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Stockholders' Equity (Tables)
 12 Months Ended
Dec. 31, 2018
Equity [Abstract]  
Schedule of Share-based Compensation, Stock Options, Activity
The following table summarizes the activity for stock options and warrants for the year ended December 31, 2018:
 
Stock Options
 
Warrants
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2017
1,072,499

 
$
33.50

 
4.76
 
$
0.1

 
209,818

 
$
53.20

 
0.95
 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Changes during the Year:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Granted
157,360

 
$
4.00

 
 
 
 
 
—

 
$
—

 
 
 
 
Exercised
(77,498
)
 
$
4.60

 
 
 
 
 
—

 
$
—

 
 
 
 
Forfeited
(3,030
)
 
$
3.80

 
 
 
 
 
—

 
$
—

 
 
 
 
Expired
(130,801
)
 
$
32.50

 
 
 
 
 
(179,818
)
 
$
60.40

 
 
 
 
Outstanding at December 31, 2018
1,018,530

 
$
30.50

 
5.30
 
$
3.3

 
30,000

 
$
5.90

 
4.19
 
$
—

Vested at December 31, 2018 or expected to vest in the future
1,008,918

 
$
30.80

 
5.26
 
$
3.3

 
30,000

 
$
5.90

 
4.19
 
$
—

Exercisable at December 31, 2018
895,861

 
$
34.20

 
4.78
 
$
3.3

 
30,000

 
$
5.90

 
4.19
 
$
—

The following table summarizes the components of share-based compensation expense for the years ended December 31, 2018 and 2017 ($ in thousands):
 
Year Ended December 31,
 
2018
 
2017
Research and development
$
446

 
$
269

General and administrative
2,007

 
1,694

Discontinued operations
—

 
889

Total share-based compensation expense
$
2,453

 
$
2,852
Restricted Stock
During the years ended December 31, 2018 and 2017, the Company issued restricted stock for services as follows ($ in thousands, except share data):
 
 
 
2018
 
2017
Number of Restricted Stock Issued
91,740

 
181,908

Value of Restricted Stock Issued
$
347.7

 
$
627.7