As filed with the Securities and Exchange Commission on October 29, 2009

Registration No. 333-159282               

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

POST-EFFECTIVE AMENDMENT NO. 1

FORM S-8

REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

NEOSTEM, INC.

(Exact name of registrant as specified in its charter)

Delaware	22-2343568
(State or other jurisdiction	(I.R.S. employer
of incorporation or organization)	identification number)

420 Lexington Avenue, Suite 450

New York, NY 10170

(Address of principal executive offices; zip code)

NeoStem, Inc. 2009 Equity Compensation Plan

(Full title of the plan)

Catherine M. Vaczy, Esq.

Vice President and General Counsel

NeoStem, Inc.

420 Lexington Avenue, Suite 450

New York, NY 10170

(212) 584-4180

(Name, address and telephone number, including area code, of agent for service)

Copies to:

Alan Wovsaniker, Esq.

Lowenstein Sandler PC

65 Livingston Avenue

Roseland, New Jersey 07068

(973) 597-2500

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.  See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer   o	Accelerated filer  o
Non-accelerated filer  o (Do not check if a smaller reporting company)	Smaller reporting company  þ

Calculation of Registration Fee

Title of Securities to be Registered	Amount to be Registered	Proposed Maximum Offering Price per Share	Proposed Maximum Aggregate Offering Price	Amount of Registration Fee
Common Stock, par value $0.001 per share	5,950,000 shares (1)(2)	$1.925 (3)	$11,453,750 (3)	$639.12

(1) This represents shares of common stock, par value $0.001 per share (“Common Stock”), which may be issued with respect to awards, including stock options, stock appreciation rights, stock awards and restricted stock units, which may be granted under the NeoStem, Inc. 2009 Equity Compensation Plan (the “Plan”).

 (2) In accordance with Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this Post-Effective Amendment No. 1 to Registration Statement File No. 333-159282 (this “Post-Effective Amendment”) also covers such indeterminate number of additional shares as may be offered and issued under the Plan to prevent dilution resulting from any equity restructuring or change in capitalization of the registrant, including, but not limited to, spin offs, stock dividends, large non-recurring dividends, rights offerings, stock splits or similar transactions.

(3) Estimated, in accordance with Rule 457(c) and Rule 457(h)(1) of the Securities Act, solely for the purpose of calculating the registration fee.  The proposed maximum offering price per share and the proposed maximum aggregate offering price are based on the average of the high and low prices for a share of Common Stock on the NYSE Amex on October 26, 2009, which is within five days prior to the date of this registration statement.

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EXPLANATORY NOTE

This Post-Effective Amendment No. 1 to Registration  Statement File No. 333-159282 is being filed by the registrant, NeoStem, Inc. (the “Company”), for the purpose of increasing the number of shares of common stock, par value $0.001 per share (“Common Stock”), to be issued under the 2009 Equity Compensation Plan (the “Plan”) by 5,950,000 shares, from 3,800,000 shares to 9,750,000 shares, pursuant to General Instruction E on Form S-8 (Registration of Additional Securities).  The contents of the original registration statement (File No. 333-159282) are hereby incorporated by reference and made a part hereof.  The stockholders of the registrant approved amending the Plan for this purpose at the special meeting of stockholders held on October 29, 2009.

PART II

 INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.                      Incorporation of Certain Documents by Reference

The Securities and Exchange Commission allows us to “incorporate” into this registration statement information we file with other documents.  This means that we may disclose important information to you by referring to other documents that contain that information.  The information incorporated by reference is considered to be part of this registration statement, and information we file later with the Securities and Exchange Commission will automatically update and supersede this information.  We incorporate by reference the documents listed below, except to the extent information in those documents is different from the information contained in this registration statement:

(i)           our Prospectus filed pursuant to Rule 424(b)(3) of the Securities Act and filed with the Securities and Exchange Commission on October 7, 2009;

(ii)          our Quarterly Report on Form 10-Q for the quarter ended June 30, 2009 filed with the Securities and Exchange Commission on August 13, 2009;

(iii)         our Amendment No. 1 to our Quarterly Report on Form 10-Q/A for the quarter ended June 30, 2009 filed with the Securities and Exchange Commission on September 24, 2009;

(iv)         our Current Report on Form 8-K filed with the Securities and Exchange Commission on June 12, 2009;

(v)          our Current Report on Form 8-K filed with the Securities and Exchange Commission on June 16, 2009;

(vi)         our Current Report on Form 8-K filed with the Securities and Exchange Commission on July 6, 2009;

(vii)        our Current Report on Form 8-K filed with the Securities and Exchange Commission on July 8, 2009;

(viii)       our Current Report on Form 8-K filed with the Securities and Exchange Commission on July 10, 2009;

(ix)          our Current Report on Form 8-K filed with the Securities and Exchange Commission on July 13, 2009;

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(x)           our Current Report on Form 8-K filed with the Securities and Exchange Commission on July 17, 2009;

(xi)          our Current Report on Form 8-K filed with the Securities and Exchange Commission on August 4, 2009;

(xii)         our Current Report on Form 8-K filed with the Securities and Exchange Commission on September 1, 2009;

(xiii)        our Current Report on Form 8-K filed with the Securities and Exchange Commission on September 2, 2009;

(xiv)        our Current Report on Form 8-K filed with the Securities and Exchange Commission on September 9, 2009 (excluding any information deemed furnished pursuant to Item 7.01 of such Current Report on Form 8-K);

(xv)         our Amendment No. 1 to our Current Report on Form 8-K/A filed with the Securities and Exchange Commission on September 9, 2009;

(xvi)        our Current Report on Form 8-K filed with the Securities and Exchange Commission on October 6, 2009; and

(xvii)       our Current Report on Form 8-K filed with the Securities and Exchange Commission on October 13, 2009 (excluding any information deemed furnished pursuant to Item 7.01 of such Current Report on Form 8-K).

All documents subsequently filed by us with the Securities and Exchange Commission pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), prior to the filing of a post-effective amendment to this registration statement, which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be a part hereof from the date of filing of such documents.

Item 8. Exhibits

The exhibits accompanying this registration statement are listed on the accompanying exhibit index.

Item 9. Undertakings

(a)           The undersigned registrant hereby undertakes:

(1)           To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by section 10(a)(3) of the Securities Act;

(ii) To reflect in the prospectus any facts or events arising after the effective date of this registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement.  Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b) promulgated under the Securities Act if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement; and

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(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.

Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8 and the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Securities and Exchange Commission by the undersigned registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the registration statement; andthat paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) do not apply if the registration statement is on Form S-3 and the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Securities and Exchange Commission by the undersigned registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is deemed part of the registration statement.  Provided further, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is for an offering of asset-backed securities on Form S-1 or Form S-3, and the information required to be included in a post-effective amendment is provided pursuant to Item 1100(c) of Regulation AB.

(2)           That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3)           To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(5)           That, for the purpose of determining liability under the Securities Act to any purchaser:

(i) If the registrant is relying on Rule 430B:

(A) Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and

(B) Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by section 10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus.  As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.  Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date; or

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(ii) If the registrant is subject to Rule 430C, each prospectus filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration statement as of the date it is first used after effectiveness.  Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such first use, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such date of first use.

(6)           That, for the purpose of determining liability of the registrant under the Securities Act to any purchaser in the initial distribution of the securities:

The undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:

(i) Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;

(ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;

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(iii) The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and

(iv) Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.

(b)           The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the undersigned registrant’s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(h)           Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

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SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Post-Effective Amendment No. 1 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on October 29, 2009.

NEOSTEM, INC.
By:	/s/ ROBIN L. SMITH,
	Robin L. Smith, Chief Executive Officer

POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below under the heading “Name” constitutes and appoints Robin L. Smith and Catherine M. Vaczy or either of them, his true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities to sign any and all amendments (including post-effective amendments) to this Post-Effective Amendment No. 1 and any related registration statement filed under Rule 462(b), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, each acting alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, each acting alone, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated:

Name	Title	Date
/s/ ROBIN L. SMITH	Chief Executive Officer and Chairman of the Board	October 29, 2009
Robin L. Smith	(Principal Executive Officer)
/s/ LARRY MAY	Chief Financial Officer	October 29, 2009
Larry May	(Principal Financial Officer and Principal Accounting Officer)
/s/ DREW BERNSTEIN	Director	October 29, 2009
Drew Bernstein
/s/ RICHARD BERMAN	Director	October 29, 2009
Richard Berman
/s/ STEVEN S. MYERS	Director	October 29, 2009
Steven S. Myers
/s/ JOSEPH ZUCKERMAN	Director	October 29, 2009
Joseph Zuckerman

EXHIBIT INDEX

Exhibit Number	Description
4.1	Registrant’s Amended and Restated Certificate of Incorporation dated August 29, 2006 (1)
4.2	Amendment effective August 9, 2007 to Registrant’s Amended and Restated Certificate of Incorporation (2)
4.3	Registrant’s Restated Certificate of Incorporation with Certificate of Designations for Series D Preferred Stock as certified June 23, 2009*
4.4	Registrant’s Amended and Restated By-Laws dated August 1, 2006 (3)
4.5	NeoStem, Inc. 2009 Equity Compensation Plan (4)
5.1	Opinion of Lowenstein Sandler PC*
23.1	Consent of Independent Registered Public Accounting Firm*
23.2	Consent of Lowenstein Sandler PC (contained in Exhibit 5.1)*
24.1	Power of Attorney (included on the signature page of this registration statement)*

* Filed herewith.

(1)           Incorporated by reference to Exhibit 3.1 of Registrant’s Registration Statement on Form S-1, filed with the Securities and Exchange Commission on September 1, 2006 (File No. 333-137045).

(2)           Incorporated by reference to Exhibit 3.1 of Registrant’s Registration Statement on Form S-3, filed with the Securities and Exchange Commission on September 11, 2007 (File No. 333-145988).

(3)           Incorporated by reference to Exhibit 3.2 of Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 7, 2006.

(4)           Incorporated by reference to Exhibit 4.4 of Registrant’s Registration Statement on Form S-8, filed with the Securities and Exchange Commission on May 15, 2009 (File No. 333-159282).