek Biosciences, Inc.:
|
|||
Series C (a)(c)(d)
|
200
|
46,456
|
|
Series D1 (a)(c)(d)
|
6,308
|
1,326,888
|
|
Series D2 (a)(c)(d)
|
85
|
15,910
|
|
1,389,254
|
|||
Financial Services - 0.1%
|
|||
Diversified Financial Services - 0.1%
|
|||
Paragon Biosciences Emalex Capital, Inc.:
|
|||
Series C (a)(c)(d)
|
158,879
|
1,881,127
|
|
Series D1 (a)(c)(d)
|
14,400
|
171,072
|
|
Series D2 (a)(c)(d)
|
22,477
|
253,765
|
|
2,305,964
|
|||
Pharmaceuticals - 0.1%
|
|||
Pharmaceuticals - 0.1%
|
|||
Agomab Therapeutics SA Series C (c)(d)
|
7,729
|
1,928,609
|
|
Software - 0.1%
|
|||
Systems Software - 0.1%
|
|||
Evozyne, Inc.:
|
|||
Series A (a)(c)(d)
|
5,900
|
98,412
|
|
Series B (c)(d)
|
56,643
|
959,532
|
|
1,057,944
|
|||
TOTAL CONVERTIBLE PREFERRED STOCKS
(Cost $6,200,752)
|
6,681,771
|
||
Convertible Bonds - 0.1%
|
|||
Principal
Amount (e)
|
Value ($)
|
||
Software - 0.1%
|
|||
Systems Software - 0.1%
|
|||
Evozyne, Inc. 6% 9/13/28 pay-in-kind (c)(d)
(Cost $907,225)
|
907,225
|
980,710
|
|
Money Market Funds - 0.8%
|
|||
Shares
|
Value ($)
|
||
Fidelity Cash Central Fund 5.39% (f)
|
2,616,442
|
2,616,965
|
|
Fidelity Securities Lending Cash Central Fund 5.39% (f)(g)
|
9,789,968
|
9,790,947
|
|
TOTAL MONEY MARKET FUNDS
(Cost $12,407,912)
|
12,407,912
|
||
TOTAL INVESTMENT IN SECURITIES - 100.8%
(Cost $1,025,919,555)
|
1,493,913,374
|
NET OTHER ASSETS (LIABILITIES) - (0.8)%
|
(12,561,475)
|
NET ASSETS - 100.0%
|
1,481,351,899
|
(a)
|
Non-income producing
|
(b)
|
Security or a portion of the security is on loan at period end.
|
(c)
|
Restricted securities (including private placements) - Investment in securities not registered under the Securities Act of 1933 (excluding 144A issues). At the end of the period, the value of restricted securities (excluding 144A issues) amounted to $7,662,481 or 0.5% of net assets.
|
(d)
|
Level 3 security
|
(e)
|
Amount is stated in United States dollars unless otherwise noted.
|
(f)
|
Affiliated fund that is generally available only to investment companies and other accounts managed by Fidelity Investments. The rate quoted is the annualized seven-day yield of the fund at period end. A complete unaudited listing of the fund's holdings as of its most recent quarter end is available upon request. In addition, each Fidelity Central Fund's financial statements are available on the SEC's website or upon request.
|
(g)
|
Investment made with cash collateral received from securities on loan.
|
Additional information on each restricted holding is as follows:
|
||
Security
|
Acquisition Date
|
Acquisition Cost ($)
|
Agomab Therapeutics SA warrants 10/10/33
|
10/03/23
|
0
|
Agomab Therapeutics SA Series C
|
10/03/23
|
1,687,596
|
Castle Creek Biosciences, Inc. Series C
|
12/09/19
|
82,370
|
Castle Creek Biosciences, Inc. Series D1
|
4/19/22
|
1,356,409
|
Castle Creek Biosciences, Inc. Series D2
|
6/28/21
|
14,700
|
Evozyne, Inc. Series A
|
4/09/21
|
132,573
|
Evozyne, Inc. Series B
|
9/14/23
|
877,400
|
Evozyne, Inc. 6% 9/13/28 pay-in-kind
|
9/14/23 - 3/13/24
|
907,225
|
Paragon Biosciences Emalex Capital, Inc. Series C
|
2/26/21
|
1,700,005
|
Paragon Biosciences Emalex Capital, Inc. Series D1
|
10/21/22
|
155,952
|
Paragon Biosciences Emalex Capital, Inc. Series D2
|
5/18/22
|
193,747
|
Affiliate
|
Value,
beginning
of period ($)
|
Purchases ($)
|
Sales
Proceeds ($)
|
Dividend
Income ($)
|
Realized
Gain (loss) ($)
|
Change in
Unrealized
appreciation
(depreciation) ($)
|
Value,
end
of period ($)
|
% ownership,
end
of period
|
Fidelity Cash Central Fund 5.39%
|
14,130,101
|
180,001,889
|
191,515,410
|
282,426
|
385
|
-
|
2,616,965
|
0.0%
|
Fidelity Securities Lending Cash Central Fund 5.39%
|
43,199,783
|
51,045,374
|
84,454,210
|
187,261
|
-
|
-
|
9,790,947
|
0.0%
|
Total
|
57,329,884
|
231,047,263
|
275,969,620
|
469,687
|
385
|
-
|
12,407,912
|
|