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Share-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2022
Share-based Payment Arrangement, Noncash Expense [Abstract]  
Schedule Share-based Compensation Expense The following table summarizes the components of share-based compensation expense for the three months ended March 31, 2022 and 2021 (in thousands):
Three Months Ended March 31,
20222021
Research and development$218 $96 
General and administrative542 501 
Total share-based compensation expense$760 $597 
Schedule of Total Compensation Cost Related to Nonvested Awards
Total compensation cost related to non-vested awards not yet recognized and the weighted-average periods over which the awards were expected to be recognized at March 31, 2022 were as follows (in thousands):
Stock OptionsRestricted Stock UnitsRestricted Stock
Unrecognized compensation cost$814 $444 $1,004 
Expected weighted-average period in years of compensation cost to be recognized1.770.962.25
Schedule of Fair Value of Share-based Compensation Awards
Total fair value of shares vested and the weighted average estimated fair values of shares granted for the three months ended March 31, 2022 and 2021 were as follows (in thousands):
Stock Options
Three Months Ended March 31,
20222021
Total fair value of shares vested$377 $397 
Weighted average estimated fair value of shares granted$0.62 $1.08