Shareholders' Equity - Stock options and warrants (Details)	3 Months Ended	12 Months Ended
	Mar. 31, 2017 USD ($) $ / shares $ / warrant shares	Dec. 31, 2016 USD ($) $ / shares $ / warrant shares
Stock Options and Warrants [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value | $	$ 386,500	$ 0
Common Stock Warrants, Shares	336,062	388,062
Weighted Average Exercise Price, Warrants Outstanding | $ / warrant	80.40	76.50
Weighted Average Remaining Contractual Term warrant outstanding	1 year 1 month 24 days	1 year 2 months 27 days
Aggregate Intrinsic Value, Warrants Outstanding | $	$ 0	$ 0
Warrants Granted	0
Warrants Canceled	(52,000)
Weighted Average Exercise Price, Warrants Granted | $ / shares	$ 0.00
Warrants Exercised	0
Weighted Average Exercise Price, Warrants Exercised | $ / shares	$ 0.00
Warrants Expired	0
Weighted Average Exercise Price, Warrants Expired | $ / shares	$ 0.00
Weighted Average Exercise Price, Warrants Canceled | $ / shares	$ 51.30
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value | $	$ 357,700
shares, vested and expected to vest	336,062
Weighted Average Exercise Price, Warrants vested & expected to vest | $ / warrant	80.40
Aggregate Intrinsic Value, Warrants vested and expected to vest | $	$ 0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value | $	$ 133,600
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number	336,062
Weighted Average Exercise Price, Warrants Exercisable | $ / warrant	80.40
weighted Average Remaining Contractual Term, warrants vested	1 year 1 month 24 days
Aggregate Intrinsic Value, Warrants vested | $	$ 0
US Equity Plan [Member]
Stock Options and Warrants [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number	1,133,459	952,790
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price | $ / shares	$ 33.30	$ 39.90
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term	7 years 9 months 18 days	7 years 7 months 6 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures	209,418
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares	$ 3.60
Stock Options Exercised	0
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price | $ / shares	$ 0.00
Stock Options Expired	(6,294)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price | $ / shares	$ 8.40
Stock Options Forfeited	(22,455)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price | $ / shares	$ 43.20
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number	1,103,988
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price | $ / shares	$ 34.00
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term	7 years 9 months 4 days
Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest	1 year 1 month 24 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number	821,156
Weighted average estimated fair value of shares granted | $ / shares	$ 43.10
Options, Vested, weighted Average Remaining Contractual Term	7 years 2 months 23 days