NPORT-EX 2 QTLY_63_20201130.htm

Quarterly Holdings Report
for

Fidelity® Select Portfolio®

Health Care Portfolio

November 30, 2020







HEA-QTLY-0121
1.810696.116





Schedule of Investments November 30, 2020 (Unaudited)

Showing Percentage of Net Assets

Common Stocks - 99.3%   
 Shares Value 
Biotechnology - 23.7%   
Biotechnology - 23.7%   
Acceleron Pharma, Inc. (a) 500,000 $59,035,000 
ADC Therapeutics SA (a)(b) 971,875 36,260,656 
Alnylam Pharmaceuticals, Inc. (a) 860,000 111,722,600 
Aprea Therapeutics, Inc. (a) 600,000 15,144,000 
Arcutis Biotherapeutics, Inc. (a) 600,000 16,272,000 
Argenx SE ADR (a) 606,200 173,870,284 
Ascendis Pharma A/S sponsored ADR (a) 912,802 154,017,081 
BeiGene Ltd. ADR (a) 175,000 44,745,750 
Black Diamond Therapeutics, Inc. (a) 300,000 10,002,000 
Blueprint Medicines Corp. (a) 400,000 43,232,000 
Denali Therapeutics, Inc. (a) 360,000 21,949,200 
Exelixis, Inc. (a) 1,800,000 34,488,000 
Fate Therapeutics, Inc. (a) 760,000 44,433,400 
Forma Therapeutics Holdings, Inc. 320,000 13,996,800 
Fusion Pharmaceuticals, Inc. (a) 116,564 1,574,780 
Generation Bio Co. 154,622 7,381,314 
Generation Bio Co. (b) 142,537 6,873,134 
Innovent Biologics, Inc. (a)(c) 6,600,000 43,349,279 
Insmed, Inc. (a) 1,371,622 53,506,974 
Kura Oncology, Inc. (a) 1,280,000 46,464,000 
Kymera Therapeutics, Inc. (a) 420,000 19,588,800 
Mirati Therapeutics, Inc. (a) 210,000 49,948,500 
Morphic Holding, Inc. (a) 260,225 8,163,258 
Neurocrine Biosciences, Inc. (a) 1,080,000 102,535,200 
ORIC Pharmaceuticals, Inc. (a) 710,235 24,084,069 
Passage Bio, Inc. 555,000 11,383,050 
Poseida Therapeutics, Inc. (a) 219,578 2,549,301 
Poseida Therapeutics, Inc. 1,415,125 15,608,121 
Prelude Therapeutics, Inc. (b) 288,128 14,829,948 
PTC Therapeutics, Inc. (a) 481,381 30,120,009 
Regeneron Pharmaceuticals, Inc. (a) 785,000 405,083,550 
Relay Therapeutics, Inc. (a) 540,000 28,787,400 
Repare Therapeutics, Inc. 500,000 14,935,000 
Revolution Medicines, Inc. 1,280,000 55,846,400 
Sage Therapeutics, Inc. (a) 134,379 9,956,140 
Sarepta Therapeutics, Inc. (a) 860,000 121,139,600 
Scholar Rock Holding Corp. (a) 134,347 6,693,168 
Shattuck Labs, Inc. 100,000 3,616,000 
Shattuck Labs, Inc. 980,433 31,907,212 
Stoke Therapeutics, Inc. (a) 589,572 30,710,805 
Taysha Gene Therapies, Inc. 271,778 6,147,618 
TG Therapeutics, Inc. (a) 1,280,000 37,555,200 
Turning Point Therapeutics, Inc. (a) 500,000 53,250,000 
uniQure B.V. (a) 488,362 23,480,445 
Vaxcyte, Inc. 600,000 19,260,000 
Vertex Pharmaceuticals, Inc. (a) 360,000 81,990,000 
Viela Bio, Inc. (a) 1,080,000 41,407,200 
Xencor, Inc. (a) 1,200,000 50,784,000 
Zentalis Pharmaceuticals, Inc. (b) 1,033,324 52,658,191 
Zymeworks, Inc. (a) 867,545 45,676,244 
  2,338,012,681 
Diversified Financial Services - 0.0%   
Other Diversified Financial Services - 0.0%   
Jaws Acquisition Corp. (a) 400,000 4,572,000 
Health Care Equipment & Supplies - 21.7%   
Health Care Equipment - 21.7%   
Becton, Dickinson & Co. 720,000 169,084,800 
Boston Scientific Corp. (a) 9,000,000 298,350,000 
Danaher Corp. 2,140,000 480,708,200 
DexCom, Inc. (a) 88,000 28,131,840 
Genmark Diagnostics, Inc. (a) 2,000,000 26,740,000 
Hologic, Inc. (a) 2,680,000 185,268,400 
Insulet Corp. (a) 1,000,000 257,710,000 
Intuitive Surgical, Inc. (a) 156,000 113,263,800 
Masimo Corp. (a) 500,000 127,245,000 
Outset Medical, Inc. 21,700 1,388,800 
Outset Medical, Inc. 1,451,090 83,582,784 
Penumbra, Inc. (a) 1,119,138 248,336,722 
Shockwave Medical, Inc. (a) 480,000 46,958,400 
Tandem Diabetes Care, Inc. (a) 740,000 69,471,200 
  2,136,239,946 
Health Care Providers & Services - 26.0%   
Health Care Facilities - 0.3%   
HCA Holdings, Inc. 220,000 33,024,200 
Health Care Services - 7.5%   
1Life Healthcare, Inc. (a) 1,280,000 42,073,600 
Alignment Healthcare Partners unit (d)(e) 2,145,460 32,051,027 
Cigna Corp. 2,500,000 522,850,000 
Guardant Health, Inc. (a) 119,700 14,498,064 
Oak Street Health, Inc. 2,758,058 123,592,716 
  735,065,407 
Managed Health Care - 18.2%   
Anthem, Inc. 630,000 196,257,600 
Centene Corp. (a) 5,150,000 317,497,500 
Humana, Inc. 1,190,000 476,618,800 
UnitedHealth Group, Inc. 2,400,000 807,216,001 
  1,797,589,901 
TOTAL HEALTH CARE PROVIDERS & SERVICES  2,565,679,508 
Health Care Technology - 1.7%   
Health Care Technology - 1.7%   
Castlight Health, Inc. (a) 1,845,550 2,325,393 
Castlight Health, Inc. Class B (a) 4,000,000 5,040,000 
Inspire Medical Systems, Inc. (a) 600,000 111,444,000 
Phreesia, Inc. (a) 482,947 21,326,940 
Veeva Systems, Inc. Class A (a) 90,000 24,918,300 
  165,054,633 
Life Sciences Tools & Services - 6.8%   
Life Sciences Tools & Services - 6.8%   
10X Genomics, Inc. Class B (c) 1,240,000 189,856,400 
Bio-Rad Laboratories, Inc. Class A (a) 145,168 78,172,968 
Bruker Corp. 2,500,000 126,525,000 
Lonza Group AG 190,000 119,542,831 
Maravai LifeSciences Holdings, Inc. 600,000 16,890,000 
Sotera Health Co. 174,800 4,730,088 
Thermo Fisher Scientific, Inc. 300,000 139,494,000 
  675,211,287 
Pharmaceuticals - 18.4%   
Pharmaceuticals - 18.4%   
Arvinas Holding Co. LLC (a) 500,000 12,100,000 
AstraZeneca PLC (United Kingdom) 3,500,000 366,222,058 
Bristol-Myers Squibb Co. 1,600,000 99,840,000 
Eli Lilly & Co. 2,800,000 407,820,000 
Harmony Biosciences Holdings, Inc. 1,719,128 70,634,672 
IMARA, Inc. 257,058 6,557,550 
Nektar Therapeutics (a)(b) 2,000,000 32,780,000 
Pliant Therapeutics, Inc. 912,700 25,117,504 
Roche Holding AG (participation certificate) 1,500,000 492,670,601 
Royalty Pharma PLC (d)(e) 14,453 
Royalty Pharma PLC 320,000 13,632,000 
Royalty Pharma PLC 1,853,000 74,990,910 
Sanofi SA 1,400,000 141,118,364 
Theravance Biopharma, Inc. (a) 1,308,635 21,710,255 
UCB SA 480,000 51,366,103 
  1,816,560,017 
Professional Services - 0.3%   
Research & Consulting Services - 0.3%   
Clarivate Analytics PLC (a) 1,000,000 27,440,000 
Software - 0.7%   
Application Software - 0.7%   
Nuance Communications, Inc. (a) 1,500,000 64,695,000 
TOTAL COMMON STOCKS   
(Cost $6,228,902,671)  9,793,465,072 
Convertible Preferred Stocks - 0.1%   
Pharmaceuticals - 0.1%   
Pharmaceuticals - 0.1%   
Aristea Therapeutics, Inc. Series B (d)(e)   
(Cost $5,719,912) 1,037,400 5,719,912 
Money Market Funds - 1.2%   
Fidelity Cash Central Fund 0.09% (f) 91,084,882 91,103,099 
Fidelity Securities Lending Cash Central Fund 0.09% (f)(g) 32,739,026 32,742,300 
TOTAL MONEY MARKET FUNDS   
(Cost $123,843,228)  123,845,399 
TOTAL INVESTMENT IN SECURITIES - 100.6%   
(Cost $6,358,465,811)  9,923,030,383 
NET OTHER ASSETS (LIABILITIES) - (0.6)%  (61,479,930) 
NET ASSETS - 100%  $9,861,550,453 

Legend

 (a) Non-income producing

 (b) Security or a portion of the security is on loan at period end.

 (c) Security exempt from registration under Rule 144A of the Securities Act of 1933. These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers. At the end of the period, the value of these securities amounted to $233,205,679 or 2.4% of net assets.

 (d) Restricted securities (including private placements) - Investment in securities not registered under the Securities Act of 1933 (excluding 144A issues). At the end of the period, the value of restricted securities (excluding 144A issues) amounted to $37,770,939 or 0.4% of net assets.

 (e) Level 3 security

 (f) Affiliated fund that is generally available only to investment companies and other accounts managed by Fidelity Investments. The rate quoted is the annualized seven-day yield of the fund at period end. A complete unaudited listing of the fund's holdings as of its most recent quarter end is available upon request. In addition, each Fidelity Central Fund's financial statements are available on the SEC's website or upon request.

 (g) Investment made with cash collateral received from securities on loan.

Additional information on each restricted holding is as follows:

Security Acquisition Date Acquisition Cost 
Alignment Healthcare Partners unit 2/28/20 $26,000,002 
Aristea Therapeutics, Inc. Series B 10/6/20 $5,719,912 
Royalty Pharma PLC 5/21/15 $1,704,009 

Affiliated Central Funds

Information regarding fiscal year to date income earned by the Fund from investments in Fidelity Central Funds is as follows:

Fund Income earned 
Fidelity Cash Central Fund $127,336 
Fidelity Securities Lending Cash Central Fund 596,175 
Total $723,511 

Amounts in the income column in the above table include any capital gain distributions from underlying funds. Amount for Fidelity Securities Lending Cash Central Fund represents the income earned on investing cash collateral, less rebates paid to borrowers and any lending agent fees associated with the loan, plus any premium payments received for lending certain types of securities.

Investment Valuation

Investments are valued as of 4:00 p.m. Eastern time on the last calendar day of the period. Security transactions are accounted for as of trade date. The Board of Trustees (the Board) has delegated the day to day responsibility for the valuation of the Fund's investments to the Fair Value Committee (the Committee) established by the Fund's investment adviser. In accordance with valuation policies and procedures approved by the Board, the Fund attempts to obtain prices from one or more third party pricing vendors or brokers to value its investments. When current market prices, quotations or currency exchange rates are not readily available or reliable, investments will be fair valued in good faith by the Committee, in accordance with procedures adopted by the Board. Factors used in determining fair value vary by investment type and may include market or investment specific events. The frequency with which these procedures are used cannot be predicted and they may be utilized to a significant extent. The Committee oversees the Fund’s valuation policies and procedures and reports to the Board on the Committee's activities and fair value determinations. The Board monitors the appropriateness of the procedures used in valuing the Fund's investments and ratifies the fair value determinations of the Committee. The Fund categorizes the inputs to valuation techniques used to value its investments into a disclosure hierarchy consisting of three levels: Level 1 - quoted prices in active markets for identical investments: Level 2 - other significant observable inputs (including quoted prices for similar investments, interest rates, prepayment speeds etc.): Level 3 - unobservable inputs (including the Fund's own assumptions based on the best information available). Changes in valuation techniques may result in transfers in or out of an assigned level within the disclosure hierarchy. Valuation techniques used to value the Fund's investments by major category are as follows:

Equity securities, including restricted securities, for which market quotations are readily available, are valued at the last reported sale price or official closing price as reported by a third party pricing vendor on the primary market or exchange on which they are traded and are categorized as Level 1 in the hierarchy. In the event there were no sales during the day or closing prices are not available, securities are valued at the last quoted bid price or may be valued using the last available price and are generally categorized as Level 2 in the hierarchy. For foreign equity securities, when market or security specific events arise, comparisons to the valuation of American Depositary Receipts (ADRs), futures contracts, Exchange-Traded Funds (ETFs) and certain indexes as well as quoted prices for similar securities may be used and would be categorized as Level 2 in the hierarchy. For equity securities, including restricted securities, where observable inputs are limited, assumptions about market activity and risk are used and these securities may be categorized as Level 3 in the hierarchy. 

Investments in open-end mutual funds, including the Fidelity Central Funds, are valued at their closing net asset value each business day and are categorized as Level 1 in the hierarchy.

For additional information on the Fund's significant accounting policies, please refer to the Fund's most recent semiannual or annual shareholder report.





The fund's schedule of investments as of the date on the cover of this report has not been audited. This report is provided for the general information of the fund's shareholders. For more information regarding the fund and its holdings, please see the fund's most recent prospectus and annual report.

Third party trademarks and service marks are the property of their respective owners. All other trademarks and service marks are the property of FMR LLC or an affiliate.