Stockholders' Equity - Stock Options and Warrants (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Stock Options, Shares
Outstanding, beginning balance (shares)	142,041
Granted (shares)	37,458
Proceeds from option exercises (in shares)	1,227,776
Forfeited (shares)	(5,844)
Expired (shares)	(10,079)
Outstanding, ending balance (shares)	1,391,352	142,041
Vested or expected to vest (shares)	1,389,844
Exercisable (shares)	1,145,342
Stock Options, Weighted Average Exercise Price
Outstanding, beginning balance (in dollars per share)	$ 84.60
Granted (in dollars per share)	13.49
Exercised (in dollars per share)	3.77
Forfeited (in dollars per share)	16.68
Expired (in dollars per share)	192.41
Outstanding, ending balance (in dollars per share)	10.83	$ 84.60
Vested or expected to vest (in dollars per share)	10.83
Exercisable (in dollars per share)	$ 11.60
Stock Options, Weighted Average Contractual Term and Intrinsic Value
Options outstanding, weighted average remaining contractual term (in years)	7 years 10 days	7 years 11 months 19 days
Options vested or expected to vest, weighted average remaining contractual term (in years)	7 years 10 days
Options exercisable, weighted average remaining contractual term (in years)	6 years 9 months 3 days
Options outstanding, aggregate intrinsic value	$ 187.6	$ 0
Options vested or expected to vest, aggregate intrinsic value	187.6
Options exercisable, aggregate intrinsic value	$ 187.6
Warrants, Shares
Warrants outstanding, beginning balance (shares)	1,423,774
Warrants granted (shares)	0
Warrants exercised (shares)	0
Warrants forfeited (shares)	0
Warrants expired (shares)	0
Warrants outstanding, ending balance (shares)	1,423,744	1,423,774
Warrants vested or expected to vest (shares)	1,423,744
Warrants exercisable (shares)	1,423,744
Warrants, Weighted Average Exercise Price
Warrants outstanding, beginning balance (in dollars per share)	$ 42.57
Warrants granted (in dollars per share)	0
Warrants exercised (in dollars per share)	0
Warrants forfeited (in dollars per share)	0
Warrants expired (in dollars per share)	0
Warrants outstanding, ending balance (in dollars per share)	42.57	$ 42.57
Warrants vested or expected to vest (in dollars per share)	42.57
Warrants exercisable (in dollars per share)	$ 42.57
Warrants, Weighted Average Contractual Term and Intrinsic Value
Warrants outstanding, weighted average remaining contractual term (in years)	3 years 4 months 13 days	4 years 4 months 13 days
Warrants vested or expected to vest, weighted average remaining contractual term (in years)	3 years 4 months 13 days
Warrants exercisable, weighted average remaining contractual term (in years)	3 years 4 months 13 days
Warrants outstanding, aggregate intrinsic value	$ 0	$ 0
Warrants vested or expected to vest, aggregate intrinsic value	0
Warrants exercisable, aggregate intrinsic value	$ 0