Shareholders' Equity - Stock options and warrants (Details)	9 Months Ended	12 Months Ended
	Sep. 30, 2017 USD ($) $ / shares $ / warrant shares	Dec. 31, 2016 USD ($) $ / shares $ / warrant shares
Warrants, Number of Shares [Roll Forward]
Warrants, Shares, Beginning of Period	388,062
Warrants Granted	0
Warrants Exercised	0
Warrants Canceled	(1,691)
Warrants Expired	(167,393)
Warrants, Shares, End of Period	218,978	388,062
Warrants Weighted Average Exercise Price [Roll Forward]
Weighted Average Exercise Price, Warrants Outstanding, Beginning of Period | $ / warrant	76.50
Weighted Average Exercise Price, Warrants Granted | $ / shares	$ 0.00
Weighted Average Exercise Price, Warrants Exercised | $ / shares	0.00
Weighted Average Exercise Price, Warrants Canceled | $ / shares	700.00
Weighted Average Exercise Price, Warrants Expired | $ / shares	$ 104.50
Weighted Average Exercise Price, Warrants Outstanding, End of Period | $ / warrant	54.80	76.50
Weighted Average Remaining Contractual Term, Warrant outstanding	1 year 1 month 24 days	1 year 2 months 27 days
Aggregate Intrinsic Value, Warrants Outstanding | $	$ 0	$ 0
Warrants, vested and expected to vest	218,978
Weighted Average Exercise Price, Warrants vested & expected to vest | $ / warrant	54.80
Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest	1 year 1 month 24 days
Aggregate Intrinsic Value, Warrants vested and expected to vest | $	$ 0
Warrants, Vested. Number	218,978
Warrants, Vested, Weighted Average Exercise Price | $ / warrant	54.80
Warrants, Vested, Weighted Average Remaining Contractual Term	1 year 1 month 24 days
Warrants, Vested, Aggregate Intrinsic Value | $	$ 0
US Equity Plan [Member]
Options, Outstanding [Roll Forward]
Options, Outstanding, Beginning of Period	952,790
Options, Grants in Period, Net of Forfeitures	447,757
Options, Exercises in Period	(3,835)
Options, Forfeitures in Period	(244,413)
Options, Expirations in Period	(46,509)
Options, Outstanding, End of Period	1,105,790	952,790
Options, Outstanding, Weighted Average Exercise Price [Abstract]
Options, Outstanding, Weighted Average Exercise Price, Beginning of Period | $ / shares	$ 39.90
Options, Grants in Period, Weighted Average Exercise Price | $ / shares	11.70
Options, Exercises in Period, Weighted Average Exercise Price | $ / shares	4.70
Options, Forfeitures in Period, Weighted Average Exercise Price | $ / shares	18.70
Options, Expirations in Period, Weighted Average Exercise Price | $ / shares	41.20
Options, Outstanding, Weighted Average Exercise Price, End of Period | $ / shares	$ 33.30	$ 39.90
Options, Outstanding, Weighted Average Remaining Contractual Term	5 years 1 month 10 days	7 years 7 months 6 days
Options, Outstanding, Intrinsic Value | $	$ 8,200	$ 0
Options, Vested and Expected to Vest, Outstanding, Number	1,105,336
Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price | $ / shares	$ 33.30
Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term	5 years 1 month 10 days
Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value | $	$ 8,200
Options, Vested and Expected to Vest, Exercisable, Number	1,097,350
Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price | $ / shares	$ 32.70
Options, Vested, Weighted Average Remaining Contractual Term	5 years 1 month 13 days
Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value | $	$ 8,200