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N/A 572956.00000000 NS USD 12444604.32000000 0.258702290441 Long EC CORP NL N 1 N N CELLDEX THERAPEUTICS INC 529900F018DMYWH38923 CELLDEX THERAPEUTICS INC 15117B202 755200.00000000 NS USD 24015360.00000000 0.499238744600 Long EC CORP US N 1 N N N ELEVATEBIO, LLC N/A ELEVATEBIO LLC SER C PC PP N/A 216600.00000000 NS USD 909720.00000000 0.018911541227 Long EP CORP US Y 3 N N N IONIS PHARMACEUTICALS INC 549300SI4ZGLG0BLUZ92 IONIS PHARMACEUTICALS INC 462222100 987777.00000000 NS USD 40400079.30000000 0.839849366051 Long EC CORP US N 1 N N NUVALENT INC N/A NUVALENT INC-A 670703107 218574.00000000 NS USD 9201965.40000000 0.191293307872 Long EC CORP US N 1 N N N MONTE ROSA THERAPEUTICS INC N/A MONTE ROSA THERAPEUTICS INC 61225M102 1257805.00000000 NS USD 9282600.90000000 0.192969583630 Long EC CORP US N 1 N N N ARCUS BIOSCIENCES INC N/A ARCUS BIOSCIENCES INC 03969F109 3193396.00000000 NS USD 65592353.84000000 1.363554174765 Long EC CORP US N 1 N N ARCTURUS THERAPEUTICS HOLDINGS INC N/A ARCTURUS THERAPEUTICS HOLDINGS INC 03969T109 831630.00000000 NS USD 22736764.20000000 0.472658898950 Long EC CORP US N 1 N N RAPT THERAPEUTICS INC 549300MB473BIU78ES48 RAPT THERAPEUTICS INC 75382E109 896800.00000000 NS USD 17962904.00000000 0.373418413979 Long EC CORP US N 1 N N N FULCRUM THERAPEUTICS INC N/A FULCRUM THERAPEUTICS INC 359616109 2029597.00000000 NS USD 5520503.84000000 0.114761944299 Long EC CORP US N 1 N N 2023-06-30 Stacie M. Smith Stacie M. Smith Stacie M. Smith President and Treasurer XXXX NPORT-EX 2 QTLY_142_20230531.htm 010 - Quarterly Front Cover
Quarterly Holdings Report
for
Fidelity® Select Portfolios®
Biotechnology Portfolio
May 31, 2023
BIO-NPRT1-0723
1.802156.119
Common Stocks - 98.5%
 
 
Shares
Value ($)
 
Biotechnology - 90.8%
 
 
 
Biotechnology - 90.8%
 
 
 
AbbVie, Inc.
 
4,422,938
610,188,523
Absci Corp. (a)(b)
 
992,700
1,886,130
Acelyrin, Inc. (a)
 
81,714
1,479,023
Acelyrin, Inc.
 
1,206,226
19,649,422
Acelyrin, Inc. rights (a)(c)
 
146,574
2,268,306
Adverum Biotechnologies, Inc. (a)(b)(d)
 
7,472,259
9,190,879
Aerovate Therapeutics, Inc. (a)(b)
 
354,451
5,759,829
Aldeyra Therapeutics, Inc. (a)
 
784,037
7,440,511
Alector, Inc. (a)
 
1,861,922
13,852,700
Alkermes PLC (a)
 
469,736
13,589,462
Allena Pharmaceuticals, Inc. (a)
 
93,683
19
Allogene Therapeutics, Inc. (a)(b)
 
1,267,385
6,653,771
Allovir, Inc. (a)(b)
 
852,383
3,213,484
Alnylam Pharmaceuticals, Inc. (a)
 
843,648
156,083,316
Alpine Immune Sciences, Inc. (a)
 
280,700
2,795,772
ALX Oncology Holdings, Inc. (a)
 
1,280,549
8,541,262
Ambrx Biopharma, Inc. ADR (a)(b)
 
1,361,508
20,095,858
Amgen, Inc.
 
6,132
1,353,026
Amicus Therapeutics, Inc. (a)
 
2,142,701
24,126,813
AnaptysBio, Inc. (a)(b)
 
289,228
5,524,255
Annexon, Inc. (a)
 
1,321,916
3,952,529
Apellis Pharmaceuticals, Inc. (a)(b)
 
1,122,579
96,373,407
Applied Therapeutics, Inc. (a)(b)
 
2,639,536
3,405,001
Arcellx, Inc. (a)
 
1,359,901
60,039,629
Arcturus Therapeutics Holdings, Inc. (a)(b)
 
831,630
22,736,764
Arcus Biosciences, Inc. (a)(b)
 
3,193,396
65,592,354
Arcutis Biotherapeutics, Inc. (a)(b)
 
756,674
5,682,622
Argenx SE ADR (a)
 
329,247
127,978,309
Arrowhead Pharmaceuticals, Inc. (a)
 
1,043,532
35,907,936
Ars Pharmaceuticals, Inc. (a)(b)
 
1,062,883
7,397,666
Ascendis Pharma A/S sponsored ADR (a)
 
659,409
57,348,801
Astria Therapeutics, Inc. (a)
 
674,298
7,376,820
aTyr Pharma, Inc. (a)(b)
 
2,258,063
5,125,803
Aura Biosciences, Inc. (a)
 
356,492
4,035,489
Avidity Biosciences, Inc. (a)
 
344,450
3,658,059
Axcella Health, Inc. (a)(b)
 
1,661,354
650,919
Beam Therapeutics, Inc. (a)(b)
 
1,098,650
35,046,935
BeiGene Ltd. ADR (a)
 
37,198
8,218,154
Bicycle Therapeutics PLC ADR (a)
 
287,147
6,885,785
BioCryst Pharmaceuticals, Inc. (a)(b)
 
2,682,281
22,182,464
Biogen, Inc. (a)
 
643,636
190,780,147
Biohaven Ltd. (a)(b)
 
2,606,283
45,636,015
BioInvent International AB (a)
 
117,443
238,635
BioMarin Pharmaceutical, Inc. (a)
 
397,336
34,544,392
Biomea Fusion, Inc. (a)(b)
 
392,829
13,340,473
BioNTech SE ADR
 
60,750
6,383,610
BioXcel Therapeutics, Inc. (a)(b)
 
274,527
4,925,014
Blueprint Medicines Corp. (a)
 
1,016,008
57,424,772
BridgeBio Pharma, Inc. (a)(b)
 
1,532,918
21,031,635
Candel Therapeutics, Inc. (a)(b)
 
602,870
910,334
Celldex Therapeutics, Inc. (a)
 
755,200
24,015,360
Centessa Pharmaceuticals PLC ADR (a)(b)
 
2,611,233
11,776,661
Century Therapeutics, Inc. (a)
 
596,418
1,896,609
Cerevel Therapeutics Holdings (a)
 
947,780
30,897,628
Chinook Therapeutics, Inc. (a)
 
261,381
6,322,806
Chinook Therapeutics, Inc. rights (a)(c)
 
115,821
1
Codiak Biosciences, Inc. (a)(b)
 
448,539
4,934
Codiak Biosciences, Inc. warrants 9/15/27 (a)
 
46,000
0
Compass Therapeutics, Inc. (a)(b)
 
1,412,800
4,097,120
Crinetics Pharmaceuticals, Inc. (a)(b)
 
1,080,483
23,586,944
CRISPR Therapeutics AG (a)(b)
 
252,322
16,158,701
Cyclerion Therapeutics, Inc. (a)
 
41,864
182,108
Cyclerion Therapeutics, Inc. (a)(e)
 
4,740
20,619
Cytokinetics, Inc. (a)(b)
 
1,199,771
45,219,369
Day One Biopharmaceuticals, Inc. (a)
 
366,445
4,873,719
Denali Therapeutics, Inc. (a)
 
333,369
10,074,411
Design Therapeutics, Inc. (a)(b)
 
957,005
5,387,938
Disc Medicine, Inc. (a)(b)
 
114,190
4,239,875
Disc Medicine, Inc. rights (a)(c)
 
1,555,907
16
Dyne Therapeutics, Inc. (a)
 
320,713
4,178,890
Enanta Pharmaceuticals, Inc. (a)
 
137,615
3,231,200
Entrada Therapeutics, Inc. (a)(b)
 
581,805
6,667,485
EQRx, Inc. (a)
 
507,567
893,318
EQRx, Inc.:
 
 
 
 rights (a)(c)
 
116,649
36,161
 rights (a)(c)
 
49,993
9,499
Evelo Biosciences, Inc. (a)(b)
 
1,098,999
150,013
Exact Sciences Corp. (a)
 
60,900
4,968,222
Exelixis, Inc. (a)
 
632,234
12,189,472
Fate Therapeutics, Inc. (a)(b)
 
516,787
2,609,774
FibroGen, Inc. (a)
 
606,719
10,465,903
Foghorn Therapeutics, Inc. (a)(b)
 
178,719
1,124,143
Fusion Pharmaceuticals, Inc. (a)
 
1,142,702
5,827,780
Fusion Pharmaceuticals, Inc. (e)
 
1,483,000
7,563,300
Generation Bio Co. (a)
 
137,100
479,850
Geron Corp. (a)
 
3,753,406
12,273,638
Geron Corp. warrants 12/31/25 (a)
 
2,100,000
2,276,765
Gilead Sciences, Inc.
 
1,463,336
112,589,072
Gritstone Bio, Inc. (a)
 
669,785
1,292,685
Halozyme Therapeutics, Inc. (a)
 
162,200
5,260,146
Hookipa Pharma, Inc. (a)
 
1,480,200
1,939,062
Icosavax, Inc. (a)
 
890,557
8,941,192
Ideaya Biosciences, Inc. (a)(b)
 
1,094,957
25,008,818
Idorsia Ltd. (a)(b)
 
1,011,061
8,276,102
IGM Biosciences, Inc. (a)(b)
 
844,409
10,175,128
Immuneering Corp. (a)(b)
 
658,185
5,100,934
Immunocore Holdings PLC ADR (a)(b)
 
256,818
14,171,217
ImmunoGen, Inc. (a)
 
1,667,123
22,739,558
Incyte Corp. (a)
 
116,100
7,145,955
Inhibrx, Inc. (a)(b)
 
210,609
4,983,009
Inozyme Pharma, Inc. (a)
 
702,996
4,210,946
Insmed, Inc. (a)
 
329,092
6,262,621
Intellia Therapeutics, Inc. (a)
 
834,701
31,100,959
Ionis Pharmaceuticals, Inc. (a)(b)
 
987,777
40,400,079
Iovance Biotherapeutics, Inc. (a)
 
463,700
4,052,738
iTeos Therapeutics, Inc. (a)
 
139,700
2,274,316
Janux Therapeutics, Inc. (a)
 
425,448
4,943,706
Kalvista Pharmaceuticals, Inc. (a)
 
81,600
795,600
Karuna Therapeutics, Inc. (a)
 
351,242
79,573,875
Keros Therapeutics, Inc. (a)
 
400,129
19,150,174
Kinnate Biopharma, Inc. (a)
 
979,677
4,212,611
Krystal Biotech, Inc. (a)(d)
 
1,985,122
233,946,628
Kymera Therapeutics, Inc. (a)(b)
 
814,313
23,973,375
Legend Biotech Corp. ADR (a)
 
839,216
53,852,491
Lexicon Pharmaceuticals, Inc. (a)
 
80,371
265,224
Madrigal Pharmaceuticals, Inc. (a)
 
275,808
76,787,705
Magenta Therapeutics, Inc. (c)(f)
 
448,100
2,007,488
MannKind Corp. (a)(b)
 
6,449,301
29,924,757
Merus BV (a)(b)
 
572,956
12,444,604
Minerva Neurosciences, Inc. (a)
 
89,000
531,330
Mirati Therapeutics, Inc. (a)(b)
 
37,548
1,395,284
Moderna, Inc. (a)
 
687,986
87,862,692
Monte Rosa Therapeutics, Inc. (a)
 
1,257,805
9,282,601
Moonlake Immunotherapeutics (a)(b)
 
381,585
10,382,928
Morphic Holding, Inc. (a)(b)
 
857,637
49,314,128
Natera, Inc. (a)
 
426,932
20,112,767
Nurix Therapeutics, Inc. (a)(b)
 
366,646
3,710,458
Nuvalent, Inc. Class A (a)
 
218,574
9,201,965
Omega Therapeutics, Inc. (a)(b)
 
817,575
6,205,394
Oragenics, Inc. (a)(e)
 
2,597
7,739
PepGen, Inc.
 
410,891
6,155,147
Poseida Therapeutics, Inc. (a)
 
570,083
1,294,088
Prelude Therapeutics, Inc. (a)
 
748,056
4,174,152
Prime Medicine, Inc. (b)
 
53,800
738,136
Protagonist Therapeutics, Inc. (a)
 
316,785
8,258,585
Prothena Corp. PLC (a)(b)
 
998,617
66,338,127
PTC Therapeutics, Inc. (a)
 
1,118,544
46,945,292
Rallybio Corp. (a)(b)
 
1,550,692
11,102,955
RAPT Therapeutics, Inc. (a)
 
896,800
17,962,904
Recursion Pharmaceuticals, Inc. (a)(b)
 
89,200
782,284
Regeneron Pharmaceuticals, Inc. (a)
 
247,548
182,086,407
Regulus Therapeutics, Inc. (a)(b)(d)
 
2,205,269
2,866,850
Relay Therapeutics, Inc. (a)(b)
 
269,689
3,004,335
Repare Therapeutics, Inc. (a)(b)
 
77,660
823,973
Replimune Group, Inc. (a)
 
1,121,714
21,301,349
Revolution Medicines, Inc. (a)
 
564,235
14,066,379
Rezolute, Inc. (a)(b)
 
26,700
56,871
Rhythm Pharmaceuticals, Inc. (a)(b)
 
696,903
11,610,404
Rocket Pharmaceuticals, Inc. (a)
 
223,736
4,682,794
Roivant Sciences Ltd. (a)
 
4,257,910
38,704,402
Sage Therapeutics, Inc. (a)
 
1,085,353
53,724,974
Sarepta Therapeutics, Inc. (a)
 
228,299
28,217,756
Scholar Rock Holding Corp. (a)(b)
 
1,693,925
9,858,644
Scholar Rock Holding Corp. warrants 12/31/25 (a)(e)
 
17,850
27,902
Selecta Biosciences, Inc. (a)
 
1,889,454
2,229,556
Sensorion SA (a)(b)
 
1,689,742
478,634
Seres Therapeutics, Inc. (a)(b)
 
854,347
4,229,018
Shattuck Labs, Inc. (a)
 
110,936
289,543
SpringWorks Therapeutics, Inc. (a)(b)
 
463,611
12,693,669
SpringWorks Therapeutics, Inc. (e)
 
54,800
1,350,382
Stoke Therapeutics, Inc. (a)
 
146,536
1,641,203
Tango Therapeutics, Inc. (a)
 
1,063,788
2,872,228
Taysha Gene Therapies, Inc. (a)(b)
 
811,647
567,260
Tenaya Therapeutics, Inc. (a)(b)
 
2,081,279
14,985,209
TG Therapeutics, Inc. (a)(b)
 
1,888,865
50,300,475
Travere Therapeutics, Inc. (a)
 
167,028
2,988,131
Twist Bioscience Corp. (a)(b)
 
298,525
4,522,654
Tyra Biosciences, Inc. (a)
 
301,101
4,356,931
Ultragenyx Pharmaceutical, Inc. (a)
 
826,251
40,783,749
uniQure B.V. (a)
 
255,608
4,930,678
United Therapeutics Corp. (a)
 
265,269
55,637,520
Vaxcyte, Inc. (a)
 
1,371,380
67,910,738
Vera Therapeutics, Inc. (a)
 
595,468
4,972,158
Vertex Pharmaceuticals, Inc. (a)
 
767,162
248,230,608
Verve Therapeutics, Inc. (a)(b)
 
365,293
5,654,736
Vigil Neuroscience, Inc. (a)(b)
 
95,973
959,730
Viking Therapeutics, Inc. (a)
 
451,052
9,905,102
Viridian Therapeutics, Inc. (a)
 
260,700
6,212,481
Vor Biopharma, Inc. (a)(b)
 
1,114,702
5,239,099
Werewolf Therapeutics, Inc. (a)
 
2,100
6,699
X4 Pharmaceuticals, Inc. warrants 4/12/24 (a)
 
450,000
10
Xencor, Inc. (a)
 
191,643
5,193,525
Xenon Pharmaceuticals, Inc. (a)
 
961,033
37,028,601
Zealand Pharma A/S (a)
 
703,933
26,938,132
Zentalis Pharmaceuticals, Inc. (a)
 
638,433
16,624,795
 
 
 
4,362,531,091
Consumer Staples Distribution & Retail - 0.0%
 
 
 
Drug Retail - 0.0%
 
 
 
MedAvail Holdings, Inc. (a)(e)
 
2,777
670
Health Care Equipment & Supplies - 0.0%
 
 
 
Health Care Equipment - 0.0%
 
 
 
Alpha Tau Medical Ltd. Class A (a)(b)
 
362,046
1,444,564
Novocure Ltd. (a)
 
11,113
798,025
 
 
 
2,242,589
Health Care Providers & Services - 0.0%
 
 
 
Health Care Services - 0.0%
 
 
 
23andMe Holding Co. Class A (a)(b)
 
814,674
1,564,174
Health Care Technology - 0.4%
 
 
 
Health Care Technology - 0.4%
 
 
 
Akili, Inc. (a)(b)
 
1,500
1,755
Schrodinger, Inc. (a)(b)
 
539,101
18,032,928
 
 
 
18,034,683
Pharmaceuticals - 7.3%
 
 
 
Pharmaceuticals - 7.3%
 
 
 
Adimab LLC (a)(c)(e)(g)
 
1,954,526
77,887,861
Afferent Pharmaceuticals, Inc. rights 12/31/24 (a)(c)
 
8,274,568
9,267,516
Amylyx Pharmaceuticals, Inc. (a)(b)
 
115,100
2,841,819
Aradigm Corp. (a)(c)
 
11,945
549
Aradigm Corp. (a)(c)
 
148,009
6,808
Arvinas Holding Co. LLC (a)
 
244,716
5,342,150
Atea Pharmaceuticals, Inc. (a)
 
66,800
266,532
Axsome Therapeutics, Inc. (a)(b)
 
378,073
27,894,226
Corcept Therapeutics, Inc. (a)
 
88,400
2,076,516
DICE Therapeutics, Inc. (a)
 
408,046
12,898,334
Edgewise Therapeutics, Inc. (a)
 
894,385
9,051,176
Enliven Therapeutics, Inc. (a)(b)
 
224,900
4,115,670
Fulcrum Therapeutics, Inc. (a)(b)
 
2,029,597
5,520,504
GH Research PLC (a)(b)
 
654,224
7,327,309
Harmony Biosciences Holdings, Inc. (a)
 
124,525
4,306,075
Ikena Oncology, Inc. (a)
 
798,227
5,148,564
Intra-Cellular Therapies, Inc. (a)
 
172,202
10,225,355
Longboard Pharmaceuticals, Inc. (a)
 
851,171
5,898,615
Nuvation Bio, Inc. (a)
 
2,927,126
4,741,944
OptiNose, Inc. (a)(b)
 
794,031
992,539
OptiNose, Inc. warrants (a)
 
91,712
28,259
Pharvaris BV (a)
 
353,507
3,022,485
Pliant Therapeutics, Inc. (a)
 
254,631
5,507,669
Reata Pharmaceuticals, Inc. (a)(b)
 
229,417
20,659,001
Structure Therapeutics, Inc. ADR
 
301,997
9,663,904
Terns Pharmaceuticals, Inc. (a)
 
1,081,349
11,473,113
Theseus Pharmaceuticals, Inc. (a)(b)
 
804,440
5,856,323
UCB SA
 
436,877
38,068,032
Ventyx Biosciences, Inc. (a)
 
821,752
28,325,791
Verona Pharma PLC ADR (a)
 
938,853
20,204,117
Verrica Pharmaceuticals, Inc. (a)(b)
 
1,162,976
6,594,074
WAVE Life Sciences (a)(b)
 
970,833
3,844,499
 
 
 
349,057,329
 
TOTAL COMMON STOCKS
 (Cost $3,559,709,350)
 
 
 
4,733,430,536
 
 
 
 
Convertible Preferred Stocks - 1.4%
 
 
Shares
Value ($)
 
Biotechnology - 1.2%
 
 
 
Biotechnology - 1.2%
 
 
 
ElevateBio LLC Series C (a)(c)(e)
 
216,600
909,720
Korro Bio, Inc.:
 
 
 
 Series B1 (a)(c)(e)
 
957,854
2,116,857
 Series B2 (a)(c)(e)
 
899,280
2,023,380
National Resilience, Inc. Series B (a)(c)(e)
 
732,064
44,458,247
SalioGen Therapeutics, Inc. Series B (a)(c)(e)
 
94,461
6,368,561
 
 
 
55,876,765
Health Care Providers & Services - 0.1%
 
 
 
Health Care Services - 0.1%
 
 
 
Scorpion Therapeutics, Inc. Series B (a)(c)(e)
 
3,099,905
5,486,832
Pharmaceuticals - 0.1%
 
 
 
Pharmaceuticals - 0.1%
 
 
 
Afferent Pharmaceuticals, Inc. Series C (a)(c)(e)
 
8,274,568
83
Aristea Therapeutics, Inc. Series B (a)(c)(e)
 
836,400
4,608,564
 
 
 
4,608,647
 
TOTAL CONVERTIBLE PREFERRED STOCKS
 (Cost $38,020,306)
 
 
 
65,972,244
 
 
 
 
Money Market Funds - 9.1%
 
 
Shares
Value ($)
 
Fidelity Cash Central Fund 5.14% (h)
 
9,635,380
9,637,307
Fidelity Securities Lending Cash Central Fund 5.14% (h)(i)
 
429,938,011
429,981,005
 
TOTAL MONEY MARKET FUNDS
 (Cost $439,584,978)
 
 
439,618,312
 
 
 
 
 
TOTAL INVESTMENT IN SECURITIES - 109.0%
 (Cost $4,037,314,634)
 
 
 
5,239,021,092
NET OTHER ASSETS (LIABILITIES) - (9.0)%  
(433,288,320)
NET ASSETS - 100.0%
4,805,732,772
 
 
Legend
 
(a)
Non-income producing
 
(b)
Security or a portion of the security is on loan at period end.
 
(c)
Level 3 security
 
(d)
Affiliated company
 
(e)
Restricted securities (including private placements) - Investment in securities not registered under the Securities Act of 1933 (excluding 144A issues).  At the end of the period, the value of restricted securities (excluding 144A issues) amounted to $152,830,717 or 3.2% of net assets.
 
(f)
Security or a portion of the security purchased on a delayed delivery or when-issued basis.
 
(g)
Investment is owned by a wholly-owned subsidiary (Subsidiary) that is treated as a corporation for U.S. tax purposes.
 
(h)
Affiliated fund that is generally available only to investment companies and other accounts managed by Fidelity Investments. The rate quoted is the annualized seven-day yield of the fund at period end. A complete unaudited listing of the fund's holdings as of its most recent quarter end is available upon request. In addition, each Fidelity Central Fund's financial statements are available on the SEC's website or upon request.
 
(i)
Investment made with cash collateral received from securities on loan.
 
 
 
Additional information on each restricted holding is as follows:
Security
Acquisition Date
Acquisition Cost ($)
 
Adimab LLC
9/17/14 - 6/05/15
31,384,801
 
 
 
Afferent Pharmaceuticals, Inc. Series C
7/01/15
0
 
 
 
Aristea Therapeutics, Inc. Series B
10/06/20
4,611,659
 
 
 
Cyclerion Therapeutics, Inc.
4/02/19
1,404,026
 
 
 
ElevateBio LLC Series C
3/09/21
908,637
 
 
 
Fusion Pharmaceuticals, Inc.
2/13/23
5,042,200
 
 
 
Korro Bio, Inc. Series B1
12/17/21
2,499,999
 
 
 
Korro Bio, Inc. Series B2
12/17/21
2,499,998
 
 
 
MedAvail Holdings, Inc.
7/02/12
416,675
 
 
 
National Resilience, Inc. Series B
12/01/20
9,999,994
 
 
 
Oragenics, Inc.
7/31/12
2,337,087
 
 
 
SalioGen Therapeutics, Inc. Series B
12/10/21
10,000,019
 
 
 
Scholar Rock Holding Corp. warrants 12/31/25
6/17/22
0
 
 
 
Scorpion Therapeutics, Inc. Series B
1/08/21
7,500,000
 
 
 
SpringWorks Therapeutics, Inc.
9/07/22
1,425,348
 
 
 
 
 
Affiliated Central Funds
 
Fiscal year to date information regarding the Fund's investments in Fidelity Central Funds, including the ownership percentage, is presented below.
 
 
Affiliate
Value,
beginning
of period ($)
Purchases ($)
Sales
Proceeds ($)
Dividend
Income ($)
Realized
Gain (loss) ($)
Change in
Unrealized
appreciation
(depreciation) ($)
Value,
end
of period ($)
% ownership,
end
of period
Fidelity Cash Central Fund 5.14%
16,575,392
212,350,836
219,288,921
165,989
-
-
9,637,307
0.0%
Fidelity Securities Lending Cash Central Fund 5.14%
353,621,750
420,034,591
343,675,336
1,570,139
307
(307)
429,981,005
1.5%
Total
370,197,142
632,385,427
562,964,257
1,736,128
307
(307)
439,618,312
 
 
 
 
 
 
 
 
 
 
Amounts in the dividend income column in the above table include any capital gain distributions from underlying funds.
 
Amounts in the dividend income column for Fidelity Securities Lending Cash Central Fund represents the income earned on investing cash collateral, less rebates paid to borrowers and any lending agent fees associated with the loan, plus any premium payments received for lending certain types of securities.
 
Other Affiliated Issuers
An affiliated company is a company in which the Fund has ownership of at least 5% of the voting securities. Fiscal year to date transactions with companies which are or were affiliates are presented in the table below. Certain corporate actions, such as mergers, are excluded from the amounts in this table if applicable. A dash in the Value end of period ($) column means either the issuer is no longer held at period end, or the issuer is held at period end but is no longer an affiliate.
Affiliate
Value,
beginning
of period ($)
Purchases ($)
Sales
Proceeds ($)
Dividend
Income ($)
Realized
Gain (loss) ($)
Change in
Unrealized
appreciation
(depreciation) ($)
Value,
end
of period ($)
Adverum Biotechnologies, Inc.
5,380,026
-
-
-
-
3,810,853
9,190,879
Applied Therapeutics, Inc.
2,665,931
-
-
-
-
739,070
-
Krystal Biotech, Inc.
171,824,409
-
9,387,317
-
942,317
70,567,219
233,946,628
Regulus Therapeutics, Inc.
2,941,300
13,758
-
-
-
(88,208)
2,866,850
Total
182,811,666
13,758
9,387,317
-
942,317
75,028,934
246,004,357
 
 
 
Investment Valuation
Investments are valued as of 4:00 p.m. Eastern time on the last calendar day of the period. Securities transactions are accounted for as of trade date. The Board of Trustees (the Board) has designated the Fund's investment adviser as the valuation designee responsible for the fair valuation function and performing fair value determinations as needed. The investment adviser has established a Fair Value Committee (the Committee) to carry out the day-to-day fair valuation responsibilities and has adopted policies and procedures to govern the fair valuation process and the activities of the Committee. In accordance with these fair valuation policies and procedures, which have been approved by the Board, the Fund attempts to obtain prices from one or more third party pricing services or brokers to value its investments. When current market prices, quotations or currency exchange rates are not readily available or reliable, investments will be fair valued in good faith by the Committee, in accordance with the policies and procedures. Factors used in determining fair value vary by investment type and may include market or investment specific events, transaction data, estimated cash flows, and market observations of comparable investments. The frequency that the fair valuation procedures are used cannot be predicted and they may be utilized to a significant extent. The Committee manages the Fund's fair valuation practices and maintains the fair valuation policies and procedures. The Fund's investment adviser reports to the Board information regarding the fair valuation process and related material matters.   
 
The inputs to valuation techniques used to value investments are categorized into a disclosure hierarchy consisting of three levels as shown below:
 
Level 1 - Unadjusted quoted prices in active markets for identical investments
Level 2 - other significant observable inputs (including quoted prices for similar investments, interest rates, prepayment speeds, etc.)
Level 3 - unobservable inputs (including the Fund's own assumptions based on the best information available)
 
Valuation techniques used to value investments by major category are as follows:
Equity securities, including restricted securities, for which market quotations are readily available, are valued at the last reported sale price or official closing price as reported by a third party pricing service on the primary market or exchange on which they are traded and are categorized as Level 1 in the hierarchy. In the event there were no sales during the day or closing prices are not available, securities are valued at the last quoted bid price or may be valued using the last available price and are generally categorized as Level 2 in the hierarchy. For any foreign equity securities, when market or security specific events arise, comparisons to the valuation of American Depositary Receipts (ADRs), futures contracts, Exchange-Traded Funds (ETFs) and certain indexes as well as quoted prices for similar securities may be used and would be categorized as Level 2 in the hierarchy. For equity securities, including restricted securities, where observable inputs are limited, assumptions about market activity and risk are used and these securities may be categorized as Level 3 in the hierarchy.
 
Securities, including private placements or other restricted securities, for which observable inputs are not available are valued using alternate valuation approaches, including the market approach, the income approach and cost approach, and are categorized as Level 3 in the hierarchy. The market approach considers factors including the price of recent investments in the same or a similar security or financial metrics of comparable securities. The income approach considers factors including expected future cash flows, security specific risks and corresponding discount rates. The cost approach considers factors including the value of the security's underlying assets and liabilities.
 
Investments in any open-end mutual funds are valued at their closing net asset value (NAV) each business day and are categorized as Level 1 in the hierarchy.
 
Changes in valuation techniques may result in transfers in or out of an assigned level within the disclosure hierarchy.
 
For additional information on the Fund's significant accounting policies, please refer to the Fund's most recent semiannual or annual shareholder report.
The fund's schedule of investments as of the date on the cover of this report has not been audited. This report is provided for the general information of the fund's shareholders. For more information regarding the fund and its holdings, please see the fund's most recent prospectus and annual report.
 
Third party trademarks and service marks are the property of their respective owners. All other trademarks and service marks are the property of FMR LLC or an affiliate.