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Share-Based Compensation - Narrative (Details) - USD ($)
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2017
Sep. 30, 2017
Dec. 31, 2018
Dec. 31, 2017
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Share-based Compensation Arrangement by Share-based Payment Award Accelerated Compensation Cost   $ 1,900,000    
Allocated Share-based Compensation Expense     $ 2,453,000 $ 2,852,000
Share-based Compensation Arrangement by Share-based Payment Award, Plan Modification, Incremental Compensation Cost $ 300,000      
Research and Development Expense [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Allocated Share-based Compensation Expense     446,000 269,000
General and Administrative Expense [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Allocated Share-based Compensation Expense     2,007,000 1,694,000
Discontinued Operations, Disposed of by Sale [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Allocated Share-based Compensation Expense     $ 0 $ 889,000
Stock Options [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price     $ 2.61 $ 1.72
Stock Option [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Adjustments to Additional Paid in Capital, Share-based Compensation, Stock Options, Requisite Service Period Recognition     $ 218,000 $ 5,002,000
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum     68.00% 71.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum     73.00% 74.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate     0.00% 0.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum     2.35% 1.99%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum     2.96% 2.28%