Common Stocks - 97.7%
|
|||
Shares
|
Value ($)
|
||
Biotechnology - 18.4%
|
|||
Biotechnology - 18.4%
|
|||
Acelyrin, Inc. (a)(b)
|
800,000
|
14,480,000
|
|
Akero Therapeutics, Inc. (a)
|
1,000,000
|
44,580,000
|
|
Alnylam Pharmaceuticals, Inc. (a)
|
130,000
|
24,051,300
|
|
Ambrx Biopharma, Inc. ADR (a)
|
354,700
|
5,235,372
|
|
Apellis Pharmaceuticals, Inc. (a)
|
520,000
|
44,642,000
|
|
Arcellx, Inc. (a)
|
500,000
|
22,075,000
|
|
Arcus Biosciences, Inc. (a)
|
430,148
|
8,835,240
|
|
Arcutis Biotherapeutics, Inc. (a)
|
1,100,000
|
8,261,000
|
|
Argenx SE ADR (a)
|
465,000
|
180,745,500
|
|
Ascendis Pharma A/S sponsored ADR (a)
|
900,000
|
78,273,000
|
|
Avidity Biosciences, Inc. (a)
|
500,000
|
5,310,000
|
|
Beam Therapeutics, Inc. (a)(b)
|
400,000
|
12,760,000
|
|
Blueprint Medicines Corp. (a)
|
670,000
|
37,868,400
|
|
Caris Life Sciences, Inc. (c)(d)
|
1,420,479
|
7,954,682
|
|
Celldex Therapeutics, Inc. (a)
|
800,000
|
25,440,000
|
|
Cerevel Therapeutics Holdings (a)
|
1,370,364
|
44,673,866
|
|
Cytokinetics, Inc. (a)
|
1,500,000
|
56,535,000
|
|
Generation Bio Co. (a)
|
509,353
|
1,782,736
|
|
Janux Therapeutics, Inc. (a)
|
500,000
|
5,810,000
|
|
Karuna Therapeutics, Inc. (a)
|
284,951
|
64,555,649
|
|
Keros Therapeutics, Inc. (a)
|
540,000
|
25,844,400
|
|
Legend Biotech Corp. ADR (a)
|
1,700,000
|
109,089,000
|
|
Morphic Holding, Inc. (a)
|
400,000
|
23,000,000
|
|
Nuvalent, Inc. Class A (a)
|
600,000
|
25,260,000
|
|
Poseida Therapeutics, Inc. (a)
|
1,927,613
|
4,375,682
|
|
PTC Therapeutics, Inc. (a)
|
580,000
|
24,342,600
|
|
Regeneron Pharmaceuticals, Inc. (a)
|
350,000
|
257,446,000
|
|
Relay Therapeutics, Inc. (a)
|
86,286
|
961,226
|
|
Repligen Corp. (a)
|
520,000
|
87,318,400
|
|
Sarepta Therapeutics, Inc. (a)
|
250,000
|
30,900,000
|
|
Shattuck Labs, Inc. (a)
|
1,162,800
|
3,034,908
|
|
uniQure B.V. (a)
|
670,000
|
12,924,300
|
|
Vaxcyte, Inc. (a)
|
1,280,000
|
63,385,600
|
|
Vertex Pharmaceuticals, Inc. (a)
|
150,000
|
48,535,500
|
|
Xencor, Inc. (a)
|
1,400,000
|
37,940,000
|
|
Xenon Pharmaceuticals, Inc. (a)
|
800,000
|
30,824,000
|
|
Zai Lab Ltd. (a)(e)
|
5,000,000
|
16,325,788
|
|
Zentalis Pharmaceuticals, Inc. (a)
|
1,280,000
|
33,331,200
|
|
1,528,707,349
|
|||
Health Care Equipment & Supplies - 21.3%
|
|||
Health Care Equipment - 21.3%
|
|||
Boston Scientific Corp. (a)
|
10,850,000
|
558,558,000
|
|
Insulet Corp. (a)
|
660,000
|
181,005,000
|
|
Intuitive Surgical, Inc. (a)
|
210,000
|
64,646,400
|
|
iRhythm Technologies, Inc. (a)
|
440,000
|
50,278,800
|
|
Masimo Corp. (a)
|
1,430,000
|
231,431,200
|
|
Nevro Corp. (a)
|
600,000
|
16,536,000
|
|
Novocure Ltd. (a)
|
500,000
|
35,905,000
|
|
Outset Medical, Inc. (a)
|
1,000,000
|
20,830,000
|
|
Penumbra, Inc. (a)
|
1,180,000
|
362,661,200
|
|
PROCEPT BioRobotics Corp. (a)
|
600,000
|
20,070,000
|
|
ResMed, Inc.
|
580,000
|
122,258,200
|
|
Stryker Corp.
|
300,000
|
82,674,000
|
|
Tandem Diabetes Care, Inc. (a)
|
850,000
|
22,091,500
|
|
1,768,945,300
|
|||
Health Care Providers & Services - 25.9%
|
|||
Health Care Facilities - 2.6%
|
|||
Acadia Healthcare Co., Inc. (a)
|
1,000,000
|
70,630,000
|
|
Surgery Partners, Inc. (a)
|
3,858,785
|
144,627,262
|
|
The Oncology Institute, Inc. (a)
|
1,699,893
|
726,704
|
|
215,983,966
|
|||
Health Care Services - 6.9%
|
|||
agilon health, Inc. (a)(b)
|
10,203,500
|
202,845,580
|
|
Cigna Group
|
828,000
|
204,855,480
|
|
CVS Health Corp.
|
800,000
|
54,424,000
|
|
LifeStance Health Group, Inc. (a)
|
4,800,000
|
39,312,000
|
|
Privia Health Group, Inc. (a)
|
2,800,000
|
69,860,000
|
|
571,297,060
|
|||
Managed Health Care - 16.4%
|
|||
Alignment Healthcare, Inc. (a)
|
3,800,000
|
22,306,000
|
|
Centene Corp. (a)
|
3,350,000
|
209,073,500
|
|
Humana, Inc.
|
490,000
|
245,916,300
|
|
Molina Healthcare, Inc. (a)
|
145,000
|
39,715,500
|
|
UnitedHealth Group, Inc.
|
1,730,000
|
842,925,199
|
|
1,359,936,499
|
|||
TOTAL HEALTH CARE PROVIDERS & SERVICES
|
2,147,217,525
|
||
Health Care Technology - 1.9%
|
|||
Health Care Technology - 1.9%
|
|||
Doximity, Inc. (a)(b)
|
690,000
|
21,162,300
|
|
Evolent Health, Inc. (a)
|
841,400
|
24,518,396
|
|
Evolent Health, Inc. (c)
|
1,178,600
|
32,627,184
|
|
Medlive Technology Co. Ltd. (f)
|
970,500
|
853,941
|
|
Phreesia, Inc. (a)
|
1,080,000
|
32,421,600
|
|
Veeva Systems, Inc. Class A (a)
|
260,000
|
43,082,000
|
|
154,665,421
|
|||
Life Sciences Tools & Services - 15.9%
|
|||
Life Sciences Tools & Services - 15.9%
|
|||
10X Genomics, Inc. (a)
|
1,000,000
|
52,460,000
|
|
10X Genomics, Inc. Class B (a)(f)
|
500,000
|
26,230,000
|
|
Bruker Corp.
|
1,120,000
|
77,392,000
|
|
Danaher Corp.
|
2,080,000
|
477,609,600
|
|
IQVIA Holdings, Inc. (a)
|
585,000
|
115,192,350
|
|
Lonza Group AG
|
69,000
|
43,138,732
|
|
Olink Holding AB ADR (a)
|
1,159,712
|
22,591,190
|
|
Sartorius Stedim Biotech
|
170,000
|
44,628,713
|
|
Thermo Fisher Scientific, Inc.
|
775,000
|
394,056,500
|
|
West Pharmaceutical Services, Inc.
|
190,000
|
63,579,700
|
|
1,316,878,785
|
|||
Personal Care Products - 0.2%
|
|||
Personal Care Products - 0.2%
|
|||
The Beauty Health Co. (a)(b)
|
482,705
|
3,880,948
|
|
The Beauty Health Co. (a)(c)
|
1,800,000
|
14,472,000
|
|
18,352,948
|
|||
Pharmaceuticals - 14.1%
|
|||
Pharmaceuticals - 14.1%
|
|||
Arvinas Holding Co. LLC (a)
|
690,000
|
15,062,700
|
|
AstraZeneca PLC (United Kingdom)
|
1,500,000
|
218,475,937
|
|
Eli Lilly & Co.
|
1,050,000
|
450,933,000
|
|
Enliven Therapeutics, Inc. (a)(b)
|
400,000
|
7,320,000
|
|
Merck & Co., Inc.
|
1,450,000
|
160,094,500
|
|
Novo Nordisk A/S Series B
|
535,000
|
86,098,107
|
|
Pharvaris BV (a)
|
620,000
|
5,301,000
|
|
Royalty Pharma PLC
|
4,200,000
|
137,508,000
|
|
UCB SA
|
600,000
|
52,282,037
|
|
Ventyx Biosciences, Inc. (a)
|
800,400
|
27,589,788
|
|
Verona Pharma PLC ADR (a)
|
600,000
|
12,912,000
|
|
1,173,577,069
|
|||
TOTAL COMMON STOCKS
(Cost $5,527,243,691)
|
8,108,344,397
|
||
Preferred Stocks - 1.3%
|
|||
Shares
|
Value ($)
|
||
Convertible Preferred Stocks - 1.2%
|
|||
Biotechnology - 0.7%
|
|||
Biotechnology - 0.7%
|
|||
Asimov, Inc. Series B (a)(c)(d)
|
101,438
|
4,908,585
|
|
Caris Life Sciences, Inc. Series D (a)(c)(d)
|
3,206,021
|
17,953,718
|
|
Cleerly, Inc. Series C (c)(d)
|
1,285,367
|
15,013,087
|
|
Element Biosciences, Inc. Series C (a)(c)(d)
|
572,265
|
9,413,759
|
|
ElevateBio LLC Series C (a)(c)(d)
|
254,900
|
1,070,580
|
|
Inscripta, Inc. Series E (a)(c)(d)
|
1,282,228
|
5,423,824
|
|
53,783,553
|
|||
Financial Services - 0.1%
|
|||
Specialized Finance - 0.1%
|
|||
Saluda Medical, Inc. Series E (c)(d)
|
1,155,359
|
9,312,194
|
|
Health Care Providers & Services - 0.0%
|
|||
Health Care Services - 0.0%
|
|||
dMed Biopharmaceutical Co. Ltd. Series C (a)(c)(d)
|
380,451
|
3,374,600
|
|
Health Care Technology - 0.3%
|
|||
Health Care Technology - 0.3%
|
|||
Aledade, Inc.:
|
|||
Series B1(a)(c)(d)
|
201,220
|
10,085,146
|
|
Series E1(c)(d)
|
56,664
|
2,840,000
|
|
Omada Health, Inc. Series E (a)(c)(d)
|
2,153,073
|
6,975,957
|
|
Wugen, Inc. Series B (a)(c)(d)
|
454,342
|
2,271,710
|
|
22,172,813
|
|||
Pharmaceuticals - 0.1%
|
|||
Pharmaceuticals - 0.1%
|
|||
Aristea Therapeutics, Inc. Series B (a)(c)(d)
|
1,037,400
|
5,716,074
|
|
Galvanize Therapeutics Series B (a)(c)(d)
|
3,696,429
|
6,246,965
|
|
11,963,039
|
|||
TOTAL CONVERTIBLE PREFERRED STOCKS
|
100,606,199
|
||
Nonconvertible Preferred Stocks - 0.1%
|
|||
Financial Services - 0.1%
|
|||
Diversified Financial Services - 0.1%
|
|||
Thriveworks TopCo LLC Series B (a)(c)(d)(g)
|
473,270
|
7,099,050
|
|
TOTAL PREFERRED STOCKS
(Cost $142,088,836)
|
107,705,249
|
||
Money Market Funds - 2.2%
|
|||
Shares
|
Value ($)
|
||
Fidelity Cash Central Fund 5.14% (h)
|
85,162,186
|
85,179,218
|
|
Fidelity Securities Lending Cash Central Fund 5.14% (h)(i)
|
95,501,533
|
95,511,083
|
|
TOTAL MONEY MARKET FUNDS
(Cost $180,688,551)
|
180,690,301
|
||
TOTAL INVESTMENT IN SECURITIES - 101.2%
(Cost $5,850,021,078)
|
8,396,739,947
|
NET OTHER ASSETS (LIABILITIES) - (1.2)%
|
(103,173,852)
|
NET ASSETS - 100.0%
|
8,293,566,095
|
(a)
|
Non-income producing
|
(b)
|
Security or a portion of the security is on loan at period end.
|
(c)
|
Restricted securities (including private placements) - Investment in securities not registered under the Securities Act of 1933 (excluding 144A issues). At the end of the period, the value of restricted securities (excluding 144A issues) amounted to $162,759,115 or 2.0% of net assets.
|
(d)
|
Level 3 security
|
(e)
|
Affiliated company
|
(f)
|
Security exempt from registration under Rule 144A of the Securities Act of 1933. These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers. At the end of the period, the value of these securities amounted to $27,083,941 or 0.3% of net assets.
|
(g)
|
Investment is owned by a wholly-owned subsidiary (Subsidiary) that is treated as a corporation for U.S. tax purposes.
|
(h)
|
Affiliated fund that is generally available only to investment companies and other accounts managed by Fidelity Investments. The rate quoted is the annualized seven-day yield of the fund at period end. A complete unaudited listing of the fund's holdings as of its most recent quarter end is available upon request. In addition, each Fidelity Central Fund's financial statements are available on the SEC's website or upon request.
|
(i)
|
Investment made with cash collateral received from securities on loan.
|
Additional information on each restricted holding is as follows:
|
||
Security
|
Acquisition Date
|
Acquisition Cost ($)
|
Aledade, Inc. Series B1
|
5/07/21
|
7,704,855
|
Aledade, Inc. Series E1
|
5/20/22
|
2,822,683
|
Aristea Therapeutics, Inc. Series B
|
10/06/20
|
5,719,912
|
Asimov, Inc. Series B
|
10/29/21
|
9,401,345
|
Caris Life Sciences, Inc.
|
10/06/22
|
7,954,682
|
Caris Life Sciences, Inc. Series D
|
5/11/21
|
25,968,770
|
Cleerly, Inc. Series C
|
7/08/22
|
15,142,394
|
dMed Biopharmaceutical Co. Ltd. Series C
|
12/01/20
|
5,403,602
|
Element Biosciences, Inc. Series C
|
6/21/21
|
11,763,880
|
ElevateBio LLC Series C
|
3/09/21
|
1,069,306
|
Evolent Health, Inc.
|
3/28/23
|
34,179,400
|
Galvanize Therapeutics Series B
|
3/29/22
|
6,399,572
|
Inscripta, Inc. Series E
|
3/30/21
|
11,322,073
|
Omada Health, Inc. Series E
|
12/22/21
|
12,908,103
|
Saluda Medical, Inc. Series E
|
4/06/23
|
9,328,137
|
The Beauty Health Co.
|
12/08/20
|
18,000,000
|
Thriveworks TopCo LLC Series B
|
7/23/21 - 2/25/22
|
13,610,827
|
Wugen, Inc. Series B
|
7/09/21
|
3,523,377
|
Affiliate
|
Value,
beginning
of period ($)
|
Purchases ($)
|
Sales
Proceeds ($)
|
Dividend
Income ($)
|
Realized
Gain (loss) ($)
|
Change in
Unrealized
appreciation
(depreciation) ($)
|
Value,
end
of period ($)
|
% ownership,
end
of period
|
Fidelity Cash Central Fund 5.14%
|
-
|
503,597,873
|
418,418,655
|
580,240
|
-
|
-
|
85,179,218
|
0.2%
|
Fidelity Securities Lending Cash Central Fund 5.14%
|
189,954,325
|
148,266,459
|
242,709,701
|
392,620
|
-
|
-
|
95,511,083
|
0.3%
|
Total
|
189,954,325
|
651,864,332
|
661,128,356
|
972,860
|
-
|
-
|
180,690,301
|
|
Affiliate
|
Value,
beginning
of period ($)
|
Purchases ($)
|
Sales
Proceeds ($)
|
Dividend
Income ($)
|
Realized
Gain (loss) ($)
|
Change in
Unrealized
appreciation
(depreciation) ($)
|
Value,
end
of period ($)
|
Zai Lab Ltd.
|
24,532,952
|
1,003,217
|
6,666,665
|
-
|
(8,304,126)
|
5,760,410
|
16,325,788
|
Total
|
24,532,952
|
1,003,217
|
6,666,665
|
-
|
(8,304,126)
|
5,760,410
|
16,325,788
|