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Share-Based Compensation Share-Based Compensation (Details) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]    
Allocated Share-based Compensation Expense $ 2,604,400 $ 9,750,100
Cost of Sales [Member]    
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]    
Allocated Share-based Compensation Expense 333,700 545,300
Research and Development Expense [Member]    
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]    
Allocated Share-based Compensation Expense 339,100 1,811,500
General and Administrative Expense [Member]    
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]    
Allocated Share-based Compensation Expense $ 1,931,600 $ 7,393,300
Stock Options [Member]    
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price $ 3.23 $ 19.50
Stock Option [Member]    
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]    
Adjustments to Additional Paid in Capital, Share-based Compensation, Stock Options, Requisite Service Period Recognition $ 2,359,800 $ 6,133,000
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum 73.00% 71.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum 76.00% 75.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate 0.00% 0.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum 1.70% 1.19%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum 2.19% 2.14%