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Share-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2016
Share-based Compensation [Abstract]  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
The following table summarizes the components of share-based compensation expense for the three and six months ended June 30, 2016 and 2015 (in thousands):
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2016
 
2015
 
2016
 
2015
Cost of goods sold
$
11.7

 
$
378.2

 
$
136.0

 
$
495.1

Research and development
6.0

 
1,104.2

 
98.3

 
1,526.9

Selling, general and administrative
317.8

 
2,933.9

 
1,000.8

 
6,110.1

Total share-based compensation expense
$
335.5

 
$
4,416.3

 
$
1,235.1

 
$
8,132.1

 
 
 
 
 
 
 
 
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at June 30, 2016 were as follows (in thousands):
 
Stock Options
 
Restricted Stock
Unrecognized compensation cost
$
1,696.8

 
$
551.0

Expected weighted-average period in years of compensation cost to be recognized
2.09

 
2.02
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block]
Total fair value of shares vested and the weighted average estimated fair values of shares granted for the six months ended June 30, 2016 and 2015 were as follows, as adjusted for the Reverse Stock Split (in thousands):
 
Stock Options
 
Warrants
 
Six Months Ended June 30,
 
Six Months Ended June 30,
 
2016
 
2015
 
2016
 
2015
Total fair value of shares vested
$
1,153.1

 
$
4,915.3

 
$
—

 
$
14.0

Weighted average estimated fair value of shares granted
$
4.02

 
$
2.17

 
$
—

 
$
—