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Share-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2014
Share-based Compensation [Abstract]  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
The following table summarizes the components of share-based compensation expense for the three months ended March 31, 2014 and 2013 (in thousands):
 
 
Three Months Ended March 31,
 
 
2014
 
2013
Cost of goods sold
 
$
138.1

 
$
86.4

Research and development
 
476.8

 
217.4

Selling, general and administrative
 
3,278.7

 
1,914.7

Total share-based compensation expense
 
$
3,893.6

 
$
2,218.5

 
 
 
 
 
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at March 31, 2014 were as follows (dollars in thousands):
 
Stock Options
 
Warrants
 
Restricted Stock
Unrecognized compensation cost
$
6,490.0

 
$
46.2

 
$
208.2

Expected weighted-average period in years of compensation cost to be recognized
5.62

 
1.30

 
0.35

Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block]

Total fair value of shares vested and the weighted average estimated fair values of shares granted for the three months ended March 31, 2014 and 2013 were as follows (dollars in thousands):
 
Stock Options
 
Warrants
 
Three Months Ended March 31,
 
Three Months Ended March 31,
 
2014
 
2013
 
2014
 
2013
Total fair value of shares vested
$
1,927.4

 
$
1,305.0

 
$
8.7

 
$
43.8

Weighted average estimated fair value of shares granted
$
5.47

 
$
4.71

 
$

 
$
3.82