Stockholders' Equity - Stock Options and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2022	Dec. 31, 2021
Stock Options, Shares
Options, Outstanding, Beginning of Period (in shares)	142,041
Options, Granted (in shares)	37,458
Options, Exercised (in shares)	0
Options, Forfeited (in shares)	(2,910)
Options, Expired (in shares)	(5,388)
Options, Outstanding, End of Period (in shares)	1,398,977	142,041
Options, Vested and expected to vest (in shares)	1,396,921
Options, Vested (in shares)	1,110,635
Stock Options, Weighted Average Exercise Price
Options, Outstanding. Beginning of Period (in dollars per share)	$ 84.60
Options, Granted (in dollars per share)	13.49
Options, Exercised (in dollars per share)	0
Options, Forfeited (in dollars per share)	19.96
Options, Expired (in dollars per share)	352.31
Options, Outstanding, End of Period (in dollars per share)	10.83	$ 84.60
Options, Vested and expected to vest (in dollars per share)	10.83
Options, Vested (in dollars per share)	$ 11.82
Stock Options, Weighted Average Contractual Term and Intrinsic Value
Options, Outstanding, Weighted Average Remaining Contractual Term	7 years 3 months 18 days	7 years 11 months 19 days
Options, Vested and expected to vest, Weighted Average Remaining Contractual Term	7 years 3 months 18 days
Options, Vested, Weighted Average Remaining Contractual Term	6 years 11 months 19 days
Options, Outstanding, Aggregate Intrinsic Value	$ 0	$ 0
Options, Vested and expected to vest, Aggregate Intrinsic Value	0
Options, Vested, Aggregate Intrinsic Value	$ 0
Warrants, Shares
Warrants, Outstanding, Beginning of Period (in shares)	1,423,774
Warrants, Granted (in shares)	0
Warrants, Exercised (in shares)	0
Warrants, Forfeited (in shares)	0
Warrants, Expired (in shares)	0
Warrants, Outstanding, End of Period (in shares)	1,423,774	1,423,774
Warrants, Vested and expected to vest (in shares)	1,423,774
Warrants, Vested (in shares)	1,423,774
Warrants, Weighted Average Exercise Price
Warrants Outstanding, Beginning of Period (in dollars per share)	$ 42.57
Warrants, Granted (in dollars per share)	0
Warrants, Exercised (in dollars per share)	0
Warrants, Forfeited (in dollars per share)	0
Warrants, Expired (in dollars per share)	0
Warrants Outstanding, End of Period (in dollars per share)	42.57	$ 42.57
Weighted Average Exercise Price, Warrants Vested And Expected To Vest	42.57
Warrants, Vested, Weighted Average Exercise Price (in dollars per share)	$ 42.57
Warrants, Weighted Average Contractual Term and Intrinsic Value
Warrants, Outstanding, Weighted Average Remaining Contractual Term	3 years 7 months 17 days	4 years 4 months 13 days
Warrants, Vested and expected to vest, Weighted Average Remaining Contractual Term	3 years 7 months 17 days
Warrants, Vested, Weighted Average Remaining Contractual Term	3 years 7 months 17 days
Warrants Outstanding, Aggregate Intrinsic Value	$ 0	$ 0
Warrants, Vested and expected to vest, Aggregate Intrinsic Value	0
Warrants, Vested, Aggregate Intrinsic Value	$ 0