June 9, 2011

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Washington, D.C. 20549

Attention:  David Link, Esq. Jay Williamson, Esq.

Re: NeoStem, Inc. (the “Company”)

Registration Statement on Form S-3

Filed May 2, 2011

File No. 333-173855

Ladies and Gentlemen:

In connection with the above-captioned Registration Statement on Form S-3, and pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), the Company hereby requests that the effective date of the above-mentioned Registration Statement on Form S-3 be accelerated to 9:30 a.m. (New York time) on Monday, June 13, 2011, or as soon thereafter as practicable.

The Company hereby acknowledges that:

·     should the Commission or the staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing;

·     the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and

·     the Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Very truly yours,
NEOSTEM, INC.
By:	/s/ Robin L. Smith, M.D., M.B.A
	Robin L. Smith, M.D., M.B.A
	Chief Executive Officer and Chairman of the Board