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Share-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Share-based Compensation, Stock Options, Activity
The following table summarizes the activity for stock options and warrants for the year ended December 31, 2018:
 
Stock Options
 
Warrants
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2017
1,072,499

 
$
33.50

 
4.76
 
$
0.1

 
209,818

 
$
53.20

 
0.95
 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Changes during the Year:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Granted
157,360

 
$
4.00

 
 
 
 
 
—

 
$
—

 
 
 
 
Exercised
(77,498
)
 
$
4.60

 
 
 
 
 
—

 
$
—

 
 
 
 
Forfeited
(3,030
)
 
$
3.80

 
 
 
 
 
—

 
$
—

 
 
 
 
Expired
(130,801
)
 
$
32.50

 
 
 
 
 
(179,818
)
 
$
60.40

 
 
 
 
Outstanding at December 31, 2018
1,018,530

 
$
30.50

 
5.30
 
$
3.3

 
30,000

 
$
5.90

 
4.19
 
$
—

Vested at December 31, 2018 or expected to vest in the future
1,008,918

 
$
30.80

 
5.26
 
$
3.3

 
30,000

 
$
5.90

 
4.19
 
$
—

Exercisable at December 31, 2018
895,861

 
$
34.20

 
4.78
 
$
3.3

 
30,000

 
$
5.90

 
4.19
 
$
—

The following table summarizes the components of share-based compensation expense for the years ended December 31, 2018 and 2017 ($ in thousands):
 
Year Ended December 31,
 
2018
 
2017
Research and development
$
446

 
$
269

General and administrative
2,007

 
1,694

Discontinued operations
—

 
889

Total share-based compensation expense
$
2,453

 
$
2,852
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Total compensation cost related to unvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at December 31, 2018 were as follows ($ in thousands):
 
Stock Options
 
Restricted Stock
Unrecognized compensation cost
$
540

 
$
—

Expected weighted-average period in years of compensation cost to be recognized
1.95

 
0.00
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block]
Total fair value of shares vested and the weighted average estimated fair values of shares granted for the years ended December 31, 2018 and 2017 were as follows ($ in thousands):
 
 
Stock Options
 
 
Year Ended December 31,
 
 
2018
 
2017
Total fair value of shares vested
 
$
218

 
$
5,002

Weighted average estimated fair value of shares granted
 
2.61

 
1.72
Schedule of Range of Fair Value of Stock Options and Warrants
The range of assumptions made in calculating the fair values of stock options was as follow:
 
Stock Options
 
Year Ended December 31,
 
2018
 
2017
Expected term - minimum (in years)
5.5
 
6
Expected term - maximum (in years)
6
 
6
Expected volatility - minimum
68%
 
71%
Expected volatility - maximum
73%
 
74%
Weighted Average volatility
72%
 
35%
Expected dividend yield
—
 
—
Risk-free interest rate - minimum
2.35%
 
1.99%
Risk-free interest rate - maximum
2.96%
 
2.28%