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Share-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2016
Share-based Compensation [Abstract]  
Schedule of Share-based Compensation, Stock Options, Activity
The following table summarizes the activity for stock options and warrants for the year ended December 31, 2016, as adjusted for the Reverse Stock Split:
 
Stock Options
 
Warrants
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2015
666,348

 
$
64.60

 
6.88
 
$
0.1

 
321,404

 
$
137.20

 
1.26
 
$
—

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Changes during the Year:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Granted
464,815

 
$
5.30

 
 
 
 
 
171,845

 
$
9.30

 
 
 
 
Exercised
—

 
$
—

 
 
 
 
 
—

 
$
—

 
 
 
 
Forfeited
(70,513
)
 
$
32.70

 
 
 
 
 
251

 
$
700.00

 
 
 
 
Expired
(107,860
)
 
$
48.30

 
 
 
 
 
(105,438
)
 
$
152.70

 
 
 
 
Outstanding at December 31, 2016
952,790

 
$
39.90

 
7.60
 
$
—

 
388,062

 
$
76.50

 
1.24
 
$
—

Vested at December 31, 2016 or expected to vest in the future
938,889

 
$
40.3

 
7.58
 
$
—

 
388,062

 
$
76.50

 
1.24
 
$
—

Exercisable at December 31, 2016
769,224

 
$
46.2

 
7.27
 
$
—

 
388,062

 
$
76.50

 
1.24
 
$
—

The following table summarizes the components of share-based compensation expense for the years ended December 31, 2016 and 2015 ($ in thousands):
 
Year Ended December 31,
 
2016
 
2015
Cost of revenues
$
333.7

 
$
545.3

Research and development
339.1

 
1,811.5

Selling, general and administrative
1,931.6

 
7,393.3

Total share-based compensation expense
$
2,604.4

 
$
9,750.1
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at December 31, 2016 were as follows ($ in thousands):
 
Stock Options
 
Restricted Stock
Unrecognized compensation cost
$
1,245.5

 
$
382.3

Expected weighted-average period in years of compensation cost to be recognized
1.80

 
1.76
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block]
Total fair value of shares vested and the weighted average estimated fair values of shares granted for the years ended December 31, 2016 and 2015 were as follows ($ in thousands):
 
 
Stock Options
 
 
Year Ended December 31,
 
 
2016
 
2015
Total fair value of shares vested
 
$
2,359.8

 
$
6,133.0

Weighted average estimated fair value of shares granted
 
3.23

 
19.50
Schedule of Range of Fair Value of Stock Options and Warrants
The range of assumptions made in calculating the fair values of stock options was as follow:
 
Stock Options
 
Year Ended December 31,
 
2016
 
2015
Expected term - minimum (in years)
5
 
2
Expected term - maximum (in years)
10
 
10
Expected volatility - minimum
73%
 
71%
Expected volatility - maximum
76%
 
75%
Weighted Average volatility
72%
 
74%
Expected dividend yield
—
 
—
Risk-free interest rate - minimum
1.70%
 
1.19%
Risk-free interest rate - maximum
2.19%
 
2.14%