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The Business - Narrative (Details)
$ in Millions
1 Months Ended 3 Months Ended
Mar. 31, 2018
USD ($)
Jan. 31, 2018
patient
Dec. 31, 2017
USD ($)
Oct. 31, 2017
USD ($)
Oct. 31, 2016
patient
Mar. 31, 2018
USD ($)
Mar. 31, 2016
cohort
Feb. 28, 2017
USD ($)
Research and Development Arrangement, Contract to Perform for Others [Line Items]                
Revenue from grants $ 0.3   $ 1.9 $ 1.9   $ 7.9    
Number of patients enrolled | patient   110     19      
Interim efficacy analysis, threshold (percent)         50.00%      
Interim efficacy analysis, follow-up milestone period         6 months      
Grants receivable $ 8.6         $ 8.6   $ 12.2
The Sanford Project: T-Rex Study [Member]                
Research and Development Arrangement, Contract to Perform for Others [Line Items]                
Number of cohorts | cohort             2