Shareholders' Equity - Stock options and warrants (Details)	6 Months Ended	12 Months Ended
	Jun. 30, 2016 USD ($) $ / shares $ / warrant shares	Dec. 31, 2015 USD ($) $ / shares $ / warrant shares	Mar. 10, 2016 shares
Stock Options and Warrants [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value | $	$ 18,900	$ 100
Common Stock Warrants, Shares	460,049	321,404	141,844
Weighted Average Exercise Price, Warrants Outstanding | $ / warrant	98.00	137.20
Weighted Average Remaining Contractual Term warrant outstanding	1 year 22 days	1 year 3 months 4 days
Aggregate Intrinsic Value, Warrants Outstanding | $	$ 0	$ 0
Warrants Granted	141,845
Warrants Canceled	(3,200.0)
Weighted Average Exercise Price, Warrants Granted | $ / shares	$ 122.60
Warrants Exercised	0
Weighted Average Exercise Price, Warrants Exercised | $ / shares	$ 0.00
Warrants Expired	0
Weighted Average Exercise Price, Warrants Expired | $ / shares	$ 0.00
Weighted Average Exercise Price, Warrants Canceled | $ / shares	$ 147.50
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value | $	$ 18,400
shares, vested and expected to vest	460,049
Weighted Average Exercise Price, Warrants vested & expected to vest | $ / warrant	98.00
Aggregate Intrinsic Value, Warrants vested and expected to vest | $	$ 0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value | $	$ 9,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number	460,300
Weighted Average Exercise Price, Warrants Exercisable | $ / warrant	98.00
weighted Average Remaining Contractual Term, warrants vested	1 year 22 days
Aggregate Intrinsic Value, Warrants vested | $	$ 0
US Equity Plan [Member]
Stock Options and Warrants [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number	692,332	666,348.0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price | $ / shares	$ 55.00	$ 64.60
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term	7 years 4 months 2 days	6 years 10 months 17 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures	169,038
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares	$ 6.20
Stock Options Exercised	0
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price | $ / shares	$ 0.00
Stock Options Expired	(56,024)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price | $ / shares	$ 35.90
Stock Options Forfeited	(87,030)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price | $ / shares	$ 46.50
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number	675,324
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price | $ / shares	$ 56.00
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term	7 years 3 months 15 days
Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest	1 year 22 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number	489,652
Weighted average estimated fair value of shares granted | $ / shares	$ 71.00
Options, Vested, weighted Average Remaining Contractual Term	6 years 6 months 18 days