NPORT-EX 2 QTLY_63_20221130.htm 010 - Quarterly Front Cover
Quarterly Holdings Report
for
Fidelity® Select Portfolios®
Health Care Portfolio
November 30, 2022
HEA-NPRT3-0123
1.810696.118
Common Stocks - 97.6%
 
 
Shares
Value ($)
 
Biotechnology - 19.0%
 
 
 
Biotechnology - 19.0%
 
 
 
ADC Therapeutics SA (a)(b)
 
1,080,000
3,952,800
Agios Pharmaceuticals, Inc. (a)(b)
 
360,000
10,850,400
Alnylam Pharmaceuticals, Inc. (a)
 
375,000
82,721,250
Ambrx Biopharma, Inc. ADR (a)
 
354,700
173,785
Arcutis Biotherapeutics, Inc. (a)
 
865,485
14,912,307
Argenx SE ADR (a)
 
485,000
193,015,450
Ascendis Pharma A/S sponsored ADR (a)(b)
 
950,000
116,907,000
Beam Therapeutics, Inc. (a)(b)
 
400,000
18,476,000
Biogen, Inc. (a)
 
70,000
21,361,900
Blueprint Medicines Corp. (a)
 
1,000,000
47,790,000
Caris Life Sciences, Inc. (c)(d)
 
1,420,479
7,954,682
Celldex Therapeutics, Inc. (a)
 
670,000
24,850,300
Century Therapeutics, Inc. (a)
 
815,000
8,557,500
Cerevel Therapeutics Holdings (a)
 
1,359,900
39,382,704
Cytokinetics, Inc. (a)
 
1,500,000
63,750,000
Denali Therapeutics, Inc. (a)
 
500,000
15,955,000
Erasca, Inc. (a)
 
2,078,693
15,694,132
Fate Therapeutics, Inc. (a)(b)
 
350,000
7,287,000
Generation Bio Co. (a)(b)
 
509,353
2,714,851
Instil Bio, Inc. (a)
 
1,569,316
2,087,190
Janux Therapeutics, Inc. (a)(b)
 
500,000
6,820,000
Karuna Therapeutics, Inc. (a)
 
240,000
56,474,400
Keros Therapeutics, Inc. (a)
 
400,000
19,936,000
Legend Biotech Corp. ADR (a)
 
1,520,000
78,295,200
Mirati Therapeutics, Inc. (a)
 
159,044
14,533,441
Morphic Holding, Inc. (a)
 
320,000
8,806,400
Nuvalent, Inc. Class A (a)
 
382,530
12,577,586
Poseida Therapeutics, Inc. (a)
 
1,922,313
8,765,747
PTC Therapeutics, Inc. (a)
 
1,150,000
47,713,500
Regeneron Pharmaceuticals, Inc. (a)
 
340,000
255,578,000
Relay Therapeutics, Inc. (a)(b)
 
1,200,000
22,296,000
Repligen Corp. (a)
 
80,000
14,307,200
Sarepta Therapeutics, Inc. (a)
 
670,608
82,357,368
Scholar Rock Holding Corp. (a)
 
155,315
1,206,798
Seagen, Inc. (a)
 
380,000
46,128,200
Shattuck Labs, Inc. (a)
 
1,162,800
2,639,556
Stoke Therapeutics, Inc. (a)
 
500,000
3,770,000
uniQure B.V. (a)(b)
 
670,000
17,728,200
Vaxcyte, Inc. (a)
 
750,000
34,545,000
Vertex Pharmaceuticals, Inc. (a)
 
340,000
107,576,000
Verve Therapeutics, Inc. (a)(b)
 
280,000
6,504,400
Xencor, Inc. (a)
 
1,400,000
41,608,000
Xenon Pharmaceuticals, Inc. (a)
 
500,000
18,440,000
Zai Lab Ltd. (a)(e)
 
5,000,000
18,110,705
Zentalis Pharmaceuticals, Inc. (a)
 
902,900
19,972,148
 
 
 
1,645,084,100
Health Care Equipment & Supplies - 19.8%
 
 
 
Health Care Equipment - 19.8%
 
 
 
Boston Scientific Corp. (a)
 
10,500,000
475,335,000
Inspire Medical Systems, Inc. (a)
 
230,000
55,561,100
Insulet Corp. (a)
 
950,000
284,401,500
Intuitive Surgical, Inc. (a)
 
164,000
44,343,960
Masimo Corp. (a)
 
949,905
137,679,231
Nevro Corp. (a)
 
900,000
42,039,000
Novocure Ltd. (a)
 
483,601
37,159,901
Outset Medical, Inc. (a)
 
1,080,000
22,766,400
Penumbra, Inc. (a)
 
1,425,000
298,551,750
PROCEPT BioRobotics Corp. (a)
 
600,000
25,740,000
ResMed, Inc.
 
600,000
138,120,000
Stryker Corp.
 
340,000
79,522,600
Tandem Diabetes Care, Inc. (a)
 
1,650,000
69,382,500
 
 
 
1,710,602,942
Health Care Providers & Services - 28.8%
 
 
 
Health Care Facilities - 2.3%
 
 
 
HCA Holdings, Inc. (b)
 
400,000
96,088,000
Surgery Partners, Inc. (a)
 
3,647,681
103,265,849
The Oncology Institute, Inc. (a)(c)
 
2,232,581
3,147,939
 
 
 
202,501,788
Health Care Services - 7.8%
 
 
 
agilon health, Inc. (a)(b)
 
7,091,000
124,517,960
Cigna Corp.
 
1,080,000
355,201,200
Guardant Health, Inc. (a)
 
648,385
33,936,471
LifeStance Health Group, Inc. (a)
 
4,151,389
21,130,570
Oak Street Health, Inc. (a)(b)
 
6,416,439
138,723,411
 
 
 
673,509,612
Managed Health Care - 18.7%
 
 
 
Alignment Healthcare, Inc. (a)
 
3,599,800
47,877,340
Centene Corp. (a)
 
2,540,000
221,107,000
Humana, Inc.
 
550,000
302,445,000
Molina Healthcare, Inc. (a)
 
330,000
111,134,100
UnitedHealth Group, Inc.
 
1,700,000
931,191,999
 
 
 
1,613,755,439
TOTAL HEALTH CARE PROVIDERS & SERVICES
 
 
2,489,766,839
Health Care Technology - 0.9%
 
 
 
Health Care Technology - 0.9%
 
 
 
Doximity, Inc. (a)(b)
 
1,236,300
42,021,837
Medlive Technology Co. Ltd. (f)
 
3,000,000
3,779,171
Phreesia, Inc. (a)
 
1,150,000
31,993,000
 
 
 
77,794,008
Life Sciences Tools & Services - 15.7%
 
 
 
Life Sciences Tools & Services - 15.7%
 
 
 
10X Genomics, Inc. Class B (a)(f)
 
500,000
19,330,000
Agilent Technologies, Inc.
 
200,000
30,996,000
Bruker Corp.
 
1,280,000
86,284,800
Danaher Corp.
 
1,800,000
492,138,000
IQVIA Holdings, Inc. (a)
 
315,000
68,676,300
Lonza Group AG
 
95,000
49,978,786
Olink Holding AB ADR (a)(b)
 
1,200,000
28,596,000
Sartorius Stedim Biotech
 
132,000
45,052,024
Seer, Inc. (a)
 
800,000
5,168,000
Stevanato Group SpA
 
188,434
2,884,925
Thermo Fisher Scientific, Inc.
 
825,000
462,181,500
West Pharmaceutical Services, Inc.
 
260,000
61,011,600
 
 
 
1,352,297,935
Personal Products - 0.3%
 
 
 
Personal Products - 0.3%
 
 
 
The Beauty Health Co. (a)(b)
 
801,005
8,610,804
The Beauty Health Co. (a)(c)
 
1,800,000
19,350,000
 
 
 
27,960,804
Pharmaceuticals - 12.8%
 
 
 
Pharmaceuticals - 12.8%
 
 
 
Arvinas Holding Co. LLC (a)
 
500,000
20,520,000
AstraZeneca PLC (United Kingdom)
 
1,420,000
192,183,730
Bristol-Myers Squibb Co.
 
200,000
16,056,000
Eli Lilly & Co.
 
1,380,000
512,090,400
Pharvaris BV (a)
 
620,000
1,277,200
Roche Holding AG (participation certificate)
 
328,000
107,132,637
Royalty Pharma PLC
 
5,250,000
230,842,500
Theseus Pharmaceuticals, Inc. (a)
 
600,000
3,954,000
UCB SA
 
280,000
22,600,632
 
 
 
1,106,657,099
Specialty Retail - 0.3%
 
 
 
Specialty Stores - 0.3%
 
 
 
Warby Parker, Inc. (a)(b)
 
1,280,000
21,798,400
 
TOTAL COMMON STOCKS
 (Cost $5,492,213,385)
 
 
 
8,431,962,127
 
 
 
 
Preferred Stocks - 1.2%
 
 
Shares
Value ($)
 
Convertible Preferred Stocks - 1.1%
 
 
 
Biotechnology - 0.6%
 
 
 
Biotechnology - 0.6%
 
 
 
Asimov, Inc. Series B (a)(c)(d)
 
101,438
5,944,267
Caris Life Sciences, Inc. Series D (a)(c)(d)
 
3,206,021
17,953,718
Cleerly, Inc. Series C (c)(d)
 
1,285,367
14,948,818
Element Biosciences, Inc. Series C (a)(c)(d)
 
572,265
7,817,140
ElevateBio LLC Series C (a)(c)(d)
 
254,900
1,165,658
Inscripta, Inc. Series E (a)(c)(d)
 
1,282,228
8,001,103
 
 
 
55,830,704
Health Care Providers & Services - 0.0%
 
 
 
Health Care Services - 0.0%
 
 
 
dMed Biopharmaceutical Co. Ltd. Series C (a)(c)(d)
 
380,451
3,412,645
 
 
 
 
Health Care Technology - 0.3%
 
 
 
Health Care Technology - 0.3%
 
 
 
Aledade, Inc.:
 
 
 
  Series B1(a)(c)(d)
 
201,220
9,664,597
  Series E1(c)(d)
 
56,664
2,721,572
Omada Health, Inc. Series E (c)(d)
 
2,153,073
6,588,403
Wugen, Inc. Series B (a)(c)(d)
 
454,342
2,371,665
 
 
 
21,346,237
Pharmaceuticals - 0.2%
 
 
 
Pharmaceuticals - 0.2%
 
 
 
Aristea Therapeutics, Inc. Series B (a)(c)(d)
 
1,037,400
7,977,606
Galvanize Therapeutics Series B (c)(d)
 
3,696,429
6,246,965
 
 
 
14,224,571
TOTAL CONVERTIBLE PREFERRED STOCKS
 
 
94,814,157
Nonconvertible Preferred Stocks - 0.1%
 
 
 
Diversified Financial Services - 0.1%
 
 
 
Other Diversified Financial Services - 0.1%
 
 
 
Thriveworks TopCo LLC Series B (a)(c)(d)(g)
 
473,270
8,225,433
 
 
 
 
 
TOTAL PREFERRED STOCKS
 (Cost $132,756,423)
 
 
 
103,039,590
 
 
 
 
Money Market Funds - 3.6%
 
 
Shares
Value ($)
 
Fidelity Cash Central Fund 3.86% (h)
 
74,252,458
74,267,309
Fidelity Securities Lending Cash Central Fund 3.86% (h)(i)
 
236,798,149
236,821,829
 
TOTAL MONEY MARKET FUNDS
 (Cost $311,087,388)
 
 
311,089,138
 
 
 
 
 
TOTAL INVESTMENT IN SECURITIES - 102.4%
 (Cost $5,936,057,196)
 
 
 
8,846,090,855
NET OTHER ASSETS (LIABILITIES) - (2.4)%  
(208,276,754)
NET ASSETS - 100.0%
8,637,814,101
 
 
Legend
 
(a)
Non-income producing
 
(b)
Security or a portion of the security is on loan at period end.
 
(c)
Restricted securities (including private placements) - Investment in securities not registered under the Securities Act of 1933 (excluding 144A issues).  At the end of the period, the value of restricted securities (excluding 144A issues) amounted to $133,492,211 or 1.5% of net assets.
 
(d)
Level 3 security
 
(e)
Affiliated company
 
(f)
Security exempt from registration under Rule 144A of the Securities Act of 1933.  These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers. At the end of the period, the value of these securities amounted to $23,109,171 or 0.3% of net assets.
 
(g)
Investment is owned by a wholly-owned subsidiary (Subsidiary) that is treated as a corporation for U.S. tax purposes.
 
(h)
Affiliated fund that is generally available only to investment companies and other accounts managed by Fidelity Investments. The rate quoted is the annualized seven-day yield of the fund at period end. A complete unaudited listing of the fund's holdings as of its most recent quarter end is available upon request. In addition, each Fidelity Central Fund's financial statements are available on the SEC's website or upon request.
 
(i)
Investment made with cash collateral received from securities on loan.
 
 
 
Additional information on each restricted holding is as follows:
Security
Acquisition Date
Acquisition Cost ($)
 
Aledade, Inc. Series B1
5/07/21
7,704,855
 
 
 
Aledade, Inc. Series E1
5/20/22
2,822,683
 
 
 
Aristea Therapeutics, Inc. Series B
10/06/20
5,719,912
 
 
 
Asimov, Inc. Series B
10/29/21
9,401,345
 
 
 
Caris Life Sciences, Inc.
10/06/22
7,954,682
 
 
 
Caris Life Sciences, Inc. Series D
5/11/21
25,968,770
 
 
 
Cleerly, Inc. Series C
7/08/22
15,142,394
 
 
 
dMed Biopharmaceutical Co. Ltd. Series C
12/01/20
5,403,602
 
 
 
Element Biosciences, Inc. Series C
6/21/21
11,763,880
 
 
 
ElevateBio LLC Series C
3/09/21
1,069,306
 
 
 
Galvanize Therapeutics Series B
3/29/22
6,399,572
 
 
 
Inscripta, Inc. Series E
3/30/21
11,322,073
 
 
 
Omada Health, Inc. Series E
12/22/21
12,908,103
 
 
 
The Beauty Health Co.
12/08/20
18,000,000
 
 
 
The Oncology Institute, Inc.
6/28/21
22,325,810
 
 
 
Thriveworks TopCo LLC Series B
7/23/21 - 2/25/22
13,606,551
 
 
 
Wugen, Inc. Series B
7/09/21
3,523,377
 
 
 
 
 
Affiliated Central Funds
 
Fiscal year to date information regarding the Fund's investments in Fidelity Central Funds, including the ownership percentage, is presented below.
 
 
Affiliate
Value,
beginning
of period ($)
Purchases ($)
Sales
Proceeds ($)
Dividend
Income ($)
Realized
Gain (loss) ($)
Change in
Unrealized
appreciation
(depreciation) ($)
Value,
end
of period ($)
% ownership,
end
of period
Fidelity Cash Central Fund 3.86%
36,264,694
739,029,870
701,027,255
545,297
-
-
74,267,309
0.2%
Fidelity Securities Lending Cash Central Fund 3.86%
202,861,851
1,049,983,297
1,016,023,319
1,586,607
-
-
236,821,829
0.7%
Total
239,126,545
1,789,013,167
1,717,050,574
2,131,904
-
-
311,089,138
 
 
 
 
 
 
 
 
 
 
Amounts in the income column in the above table include any capital gain distributions from underlying funds.
 
Amount for Fidelity Securities Lending Cash Central Fund represents the income earned on investing cash collateral, less rebates paid to borrowers and any lending agent fees associated with the loan, plus any premium payments received for lending certain types of securities.
 
Other Affiliated Issuers
An affiliated company is a company in which the Fund has ownership of at least 5% of the voting securities. Fiscal year to date transactions with companies which are or were affiliates are as follows:
Affiliate
Value,
beginning
of period ($)
Purchases ($)
Sales
Proceeds ($)
Dividend
Income ($)
Realized
Gain (loss) ($)
Change in
Unrealized
appreciation
(depreciation) ($)
Value,
end
of period ($)
Zai Lab Ltd.
26,625,199
7,708,620
4,441,986
-
(22,717,266)
10,936,138
18,110,705
Total
26,625,199
7,708,620
4,441,986
-
(22,717,266)
10,936,138
18,110,705
 
 
 
Investment Valuation
Investments are valued as of 4:00 p.m. Eastern time on the last calendar day of the period. Securities transactions are accounted for as of trade date. The Board of Trustees (the Board) has designated the Fund's investment adviser as the valuation designee responsible for the fair valuation function and performing fair value determinations as needed. The investment adviser has established a Fair Value Committee (the Committee) to carry out the day-to-day fair valuation responsibilities and has adopted policies and procedures to govern the fair valuation process and the activities of the Committee. In accordance with these fair valuation policies and procedures, which have been approved by the Board, the Fund attempts to obtain prices from one or more third party pricing services or brokers to value its investments. When current market prices, quotations or currency exchange rates are not readily available or reliable, investments will be fair valued in good faith by the Committee, in accordance with the policies and procedures. Factors used in determining fair value vary by investment type and may include market or investment specific events, transaction data, estimated cash flows, and market observations of comparable investments. The frequency that the fair valuation procedures are used cannot be predicted and they may be utilized to a significant extent. The Committee manages the Fund's fair valuation practices and maintains the fair valuation policies and procedures. The Fund's investment adviser reports to the Board information regarding the fair valuation process and related material matters.   
 
The inputs to valuation techniques used to value investments are categorized into a disclosure hierarchy consisting of three levels as shown below:
 
Level 1 - Unadjusted quoted prices in active markets for identical investments
Level 2 - other significant observable inputs (including quoted prices for similar investments, interest rates, prepayment speeds, etc.)
Level 3 - unobservable inputs (including the Fund's own assumptions based on the best information available)
 
Valuation techniques used to value investments by major category are as follows:
Equity securities, including restricted securities, for which market quotations are readily available, are valued at the last reported sale price or official closing price as reported by a third party pricing service on the primary market or exchange on which they are traded and are categorized as Level 1 in the hierarchy. In the event there were no sales during the day or closing prices are not available, securities are valued at the last quoted bid price or may be valued using the last available price and are generally categorized as Level 2 in the hierarchy. For any foreign equity securities, when market or security specific events arise, comparisons to the valuation of American Depositary Receipts (ADRs), futures contracts, Exchange-Traded Funds (ETFs) and certain indexes as well as quoted prices for similar securities may be used and would be categorized as Level 2 in the hierarchy. For equity securities, including restricted securities, where observable inputs are limited, assumptions about market activity and risk are used and these securities may be categorized as Level 3 in the hierarchy.
 
Securities, including private placements or other restricted securities, for which observable inputs are not available are valued using alternate valuation approaches, including the market approach, the income approach and cost approach, and are categorized as Level 3 in the hierarchy. The market approach considers factors including the price of recent investments in the same or a similar security or financial metrics of comparable securities. The income approach considers factors including expected future cash flows, security specific risks and corresponding discount rates. The cost approach considers factors including the value of the security's underlying assets and liabilities.
 
Investments in any open-end mutual funds are valued at their closing net asset value (NAV) each business day and are categorized as Level 1 in the hierarchy.
 
Changes in valuation techniques may result in transfers in or out of an assigned level within the disclosure hierarchy.
 
For additional information on the Fund's significant accounting policies, please refer to the Fund's most recent semiannual or annual shareholder report.
The fund's schedule of investments as of the date on the cover of this report has not been audited. This report is provided for the general information of the fund's shareholders. For more information regarding the fund and its holdings, please see the fund's most recent prospectus and annual report.
 
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