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Share-Based Compensation (Q1) (Tables)
 3 Months Ended 12 Months Ended
Mar. 31, 2022
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]    
Schedule Share-based Compensation Expense The following table summarizes the components of share-based compensation expense for the three months ended March 31, 2022 and 2021 (in thousands):
 
 ​ ​
Three Months Ended
March 31,
 
 ​ ​
2022
 ​ ​
2021
Research and development
 ​ ​
$218
 ​ ​
$96
General and administrative
 ​ ​
542
​ ​
501
Total share-based compensation expense
 ​ ​
$760
 ​ ​
$597
The following table summarizes the components of share-based compensation expense for the years ended December 31, 2021 and 2020 ($ in thousands):

 
 ​ ​
Year Ended December 31,
 
 ​ ​
2021
 ​ ​
2020
Research and development
 ​ ​
$760
 ​ ​
$179
General and administrative
 ​ ​
1,245
 ​ ​
1,086
Total share-based compensation expense
 ​ ​
$2,005
 ​ ​
$1,265

Total compensation cost related to unvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at December 31, 2021 were as follows ($ in thousands):

 
 ​ ​
Stock
Options
 ​ ​
Restricted
Stock
Units
 ​ ​
Restricted
Stock
Unrecognized compensation cost
 ​ ​
$757
 ​ ​
$149
 ​ ​
$546
Expected weighted-average period in years of compensation cost to be recognized
 ​ ​
1.64
 ​ ​
1.57
​ ​
1.70
Schedule of Total Compensation Cost Related to Nonvested Awards

Total compensation cost related to non-vested awards not yet recognized and the weighted-average periods over which the awards were expected to be recognized at March 31, 2022 were as follows (in thousands):
 
 ​ ​
Stock
Options
 ​ ​
Restricted
Stock
Units
 ​ ​
Restricted
Stock
Unrecognized compensation cost
 ​ ​
$814
 ​ ​
$444
 ​ ​
$1,004
Expected weighted-average period in years of compensation cost to be recognized
 ​ ​
1.77
​ ​
0.96
​ ​
2.25
 
Schedule of Fair Value of Share-based Compensation Awards

Total fair value of shares vested and the weighted average estimated fair values of shares granted for the three months ended March 31, 2022 and 2021 were as follows (in thousands):
 
 ​ ​
Stock Options
 
 ​ ​
Three Months Ended
March 31,
 
 ​ ​
2022
 ​ ​
2021
Total fair value of shares vested
 ​ ​
$377
 ​ ​
$397
Weighted average estimated fair value of shares granted
 ​ ​
$0.62
 ​ ​
$1.08

The range of assumptions made in calculating the fair values of stock options was as follow:

 
 ​ ​
Stock Options
 
 ​ ​
Year Ended
December 31,
 
 ​ ​
2021
 ​ ​
2020
Expected term - minimum (in years)
 ​ ​
6
 ​ ​
6
Expected term - maximum (in years)
 ​ ​
6
 ​ ​
6
Expected volatility - minimum
 ​ ​
79%
 ​ ​
75%
Expected volatility - maximum
 ​ ​
84%
 ​ ​
79%
Weighted Average volatility
 ​ ​
81%
 ​ ​
75%
Expected dividend yield
 ​ ​
—
 ​ ​
—
Risk-free interest rate - minimum
 ​ ​
0.63%
 ​ ​
0.40%
Risk-free interest rate - maximum
 ​ ​
1.16%
 ​ ​
1.71%