Fair Value Measurements Financial instruments with significant Level 3 inputs (Details) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Jun. 30, 2015	May. 08, 2014	Oct. 31, 2011
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Liabilities Arising from Contingencies, Amount Recognized	$ 0	$ 12,800,000
Percentage of Net Sales						10.00%
Percentage of license cost						30.00%
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Available-for-sale Securities	0	7,080,000
Business Combination, Contingent Consideration, Liability	0	18,260,000			$ 11,900,000
Fair Value, Net Asset (Liability)	0	18,260,000
Changes in acquisition-related contingent consideration	(18,260,000)	(3,080,000)	$ 1,900,000
Fair Value, Inputs, Level 1 [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Available-for-sale Securities	0	0
Business Combination, Contingent Consideration, Liability	0	0
Fair Value, Inputs, Level 2 [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Available-for-sale Securities	0	7,080,000
Business Combination, Contingent Consideration, Liability	0	0
Fair Value, Inputs, Level 3 [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Available-for-sale Securities	0	0
Business Combination, Contingent Consideration, Liability	$ 0	18,260,000
Amorcyte, LLC [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Business Combination, Contingent Consideration, Liability		$ 5,500,000		$ 0