10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

FOR THE QUARTERLY PERIOD ENDED March 31, 2014

OR

o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the Transition Period from __________________   to _________________________

Commission File Number 001-33650

NEOSTEM, INC.

(Exact name of registrant as specified in its charter)

DELAWARE	22-2343568
(State or other jurisdiction of	(I.R.S. Employer
incorporation or organization)	Identification No.)
420 LEXINGTON AVE, SUITE 350 NEW YORK, NEW YORK	10170
(Address of principal executive offices)	(zip code)

Registrant’s telephone number, including area code: 212-584-4180

 (Former name, former address and former fiscal year, if changed since last report)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.   Yes     x         No     o

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).

Yes  x        No     o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer     o	Accelerated filer     x
Non-accelerated filer   o     (Do not check if a smaller reporting company)	Smaller reporting company     o

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes  o     No  x

34,008,862 SHARES. $.001 PAR VALUE, AS OF May 8, 2014

(Indicate the number of shares outstanding of each of the issuer's classes of common stock, as of the latest practicable date)

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This Quarterly Report on Form 10-Q includes “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995, as well as historical information. Such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance or achievements, or industry results, to be materially different from anticipated results, performance or achievements expressed or implied by such forward-looking statements. When used in this Quarterly Report on Form 10-Q, statements that are not statements of current or historical fact may be deemed to be forward-looking statements. Without limiting the foregoing, the words “plan,” “intend,” “may,” “will,” “expect,” “believe,” “could,” “anticipate,” “estimate,” or “continue” or similar expressions or other variations or comparable terminology are intended to identify such forward-looking statements, although some forward-looking statements are expressed differently. We remind readers that forward-looking statements are merely predictions and therefore inherently subject to uncertaintities and other factors and involve known and unknown risks that could cause the actual results, performance, levels of activity or our achievements or industry results, to be materially different from any future results, performance levels of activity or our achievements or industry results expressed or implied by such forward-looking statements. Factors that could cause our actual results to differ materially from anticipated results expressed or implied by forward-looking statements include, among others:

• our ability to obtain sufficient capital or strategic business arrangements to fund our operations and expansion plans, including meeting our financial obligations under various licensing and other strategic arrangements, the funding of our clinical trials for product candidates in our development programs for our Targeted Immunotherapy Program, our CD34 Cell Program and our T Regulatory Cell Program, and the commercialization of the relevant technology;

• our ability to build and maintain the management and human resources infrastructure necessary to support the growth of our business;

• our ability to integrate our acquired businesses successfully and grow such acquired businesses as anticipated, including expanding our PCT business internationally;

• whether a large global market is established for our cellular-based products and services and our ability to capture a meaningful share of this market;

• scientific and medical developments beyond our control;

• our ability to obtain and maintain, as applicable, appropriate governmental licenses, accreditations or certifications or comply with healthcare laws and regulations or any other adverse effect or limitations caused by government regulation of our business;

• whether any of our current or future patent applications result in issued patents, the scope of those patents and our ability to obtain and maintain other rights to technology required or desirable for the conduct of our business;  our ability to commercialize products without infringing the claims of third party patents;

• whether any potential strategic benefits of various licensing transactions will be realized and whether any potential benefits from the acquisition of these licensed technologies will be realized;

• the results of our development activities, including the results of our planned Melapuldencel-T Phase 3 clinical trial, our PreSERVE Phase 2 clinical trial of AMR-001 and planned clinical trials;

• our ability to complete our other planned clinical trials (or initiate other trials) in accordance with our estimated timelines due to delays associated with enrolling patients due to the novelty of the treatment, the size of the patient population and the need of patients to meet the inclusion criteria of the trial or otherwise;

• the other factors discussed in “Risk Factors” in our Form 10-K filed with the Securities and Exchange Commission (“the SEC”) on March 13, 2014, and elsewhere in the Annual Report on Form 10-K; and

• The CSC Acquisition and the ongoing operations of our NeoStem Oncology, LLC (see Note 15, Subsequent Events, to the interim financial statements included herein) will subject the combined company to additional risks.  Our Current Report on Form 8-K to be filed on the date hereof reporting the closing of the CSC Acquisition will contain a discussion of the risk factors related to the CSC Acquisition and our NeoStem Oncology, LLC subsidiary.

The factors discussed herein, and in the Company's other periodic filings with the Securities and Exchange Commission (the “SEC”) which are available for review at www.sec.gov under “Search for Company Filings” could cause actual results and developments to be materially different from those expressed or implied by such statements. All forward-looking statements attributable to us are expressly qualified in their entirety by these and other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by law, the Company undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.

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TABLE OF CONTENTS

	PART I- FINANCIAL INFORMATION	Page No.
Item 1.	Consolidated Financial Statements:	4
	Consolidated Balance Sheets at March 31, 2014 and December 31, 2013	4
	Consolidated Statements of Operations for the three months ended March 31, 2014 and 2013	5
	Consolidated Statements of Comprehensive Loss for the three months ended March 31, 2014 and 2013	6
	Consolidated Statements of Equity for the three months ended March 31, 2014 and 2013	7
	Consolidated Statements of Cash Flows for the three months ended March 31, 2014 and 2013	8
	Notes to Unaudited Consolidated Financial Statements	9
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	21
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	27
Item 4.	Controls and Procedures	27
	PART II- OTHER INFORMATION
Item 1.	Legal Proceedings	28
Item 1A.	Risk Factors	28
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	28
Item 3.	Defaults Upon Senior Securities	29
Item 4.	Mine Safety Disclosures	29
Item 5.	Other Information	29
Item 6.	Exhibits	30
	Signatures	31

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PART I. FINANCIAL INFORMATION

Item 1. Consolidated Financial Statements

NEOSTEM, INC. AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEETS

	March 31, 2014			December 31, 2013
	(Unaudited)
ASSETS
Current Assets
Cash and cash equivalents	$	41,359,652		$	46,133,759
Accounts receivable, net of allowance for doubtful accounts of $390,118 and $391,829 at March 31, 2014 and December 31, 2013, respectively	1,887,558			1,860,835
Inventory	1,475,812			1,270,223
Prepaid expenses and other current assets	1,833,082			1,561,933
Total current assets	46,556,104			50,826,750
Property, plant and equipment, net	13,790,672			12,844,216
Goodwill	11,117,770			11,117,770
Intangible assets, net	13,724,314			13,875,617
Other assets	1,204,765			1,151,729
Total assets	$	86,393,625		$	89,816,082
LIABILITIES AND EQUITY
Current Liabilities
Accounts payable	$	3,296,078		$	3,354,908
Accrued liabilities	2,381,625			4,018,026
Notes payable	836,219			381,097
Mortgages payable	216,005			213,112
Derivative liabilities	23,175			23,175
Unearned revenues	2,033,116			1,816,601
Total current liabilities	8,786,218			9,806,919
Long-term Liabilities
Deferred income taxes	4,426,635			4,379,226
Notes payable	870,864			531,164
Mortgages payable	2,967,948			3,023,609
Acquisition-related contingent consideration	9,640,000			9,450,000
Other long-term liabilities	635,008			598,729
Total liabilities	27,326,673			27,789,647
Commitments and Contingencies
EQUITY
Stockholders' Equity
Preferred stock, authorized, 20,000,000 shares; Series B convertible redeemable preferred stock liquidation value, 1/100 share of common stock, $.01 par value; 825,000 shares designated; issued and outstanding, 10,000 shares at March 31, 2014 and December 31, 2013	100			100
Common stock, $.001 par value, authorized 500,000,000 shares; issued and outstanding, 28,593,410 and 27,196,537 shares, at March 31, 2014 and December 31, 2013, respectively	28,594			27,197
Additional paid-in capital	310,377,112			299,594,525
Treasury stock, at cost	(705,742		)	(705,742		)
Accumulated deficit	(250,055,662		)	(236,373,605		)
Total NeoStem, Inc. stockholders' equity	59,644,402			62,542,475
Noncontrolling interests	(577,450		)	(516,040		)
Total equity	59,066,952			62,026,435
Total liabilities and equity	$	86,393,625		$	89,816,082

See accompanying notes to consolidated financial statements.

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NEOSTEM, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF OPERATIONS

 (Unaudited)

	Three Months Ended March 31,
	2014			2013
Revenues	$	4,055,575		2,523,912
Costs and expenses:
Cost of revenues	3,825,444			2,392,089
Research and development	4,759,083			3,161,326
Selling, general, and administrative	8,970,016			5,801,872
Total operating costs and expenses	17,554,543			11,355,287
Operating loss	(13,498,968		)	(8,831,375		)
Other income (expense):
Other income (expense), net	(189,551		)	10,606
Interest expense	(94,156		)	(43,560		)
	(283,707		)	(32,954		)
Loss before provision for income taxes and noncontrolling interests	(13,782,675		)	(8,864,329		)
Provision for income taxes	47,409			—
Net loss	(13,830,084		)	(8,864,329		)
Less - loss attributable to noncontrolling interests	(148,027		)	(63,754		)
Net loss attributable to NeoStem, Inc. common stockholders	$	(13,682,057	)	(8,800,575		)
Basic and diluted loss per share attributable to NeoStem, Inc. common stockholders	$	(0.49	)	$	(0.53	)
Weighted average common shares outstanding	28,120,847			16,698,897

See accompanying notes to consolidated financial statements.

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NEOSTEM, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(Unaudited) 

	Three Months Ended March 31,
	2014			2013
Net loss	$	(13,830,084	)	$	(8,864,329	)
Total other comprehensive (loss) income	—			—
Comprehensive loss	(13,830,084		)	(8,864,329		)
Comprehensive loss attributable to noncontrolling interests	(148,027		)	(63,754		)
Comprehensive net loss attributable to NeoStem, Inc. common stockholders	$	(13,682,057	)	$	(8,800,575	)

See accompanying notes to consolidated financial statements.

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NEOSTEM, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF EQUITY

(Unaudited) 

	Series B Convertible Preferred Stock			Common Stock			Additional Paid in Capital			Accumulated Other Comprehensive Income		Accumulated Deficit			Treasury Stock			Total NeoStem, Inc. Stockholders' Equity			Non- Controlling Interest in Subsidiary			Total Equity
	Shares	Amount		Shares	Amount
Balance at December 31, 2012	10,000	$	100	16,375,365	$	16,375	$	231,218,615		$	—	$	(197,392,361	)	$	(665,600	)	$	33,177,129		$	(356,970	)	$	32,820,159
Net loss	—	—		—	—		—			—		(8,800,575		)	—			(8,800,575		)	(63,754		)	(8,864,329		)
Equity-based compensation	—	—		177,492	178		2,218,352			—		—			—			2,218,530			—			2,218,530
Net proceeds from issuance of common stock	—	—		454,254	455		2,729,808			—		—			—			2,730,263			—			2,730,263
Proceeds from warrant exercises	—	—		20,761	21		105,860			—		—			—			105,881			—			105,881
Warrant inducements	—	—		—	—		(6,239		)	—		—			—			(6,239		)	—			(6,239		)
Balance at March 31, 2013	10,000	$	100	17,027,872	$	17,029	$	236,266,396		$	—	$	(206,192,936	)	$	(665,600	)	$	29,424,989		$	(420,724	)	$	29,004,265
	Series B Convertible Preferred Stock			Common Stock			Additional Paid in Capital			Accumulated Other Comprehensive Income		Accumulated Deficit			Treasury Stock			Total NeoStem, Inc. Stockholders' Equity			Non- Controlling Interest in Subsidiary			Total Equity
	Shares	Amount		Shares	Amount
Balance at December 31, 2013	10,000	$	100	27,196,537	$	27,197	$	299,594,525		$	—	$	(236,373,605	)	$	(705,742	)	$	62,542,475		$	(516,040	)	$	62,026,435
Net loss	—	—		—	—		—			—		(13,682,057		)	—			(13,682,057		)	(148,027		)	(13,830,084		)
Equity-based compensation	—	—		329,698	330		3,893,286			—		—			—			3,893,616			—			3,893,616
Net proceeds from issuance of common stock	—	—		804,375	804		5,629,821			—		—			—			5,630,625			—			5,630,625
Proceeds from option exercises	—	—		12,800	13		71,347			—		—			—			71,360			—			71,360
Proceeds from warrant exercises	—	—		250,000	250		1,274,750			—		—			—			1,275,000			—			1,275,000
Change in ownership in subsidiary	—	—		—	—		(86,617		)	—		—			—			(86,617		)	86,617			—
Balance at March 31, 2014	10,000	$	100	28,593,410	$	28,594	$	310,377,112		$	—	$	(250,055,662	)	$	(705,742	)	$	59,644,402		$	(577,450	)	$	59,066,952

See accompanying notes to consolidated financial statements.

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NEOSTEM, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

	Three Months Ended March 31,
	2014			2013
Cash flows from operating activities:
Net loss	$	(13,830,084	)	$	(8,864,329	)
Adjustments to reconcile net loss to net cash used in operating activities:
Equity-based compensation expense	3,893,616			2,218,530
Depreciation and amortization	444,452			554,954
Changes in fair value of derivative liability	—			(10,606		)
Change in acquisition-related contingent consideration	190,000			—
Bad debt recovery	(1,711		)	—
Deferred income taxes	47,409			—
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(271,149		)	(192,009		)
Accounts receivable	(25,012		)	167,444
Inventory	(205,589		)	(428,549		)
Unearned revenues	216,515			346,912
Other assets	(53,035		)	(22,986		)
Accounts payable, accrued expenses and other liabilities	(1,658,952		)	(905,094		)
Net cash used in operating activities	(11,253,540		)	(7,135,733		)
Cash flows from investing activities:
Acquisition of property and equipment	(1,239,606		)	(53,571		)
Net cash used in investing activities	(1,239,606		)	(53,571		)
Cash flows from financing activities:
Proceeds from exercise of options	71,360			—
Proceeds from exercise of warrants	1,275,000			105,881
Net proceeds from issuance of common stock	5,630,625			2,730,262
Repayment of mortgage loan	(52,768		)	(43,446		)
Proceeds from notes payable	958,014			—
Repayment of notes payable	(163,192		)	(81,015		)
Payment for warrant inducement	—			(6,239		)
Net cash provided by financing activities	7,719,039			2,705,443
Net decrease in cash and cash equivalents	(4,774,107		)	(4,483,861		)
Cash and cash equivalents at beginning of period	46,133,759			13,737,452
Cash and cash equivalents at end of period	41,359,652			9,253,591
Supplemental Disclosure of Cash Flow Information:
Cash paid during the period for:
Interest	$	93,100		$	95,700
Taxes	—			—

See accompanying notes to consolidated financial statements.

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NEOSTEM, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

Note 1  – The Business

Overview

NeoStem, Inc. (“we,” “NeoStem” or the “Company”) is a leader in the emerging cellular therapy industry. We are pursuing the preservation and enhancement of human health globally through the development of cell based therapeutics that prevent, treat or cure disease. We have multiple cell therapy platforms that work to address the pathology of disease using a person's own cells to amplify the body's natural repair mechanisms including enhancing the destruction of cancer initiating cells, repairing and replacing damaged or aged tissue, cells and organs and restoring their normal function. We believe that cell therapy will play a large role in changing the natural history of diseases as more breakthrough therapies are developed, ultimately lessening the overall burden of disease on patients and their families as well as the economic burden that these diseases impose upon modern society.

Our business includes the development of novel proprietary cell therapy products, as well as a revenue-generating contract development and manufacturing service business that we leverage for the development of our therapeutics while providing service to other companies in the cell therapy industry developing products. The combination of our own therapeutic development business and a revenue-generating service provider business provides the Company with unique capabilities for cost effective in-house product development and immediate revenue and future cash flow to help underwrite our internal development programs. This business model enables the Company to be opportunistic in growing its pipeline as evidenced by the Company's acquisition in May 2014 through the issuance of equity of California Stem Cell, Inc. ("CSC"), a cell biotechnology corporation that is developing cellular immunotherapies for cancer, an area we view to be one of the most promising sub-sectors in biotechnology. CSC, now known as NeoStem Oncology, LLC, is driving the Company's Targeted Immunotherapy Program for cancer through the development of its lead product candidate, Melapuldencel-T, to treat Stage IV or recurrent melanoma. The Phase 3 protocol is the subject of a Special Protocol Assessment (SPA), indicating that the Food and Drug Administration ("FDA") is in agreement with the design, clinical endpoints, and planned clinical analyses of the Phase 3 trial that will serve as the basis for a Biologics License Application ("BLA"). This protocol calls for enrolling 250 patients and is expected to be initiated in 2014.

We are currently developing therapies to address ischemia through our CD34 Cell Program. Ischemia occurs when the supply of oxygenated blood in the body is restricted. We seek to reverse this restriction through the development and formation of new blood vessels. AMR-001 is our most clinically advanced product candidate in our CD34 Cell Program and is being developed to treat damaged heart muscle following an acute myocardial infarction (heart attack) ("AMI"). In December 2013, the Company completed enrollment in its PreSERVE AMI study. PreSERVE AMI is a randomized, double-blinded, placebo-controlled Phase 2 clinical trial testing AMR-001, an autologous (donor and recipient are the same) adult stem cell product for the treatment of patients with left ventricular dysfunction following acute ST segment elevation myocardial infarction (STEMI). With the last patient of the planned 160 patient trial infused in late December 2013, we expect the last patient six-month follow-up to occur in June 2014. Once the primary end point six-month data is collected, the data set will be locked and analysis will begin with a submission for a possible presentation of the study at the American Heart Association's Scientific Sessions to be held November 15-19, 2014. If approved by Food and Drug Administration (the "FDA ") and/or other worldwide regulatory agencies following successful completion of further trials, AMR-001 would address a significant medical need for which there is currently no effective treatment, potentially improving longevity and quality of life for those suffering a STEMI, and positioning the Company to capture a meaningful share of this worldwide market. We also expect to advance the technology into other clinical indications such as chronic heart failure ("CHF"), traumatic brain injury ("TBI"), and/or critical limb ischemia ("CLI").

Another platform technology we are developing utilizes T Regulatory Cells ("Tregs") to treat diseases caused by imbalances in an individual's immune system.  In collaborating with Becton-Dickinson and the University of California, San Francisco, we are utilizing this technology platform of our majority-owned subsidiary, Athelos Corporation ("Athelos"), to restore immune balance by enhancing Treg cell number and function.  Tregs are a natural part of the human immune system and regulate the activity of T effector cells, the cells that are responsible for protecting the body from viruses and  other foreign antigen exposure. When Tregs function properly, only harmful foreign materials are attacked by T effector cells. In autoimmune disease it is thought that deficient Treg activity permits the T effector cells to attack the body's own tissues, and in allergic diseases, like asthma, the immune system overreacts to harmless foreign substances. We plan to initiate a Phase 2 study of Treg based therapeutics  to treat type 1 diabetes in 2014. We also plan to initiate a Phase 1 study in Canada of Treg based therapeutics in support of a steroid resistant asthma indication in 2014.

Pre-clinical assets include our VSEL ^TM (Very Small Embryonic Like) Technology regenerative medicine platform. Regenerative medicine holds the promise of improving clinical outcomes and reducing overall  healthcare costs.  We are working

9

on a Department of Defense funded study of VSELs^TM for the treatment of chronic wounds. Other preclinical work with VSELs^TM includes exploring macular degeneration as a target indication.

Progenitor Cell Therapy, LLC ("PCT") is a contract manufacturer that generates revenue. This wholly owned subsidiary, which we acquired in 2011, is an industry leader in providing high quality manufacturing capabilities and support to developers of cell-based therapies to enable them to improve efficiencies and profitability and reduce capital investment for their own development activities. Since its inception more than 15 years ago, PCT has provided pre-clinical and clinical current Good Manufacturing Practice (“cGMP”) development and manufacturing services to more than 100 clients. PCT has experience advancing regenerative medicine product candidates from product inception through rigorous quality standards all the way through to human testing, BLA filing and FDA product approval. PCT's core competencies in the cellular therapy industry include manufacturing of cell therapy-based products, engineering and innovation services, product and process development, cell and tissue processing, regulatory support, storage, distribution and delivery and consulting services. PCT has two cGMP, state-of-the art cell therapy research, development, and manufacturing facilities in New Jersey and California, serving the cell therapy community with integrated and regulatory compliant distribution capabilities. The Company is pursuing commercial expansion of our manufacturing operations both in the U.S. and internationally. Additionally, with the acquisition of CSC, PCT can leverage CSC's additional manufacturing capacity in Irvine, California as well as the personnel experience and expertise in immunotherapy to provide additional manufacturing and /or development work to advance NeoStem's platform technology as well as technologies of PCT's client base.

Strategic acquisitions have been the cornerstone of NeoStem’s growth and have been selected in order to provide value to stockholders by taking advantage of the infrastructure we have created which includes strong development, regulatory and manufacturing expertise. By adding Melapuldencel-T, a late stage novel proprietary cancer cell therapy into our pipeline, we look to further advance towards our goal of delivering transformative cell based therapies to the market to help patients suffering from life-threatening medical conditions. Coupled with our best in class manufacturing capability, the stage is set for us to realize meaningful clinical development and manufacturing efficiencies, further positioning NeoStem to lead the cell therapy industry.

Basis of Presentation

The accompanying unaudited Consolidated Financial Statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“generally accepted accounting principles”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X of the Securities and Exchange Commission for interim financial information. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. In the opinion of management, the accompanying Consolidated Financial Statements of the Company and its subsidiaries, which are unaudited, include all normal and recurring adjustments considered necessary to present fairly the Company’s financial position as of March 31, 2014 and the results of its operations and its cash flows for the periods presented. The unaudited consolidated financial statements herein should be read together with the historical consolidated financial statements of the Company for the years ended December 31, 2013 and 2012 included in our Annual Report on Form 10-K for the year ended December 31, 2013. Operating results for the three months endedMarch 31, 2014 are not necessarily indicative of the results that may be expected for the year ending December 31, 2014.

Use of Estimates

The preparation of financial statements in conformity with generally accepted accounting principles in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements. Estimates also affect the reported amounts of revenues and expenses during the reporting period. Accordingly, actual results could differ from those estimates.

Reclassifications

Certain reclassifications have been made to the Consolidated Financial Statements and Notes to the Consolidated Financial Statements for the three months endedMarch 31, 2013 to conform to the presentation for the three months endedMarch 31, 2014.

Principles of Consolidation

The Consolidated Financial Statements include the accounts of NeoStem, Inc. and its wholly owned and partially owned subsidiaries and affiliates as listed below.

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Entity	Percentage of Ownership	Location
NeoStem, Inc.	Parent  Company	United States of America
NeoStem Therapies, Inc.	100%	United States of America
Stem Cell Technologies, Inc.	100%	United States of America
Amorcyte, LLC	100%	United States of America
Progenitor Cell Therapy, LLC (PCT)	100%	United States of America
NeoStem Family Storage, LLC	100%	United States of America
Athelos Corporation (1)	90%	United States of America
PCT Allendale, LLC	100%	United States of America
NeoStem Oncology, LLC (2)	100%	United States of America

(1) Pursuant to the Stock Purchase Agreement signed in March 2011, our initial ownership in Athelos was 80.1%, and Becton Dickinson's ("BD") initial minority ownership was 19.9%. Per the Agreement, BD will be diluted based on new investment in Athelos by us (subject to certain anti-dilution provisions). As of March 31, 2014, BD's ownership interest in Athelos was decreased to 10.0%, and our ownership increased to 90.0%. As a result in the change in ownership, approximately $0.1 million was transferred from additional paid in capital to non-controlling interests.

(2) On May 8, 2014, NeoStem acquired CSC, now known as NeoStem Oncology, LLC (see Note 15, Subsequent Events). Accordingly, the accounts of NeoStem Oncology, LLC are not included in the Company's consolidated financial position as of March 31, 2014 and the results of its consolidated operations and cash flows for the three months endedMarch 31, 2014 and 2013.

Note 2 – Summary of Significant Accounting Policies

In addition to the policies below, our significant accounting policies are described in Note 2 of the Notes to Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2013. There were no changes during the three months endedMarch 31, 2014.

Cash and Cash Equivalents

Cash and cash equivalents include short-term, highly liquid, investments with maturities of ninety days or less when purchased.

Accounts Receivable

Accounts receivable are carried at original invoice amount less an estimate made for doubtful accounts. The Company applies judgment in connection with establishing the allowance for doubtful accounts. Specifically, the Company analyzes the aging of accounts receivable balances, historical bad debts, customer concentration and credit-worthiness, current economic trends and changes in the Company’s customer payment terms. Significant changes in customer concentrations or payment terms, deterioration of customer credit-worthiness or weakening economic trends could have a significant impact on the collectability of the receivables and the Company’s operating results. If the financial condition of the Company’s customers were to deteriorate, resulting in an impairment of their ability to make payments, additional allowances may be required. Management regularly reviews the aging of receivables and changes in payment trends by its customers, and records a reserve when it believes collection of amounts due are at risk.

Inventories

The Company, through its PCT subsidiary, regularly enters into contracts with clients for services that have multiple stages and are dependent on one another to complete the contract and recognize revenue. The Company's inventory represents work in process for costs incurred on such projects at PCT that have not been completed. The Company reviews these projects periodically to determine that the value of each project is stated at the lower of cost or market.

Goodwill and Other Intangible Assets

Goodwill is the excess of purchase price over the fair value of identified net assets of businesses acquired. The Company’s intangible assets with an indefinite life are related to in process research and development ("IPR&D") for AMR-001, the clinical candidate acquired in the Amorcyte acquisition, as the Company expects this research and development to provide the Company with substantial benefit for a period that extends beyond the foreseeable horizon. Intangible assets with indefinite useful lives are measured at their respective fair values as of the acquisition date. The Company does not amortize goodwill and intangible assets

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with indefinite useful lives. Intangible assets related to IPR&D projects are considered to be indefinite-lived until the completion or abandonment of the associated R&D efforts. If and when development is complete, which generally occurs if and when regulatory approval to market a product is obtained, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time.

The Company reviews goodwill and indefinite-lived intangible assets at least annually for possible impairment. Goodwill and indefinite-lived intangible assets are reviewed for possible impairment between annual tests if an event occurs or circumstances change that would more likely than not reduce the fair value of the reporting unit below its carrying value. The Company tests its goodwill and indefinite-lived intangible assets each year on December 31. The Company reviews the carrying value of goodwill and indefinite-lived intangible assets utilizing a discounted cash flow model, and, where appropriate, a market value approach is also utilized to supplement the discounted cash flow model. The Company makes assumptions regarding estimated future cash flows, discount rates, long-term growth rates and market values to determine each reporting unit’s estimated fair value. If these estimates or related assumptions change in the future, the Company may be required to record impairment charges. In accordance with it's accounting policy, the Company tested goodwill and indefinite-lived intangible assets for impairment as of December 31, 2013 and 2012 for its two reporting units, and concluded there was no risk of failing step 1 of the goodwill impairment testing evaluation, and that indefinite-lived intangible assets were not impaired.

Amortized intangible assets consist of customer lists, manufacturing technology, and tradename, as well as patents and rights associated primarily with the VSEL™ Technology. These intangible assets are amortized on a straight line basis over their respective useful lives.

Revenue Recognition

Clinical Services: The Company recognizes revenue for its (i) process development and (ii) clinical manufacturing services based on the terms of individual contracts.

Revenues associated with process development services generally contain multiple stages that do not have stand-alone values and are dependent upon one another, and are recognized as revenue on a completed contract basis. We recognize revenues when all of the following conditions are met:

• persuasive evidence of an arrangement exists;

• delivery has occurred or the services have been rendered;

• the fee is fixed or determinable; and

• collectability is probable.

The Company considers signed contracts as evidence of an arrangement. The Company assesses whether the fee is fixed or determinable based on the payment terms associated with the transaction and whether the payment terms are subject to refund or adjustment. The Company assesses cash collectability based on a number of factors, including past collection history with the client and the client's creditworthiness. If the Company determines that collectability is not reasonably assured, it defers revenue recognition until collectability becomes reasonably assured, which is generally upon receipt of the cash. The Company's arrangements are generally non-cancellable, though clients typically have the right to terminate their agreement for cause if the Company materially fails to perform.

Clinical manufacturing services are generally distinct arrangements whereby the Company is paid for time and materials or for fixed monthly amounts. Revenue is recognized when efforts are expended or contractual terms have been met.

Some client agreements include multiple elements, comprised of process development and clinical manufacturing services. The Company believes that process development and clinical manufacturing services each have stand-alone value because these services can be provided separately by other companies. In accordance with ASC Update No. 2009-13, “Revenue Recognition (Topic 605): Multiple-Deliverable Revenue Arrangements,” the Company (1) separates deliverables into separate units of accounting when deliverables are sold in a bundled arrangement and (2) allocates the arrangement's consideration to each unit in the arrangement based on its relative selling price. 

Clinical Services Reimbursements: The Company separately charges the customers for the expenses associated with certain consumable resources (reimbursable expenses) that are specified in each clinical services contract. On a monthly basis, the Company

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bills customers for reimbursable expenses and immediately recognizes these billings as revenue, as the revenue is deemed earned as reimbursable expenses are incurred. For the three months endedMarch 31, 2014 and 2013, clinical services reimbursements were $0.7 million and $0.4 million, respectively.

Processing and Storage Services: The Company recognizes revenue related to the collection and cryopreservation of cord blood and autologous adult stem cells when the cryopreservation process is completed which is approximately twenty-four hours after cells have been collected. Revenue related to advance payments of storage fees is recognized ratably over the period covered by the advance payments.

Note 3 – Cash and Cash Equivalents

As of March 31, 2014 and December 31, 2013, the Company had cash and cash equivalents of approximately $41.4 million and $46.1 million, respectively, including bank deposits of approximately $0.7 million and $0.8 million, respectively, covered by the Federal Deposit Insurance Corporation.

Note 4 – Inventories

Inventories, representing work in process for costs incurred on projects at PCT that have not been completed, were $1.5 million and $1.3 million as of March 31, 2014 and December 31, 2013, respectively. The Company also has deferred revenue of approximately $1.6 million and $1.5 million of advance billings received as of March 31, 2014 and December 31, 2013, respectively, related to these contracts.

Note 5 – Loss Per Share

For the three months endedMarch 31, 2014 and 2013, the Company incurred net losses and therefore no common stock equivalents were utilized in the calculation of loss per share. At March 31, 2014 and 2013, the Company excluded the following potentially dilutive securities:

	March 31,
	2014	2013
Stock Options	3,912,697	2,631,181
Warrants	4,491,028	5,501,055
Restricted Shares	175,731	35,500

Note 6 – Fair Value Measurements

Fair value of financial assets and liabilities that are being measured and reported are defined as the exchange price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants in the principal market at the measurement date (exit price). The Company is required to classify fair value measurements in one of the following categories:

Level 1 inputs are defined as quoted prices (unadjusted) in active markets for identical assets or liabilities that the reporting entity has the ability to access at the measurement date.

Level 2 inputs are defined as inputs other than quoted prices included within Level 1 that are observable for the assets or liabilities, either directly or indirectly.

Level 3 inputs are defined as unobservable inputs for the assets or liabilities. Financial assets and liabilities are classified based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement requires judgment, and may affect the valuation of the fair value of assets and liabilities and their placement within the fair value hierarchy levels.

The Company determined the fair value of the warrant derivative liabilities to be level 3 inputs. These inputs require material subjectivity because value is derived through the use of a lattice model that values the derivatives based on probability weighted discounted cash flows.

Contingent consideration was recognized on October 17, 2011 in connection with the Company's acquisition of Amorcyte. The contingent consideration obligations relates to earn out payments equal to 10% of the net sales of Amorcyte’s lead product

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candidate AMR-001 (in the event of and following the date of first commercial sale of AMR-001), provided that in the event NeoStem sublicenses AMR-001, the applicable earn out payment will be equal to 30% of any sublicensing fees, and provided further that NeoStem will be entitled to recover direct out-of-pocket clinical development costs not previously paid or reimbursed and any costs, expenses, liabilities and settlement amounts arising out of claims of patent infringement or otherwise challenging Amorcyte’s right to use intellectual property, by reducing any earn out payments due by 50% until such costs have been recouped in full (the “Earn Out Payments”).

The fair value of contingent consideration obligations is determined using Level 3 inputs, and is based on a discounted cash flow model using a probability-weighted income approach. The measurement is based upon unobservable inputs supported by little or no market activity based on our own assumptions and experience. We base the timing to complete the development and approval of this product on the current development stage of the product and the inherent difficulties and uncertainties in developing a product candidate, such as obtaining U.S. Food and Drug Administration (FDA) and other regulatory approvals. In determining the probability of regulatory approval and commercial success, we utilize data regarding similar milestone events from several sources, including industry studies and our own experience. These fair value measurements represent Level 3 measurements as they are based on significant inputs not observable in the market. Significant judgment is employed in determining the appropriateness of these assumptions as of the acquisition date and for each subsequent period. Accordingly, changes in assumptions could have a material impact on the amount of contingent consideration expense we record in any given period. Changes in the fair value of the contingent consideration obligations are recorded in our consolidated statement of operations. The contingent consideration fair value increased from $9.5 million as of December 31, 2013 to $9.6 million as of March 31, 2014. The change in estimated fair value is based the impact of the time progression through the Phase 2 clinical trial from December 31, 2013 to March 31, 2014.

The following table sets forth by level within the fair value hierarchy the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of March 31, 2014, and December 31, 2013 (in thousands):

	March 31, 2014
	Fair Value Measurements Using Fair Value Hierarchy
	Level 1		Level 2		Level 3
Warrant derivative liabilities	$	—	$	—	$	23.2
Acquisition-related contingent consideration	—		—		9,640.0

	December 31, 2013
	Fair Value Measurements Using Fair Value Hierarchy
	Level 1		Level 2		Level 3
Warrant derivative liabilities	$	—	$	—	$	23.2
Acquisition-related contingent consideration	—		—		9,450.0

For those financial instruments with significant Level 3 inputs, the following table summarizes the activity for the three months endedMarch 31, 2014 by type of instrument (in thousands):

	Three Months Ended
	March 31, 2014
	Warrants		Acquisition-Related Contingent Consideration
Beginning liability balance	$	23.2	$	9,450.0
Change in fair value recorded in earnings	—		190.0
Ending liability balance	$	23.2	$	9,640.0

Some of the Company’s financial instruments are not measured at fair value on a recurring basis, but are recorded at amounts that approximate fair value due to their liquid or short-term nature, such as cash and cash equivalents, accounts receivable, accounts payable. Our long-term debt and notes payable are carried at cost and approximate fair value due to their variable or fixed interest rates, which are consistent with the interest rates in the market.

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Note 7 – Goodwill and Other Intangible Assets

The Company's goodwill was $11.1 million as of March 31, 2014 and December 31, 2013.

The Company's intangible assets and related accumulated amortization as of March 31, 2014 and December 31, 2013 consisted of the following (in thousands):

		March 31, 2014							December 31, 2013
	Useful Life	Gross		Accumulated Amortization			Net		Gross		Accumulated Amortization			Net
Customer list	10 years	$	1,000.0	$	(320.1	)	$	679.9	$	1,000.0	$	(295.1	)	$	704.9
Manufacturing technology	10 years	3,900.0		(1,248.4		)	2,651.6		3,900.0		(1,150.9		)	2,749.1
Tradename	10 years	800.0		(256.1		)	543.9		800.0		(236.1		)	563.9
In process R&D	Indefinite	9,400.0		—			9,400.0		9,400.0		—			9,400.0
VSEL patent rights	19 years	669.0		(220.1		)	448.9		669.0		(211.3		)	457.7
Total Intangible Assets		$	15,769.0	$	(2,044.7	)	$	13,724.3	$	15,769.0	$	(1,893.4	)	$	13,875.6

Total intangible amortization expense was classified in the operating expense categories for the periods included below as follows (in thousands):

	Three Months Ended March 31,
	2014		2013
Cost of revenue	$	79.2	$	97.5
Research and development	27.1		8.8
Selling, general and administrative	45.0		45.0
Total	$	151.3	$	151.3

Estimated intangible amortization expense on an annual basis for the succeeding five years is as follow (in thousands):

2014	$	453.9
2015	605.2
2016	605.2
2017	605.2
2018	605.2
Thereafter	10,849.6
	$	13,724.3

Note 8 – Accrued Liabilities

Accrued liabilities as of March 31, 2014 and December 31, 2013 were as follows (in thousands):

	March 31, 2014		December 31, 2013
Salaries, employee benefits and related taxes	$	846.4	$	2,325.8
Professional fees	775.4		544.8
License Fees	200.0		500.0
Other	559.8		647.4
	$	2,381.6	$	4,018.0

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Note 9 – Debt

Notes Payable

As of March 31, 2014 and December 31, 2013, the Company had notes payable of approximately $1.7 million and $0.9 million, respectively. The notes relate to certain insurance policies and equipment financings, require monthly payments, and mature within one to three years.

Mortgages Payable

In October 2007, PCT issued a note to borrow $3.1 million (the “First Mortgage”) in connection with its $3.8 million purchase of condominium units in an existing building in Allendale, New Jersey (the “Property”) that PCT uses as a laboratory and stem cell processing facility. The First Mortgage is payable in 239 consecutive monthly payments of principal and interest, based on a 20 year amortization schedule; and one final payment of all outstanding principal plus accrued interest then due. The current monthly installment is $20,766, which includes interest at an initial rate of 5.00%; the interest rate and monthly installments payments are subject to adjustment on October 1, 2017. On that date, upon prior written notice, the lender has the option to declare the entire outstanding principal balance, together with all outstanding interest, due and payable in full. The First Mortgage is secured by substantially all of the assets of PCT, including a first mortgage on the Property and assignment of an amount approximately equal to eighteen months debt service held in escrow. The Note matures on October 1, 2027 if not called by the lender on October 1, 2017. The First Mortgage had previously been subject to certain debt service coverage and total debt to tangible net worth financial covenant ratios measured semi-annually. The outstanding balance was approximately $2.4 million and 2.5 million at March 31, 2014 and December 31, 2013, respectively, of which $128,300 is payable within twelve months as of March 31, 2014.

In December 2010 PCT Allendale, a wholly-owned subsidiary of PCT, entered into a note for a second mortgage in the amount of $1 million (the "Second Mortgage") on the Allendale Property with TD Bank, N.A. The initial guarantors of the Second Mortgage were PCT, DomaniCell (a wholly-owned subsidiary of PCT, now known as NeoStem Family Storage, LLC), Regional Cancer Care Associates LLC and certain of its partners. The Second Mortgage had been subject to an annual financial covenant starting December 31, 2011. The Second Mortgage is for 124 months at a fixed rate of 6% for the first 64 months. The loan is callable for a certain period prior to the interest reset date. The outstanding balance was approximately $0.7 million and $0.8 million at March 31, 2014 and December 31, 2013, respectively, of which $87,700 is payable within twelve months as of March 31, 2014.

In December 2013, the Company modified both the First Mortgage and Second Mortgage with TD Bank, N.A., whereby (i) prior debt service coverage and total debt to tangible net worth financial covenant ratios were replaced with a minimum unencumbered liquidity covenant, and (ii) prior guarantors were released (see Note 13) and replaced with NeoStem, PCT, and NeoStem Family Storage. The Company is in compliance with the new minimum unencumbered liquidity covenant.

Note 10 – Shareholders' Equity

Reverse Stock Split

On June 28, 2013, pursuant to prior shareholder authorization, the Company’s board of directors unanimously approved a 1-for-10 reverse stock split of the Company’s common stock, which the Company effected on July 16, 2013. All share and per share amounts of common stock, options and warrants in the accompanying financial statements have been restated for all periods to give retroactive effect to the reverse stock split. The shares of common stock retained a par value of $0.001 per share. Accordingly, the stockholders’ deficit reflects the reverse stock split by reclassifying from “common stock” to “Additional paid-in capital” an amount equal to the par value of the decreased shares resulting from the reverse stock split.

Equity Issuances

In September 2011, the Company entered into a common stock purchase agreement (the “Initial Purchase Agreement”) with Aspire Capital Fund, LLC, an Illinois limited liability company (“Aspire Capital”), which provided that Aspire Capital was committed to purchase up to an aggregate of $20.0 million worth of shares of the Company’s common stock over the 24-month term. In August, 2012, the Initial Purchase Agreement was extended for an additional 24-month term through September 2015. During the three months endedMarch 31, 2014, the Company issued 0.8 million shares of Common Stock under the provisions the Initial Purchase Agreement with Aspire for gross proceeds of approximately $5.6 million. As of March 31, 2014, the full $20.0 million worth of shares of the Company's stock had been issued under the Initial Purchase Agreement.

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In March 2014, the Company entered into a new common stock purchase agreement (the “Purchase Agreement”) with Aspire Capital, which provides that, subject to certain terms and conditions, Aspire Capital is committed to purchase up to an aggregate of $30.0 million worth of shares of the Company’s common stock over the 24-month term. At the Company’s discretion, it may present Aspire Capital with purchase notices from time to time to purchase the Company’s common stock, provided certain price and other requirements are met. The purchase price for the shares of stock was based upon one of two formulas set forth in the Purchase Agreement depending on the type of purchase notice the Company submits to Aspire Capital, and is based on market prices of the Company’s common stock (in the case of regular purchases) or a discount of 5% applied to volume weighted average prices (in the case of VWAP purchases), in each case as determined by parameters defined in the Purchase Agreement. As consideration for entering into the Purchase Agreement, we are obligated to issue 150,000 shares of our common stock to Aspire Capital (the “Commitment Shares”).

Option Exercises

During the three months ended ended March 31, 2014, option holders exercised an aggregate of 12,800 options at at exercise prices between of $5.20 and $6.20 per share for gross proceeds of approximately $0.1 million.

Warrant Exercises

During the three months ended ended March 31, 2014, warrant holders exercised an aggregate of 250,000 warrants at an exercise price of $5.10 per share for gross proceeds of approximately $1.3 million.

Stock Options and Warrants

The following table summarizes the activity for stock options and warrants for the three months endedMarch 31, 2014:

	Stock Options							Warrants
	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)		Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2013	2,932,191		$	11.19	6.8	$	1,658.1	4,898,266		$	16.50	2.6	$	1,811.0
Changes during the Period:
Granted	1,169,200		$	7.70				2,722		$	12.26
Exercised	(12,800	)	$	5.58				(250,000	)	$	5.10
Forfeited	(109,329	)	$	6.97				(100,108	)	$	70.00
Expired	(66,565	)	$	14.77				(59,852	)	$	57.76
Outstanding at March 31, 2014	3,912,697		$	10.22	7.4	$	1,896.7	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014 or expected to vest in the future	3,596,457		$	10.46	7.2	$	1,848.9	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014	2,520,755		$	11.50	6.5	$	1,600.9	4,473,306		$	15.42	2.3	$	1,661.5

During the three months endedMarch 31, 2014 and 2013, the Company issued warrants for services as follows ($ in thousands, except share data):

	Three Months Ended March 31,
	2014		2013
Number of Common Stock Purchase Warrants Issued	—		3,913
Value of Common Stock Purchase Warrants Issued	$	—	$	14.9

Restricted Stock

During the three months endedMarch 31, 2014 and 2013, the Company issued restricted stock for services as follows ($ in thousands, except share data):

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	Three Months Ended March 31,
	2014		2013
Number of Restricted Stock Issued	329,698		177,492
Value of Restricted Stock Issued	$	2,511.7	$	1,127.9

The weighted average estimated fair value of restricted stock issued for services in the three months endedMarch 31, 2014 and 2013 was $7.62 and $6.35 per share, respectively. The fair value of the restricted stock was determined using the Company’s closing stock price on the date of issuance. The vesting terms of restricted stock issuances are generally within one year.

Note 11 – Share-Based Compensation

Share-based Compensation

We utilize share-based compensation in the form of stock options, warrants and restricted stock.  The following table summarizes the components of share-based compensation expense for the three months endedMarch 31, 2014 and 2013 (in thousands):

	Three Months Ended March 31,
	2014		2013
Cost of goods sold	$	138.1	$	86.4
Research and development	476.8		217.4
Selling, general and administrative	3,278.7		1,914.7
Total share-based compensation expense	$	3,893.6	$	2,218.5

Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at March 31, 2014 were as follows (dollars in thousands):

	Stock Options		Warrants		Restricted Stock
Unrecognized compensation cost	$	6,490.0	$	46.2	$	208.2
Expected weighted-average period in years of compensation cost to be recognized	5.62		1.30		0.35

Total fair value of shares vested and the weighted average estimated fair values of shares granted for the three months endedMarch 31, 2014 and 2013 were as follows (dollars in thousands):

	Stock Options				Warrants
	Three Months Ended March 31,				Three Months Ended March 31,
	2014		2013		2014		2013
Total fair value of shares vested	$	1,927.4	$	1,305.0	$	8.7	$	43.8
Weighted average estimated fair value of shares granted	$	5.47	$	4.71	$	—	$	3.82

Note 12 – Income Taxes

As of December 31, 2013, the Company had approximately $110.6 million of Federal NOLs available to offset future taxable income expiring from 2025 through 2033. In accordance with Section 382 of the Internal Revenue code, the usage of the Company’s NOLs could be limited in the event of a change in ownership. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the period when those temporary differences become deductible.  If a change of ownership did occur there would be an annual limitation on the usage of the Company’s losses which are available through 2033.

In assessing the realizability of deferred tax assets, including the net operating loss carryforwards ("NOLs"), the Company assesses the available positive and negative evidence to estimate if sufficient future taxable income will be generated to utilize its existing deferred tax assets.  Based on its assessment, the Company has provided a full valuation allowance against its net deferred tax assets as their future utilization remains uncertain at this time.

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Deferred tax liabilities were $4.4 million and $4.4 million as of March 31, 2014 and December 31, 2013, and relate to the taxable temporary differences on the goodwill recognized in the PCT acquisition in 2011, and the in-process R&D intangible asset recognized in the Amorcyte acquisition in 2011. The taxable temporary difference associated with the goodwill, which is tax deductible and will be amortized over 15 years, will continue to increase the deferred tax liability balance over the amortization period, with an associated charge to the tax provision in each period. The deferred tax liabilities will only reverse when these indefinite-lived assets are sold, impaired, or reclassified from an indefinite-lived asset to a finite-lived asset.

As of March 31, 2014, management does not believe the Company has any material uncertain tax positions that would require it to measure and reflect the potential lack of sustainability of a position on audit in its financial statements. The Company will continue to evaluate its uncertain tax positions in future periods to determine if measurement and recognition in its financial statements is necessary. The Company does not believe there will be any material changes in its unrecognized tax positions over the next year.

Note 13 – Related Party Transactions

In December 2013, the Company modified both the First Mortgage and Second Mortgage with TD Bank, N.A. (see Note 9). Pursuant to the Loan Modifications, Andrew L. Pecora, M.D., Regional Cancer Care Associates LLC (Dr. Pecora’s medical practice), and certain partners in such practice, have been released as guarantors of the Second Mortgage Loan, and NeoStem has become a guarantor of the Loans pursuant to a Guaranty of Payment delivered by NeoStem to the Lender. Dr. Pecora, currently serves as a NeoStem director, NeoStem’s Chief Visionary Officer, PCT’s Chief Medical Officer and Amorcyte’s Chief Scientific Officer.

Note 14 – Commitments and Contingencies

Lease Commitments

The Company leases offices, of which certain have escalation clauses and renewal options, and also leases equipment under certain noncancelable operating leases that expire from time to time through 2018. In January 2014, the Company signed a new lease for additional space at its current executive offices at 420 Lexington Avenue, New York, NY 10170. The new lease is believed to provide sufficient space for the near future and shall extend through 2018. This property is used as the Company's corporate headquarters.

A summary of future minimum rental payments required under operating leases that have initial or remaining terms in excess of one year as of March 31, 2014 are as follows (in thousands):  

Years ended	Operating Leases
2014	$	763.0
2015	840.4
2016	682.3
2017	386.9
2018	5.9
Total minimum lease payments	$	2,678.5

Expense incurred under operating leases was approximately $0.2 million and $0.3 million for the three months endedMarch 31, 2014 and 2013, respectively.

Contingencies

Under license agreements with third parties the Company is typically required to pay maintenance fees, make milestone payments and/or pay other fees and expenses and pay royalties upon commercialization of products. The Company also sponsors research at various academic institutions, which research agreements generally provide us with an option to license new technology discovered during the course of the sponsored research.

Note 15 – Subsequent Events

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California Stem Cell Acquisition

On May 8, 2014 (the “Closing”), NeoStem closed its acquisition (the “CSC Acquisition”) of CSC, pursuant to the terms of the Agreement and Plan of Merger, dated as of April 11, 2014 (the “Merger Agreement”), by and among NeoStem, CSC, NBS Acquisition Sub I, Inc., a Delaware corporation and a wholly-owned subsidiary of NeoStem (“Subco”), NBS Acquisition Sub II, LLC, a Delaware limited liability company and a wholly-owned subsidiary of NeoStem (“Subco II”), and Jason Livingston, solely in his capacity as CSC stockholder representative (together with his permitted successors, the “CSC Representative”).

Pursuant to the Merger Agreement, on the Closing Date, (1) Subco was merged with and into CSC (the “First Merger”) and (2) CSC was then merged with and into Subco II (the “Second Merger”, and collectively with the First Merger, the “Mergers”), with Subco II surviving the Mergers as a wholly-owned subsidiary of NeoStem. At Closing, Subco II changed its legal name to NeoStem Oncology, LLC.

CSC (which after the Mergers is known as NeoStem Oncology, LLC) is a biopharmaceutical company with deep expertise in stem cell biology that is engaged in the development of therapies using a patient’s own, i.e., autologous, cells. To date, CSC’s development efforts have been directed at immunotherapies for cancer, regenerative medicine for motor neuron replacement and dermatology. CSC’s most advanced program is an immunotherapy, Melapuldencel-T, which uses patients’ own tumor cells to maximize the ability of their immune system to identify and eliminate the cancer initiating cells that are capable of reconstituting or developing new tumors (i.e., “cancer stem cells” or “replicating cells”). The focus of that program is the treatment of metastatic melanoma. As a result of encouraging Phase 2 data, CSC expects to initiate a Phase 3 clinical trial later in 2014, for which it has received Special Protocol Assessment (“SPA”) and Fast Track designation, as well as Orphan Drug designation. CSC maintains corporate offices and research facilities in Irvine, California.

Aggregate Merger Consideration

Pursuant to the terms of the Merger Agreement, all shares of CSC common stock (“CSC Common Stock”) and CSC preferred stock (“CSC Preferred Stock”, and collectively with the CSC Common Stock, the “CSC Capital Stock”) outstanding immediately prior to the Closing, and all outstanding unexercised options to purchase CSC Common Stock (“CSC Options”) (treated as if a net exercise had occurred), were canceled and converted into the right to receive, in the aggregate (and giving effect to the liquidation preferences accorded to the CSC Preferred Stock):

(1) An aggregate of 5,329,593 shares of NeoStem common stock (subject to payment of cash in lieu of fractional shares) (the “Closing Merger Consideration”).

(2) If payable after the Closing, certain milestone payments in an amount of up to $90 million in the aggregate, payable in shares of NeoStem common stock or cash, in NeoStem’s sole discretion, in the event of the successful completion of certain milestone events in connection with the CSC business acquired by NeoStem (the “Milestone Payments”, and together with the Closing Merger Consideration, the “Merger Consideration”).

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ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS.

The following Management’s Discussion and Analysis of Financial Condition and Results of Operations contains forward-looking statements that involve risks and uncertainties. Our actual results could differ materially from those anticipated in these forward-looking statements as a result of various factors, including those set forth under “Cautionary Note Regarding Forward-Looking Statements” herein and under “Risk Factors” in our annual report on Form 10-K for the year ended December 31, 2013. The following discussion should be read in conjunction with our consolidated financial statements and related notes thereto included elsewhere in this quarterly report and in our annual report on Form 10-K for the year ended December 31, 2013.

Overview

NeoStem, Inc. (“we,” “NeoStem” or the “Company”) is a leader in the emerging cellular therapy industry. We are pursuing the preservation and enhancement of human health globally through the development of cell based therapeutics that prevent, treat or cure disease. We have multiple cell therapy platforms that work to address the pathology of disease using a person's own cells to amplify the body's natural repair mechanisms including enhancing the destruction of cancer initiating cells, repairing and replacing damaged or aged tissue, cells and organs and restoring their normal function. We believe that cell therapy will play a large role in changing the natural history of diseases as more breakthrough therapies are developed, ultimately lessening the overall burden of disease on patients and their families as well as the economic burden that these diseases impose upon modern society.

Our business includes the development of novel proprietary cell therapy products, as well as a revenue-generating contract development and manufacturing service business that we leverage for the development of our therapeutics while providing service to other companies in the cell therapy industry developing products. The combination of our own therapeutic development business and a revenue-generating service provider business provides the Company with unique capabilities for cost effective in-house product development and immediate revenue and future cash flow to help underwrite our internal development programs. This business model enables the Company to be opportunistic in growing its pipeline as evidenced by the Company's acquisition in May 2014 through the issuance of equity of California Stem Cell, Inc. ("CSC"), a cell biotechnology corporation that is developing cellular immunotherapies for cancer, an area we view to be one of the most promising sub-sectors in biotechnology. CSC, now known as NeoStem Oncology, LLC, is driving the Company's Targeted Immunotherapy Program for cancer through the development of its lead product candidate, Melapuldencel-T, to treat Stage IV or recurrent melanoma. The Phase 3 protocol is the subject of a Special Protocol Assessment (SPA), indicating that the Food and Drug Administration ("FDA") is in agreement with the design, clinical endpoints, and planned clinical analyses of the Phase 3 trial that will serve as the basis for a Biologics License Application ("BLA"). This protocol calls for enrolling 250 patients and is expected to be initiated in 2014.

We are currently developing therapies to address ischemia through our CD34 Cell Program. Ischemia occurs when the supply of oxygenated blood in the body is restricted. We seek to reverse this restriction through the development and formation of new blood vessels. AMR-001 is our most clinically advanced product candidate in our CD34 Cell Program and is being developed to treat damaged heart muscle following an acute myocardial infarction (heart attack) ("AMI"). In December 2013, the Company completed enrollment in its PreSERVE AMI study. PreSERVE AMI is a randomized, double-blinded, placebo-controlled Phase 2 clinical trial testing AMR-001, an autologous (donor and recipient are the same) adult stem cell product for the treatment of patients with left ventricular dysfunction following acute ST segment elevation myocardial infarction (STEMI). With the last patient of the planned 160 patient trial infused in late December 2013, we expect the last patient six-month follow-up to occur in June 2014. Once the primary end point six-month data is collected, the data set will be locked and analysis will begin with a submission for a possible presentation of the study at the American Heart Association's Scientific Sessions to be held November 15-19, 2014. If approved by Food and Drug Administration (the "FDA ") and/or other worldwide regulatory agencies following successful completion of further trials, AMR-001 would address a significant medical need for which there is currently no effective treatment, potentially improving longevity and quality of life for those suffering a STEMI, and positioning the Company to capture a meaningful share of this worldwide market. We also expect to advance the technology into other clinical indications such as chronic heart failure ("CHF"), traumatic brain injury ("TBI"), and/or critical limb ischemia ("CLI").

Another platform technology we are developing utilizes T Regulatory Cells ("Tregs") to treat diseases caused by imbalances in an individual's immune system.  In collaborating with Becton-Dickinson and the University of California, San Francisco, we are utilizing this technology platform of our majority-owned subsidiary, Athelos Corporation ("Athelos"), to restore immune balance by enhancing Treg cell number and function.  Tregs are a natural part of the human immune system and regulate the activity of T effector cells, the cells that are responsible for protecting the body from viruses and  other foreign antigen exposure. When Tregs function properly, only harmful foreign materials are attacked by T effector cells. In autoimmune disease it is thought that deficient Treg activity permits the T effector cells to attack the body's own tissues, and in allergic diseases, like asthma, the immune system overreacts to harmless foreign substances. We plan to initiate a Phase 2 study of Treg based therapeutics  to treat

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type 1 diabetes in 2014. We also plan to initiate a Phase 1 study in Canada of Treg based therapeutics in support of a steroid resistant asthma indication in 2014.

Pre-clinical assets include our VSEL ^TM (Very Small Embryonic Like) Technology regenerative medicine platform. Regenerative medicine holds the promise of improving clinical outcomes and reducing overall  healthcare costs.  We are working on a Department of Defense funded study of VSELs^TM for the treatment of chronic wounds. Other preclinical work with VSELs^TM includes exploring macular degeneration as a target indication.

Progenitor Cell Therapy, LLC ("PCT") is a contract manufacturer that generates revenue. This wholly owned subsidiary, which we acquired in 2011, is an industry leader in providing high quality manufacturing capabilities and support to developers of cell-based therapies to enable them to improve efficiencies and profitability and reduce capital investment for their own development activities. Since its inception more than 15 years ago, PCT has provided pre-clinical and clinical current Good Manufacturing Practice (“cGMP”) development and manufacturing services to more than 100 clients. PCT has experience advancing regenerative medicine product candidates from product inception through rigorous quality standards all the way through to human testing, BLA filing and FDA product approval. PCT's core competencies in the cellular therapy industry include manufacturing of cell therapy-based products, engineering and innovation services, product and process development, cell and tissue processing, regulatory support, storage, distribution and delivery and consulting services. PCT has two cGMP, state-of-the art cell therapy research, development, and manufacturing facilities in New Jersey and California, serving the cell therapy community with integrated and regulatory compliant distribution capabilities. The Company is pursuing commercial expansion of our manufacturing operations both in the U.S. and internationally. Additionally, with the acquisition of CSC, PCT can leverage CSC's additional manufacturing capacity in Irvine, California as well as the personnel experience and expertise in immunotherapy to provide additional manufacturing and /or development work to advance NeoStem's platform technology as well as technologies of PCT's client base.

Strategic acquisitions have been the cornerstone of NeoStem’s growth and have been selected in order to provide value to stockholders by taking advantage of the infrastructure we have created which includes strong development, regulatory and manufacturing expertise. By adding Melapuldencel-T, a late stage novel proprietary cancer cell therapy into our pipeline, we look to further advance towards our goal of delivering transformative cell based therapies to the market to help patients suffering from life-threatening medical conditions. Coupled with our best in class manufacturing capability, the stage is set for us to realize meaningful clinical development and manufacturing efficiencies, further positioning NeoStem to lead the cell therapy industry.

Results of Operations

Three Months EndedMarch 31, 2014 Compared to Three Months EndedMarch 31, 2013

Net loss for the three months endedMarch 31, 2014 was approximately $13.8 million compared to $8.9 million for the three months endedMarch 31, 2013.

Revenues

For the three months endedMarch 31, 2014, total revenues were approximately $4.1 million compared to $2.5 million for the three months endedMarch 31, 2013, representing an increase of $1.5 million, or 61%. Revenues were comprised of the following (in thousands):

	Three Months Ended March 31,
	2014		2013
Clinical Services	$	2,567.0	$	1,365.7
Clinical Services Reimbursables	748.0		362.8
Processing and Storage Services	740.6		795.5
	$	4,055.6	$	2,523.9

• Clinical Services, representing process development and clinical manufacturing services provided by PCT to its various clients, were approximately $2.6 million for the three months endedMarch 31, 2014 compared to $1.4 million for the three months endedMarch 31, 2013, representing an increase of approximately $1.2 million or 88%. The increase was primarily due to $0.7 million of higher process development revenue, such revenue being recognized on a "completed contract" basis, and $0.5 million of higher clinical manufacturing revenue (which is recognized as services are rendered).

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Overall, there were approximately 50% more Clinical Services active clients as of March 31, 2014 compared to March 31, 2013, including five new clinical service contracts initiated during the current quarter.

◦ Process Development Revenue - Process development revenues were approximately $0.8 million for the three months endedMarch 31, 2014 compared to $0.1 million for the three months endedMarch 31, 2013. In accordance with our revenue recognition policy, process development revenue is recognized upon contract completion (i.e., when the services under a particular contract are completed). The revenue for the three months endedMarch 31, 2014 primarily related to the completion of a large process development contract during the quarter. In the prior year period, only minor process development contracts had been completed, resulting in lower revenue recognition. In addition, numerous process development contracts were still in process, including five new contracts initiated during the quarter, resulting in approximately $1.5 million of deferred process development revenue as of March 31, 2014. This revenue will be recognized in future periods upon completion of those contracts. Process development revenue will continue to fluctuate from period to period as a result of our process development revenue recognition policy.

◦ Clinical Manufacturing Revenue - Clinical manufacturing revenues were approximately $1.8 million for the three months endedMarch 31, 2014, compared to $1.2 million for the three months endedMarch 31, 2013. The increase is primarily due to an increase in the number of patients our customers have enrolled and treated in clinical trials.

• Clinical Services Reimbursables, representing reimbursement of expenses for certain consumables incurred on behalf of our clinical service revenue clients, were approximately $0.7 million for the three months endedMarch 31, 2014 compared to $0.4 million for the three months endedMarch 31, 2013, representing an increase of approximately $0.4 million or 106%. Generally, clinical services reimbursables correlate with clinical services revenues. In addition, our terms for billing reimbursable expenses do not include a significant mark up in the acquisition cost of such consumables, and as a result, changes in this revenue category have little impact on our gross profit and net loss.

• Processing and Storage Services, representing revenues from our oncology stem cell processing, cord blood, and adult stem cell processing and banking activities, were approximately $0.7 million for the three months endedMarch 31, 2014 compared to $0.8 million for the three months endedMarch 31, 2013, representing a decrease of approximately $0.1 million or 7%. The decrease is primarily attributable to decreased revenue from our oncology stem cell processing services.

Operating Costs and Expenses of Revenues

     For the three months endedMarch 31, 2014, operating expenses totaled $17.6 million compared to $11.4 million for the three months endedMarch 31, 2013, representing an increase of $6.2 million or 55%. Operating expenses were comprised of the following:

• Cost of revenues were approximately $3.8 million the three months endedMarch 31, 2014 compared to $2.4 million for the three months endedMarch 31, 2013, representing an increase of $1.4 million or 60%. The increase was primarily due to greater Clinical Service revenues during the current quarter. Overall, gross profit for the three months endedMarch 31, 2014 was $0.2 million or 6%, compared to gross profit for the three months endedMarch 31, 2013 of $0.1 million or 5%. Gross profit percentages generally will increase as Clinical Service revenue increases. However, gross profit percentages will also fluctuate from period to period due to the mix of service and reimbursable revenues and costs, as well as the timing of our revenue recognition under our revenue recognition policy.

• Research and development expenses were approximately $4.8 million for the three months endedMarch 31, 2014 compared to $3.2 million for the three months endedMarch 31, 2013, representing an increase of approximately $1.6 million, or 50%. Research and development expenses related to AMR-001, including expenses associated with our Phase 2 clinical trial, increased by approximately $0.2 million for the three months endedMarch 31, 2014 compared to the prior year period. The Phase 2 clinical trial completed enrollment in the fourth quarter of 2013. Research and development expenses associated with our Regulatory T cell (“Treg”) platform increased by approximately $1.0 million, and was primarily due to our efforts to develop Tregs for the treatment of type 1 diabetes, steroid resistant asthma, and organ transplant rejection. We continue to focus efforts on initiating a Phase 2 in type 1 diabetes in 2014 within the Treg platform. Research and development associated with engineering and innovation initiatives at PCT to improve scale up, automation, and integration capabilities also increased during the current quarter compared to the prior year quarter. Equity-based compensation included in research and development expenses for the three months endedMarch 31, 2014 and March 31, 2013 were approximately $0.5 million and $0.2 million, respectively.

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• Selling, general and administrative expenses were approximately $9.0 million for the three months endedMarch 31, 2014 compared to $5.8 million for the three months endedMarch 31, 2013, representing an increase of approximately $3.2 million, or 55%. Equity-based compensation included in selling, general and administrative expenses for the three months endedMarch 31, 2014 was approximately $3.3 million, compared to approximately $1.9 million for the three months endedMarch 31, 2013, representing an increase of $1.4 million. The increase in equity-based compensation is due to the broader use of equity-based compensation during the current quarter, as well as changes in option vesting provisions initiated in 2013, impacting the timing of equity-based compensation expense recognition. Equity-based compensation expense is expected to be lower in future quarters. Non-equity-based general and administrative expenses for the three months endedMarch 31, 2014 were approximately $5.7 million, compared to approximately $3.8 million for the three months endedMarch 31, 2013, representing an increase of $1.9 million. The increase was related to higher strategic and corporate development activities, including efforts associated with the acquisition of California Stem Cell, Inc. in the second quarter of 2014, as well as increased corporate infrastructure to support our expanded research and development operations.

Historically, to minimize our use of cash, we have used a variety of equity and equity-linked instruments to compensate employees, consultants and other service providers. The use of these instruments has resulted in charges to the results of operations, which has been significant in the past. In general, these equity and equity-linked instruments were used to pay for employee and consultant compensation, director fees, marketing services, investor relations and other activities.

Other Income (Expense)

Other expense, net for the three months endedMarch 31, 2014 was approximately $190,000, and other income, net, for the three months endedMarch 31, 2013 was $11,000. Other income (expense), net for the three months endedMarch 31, 2014 primarily relates to the increase in the estimated fair value of our contingent consideration liability associated with potential earn out payments on the net sales of our product candidate AMR-001 (in the event of and following the date of first commercial sale of AMR-001).

For the three months endedMarch 31, 2014 interest expense was $94,000 compared with $44,000 for the three months endedMarch 31, 2013.

Provision for Income Taxes

The provision for income taxes for the three months endedMarch 31, 2014 relate to the taxable temporary differences on the goodwill recognized in the PCT acquisition in 2011, which is being amortized over 15 years for tax purposes. A tax provision will continue to be recognized each period over the amortization period, and will only reverse when the goodwill is eliminated through a sale, impairment, or reclassification from an indefinite-lived asset to a finite-lived asset.

Noncontrolling Interests

In March 2011, we acquired rights to use patents under licenses from Becton, Dickinson and Company ("BD") in exchange for a 19.9% interest in our Athelos subsidiary. Pursuant to the Stock Purchase Agreement signed in March 2011, BD's ownership will be diluted based on new investment in Athelos (subject to certain anti-dilution provisions). As of March 31, 2014, BD's ownership interest in Athelos was decreased to 10.0%, and our ownership increased to 90.0%. For the three months endedMarch 31, 2014 and 2013, BD’s share of Athelos’ net loss totaled approximately $0.1 million and $0.1 million, respectively.

Analysis of Liquidity and Capital Resources

At March 31, 2014 we had a cash balance of approximately $41.4 million, working capital of approximately $37.8 million, and stockholders’ equity of approximately $59.6 million.

During the three months endedMarch 31, 2014, we met our immediate cash requirements through revenue generated from our PCT operations, existing cash balances, the issuance of common stock under our purchase agreement with Aspire, and warrant exercises. Additionally, we used equity and equity-linked instruments to pay for services and compensation.

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Net cash provided by or used in operating, investing and financing activities from continuing operations were as follows (in thousands): 

	Three Months Ended March 31,
	2014			2013
Net cash used in operating activities	$	(11,253.5	)	$	(7,135.7	)
Net cash used in investing activities	(1,239.6		)	(53.6		)
Net cash provided by financing activities	7,719.0			2,705.4

Operating Activities

Our cash used in operating activities in the three months endedMarch 31, 2014 totaled approximately $11.3 million, which is the sum of (i) our net loss of $13.8 million, and adjusted for non-cash expenses totaling $4.6 million (which includes adjustments for equity-based compensation and depreciation and amortization), and (ii) changes in operating assets and liabilities providing approximately $2.0 million.

Our cash used in operating activities in the three months endedMarch 31, 2013 totaled approximately $7.1 million, which is the sum of (i) our net loss of $8.9 million, and adjusted for non-cash expenses totaling $2.8 million (which includes adjustments for equity-based compensation and depreciation and amortization), and (ii) changes in operating assets and liabilities providing approximately $1.0 million.

Investing Activities

During the three months endedMarch 31, 2014, we spent approximately $1.2 million for property and equipment. During the three months endedMarch 31, 2013, we spent approximately $0.1 million for property and equipment.

Financing Activities

During the three months endedMarch 31, 2014, our financing activities consisted of the following: 

• We raised gross proceeds of approximately $5.6 million through the issuance of approximately 0.8 million shares of Common Stock under the provisions of our equity line of credit with Aspire.

• We raised approximately $0.1 million from the exercise of 12,800 options.

• We raised approximately $1.3 million from the exercise of 250,000 warrants.

During the three months endedMarch 31, 2013, our financing activities consisted of the following: 

• We raised gross proceeds of approximately $2.8 million through the issuance of 454,300 shares of Common Stock under the provisions of our equity line of credit with Aspire.

• We raised approximately $0.1 million from the exercise of approximately 20,800 warrants. To induce the exercise of certain of these warrants, we provided consideration to the warrant holders in the form of cash.

Liquidity and Capital Requirements Outlook

We anticipate requiring additional capital for strategic transactions and otherwise in order to fund the development of cell therapy product candidates, particularly in our Targeted Immunotherapy Program, CD34 Cell Program and T Regulatory Cell Program. The most significant funding needs are anticipated to be in connection with the conduct of our Phase 3 clinical trial of Melapuldencel-T for stage IV and recurrent stage III melanoma which is expected to be initiated in 2014 and cost approximately $25 million, and other costs related to the operation of CSC (now known as NeoStem Oncology, LLC), which we acquired in May 2014. The recent acquisition of the CSC operations could result in our re-prioritizing the timing of the initiation of certain of our other earlier stage clinical trials. We also anticipate requiring additional capital to grow the PCT business, including implementing additional automation capabilities and pursuing plans to establish commercial capacity and expand internationally. Additionally, we recently completed expansion in the Allendale, New Jersey facility adding laboratory, clean room suites and support facil

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ities and we commenced construction at the Mountain View facility and expanded its manufacturing capacity with additional clean rooms, laboratory space and support facilities and the build-out is expected to be completed in May 2014.

To meet our short and long term liquidity needs, we currently expect to use existing cash balances, our revenue generating activities, and a variety of other means. Those other means include the continued use of a common stock purchase agreement with Aspire (the "Aspire Agreement"). We entered into a new $30 million common stock purchase agreement with Aspire in March 2014. Other sources of liquidity could include potential issuances of debt or equity securities in public or private financings, additional warrant exercises, option exercises, and/or sale of assets. In addition, we will continue to seek as appropriate grants for scientific and clinical studies from the National Institutes of Health, Department of Defense, and other governmental agencies and foundations, but there can be no assurance that we will be successful in qualifying for or obtaining such grants. Our history of operating losses and liquidity challenges, may make it difficult for us to raise capital on acceptable terms or at all. The demand for the equity and debt of small cap biopharmaceutical companies like ours is dependent upon many factors, including the general state of the financial markets. During times of extreme market volatility, capital may not be available on favorable terms, if at all. Our inability to obtain such additional capital could materially and adversely affect our business operations. We believe that our current cash balances and revenue generating activities, along with access to the Aspire Agreement, will be sufficient to fund the business, as now operated, into 2015.

While we continue to seek capital through a number of means, there can be no assurance that additional financing will be available or on acceptable terms, if at all, and our negotiating position in capital generating efforts may worsen as existing resources are used. Additional equity financing may be dilutive to our stockholders; debt financing, if available, may involve significant cash payment obligations and covenants that restrict our ability to operate as a business, our stock price may not reach levels necessary to induce option or warrant exercises, and asset sales may not be possible on terms we consider acceptable. If we are unable to raise the funds necessary to meet our long-term liquidity needs, we may have to delay or discontinue the acquisition and development of cell therapies, and/or the expansion of our business or raise funds on terms that we currently consider unfavorable.

Commitments and Contingencies

The following table summarizes our obligations to make future payments under current contracts as of March 31, 2014 (in thousands):

	Total		Less than 1 Year		1-3 Years		3-5 Years		More than 5 Years
Contractual Obligations
Mortgages Payable	$	3,184.0	$	216	$	468.7	$	2,254.3	$	245
Notes Payable	1,707.1		836.2		870.9		—		—
Operating Lease Obligations	2,678.5		1,017.7		1,438.3		222.5		—
	$	7,569.6	$	2,069.9	$	2,777.9	$	2,476.8	$	245.0

Under our agreements with external clinical research organizations (“CRO's”), we will incur expenses relating to our clinical trials for our therapeutic product candidates in development. The timing and amount of these expenses are based on performance, and therefore, we cannot reasonably estimate the timing of these payments.

SEASONALITY

NeoStem does not believe that its operations are seasonal in nature.

OFF-BALANCE SHEET ARRANGEMENTS

NeoStem does not have any off-balance sheet arrangements.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES

There have been no material changes in our critical accounting policies and estimates during the three months endedMarch 31, 2014, compared to those reported in our 2013 Form 10-K.

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ITEM 3.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.

Market risk is the risk of change in fair value of a financial instrument due to changes in interest rates, equity prices, creditworthiness, financing, exchange rates or other factors. Our primary market risk exposure relates to changes in interest rates. However, as of March 31, 2014, we held no investments or marketable securities, and our mortgage, representing our largest component of debt, has a fixed interest rate until 2017, and is not subject to interest rate exposure. As a result, we have no material exposure to market risk related to interest rate changes as of March 31, 2014.

ITEM 4.  CONTROLS AND PROCEDURES.  

(a)  Disclosure Controls and Procedures

Disclosure controls and procedures are the Company’s controls and other procedures that are designed to ensure that information required to be disclosed in the reports that the Company files or submits under the Securities Exchange Act of 1934, as amended (the “Exchange Act”) is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed in the reports that the Company files under the Exchange Act is accumulated and communicated to management, including the Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives. Due to the inherent limitations of control systems, not all misstatements may be detected. These inherent limitations include the realities that judgments in decision-making can be faulty and that breakdowns can occur because of a simple error or mistake. Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people, or by management override of the control. Controls and procedures can only provide reasonable, not absolute, assurance that the above objectives have been met.

As of March 31, 2014, the Company carried out an evaluation, with the participation of the Company’s management, including the Company’s Chief Executive Officer and Chief Financial Officer, of the effectiveness of the Company’s disclosure controls and procedures pursuant to Rule 13a-15(e) and 15d-15(e) of the Exchange Act. Based on that evaluation, the Company’s Chief Executive Officer and Chief Financial Officer concluded that the Company’s disclosure controls and procedures were effective, at the reasonable assurance level, in ensuring that information required to be disclosed by the Company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms and is accumulated and communicated to management, including the Chief Executive Officer and Chief Financial Officer, as appropriate to allow timely decisions regarding required disclosure.

(b)  Changes in Internal Control over Financial Reporting

There have been no changes in the Company’s internal controls over financial reporting, as such term is defined in Exchange Act Rule 13a-15, that occurred during the Company’s last quarter to which this report relates that have materially affected, or are reasonably likely to materially affect, the Company’s internal control over financial reporting.

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PART II

OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS.

There are no material changes to the disclosures provided in the Company’s Annual Report on Form 10-K for the year ended December 31, 2013.

ITEM 1A. RISK FACTORS

There have been no material changes from the risk factors previously disclosed in the Company's Annual Report on Form 10-K for the year ended December 31, 2013. See the risk factors set forth in the Company's Annual Report on Form 10-K for the year ended December 31, 2013 under the caption "Item 1 A - Risk Factors." The CSC Acquisition and the ongoing operations of our NeoStem Oncology, LLC (see Note 15, Subsequent Events, to the interim financial statements) will subject the combined company to additional risks.  Our Current Report on Form 8-K to be filed on the date hereof reporting the closing of the CSC Acquisition will contain a discussion of the risk factors related to the CSC Acquisition and our NeoStem Oncology, LLC subsidiary.

ITEM 2.  UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

As previously disclosed, and as follows:

The Company has agreed to issue equity to certain consultants for services. Effective March 17, 2014 pursuant to a three month consulting agreement for consulting services in financial and investor relations and other specified matters, the Company agreed to issue to a consultant 7,500 shares of the Company's restricted common stock, vesting as to 2,500 shares on each of April 2, 2014, May 1, 2014 and June 15, 2014. Effective April 1, 2014, pursuant a five month agreement for consulting services in financial advisory and investment banking services and other specified matters, the Company agreed to issue to a consultant 19,500 shares of the Company's restricted common stock, vesting as to half two months after the effective date and half on the last day of the term. Also effective April 1, 2014, pursuant to a three month extension for consulting services in information technology and accounting systems, the Company agreed to issue to a consultant, 3,300 shares of the Company's restricted common stock, vesting ratably throughout the term of the agreement on a monthly basis. Also effective April 1, 2014, pursuant to a three month extension for consulting services in accounting systems and regulatory compliance, the Company agreed to issue to a consultant, 2,200 shares of the Company's restricted common stock vesting ratably throughout the term of the agreement on a monthly basis. Also effective April 1, 2014 pursuant to a four month agreement for consulting services in investor relations and other specified matters, the Company agreed to issue to a consultant 12,000 shares of the Company's restricted common stock, vesting as to 3,000 shares on the last day of each month throughout the term of the agreement. Effective April 9, 2014, pursuant to a three month agreement for consulting services in investor relations, developing implementing and planning presentations to the financial community, and other specified matters, the Company agreed to issue to a consultant 10,000 shares of the Company's restricted common stock, vesting ratably throughout the term of the agreement.  Effective May 1, 2014 pursuant to a four month extension for consulting services in strategic planning and tactical application of those services and other specified matters, the Company agreed to issue to a consultant 16,000 shares of restricted common stock vesting as to 50% on the effective date and 50% at the end of the term.

The offer and sale by the Company of the securities described above were made in reliance upon the exemption from registration provided by Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), for transactions by an issuer not involving a public offering. The offer and sale of such securities were made without general solicitation or advertising to “accredited investors” as such term is defined in Rule 501(a) of Regulation D promulgated under the Securities Act and/or pursuant to Regulation D or Regulation S, each promulgated under the Securities Act and may not be resold in the United States or to U.S. persons unless registered under the Securities Act or pursuant to an exemption from registration under the Securities Act.

On May 8, 2014, pursuant to the Company's acquisition of CSC, the Company issued an aggregate of 5,329,593 shares of the Company's restricted common stock. The offer and sale of the shares of NeoStem common stock to be issued pursuant to the merger agreement have been made in a private placement in reliance upon the exemption from registration provided by Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), for transactions by an issuer not involving a public offering, and/or Regulation D under the Securities Act.

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ITEM 3.  DEFAULTS UPON SENIOR SECURITIES

Not applicable.

ITEM 4. MINE SAFTEY DISCLOSURES.

Not applicable.

ITEM 5. OTHER INFORMATION.

On May 8, 2014, NeoStem closed its acquisition of CSC (see footnote 15).

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ITEM 6. EXHIBITS

The exhibits to this Form 10-Q are listed in the Exhibit Index included elsewhere herein.

NEOSTEM, INC.

FORM 10Q

Exhibit Index

2.1	Agreement and Plan of Merger, dated as of April 11, 2014, by and among NeoStem, Inc., California Stem Cell, Inc., NBS Acquisition Company I, Inc., NBS Acquisition Company II, LLC, and Jason Livingston, solely in his capacity as CSC stockholder representative (incorporated by reference to Exhibit 4.18 to the Company's Current Report on Form 8-K filed on April 14, 2014)
4.1	Registration Rights Agreement, dated as of March 11, 2014, by and between NeoStem, Inc. and Aspire Capital Fund, LLC.(incorporated by reference to Exhibit 4.18 to the Company's Annual Report on Form 10-K filed on March 13, 2014).
31.1	Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002*
31.2	Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002*
32.1	Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002**
32.2	Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002**
10.1	Common Stock Purchase Agreement, dated as of March 11, 2014, by and between NeoStem, Inc. and Aspire Capital Fund, LLC. (incorporated by reference to Exhibit 10.10 to the Company's Annual Report on Form 10-K filed on March 13, 2014).
10.2	Letter Agreement dated March 11, 2014 to Employment Agreement dated May 26, 2006 between NeoStem, Inc. and Dr. Robin L. Smith (incorporated by reference to Exhibit 10.49 to the Company's Annual Report on Form 10-K filed on March 13, 2014).
10.3	Letter Agreement, dated March 11, 2014, between NeoStem, Inc. and Catherine M. Vaczy, Esq. (incorporated by reference to Exhibit 10.57 to the Company's Annual Report on Form 10-K filed on March 13, 2014).
10.4	Fourth Lease Modification and Additional Space Agreement, dated January 24, 2014, between SLG Graybar Mesne Lease LLC and NeoStem, Inc.*
101.INS	XBRL Instance Document***
101.SCH	XBRL Taxonomy Extension Schema***
101.CAL	XBRL Taxonomy Extension Calculation Linkbase***
101.DEF	XBRL Taxonomy Extension Definition Linkbase***
101.LAB	XBRL Taxonomy Extension Label Linkbase***
101.PRE	XBRL Taxonomy Extension Presentation Linkbase***

_______________

*	Filed herewith.
**	Furnished herewith.
***	Users of this interactive data file are advised pursuant to Rule 406T of Regulations S-T that this interactive data file is deemed not filed or part of a registration statement or prospectus for purposes of sections 11 or 12 of the Securities Act of 1933, is deemed not filed for purposes of section 18 of the Securities Exchange Act of 1934, and otherwise is not subject to liability under these sections.

30

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on May 8, 2014.

NEOSTEM, INC.

By: /s/ Robin L. Smith, M.D.

Name: Robin L. Smith, M.D.

 Title: Chief Executive Officer

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

Signature	Title	Date
/s/ Robin L. Smith, M.D. Robin L. Smith, M.D.	Director, Chief Executive Officer and  Chairman of the Board (Principal Executive Officer)	May 8, 2014
/s/ Robert Dickey IV Robert Dickey IV	Chief Financial Officer (Principal Financial Officer)	May 8, 2014
/s/ Joseph Talamo Joseph Talamo	Vice President, Corporate Controller and Chief  Accounting Officer (Principal Accounting Officer)	May 8, 2014

31

EX-10.4

Exhibit 10.4

FOURTH LEASE MODIFICATION AND ADDITIONAL SPACE AGREEMENT

FOURTH LEASE MODIFICATION AND ADDITIONAL SPACE AGREEMENT (this “Agreement”) dated as of the 24^th day of January, 2014 between SLG GRAYBAR MESNE LEASE LLC, having an office c/o SL Green Realty Corp., 420 Lexington Avenue, New York, New York (hereinafter referred to as “Landlord”) and NEOSTEM, INC., having an office at 420 Lexington Avenue, New York, New York 10170 (hereinafter referred to as “Tenant”).

WITNESSETH:

WHEREAS, Landlord’s predecessor in interest, SLG Graybar Sublease LLC, as landlord, and Tenant’s predecessor in interest, Duncan Capital Partners, LLC, DCI Master LDC, MW Crow Family, L.P., and DC Associates LLC, jointly and severally, as tenant (hereinafter, collectively, the “Original Tenant”), entered into that certain lease agreement (the “Original Lease”) dated as of June 14, 2006, covering a certain rentable portion of the fourth (4^th) floor designated as Room 448-52 (“Original Premises”) as more particularly described in the Original Lease, in the building located at 420 Lexington Avenue, New York, New York (the “Building”) under the terms and conditions contained therein which Original Lease was thereafter assigned by the Original Tenant to Tenant pursuant to that certain Assignment and Assumption of Lease (the “Assignment”) dated as of April __, 2009, which Assignment was effective as of April 1, 2009, and which Original Lease as assigned was further modified by that certain (x) Lease Modification Agreement dated as of April 13, 2009 (the “1^stModification”), (y) Second Lease Modification Agreement dated as of July 22, 2009 (the “2^ndModification”) covering certain additional storage space (the “Storage Space”); and (z) Third Lease Modification Agreement dated as of August 16, 2012 (the “3^rdModification”) whereby Tenant relocated from the Original Premises to certain substitute space located on the third (3^rd) floor designated as Room 347-55 (the “Existing Premises”) (said Original Lease, Assignment, 1^st Modification , 2^nd Modification and 3^rd Modification, are hereinafter referred to as the “Lease”, and the premises demised thereunder, i.e., the Existing Premises and the Storage Space, are sometimes collectively hereinafter referred to as the “Premises”); for a term scheduled to expire on June 30, 2015 (the “Expiration Date”); and

WHEREAS, Tenant wishes to (i) extend the term of the Lease, as modified by this Agreement, for an additional term of two (2) years and seven (7) months (the “Extended Term”) to commence as of July 1, 2015 (the “Extended Term Commencement Date”) and to expire on January 31, 2018 (the “Extended Term Expiration Date”) and (ii) add to the Existing Premises a certain portion of rentable area of the third (3^rd) floor of the Building contiguous to the Existing Premises designated as Room 345-46, approximately as indicated on the floor plan annexed hereto and made a part hereof as Exhibit A, the deemed rentable square foot area of which Tenant acknowledges and agrees solely for purposes of this Agreement shall be 1,850 rentable square feet, (“Additional Space”) for a term (the “Additional Space Term”) to commence as of the Additional Space Commencement Date (as such term is hereinafter defined) and to expire on the Extended Term Expiration Date;

WHEREAS, subject to and in accordance with the terms, covenants and conditions of this Agreement, Landlord has agreed to permit Tenant to (i) extend the term of the Lease for the period of the Extended Term and (ii) add the Additional Space to the Existing Premises for the period of the Additional Space Term; and

WHEREAS, Tenant and Landlord wish to modify the Lease as set forth below.

NOW, THEREFORE, in consideration of the mutual agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereby agree as follows:

1.Term.

The term of the Lease for the Existing Premises and the Storage Space shall be extended under the same terms, covenants and conditions contained in the Lease, except to the extent specifically modified by this Agreement, so that the term of the Lease shall expire on the Extended Term Expiration Date or on such earlier date upon which the term of the Lease shall expire, be canceled or terminated pursuant to any of the conditions or covenants of the Lease or pursuant to law.

2.Additional Space.

The Additional Space shall be added to the Existing Premises under all the applicable terms and conditions of the Lease, except as modified herein, for a term commencing on the Additional Space Commencement Date and ending on the Extended Term Expiration Date or on such earlier date upon which the term of the Lease shall expire, be canceled or terminated pursuant to any of the conditions or covenants of the Lease or pursuant to law (and the “Premises”, as such term is defined in the Lease, shall consist of the Existing Premises, the Storage Space and the Additional Space from and after the Additional Space Commencement Date).

3.Condition of the Existing Premises.

3.01The parties acknowledge that Tenant is currently in occupancy of the Existing Premises, has inspected the same and the Building and is fully familiar with the physical condition thereof and Tenant agrees to accept the Existing Premises at the Extended Term Commencement Date in its then “as is” condition. Tenant acknowledges and agrees that Landlord shall have no obligation to do any work in or to the Existing Premises in order to make it suitable and ready for continued occupancy and use by Tenant, except to the extent expressly provided for in this Article 3.

3.02Landlord, or Landlord’s designated agent, shall (x) perform the work set forth on the schedule annexed hereto and made a part hereof as Exhibit B (“Landlord’s Work”) in the Existing Premises in a building standard manner using building standard finishes and building standard materials with reasonable dispatch, subject to delay which is due to either a Tenant Delay or Force Majeure (as such terms are hereinafter defined), and (y) provide notice (which may be given in person or by telephone) to Tenant twenty-four (24) hours prior to the commencement of Landlord’s Work; provided, however, that Tenant acknowledges and agrees that (a) a portion of Landlord’s Work will be performed in the Existing Premises while Tenant remains in occupancy of the Existing Premises during normal business hours (unless Landlord, in its sole discretion, elects otherwise) and that such Landlord’s Work shall not constitute an eviction of Tenant in whole or in part, constructive or actual, and shall not be a ground for any abatement of rent and shall not impose liability on Landlord by reason of any inconvenience, injury to Tenant's business or otherwise, (b) in order to facilitate the performance by Landlord of Landlord’s Work affecting the Existing Premises without delay and/or additional expense to Landlord, Tenant shall promptly upon request and at its sole cost and expense relocate to other areas of the Existing Premises all materials, personalty, furnishings, personal property, fixtures, trade fixtures and equipment presently located in the area in which Landlord’s Work is to be performed as reasonably designated by Landlord, (c) until the completion of Landlord’s Work, Landlord, and/or its designated agents, shall be permitted to access the Existing Premises and take all materials and equipment into the Existing Premises that may be required for the performance of any portion of Landlord’s Work, provided, however, that Landlord shall not store any materials in either the Existing Premises and/or the Additional Space, as

the case may be, beyond that reasonably needed in order to complete the work scheduled to be performed therein during the succeeding twenty-four (24) hour period, and (d) Landlord, and/or its designated agents, shall perform Landlord’s Work in reasonable coordination with any work being performed in the Existing Premises by or on behalf of Tenant; provided, however, that Tenant and/or Tenant’s designees shall not interfere with or delay the performance of Landlord’s Work or increase the cost for Landlord, and/or its designated agents, to perform the same. Tenant acknowledges and agrees that the performance of Landlord’s Work is expressly conditioned upon compliance by Tenant with all the terms and conditions of the Lease, including payment of Rent.

3.03Any changes in or additions to Landlord’s Work which shall be consented to by Landlord, and further changes in or additions to the Existing Premises after said Landlord’s Work has been completed which shall be so consented to shall be made by Landlord, or its agents, but shall be paid for by Tenant promptly when billed at cost plus 5%, and in the event of the failure of Tenant so to pay for said changes or additions, Landlord at its option may consider the cost thereof, plus the above percentages, as Additional Rent payable by Tenant and collectible as such hereunder, as part of the rent for the next ensuing months.

3.04[Intentionally Omitted.]

3.05Landlord’s Work to both the Existing Premises and the Additional Space shall be deemed to be substantially completed notwithstanding that (i) minor or non-material details of construction, mechanical adjustment or decoration remain to be performed (collectively, the “Punch List Items”), or (ii) a portion of Landlord’s Work is incomplete because construction scheduling requires that such work be done after incomplete finishing or after other work to be done by or on behalf of Tenant is completed. Landlord hereby agrees that within thirty (30) days after Landlord’s receipt of a written notice from Tenant identifying any purported Punch List Items that require Landlord’s completion, Landlord shall complete said Punch List Items.

4.Condition of the Additional Space.

4.01The parties acknowledge that Tenant has inspected the Additional Space, is fully familiar with the physical condition thereof and agrees to accept the Additional Space in its “as-is” condition as of the Additional Space Commencement Date, subject to Landlord’s substantial completion of Landlord’s Work, and the repair of any holes in the sheetrock, if any, and that Landlord shall have no obligation to do any work in or to the Additional Space in order to make it suitable and ready for occupancy and use by Tenant, except to the extent expressly provided for in this Article 4.

4.02Landlord, or Landlord’s designated agent, shall perform the Landlord’s Work set forth on Exhibit B in the Additional Space in a building standard manner using building standard finishes and building standard materials, with reasonable dispatch, subject to delay which is due to either a Tenant Delay or Force Majeure. Landlord shall not store any materials in either the Existing Premises and/or the Additional Space, as the case may be, beyond that reasonably needed in order to complete the work scheduled to be performed therein during the succeeding twenty-four (24) hour period. Tenant acknowledges and agrees that the performance of Landlord’s Work is expressly conditioned upon compliance by Tenant with all the terms and conditions of the Lease, including payment of Rent.

4.03Any changes in or additions to Landlord’s Work which shall be consented to by Landlord, and further changes in or additions to the Additional Space after said Landlord’s Work has been completed which shall be so consented to shall be made by Landlord, or its agents, but shall be paid for by Tenant promptly when billed at cost plus 5%, and in the event of the failure of Tenant so to pay for said

changes or additions, Landlord at its option may consider the cost thereof, plus the above percentages, as Additional Rent payable by Tenant and collectible as such hereunder, as part of the rent for the next ensuing months.

4.04If Landlord's Work is not substantially completed and is delayed by acts, omissions or changes made or requested by Tenant, its agents, designers, architects or any other party acting or apparently acting on Tenant’s behalf, then Tenant shall pay as hereinbefore provided rent and additional rent on a per diem basis for each day of delay of Landlord's substantial completion caused by Tenant or any of the aforementioned parties.

4.05Landlord's Work to both the Additional Space and the Existing Premises shall be deemed to be substantially completed notwithstanding that (i) Punch List Items remain to be performed, or (ii) a portion of Landlord’s Work is incomplete because construction scheduling requires that such work be done after incomplete finishing or after other work to be done by or on behalf of Tenant is completed. Landlord hereby agrees that within thirty (30) days after Landlord’s receipt of a written notice from Tenant identifying any purported Punch List Items that require Landlord’s completion, Landlord shall complete said Punch List Items.

4.06For purposes of this Agreement, the “Additional Space Commencement Date” shall mean the date which is the earlier of (x) the date upon which Landlord’s Work is deemed to be substantially completed, or (y) the date Tenant or anyone claiming by, under or through Tenant first shall occupy any part of the Additional Space for the conduct of Tenant's business.

4.07Notwithstanding anything contained herein to the contrary:

(i)in the event that Landlord shall not have delivered possession of the Additional Space on or before the Outside Delivery Date (as such term is hereinafter defined), then Tenant may by written notice (a “Cancellation Notice”) given to Landlord (x) elect to terminate and cancel this Agreement with respect to the Additional Space only, and (y) elect not to extend the Lease for the Extended Term with respect to the Existing Premises and the Storage Space effective on the date (the “A.S. Cancellation Date”) occurring ten (10) days following the date such notice is given, in which event (provided that Landlord has not delivered vacant possession of the Additional Space prior to the A.S. Cancellation Date) this Agreement shall be null and void and of no further force and effect and neither Landlord nor Tenant shall have any further rights or obligations under this Agreement; provided, however, that (a) the representations and indemnifications contained in Article 12 hereof shall survive such termination; and (b) the Lease with respect to the Existing Premises and the Storage Space shall remain in full force and effect through the Expiration Date. The parties hereby agree that the Outside Delivery Date shall be extended by one (1) day for each day Landlord fails to deliver possession of the Additional Space as a result of either a Tenant Delay or by reasons of Force Majeure (as such terms are hereinafter defined), and in the event that Tenant gives to Landlord a Cancellation Notice, Tenant must exercise both the elections set forth in subsections (x) and (y) above simultaneously and shall have no right to exercise such elections individually or independently; and

(ii)for purposes of Section 4.07 of this Article, the following terms shall have the following meanings:

(a)The term “Outside Delivery Date” shall mean November 30, 2014;

(b)The term “Tenant Delay” shall mean any actual delay which Landlord may encounter in performing Landlord’s Work by reason of any act or omission of any nature of Tenant, Tenant’s agents or contractors, including, without limitation, delays due to (1) changes in or additions to the work set forth in

Exhibit B as requested by Tenant, (2) Tenant’s failure to timely submit to Landlord requested information or information required hereunder, or give authorizations or approvals required by Landlord in connection with Landlord’s Work, or (3) the postponement of any particular Landlord’s Work at the request of Tenant; and

(c)The term “Force Majeure” shall mean the inability of Landlord to perform an obligation accruing under this Article4 by reason of accidents, strikes, the inability to secure a proper supply of fuel, gas, steam, water, electricity, labor or supplies, governmental restrictions, regulations or controls or by reason of any other similar cause beyond the reasonable control of Landlord.

4.08The provisions of this Article are intended to constitute an "express provision to the contrary" within the meaning of Section 223(a), New York Real Property Law.

4.09On or following the date occurring five (5) days prior to the Additional Space Commencement Date (the “Early Access Date”), Tenant shall be permitted access to the Additional Space solely for the purpose of installing telecommunications and computer cabling provided that Tenant and/or Tenant’s designees shall not interfere with or delay the performance by Landlord of Landlord’s Work or increase Landlord’s cost to perform Landlord’s Work. Such access shall be subject to, and in accordance with, all the terms, covenants and conditions of the Lease including, without limitation, the provisions of Articles 8 and 43 of the Lease. Landlord shall provide Tenant with reasonable advance notice of such Early Access Date (which notice may be given in person or by telephone).

5. Fixed Annual Rent and Escalations for the Existing Premises and the Storage Space.

5.01(a)Tenant shall pay Fixed Annual Rent for the Existing Premises (exclusive of electricity charges) from the Extended Term Commencement Date through the Extended Term Expiration Date at the following rates:

(i)Four Hundred Twelve Thousand Seven Hundred Seventy Two and 50/100 ($412,772.50) Dollars per annum ($34,397.70 per month) for the period from July 1, 2015 through June 30, 2016;

(ii)Four Hundred Twenty Five Thousand One Hundred Fifty Five and 67/100 ($425,155.67) Dollars per annum ($35,429.63 per month) for the period from July 1, 2016 through June 30, 2017; and

(iii)Thirty Six Thousand Four Hundred Ninety Two and 52/100 ($36,492.52) Dollars per month for the period from July 1, 2017 through January 31, 2018.

(b)In addition to the payment of Fixed Annual Rent as hereinabove provided, Tenant shall continue to pay Additional Rent and other charges for the Existing Premises as originally provided for in the Lease provided, however, that as of the Extended Term Commencement Date, the phrase “Base Tax Year” as set forth in Article 32.01(b)(iii) of the Lease shall be mean New York City real estate tax year commencing on July 1, 2014 and ending on June 30, 2015.

5.02(a)Tenant shall pay Fixed Annual Rent for the Storage Space (inclusive of electricity charges) from the Extended Term Commencement Date through the Extended Term Expiration Date at the following rates:

(i)Six Thousand Three Hundred Fifty Three and 73/100 ($6,353.73) Dollars per annum ($529.47 per month) for the period from July 1, 2015 through June 30, 2016;

(ii)Six Thousand Five Hundred Forty Four and 34/100 ($6,544.34) Dollars per annum ($545.36 per month) for the period from July 1, 2016 through June 30, 2017; and

(iii)Five Hundred Sixty One and 72/100 ($561.72) Dollars per month for the period from July 1, 2017 through January 31, 2018.

(b)In addition to the payment of Fixed Annual Rent as hereinabove provided, Tenant shall continue to pay Additional Rent for the Storage Space as originally provided for in the Lease and Article 5.01(b) hereof as the same applies to the Existing Premises.

6.Fixed Annual Rent and Escalations for the Additional Space.

6.01Fixed Annual Rent. For purposes of this Article 6, the term “First Lease Year” shall mean the period from the Additional Space Commencement Date through (i) the last day of the month during which the first (1^st) anniversary of the Additional Space Commencement Date occurs, or (ii) in the event that the Additional Space Commencement Date occurs on the first (1st) day of the month, the day immediately preceding the first (1st) anniversary of the Additional Space Commencement Date, and each succeeding “Lease Year” shall mean each successive twelve (12) month period following the First Lease Year through and including the Extended Term Expiration Date. Tenant shall pay Fixed Annual Rent for the Additional Space (exclusive of electricity charges) from the Additional Space Commencement Date through the Extended Term Expiration Date at the following rates:

a)For the First Lease Year, by the sum of Ninety Two Thousand Five Hundred and 00/100 ($92,500.00) Dollars per annum ($7,708.33 per month);

b) For the Second Lease Year, by the sum of Ninety Five Thousand Two Hundred Seventy Five and 00/100 ($95,275.00) Dollars per annum ($7,939.58 per month);

c) For the Third Lease Year, by the sum of Ninety Eight Thousand One Hundred Thirty Three and 25/100 ($98,133.25) Dollars per annum ($8,177.77 per month); and

d) For the Fourth Lease Year or portion thereof, by the sum of Eight Thousand Four HundredTwenty Three and10/100 ($8,423.10) Dollars per month.

6.02Tenant shall pay Additional Rent for the Additional Space effective as of the Additional Space Commencement Date in accordance with all applicable provisions of the Lease as modified by this Agreement; provided however, that, solely with respect to the Additional Space: (i) for purposes of Article 32.01(a) of the Lease, the rentable square foot area of the Additional Space shall be deemed to be 1,850 square feet; (ii) the percentage set forth in Article 32.01(b)(i) of the Lease as “Tenant’s Share” shall mean 0.166%; (iii) for purposes of Article 32.01(b)(iii) of the Lease, the phrase “Base Tax Year” shall mean the average of the Real Estate Taxes payable for (x) the New York City real estate tax year commencing on July 1, 2013 and ending on June 30, 2014, and (y) the New York City real estate tax year commencing on July 1, 2014 and ending on June 30, 2015; (vi) for purposes of Article 32.01(b)(iv) of the Lease, the term “Comparative Year” shall mean the twelve (12) month period beginning on July 1, 2014 and ending on June 30, 2015, and each subsequent period of twelve (12) months thereafter; and (v) for purposes of Article 32.04 of the Lease, the

phrase “Base Tax Year” shall be deleted, and the phrase “Tax Year July 1, 2014 through June 30, 2015” shall be substituted in its place and stead.

1. Electric/Air Conditioning Service.

7.01(a)Tenant acknowledges and agrees that electric service shall (i) continue to be supplied to the Existing Premises from and after the Extended Term Commencement Date, and (ii) be supplied to the Additional Space as of the Additional Space Commencement Date, in each instance, on a “rent inclusion basis” in accordance with the provisions of Article 41 of the Lease, as modified by the 3^rd Modification; provided, however that, commencing on the Additional Space Commencement Date, Article 41.03 of the Lease shall be modified so that the phrase “8,015 square feet” shall be deemed to be and is hereby deleted, and the phrase “9,865 square feet” shall be substituted in its place and stead in order to reflect the addition of the Additional Space to the Existing Premises.

(b)Tenant acknowledges and agrees that electric service shall continue to be supplied to the Storage Space from and after the Extended Term Commencement Date in accordance with Section 41.10 of the Leaseas modified by the 2^nd Modification.

7.02Tenant acknowledges and agrees that air conditioning service shall be supplied to the Additional Space from and after the Additional Space Commencement Date in accordance with the provisions of Article 35 of the Lease.

2. Signage.

Effective as of the Additional Space Commencement Date, the last sentence of Article 44.01 is deleted in its entirety and the following new sentence is inserted in lieu thereof:

“Notwithstanding the foregoing, Tenant shall be permitted to list up to six (6) names (including Tenant’s name) on the sign or plaque located on the entrance to the Premises.”

9.Successors and Assigns.

This Agreement shall be binding upon and inure to the benefit of the parties and their respective successors and permitted assigns.

10.Entire Agreement.

The Lease, as modified by this Agreement, represents the entire understanding between the parties with regard to the matters addressed herein and may only be modified by written agreement executed by all parties hereto. All prior understandings or representations between the parties hereto, oral or written, with regard to the matters addressed herein, other than the Lease, are hereby merged herein. Tenant acknowledges that neither Landlord nor any representative or agent of Landlord has made any representation or warranty, express or implied, as to the physical condition, state of repair, layout, footage or use of the Premises or any matter or thing affecting or relating to the Premises except as specifically set forth in this Agreement. Tenant has not been induced by and has not relied upon any statement, representation or agreement, whether express or implied, not specifically set forth in this Agreement. Landlord shall not be liable or bound in any manner by any oral or written statement, broker's "set-up", representation, agreement or information pertaining to the Premises or this Agreement furnished by any real estate broker, agent, servant,

employee or other person, unless specifically set forth herein, and no rights are or shall be acquired by Tenant by implication or otherwise unless expressly set forth herein.

11.Effectiveness.

This Agreement shall not be binding upon Landlord and Tenant until executed and delivered by both Landlord and Tenant.

12.Ratification.

Tenant acknowledges and agrees that the Lease, as modified by this Agreement, has not been modified and remains in full force and effect, Landlord has not waived any requirement of the Lease, Landlord is not in breach of the Lease and Tenant has no claim for any failure of Landlord to perform its obligations under the Lease.

13.No Brokers/Indemnification.

13.01Tenant covenants, represents and warrants that Tenant has had no dealings or negotiations with any broker or agent in connection with the consummation of this Agreement other than SL Green Leasing LLC and Jones Lang LaSalle (collectively, the “Brokers”), and Tenant covenants and agrees to defend, hold harmless and indemnify Landlord from and against any and all cost, expense (including reasonable attorneys' fees) or liability for any compensation, commissions or charges claimed by any broker or agent (other than the Brokers) with respect to this Agreement or the negotiation thereof.

13.02Landlord covenants, represents and warrants that Landlord has had no dealings or negotiations with any broker or agent in connection with the consummation of this Agreement other than the Brokers, and Landlord covenants and agrees to defend, hold harmless and indemnify Tenant from and against any and all cost, expense (including reasonable attorneys' fees) or liability for any compensation, commissions or charges claimed by any broker or agent (including the Brokers) with respect to this Agreement or the negotiation thereof. Landlord agrees to pay any commissions due the Brokers, if any, in connection with this Agreement pursuant to a separate agreement.

14.Miscellaneous.

(a)The captions in this Agreement are for convenience only and are not to be considered in construing this Agreement.

(b)This Agreement shall be construed without regard to any presumption or other rule requiring construction against the party causing this Agreement to be drafted.

(c)Terms used in this Agreement and not otherwise defined herein shall have the respective meanings ascribed thereto in the Lease.

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

(d)If any provision of this Agreement or its application to any person or circumstances is invalid or unenforceable to any extent, the remainder of this Agreement, or the applicability of such provision to other persons or circumstances, shall be valid and enforceable to the fullest extent permitted by law and shall be deemed to be separate from such invalid or unenforceable provisions and shall continue in full force and effect.

IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Agreement as of the day and year first above written.

SLG GRAYBAR MESNE LEASE LLC, as Landlord

By:/s/ Steven M. Durels

Executive Vice President

Witness:

/s/ Monica Perez

Title: Admin. Asst.

NEOSTEM, INC., as Tenant

By: /s/ Robin L. Smith

Title: CEO

Witness:

/s/ Jessi Goebel

Title: Exec. Asst, Legal

EX-31.1

Exhibit 31.1

CERTIFICATION

I, Robin Smith, M.D., certify that:

1.  I have reviewed this Quarterly Report on Form 10-Q of NeoStem, Inc.;

2.  Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.  Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.  The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a)  Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by  this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.  The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a)  All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date: May 8, 2014

/s/ Robin Smith, M.D.

Name: Robin Smith, M.D.

Title: Chief Executive Officer of NeoStem, Inc.

A signed original of this written statement required by Section 302 has been provided to NeoStem, Inc. and will be retained by NeoStem, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.

EX-31.2

Exhibit 31.2

CERTIFICATION

I, Robert Dickey IV, certify that:

1.  I have reviewed this Quarterly Report on Form 10-Q of NeoStem, Inc.;

2.  Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.  Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.  The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a)  Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by  this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.  The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a)  All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date: May 8, 2014

/s/ Robert Dickey IV

Name: Robert Dickey IV

Title: Chief Financial Officer of NeoStem, Inc.

A signed original of this written statement required by Section 302 has been provided to NeoStem, Inc. and will be retained by NeoStem, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.

EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of NeoStem, Inc. (the “Company”) on Form 10-Q for the quarter ended March 31, 2014 filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Robin Smith, M.D., Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to my knowledge that:

1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition of the Company as of the dates presented and the results of operations of the Company for the periods presented.

Dated:  May 8, 2014

/s/ Robin Smith, M.D.

Robin Smith, M.D.

Chief Executive Officer

The foregoing certification is being furnished solely pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code) and is not being filed as part of the Form 10-Q or as a separate disclosure document.

A signed original of this written statement required by Section 906 has been provided to NeoStem, Inc. and will be retained by NeoStem, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.

EX-32.2

Exhibit 32.2

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of NeoStem, Inc. (the “Company”) on Form 10-Q for the quarter ended March 31, 2014 filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Robert Dickey IV, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to my knowledge that:

1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition of the Company as of the dates presented and the results of operations of the Company for the periods presented.

Dated:  May 8, 2014

/s/ Robert Dickey IV

Robert Dickey IV

Chief Financial Officer

The foregoing certification is being furnished solely pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code) and is not being filed as part of the Form 10-Q or as a separate disclosure document.

A signed original of this written statement required by Section 906 has been provided to NeoStem, Inc. and will be retained by NeoStem, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.

XML

Fair Value Measurements Financial instruments with significant Level 3 inputs (Details) (USD $)	3 Months Ended
	Mar. 31, 2014
Warrants
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning liability balance	$ 23,200
Change in fair value recorded in earnings	0
Ending liability balance	23,200
contingent cosideration [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning liability balance	9,450,000
Change in fair value recorded in earnings	190,000
Ending liability balance	$ 9,640,000

XML

Shareholders' Equity Stock options and warrants (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013	Dec. 31, 2013
Stock Options and Warrants [Line Items]
Stock Option Exercise	12,800
Stock Issued During Period, Shares, Other	0	3,913
Warrants Issued During Period, Value	$ 0	$ 14,900
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value	1,896,700
Common Stock Warrants, Shares	4,491,028		4,898,266
Weighted Average Exercise Price, Warrants Outstanding	15.39		16.50
Weighted Average Remaining Contractual Term warrant outstanding	2 years 4 months 24 days
Aggregate Intrinsic Value, Warrants Outstanding	1,661,500
Warrants Granted	2,722
Weighted Average Exercise Price, Warrants Granted	$ 12.26
Warrants Exercised	(250,000)
Weighted Average Exercise Price, Warrants Exercised	$ 5.10
Warrants Expired	(100,108)
Weighted Average Exercise Price, Warrants Expired	$ 70.00
Warrants Canceled	(59,852)
Weighted Average Exercise Price, Warrants Canceled	$ 57.76
Proceeds from Stock Options Exercised	100,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value	1,848,900
shares, vested and expected to vest	4,491,028
Weighted Average Exercise Price, Warrants vested & expected to vest	15.39
Aggregate Intrinsic Value, Warrants vested and expected to vest	1,661,500
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value	1,600,900
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number	4,473,306
Weighted Average Exercise Price, Warrants Exercisable	15.42
weighted Average Remaining Contractual Term, warrants vested	2 years 3 months 18 days
Aggregate Intrinsic Value, Warrants vested	$ 1,661,500
Warrants
Stock Options and Warrants [Line Items]
Weighted average estimated fair value of shares granted	$ 0.00		$ 3.82
US Equity Plan [Member]
Stock Options and Warrants [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number	3,912,697		2,932,191
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price	$ 10.22		$ 11.19
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term	7 years 4 months 21 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures	1,169,200
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price	$ 7.70
Stock Options Exercised	(12,800)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price	$ 5.58
Stock Options Expired	(109,329)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price	$ 6.97
Stock Options Forfeited	(66,565)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price	$ 14.77
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number	3,596,457
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price	$ 10.46
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term	7 years 2 months 9 days
Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest	2 years 4 months 24 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number	2,520,755
Weighted average estimated fair value of shares granted	$ 11.50
Options, Vested, weighted Average Remaining Contractual Term	6 years 5 months 27 days
Minimum [Member]
Stock Options and Warrants [Line Items]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Upper Range Limit	$ 5.20
Maximum [Member]
Stock Options and Warrants [Line Items]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Upper Range Limit	$ 6.20

XML

Shareholders' Equity Equity Issuances (Details) (USD $) In Millions, except Share data, unless otherwise specified			0 Months Ended			3 Months Ended
	Mar. 31, 2014	Dec. 31, 2013	Sep. 30, 2012 Private Placement [Member]	Mar. 31, 2014 Aspire Capital Purchase Agreement [Member]	Sep. 28, 2011 Aspire Capital Purchase Agreement [Member]	Mar. 31, 2014 Aegis Capital Purchase Agreement [Member]	Mar. 31, 2014 Aspire Capital Purchase Agreement [Member]
Class of Stock [Line Items]
Committment Value Under Purchase Agreement					$ 20.0
Term Of Agreement In Months					24
Discount Applied To Weighted Average Price				5.00%
Investment Warrants, Exercise Price			$ 5.10
Shares, Issued						800,000
Proceeds from Issuance of Common Stock Gross						5.6
Common Stock, Shares, Issued	28,593,410	27,196,537					150,000
Purchase Commitment, Remaining Minimum Amount Committed							$ 30.0

XML

The Business Principal of consolidation (Details)	3 Months Ended
	Mar. 31, 2014
NeoStem, Inc. [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Minority Interest Ownership Percentage By Parent [String]	Parent  Company
NeoStem Therapies, Inc [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	100.00%
Stem Cell Technologies, Inc [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	100.00%
Amorcyte, LLC [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	100.00%
China Biopharmaceuticals Holdings, Inc. [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary of Limited Liability Company or Limited Partnership, Ownership Interest	100.00%
Suzhou Erye Pharmaceuticals Company Ltd. [Member] | CHINA
Schedule of Subisidiary [Line Items]
Subsidiary of Limited Liability Company or Limited Partnership, Ownership Interest	51.00%
Progenitor Cell Therapy, LLC [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary, Ownership Interest by Parent	100.00%
NeoStem Family Storage, LLC [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary of Limited Liability Company or Limited Partnership, Ownership Interest	100.00%
Minority Interest Ownership Percentage By Parent [String]	1
Athelos Corporation [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary of Limited Liability Company or Limited Partnership, Ownership Interest	90.00%
Minority Interest Ownership Percentage By Parent [String]	0.90
PCT Allendale, LLC [Member] | UNITED STATES
Schedule of Subisidiary [Line Items]
Subsidiary of Limited Liability Company or Limited Partnership, Ownership Interest	100.00%
Minority Interest Ownership Percentage By Parent [String]	1

XML

Loss Per Share (Tables)

3 Months Ended

Mar. 31, 2014

Loss Per Share [Abstract]

ScheduleOfDilutiveSecuritiesExcludedFromComputationOfEarningsPerShare [Table Text Block]

At March 31, 2014 and 2013, the Company excluded the following potentially dilutive securities:

	March 31,
	2014	2013
Stock Options	3,912,697	2,631,181
Warrants	4,491,028	5,501,055
Restricted Shares	175,731	35,500

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Share-Based Compensation Share-Based Compensation (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013	Dec. 31, 2013
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	$ 3,893,600	$ 2,218,500
Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost	6,490,000
Expected weighted-average period in years of compensation cost to be recognized	5 years 7 months 13 days
Warrants
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost	46,200
Expected weighted-average period in years of compensation cost to be recognized	1 year 3 months 18 days
Total fair value of shares vested	8,700	43,800
Weighted average estimated fair value of shares granted	$ 0.00		$ 3.82
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average estimated fair value of shares granted	$ 5.47		$ 4.71
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost	208,200
Expected weighted-average period in years of compensation cost to be recognized	4 months 6 days
Cost of revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	138,100	86,400
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	476,800	217,400
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense	3,278,700	1,914,700
Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total fair value of shares vested	$ 1,927,400	$ 1,305,000

XML

Goodwill and Other Intangible Assets Goodwill (Details) (USD $)	Mar. 31, 2014	Dec. 31, 2013
Goodwill [Abstract]
Goodwill	$ 11,117,770	$ 11,117,770
Future Amortization Expense, Year One	453,900
Future Amortization Expense, Year Two	605,200
Future Amortization Expense, Year Three	605,200
Future Amortization Expense, Year Four	605,200
Finite-Lived Intangible Assets, Amortization Expense, Year Five	605,200
Thereafter	10,849,600
Finite-Lived Intangible Assets, Future Amortization Expense	$ 13,724,300	$ 13,875,600

XML

Loss Per Share (Details)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Warrants
Class of Stock [Line Items]
Dilutive Securities Excluded From Computation Of Earnings Per Share, Shares	4,491,028	5,501,055
Stock Options [Member]
Class of Stock [Line Items]
Dilutive Securities Excluded From Computation Of Earnings Per Share, Shares	3,912,697	2,631,181
Restricted Stock [Member]
Class of Stock [Line Items]
Dilutive Securities Excluded From Computation Of Earnings Per Share, Shares	175,731	35,500

XML

Commitments and Contingencies (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Operating Leases, Future Minimum Payments Due [Abstract]
2013	$ 763,000
2014	840,400
2015	682,300
2016	386,900
Thereafter	5,900
Total minimum lease payments	2,678,500
Operating Leases, Rent Expense	$ 200,000	$ 300,000

XML

Shareholders' Equity Warrant Exercises (Details) (USD $) In Millions, except Share data, unless otherwise specified	0 Months Ended	3 Months Ended
	Sep. 30, 2012 Private Placement [Member]	Mar. 31, 2014 Warrant holder A [Member]
Stock Options and Warrants [Line Items]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights		250,000
Investment Warrants, Exercise Price	$ 5.10
Proceeds from Issuance of Warrants		$ 1.3

XML

Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2014

Summary of Significant Accounting Policies [Abstract]

Summary of Significant Accounting Policies [Text Block]

Summary of Significant Accounting Policies

In addition to the policies below, our significant accounting policies are described in Note 2 of the Notes to Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2013. There were no changes during the three months endedMarch 31, 2014.

Cash and Cash Equivalents

Cash and cash equivalents include short-term, highly liquid, investments with maturities of ninety days or less when purchased.

Accounts Receivable

Accounts receivable are carried at original invoice amount less an estimate made for doubtful accounts. The Company applies judgment in connection with establishing the allowance for doubtful accounts. Specifically, the Company analyzes the aging of accounts receivable balances, historical bad debts, customer concentration and credit-worthiness, current economic trends and changes in the Company’s customer payment terms. Significant changes in customer concentrations or payment terms, deterioration of customer credit-worthiness or weakening economic trends could have a significant impact on the collectability of the receivables and the Company’s operating results. If the financial condition of the Company’s customers were to deteriorate, resulting in an impairment of their ability to make payments, additional allowances may be required. Management regularly reviews the aging of receivables and changes in payment trends by its customers, and records a reserve when it believes collection of amounts due are at risk.

Inventories

The Company, through its PCT subsidiary, regularly enters into contracts with clients for services that have multiple stages and are dependent on one another to complete the contract and recognize revenue. The Company's inventory represents work in process for costs incurred on such projects at PCT that have not been completed. The Company reviews these projects periodically to determine that the value of each project is stated at the lower of cost or market.

Goodwill and Other Intangible Assets

Goodwill is the excess of purchase price over the fair value of identified net assets of businesses acquired. The Company’s intangible assets with an indefinite life are related to in process research and development ("IPR&D") for AMR-001, the clinical candidate acquired in the Amorcyte acquisition, as the Company expects this research and development to provide the Company with substantial benefit for a period that extends beyond the foreseeable horizon. Intangible assets with indefinite useful lives are measured at their respective fair values as of the acquisition date. The Company does not amortize goodwill and intangible assets with indefinite useful lives. Intangible assets related to IPR&D projects are considered to be indefinite-lived until the completion or abandonment of the associated R&D efforts. If and when development is complete, which generally occurs if and when regulatory approval to market a product is obtained, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time.

The Company reviews goodwill and indefinite-lived intangible assets at least annually for possible impairment. Goodwill and indefinite-lived intangible assets are reviewed for possible impairment between annual tests if an event occurs or circumstances change that would more likely than not reduce the fair value of the reporting unit below its carrying value. The Company tests its goodwill and indefinite-lived intangible assets each year on December 31. The Company reviews the carrying value of goodwill and indefinite-lived intangible assets utilizing a discounted cash flow model, and, where appropriate, a market value approach is also utilized to supplement the discounted cash flow model. The Company makes assumptions regarding estimated future cash flows, discount rates, long-term growth rates and market values to determine each reporting unit’s estimated fair value. If these estimates or related assumptions change in the future, the Company may be required to record impairment charges. In accordance with it's accounting policy, the Company tested goodwill and indefinite-lived intangible assets for impairment as of December 31, 2013 and 2012 for its two reporting units, and concluded there was no risk of failing step 1 of the goodwill impairment testing evaluation, and that indefinite-lived intangible assets were not impaired.

Amortized intangible assets consist of customer lists, manufacturing technology, and tradename, as well as patents and rights associated primarily with the VSEL™ Technology. These intangible assets are amortized on a straight line basis over their respective useful lives.

Revenue Recognition

Clinical Services: The Company recognizes revenue for its (i) process development and (ii) clinical manufacturing services based on the terms of individual contracts.

Revenues associated with process development services generally contain multiple stages that do not have stand-alone values and are dependent upon one another, and are recognized as revenue on a completed contract basis. We recognize revenues when all of the following conditions are met:

• persuasive evidence of an arrangement exists;

• delivery has occurred or the services have been rendered;

• the fee is fixed or determinable; and

• collectability is probable.

The Company considers signed contracts as evidence of an arrangement. The Company assesses whether the fee is fixed or determinable based on the payment terms associated with the transaction and whether the payment terms are subject to refund or adjustment. The Company assesses cash collectability based on a number of factors, including past collection history with the client and the client's creditworthiness. If the Company determines that collectability is not reasonably assured, it defers revenue recognition until collectability becomes reasonably assured, which is generally upon receipt of the cash. The Company's arrangements are generally non-cancellable, though clients typically have the right to terminate their agreement for cause if the Company materially fails to perform.

Clinical manufacturing services are generally distinct arrangements whereby the Company is paid for time and materials or for fixed monthly amounts. Revenue is recognized when efforts are expended or contractual terms have been met.

Some client agreements include multiple elements, comprised of process development and clinical manufacturing services. The Company believes that process development and clinical manufacturing services each have stand-alone value because these services can be provided separately by other companies. In accordance with ASC Update No. 2009-13, “Revenue Recognition (Topic 605): Multiple-Deliverable Revenue Arrangements,” the Company (1) separates deliverables into separate units of accounting when deliverables are sold in a bundled arrangement and (2) allocates the arrangement's consideration to each unit in the arrangement based on its relative selling price. 

Clinical Services Reimbursements: The Company separately charges the customers for the expenses associated with certain consumable resources (reimbursable expenses) that are specified in each clinical services contract. On a monthly basis, the Company bills customers for reimbursable expenses and immediately recognizes these billings as revenue, as the revenue is deemed earned as reimbursable expenses are incurred. For the three months endedMarch 31, 2014 and 2013, clinical services reimbursements were $0.7 million and $0.4 million, respectively.

Processing and Storage Services: The Company recognizes revenue related to the collection and cryopreservation of cord blood and autologous adult stem cells when the cryopreservation process is completed which is approximately twenty-four hours after cells have been collected. Revenue related to advance payments of storage fees is recognized ratably over the period covered by the advance payments.

XML

Accrued Liabilities Accrued Liabilities (Details) (USD $)	Mar. 31, 2014	Dec. 31, 2013
Accrued Liabilities [Abstract]
Salaries, employee benefits and related taxes	$ 846.4	$ 2,325.8
Professional fees	775.4	544.8
Accrued Royalties, Current	200.0	500.0
Other	559.8	647.4
Accrued Liabilities	$ 2,381.6	$ 4,018.0

XML

Shareholders' Equity (Tables)

3 Months Ended

Mar. 31, 2014

Shareholders’ Equity [Abstract]

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

The following table summarizes the activity for stock options and warrants for the three months endedMarch 31, 2014:

	Stock Options							Warrants
	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)		Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2013	2,932,191		$	11.19	6.8	$	1,658.1	4,898,266		$	16.50	2.6	$	1,811.0
Changes during the Period:
Granted	1,169,200		$	7.70				2,722		$	12.26
Exercised	(12,800	)	$	5.58				(250,000	)	$	5.10
Forfeited	(109,329	)	$	6.97				(100,108	)	$	70.00
Expired	(66,565	)	$	14.77				(59,852	)	$	57.76
Outstanding at March 31, 2014	3,912,697		$	10.22	7.4	$	1,896.7	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014 or expected to vest in the future	3,596,457		$	10.46	7.2	$	1,848.9	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014	2,520,755		$	11.50	6.5	$	1,600.9	4,473,306		$	15.42	2.3	$	1,661.5

Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]

During the three months endedMarch 31, 2014 and 2013, the Company issued warrants for services as follows ($ in thousands, except share data):

	Three Months Ended March 31,
	2014		2013
Number of Common Stock Purchase Warrants Issued	—		3,913
Value of Common Stock Purchase Warrants Issued	$	—	$	14.9

Restricted Stock [Table Text Block]

During the three months endedMarch 31, 2014 and 2013, the Company issued restricted stock for services as follows ($ in thousands, except share data):

	Three Months Ended March 31,
	2014		2013
Number of Restricted Stock Issued	329,698		177,492
Value of Restricted Stock Issued	$	2,511.7	$	1,127.9

XML

Accrued Liabilities Accrued Liabilities (Tables)

3 Months Ended

Mar. 31, 2014

Accrued Liabilities [Abstract]

Schedule of Accrued Liabilities [Table Text Block]

Accrued liabilities as of March 31, 2014 and December 31, 2013 were as follows (in thousands):

	March 31, 2014		December 31, 2013
Salaries, employee benefits and related taxes	$	846.4	$	2,325.8
Professional fees	775.4		544.8
License Fees	200.0		500.0
Other	559.8		647.4
	$	2,381.6	$	4,018.0

XML

Debt (Details) (USD $)			0 Months Ended	3 Months Ended		3 Months Ended	0 Months Ended
	Mar. 31, 2014	Dec. 31, 2013	Oct. 31, 2007 Convertible Notes Payable [Member]	Mar. 31, 2014 Convertible Notes Payable [Member]	Dec. 31, 2013 Convertible Notes Payable [Member]	Mar. 31, 2014 PCT Allendale, LLC [Member]	Dec. 06, 2010 PCT Allendale, LLC [Member] Convertible Notes Payable [Member]	Mar. 31, 2014 PCT Allendale, LLC [Member] Convertible Notes Payable [Member]	Dec. 31, 2013 PCT Allendale, LLC [Member] Convertible Notes Payable [Member]
Debt Instrument [Line Items]
Notes Payable	$ 1,700,000	$ 900,000
Purchase of condominium units			0
Debt Instrument, Frequency of Periodic Payment			monthly payments
Debt Instrument, Periodic Payment						20,766
Debt Instrument, Periodic Payment, Interest				5.00%			6.00%
Mortgage Loans on Real Estate, Carrying Amount of Mortgages				2,400,000	2,500,000			741,800	763,000
Mortgage Loan Repayble Amount within 12 months						128,300		87,700
Mortgage Loans on Real Estate, New Mortgage Loans			$ 3.1				$ 1,000,000
Debt Instrument, Period of Loan							124 months
Debt Instrument, Period of Fixed Interest Rate							64 months

XML

Share-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2014

Share-based Compensation [Abstract]

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

The following table summarizes the components of share-based compensation expense for the three months endedMarch 31, 2014 and 2013 (in thousands):

	Three Months Ended March 31,
	2014		2013
Cost of goods sold	$	138.1	$	86.4
Research and development	476.8		217.4
Selling, general and administrative	3,278.7		1,914.7
Total share-based compensation expense	$	3,893.6	$	2,218.5

Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]

Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at March 31, 2014 were as follows (dollars in thousands):

	Stock Options		Warrants		Restricted Stock
Unrecognized compensation cost	$	6,490.0	$	46.2	$	208.2
Expected weighted-average period in years of compensation cost to be recognized	5.62		1.30		0.35

Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block]

Total fair value of shares vested and the weighted average estimated fair values of shares granted for the three months endedMarch 31, 2014 and 2013 were as follows (dollars in thousands):

	Stock Options				Warrants
	Three Months Ended March 31,				Three Months Ended March 31,
	2014		2013		2014		2013
Total fair value of shares vested	$	1,927.4	$	1,305.0	$	8.7	$	43.8
Weighted average estimated fair value of shares granted	$	5.47	$	4.71	$	—	$	3.82

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Commitments and Contingencies (Tables)

3 Months Ended

Mar. 31, 2014

Commitments and Contingencies [Abstract]

Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]

A summary of future minimum rental payments required under operating leases that have initial or remaining terms in excess of one year as of March 31, 2014 are as follows (in thousands):  

Years ended	Operating Leases
2014	$	763.0
2015	840.4
2016	682.3
2017	386.9
2018	5.9
Total minimum lease payments	$	2,678.5

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The Business

3 Months Ended

Mar. 31, 2014

The Business [Abstract]

Nature of Operations [Text Block]

The Business

Overview

NeoStem, Inc. (“we,” “NeoStem” or the “Company”) is a leader in the emerging cellular therapy industry. We are pursuing the preservation and enhancement of human health globally through the development of cell based therapeutics that prevent, treat or cure disease. We have multiple cell therapy platforms that work to address the pathology of disease using a person's own cells to amplify the body's natural repair mechanisms including enhancing the destruction of cancer initiating cells, repairing and replacing damaged or aged tissue, cells and organs and restoring their normal function. We believe that cell therapy will play a large role in changing the natural history of diseases as more breakthrough therapies are developed, ultimately lessening the overall burden of disease on patients and their families as well as the economic burden that these diseases impose upon modern society.

Our business includes the development of novel proprietary cell therapy products, as well as a revenue-generating contract development and manufacturing service business that we leverage for the development of our therapeutics while providing service to other companies in the cell therapy industry developing products. The combination of our own therapeutic development business and a revenue-generating service provider business provides the Company with unique capabilities for cost effective in-house product development and immediate revenue and future cash flow to help underwrite our internal development programs. This business model enables the Company to be opportunistic in growing its pipeline as evidenced by the Company's acquisition in May 2014 through the issuance of equity of California Stem Cell, Inc. ("CSC"), a cell biotechnology corporation that is developing cellular immunotherapies for cancer, an area we view to be one of the most promising sub-sectors in biotechnology. CSC, now known as NeoStem Oncology, LLC, is driving the Company's Targeted Immunotherapy Program for cancer through the development of its lead product candidate, Melapuldencel-T, to treat Stage IV or recurrent melanoma. The Phase 3 protocol is the subject of a Special Protocol Assessment (SPA), indicating that the Food and Drug Administration ("FDA") is in agreement with the design, clinical endpoints, and planned clinical analyses of the Phase 3 trial that will serve as the basis for a Biologics License Application ("BLA"). This protocol calls for enrolling 250 patients and is expected to be initiated in 2014.

We are currently developing therapies to address ischemia through our CD34 Cell Program. Ischemia occurs when the supply of oxygenated blood in the body is restricted. We seek to reverse this restriction through the development and formation of new blood vessels. AMR-001 is our most clinically advanced product candidate in our CD34 Cell Program and is being developed to treat damaged heart muscle following an acute myocardial infarction (heart attack) ("AMI"). In December 2013, the Company completed enrollment in its PreSERVE AMI study. PreSERVE AMI is a randomized, double-blinded, placebo-controlled Phase 2 clinical trial testing AMR-001, an autologous (donor and recipient are the same) adult stem cell product for the treatment of patients with left ventricular dysfunction following acute ST segment elevation myocardial infarction (STEMI). With the last patient of the planned 160 patient trial infused in late December 2013, we expect the last patient six-month follow-up to occur in June 2014. Once the primary end point six-month data is collected, the data set will be locked and analysis will begin with a submission for a possible presentation of the study at the American Heart Association's Scientific Sessions to be held November 15-19, 2014. If approved by Food and Drug Administration (the "FDA ") and/or other worldwide regulatory agencies following successful completion of further trials, AMR-001 would address a significant medical need for which there is currently no effective treatment, potentially improving longevity and quality of life for those suffering a STEMI, and positioning the Company to capture a meaningful share of this worldwide market. We also expect to advance the technology into other clinical indications such as chronic heart failure ("CHF"), traumatic brain injury ("TBI"), and/or critical limb ischemia ("CLI").

Another platform technology we are developing utilizes T Regulatory Cells ("Tregs") to treat diseases caused by imbalances in an individual's immune system.  In collaborating with Becton-Dickinson and the University of California, San Francisco, we are utilizing this technology platform of our majority-owned subsidiary, Athelos Corporation ("Athelos"), to restore immune balance by enhancing Treg cell number and function.  Tregs are a natural part of the human immune system and regulate the activity of T effector cells, the cells that are responsible for protecting the body from viruses and  other foreign antigen exposure. When Tregs function properly, only harmful foreign materials are attacked by T effector cells. In autoimmune disease it is thought that deficient Treg activity permits the T effector cells to attack the body's own tissues, and in allergic diseases, like asthma, the immune system overreacts to harmless foreign substances. We plan to initiate a Phase 2 study of Treg based therapeutics  to treat type 1 diabetes in 2014. We also plan to initiate a Phase 1 study in Canada of Treg based therapeutics in support of a steroid resistant asthma indication in 2014.

Pre-clinical assets include our VSEL ^TM (Very Small Embryonic Like) Technology regenerative medicine platform. Regenerative medicine holds the promise of improving clinical outcomes and reducing overall  healthcare costs.  We are working on a Department of Defense funded study of VSELs^TM for the treatment of chronic wounds. Other preclinical work with VSELs^TM includes exploring macular degeneration as a target indication.

Progenitor Cell Therapy, LLC ("PCT") is a contract manufacturer that generates revenue. This wholly owned subsidiary, which we acquired in 2011, is an industry leader in providing high quality manufacturing capabilities and support to developers of cell-based therapies to enable them to improve efficiencies and profitability and reduce capital investment for their own development activities. Since its inception more than 15 years ago, PCT has provided pre-clinical and clinical current Good Manufacturing Practice (“cGMP”) development and manufacturing services to more than 100 clients. PCT has experience advancing regenerative medicine product candidates from product inception through rigorous quality standards all the way through to human testing, BLA filing and FDA product approval. PCT's core competencies in the cellular therapy industry include manufacturing of cell therapy-based products, engineering and innovation services, product and process development, cell and tissue processing, regulatory support, storage, distribution and delivery and consulting services. PCT has two cGMP, state-of-the art cell therapy research, development, and manufacturing facilities in New Jersey and California, serving the cell therapy community with integrated and regulatory compliant distribution capabilities. The Company is pursuing commercial expansion of our manufacturing operations both in the U.S. and internationally. Additionally, with the acquisition of CSC, PCT can leverage CSC's additional manufacturing capacity in Irvine, California as well as the personnel experience and expertise in immunotherapy to provide additional manufacturing and /or development work to advance NeoStem's platform technology as well as technologies of PCT's client base.

Strategic acquisitions have been the cornerstone of NeoStem’s growth and have been selected in order to provide value to stockholders by taking advantage of the infrastructure we have created which includes strong development, regulatory and manufacturing expertise. By adding Melapuldencel-T, a late stage novel proprietary cancer cell therapy into our pipeline, we look to further advance towards our goal of delivering transformative cell based therapies to the market to help patients suffering from life-threatening medical conditions. Coupled with our best in class manufacturing capability, the stage is set for us to realize meaningful clinical development and manufacturing efficiencies, further positioning NeoStem to lead the cell therapy industry.

Basis of Presentation

The accompanying unaudited Consolidated Financial Statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“generally accepted accounting principles”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X of the Securities and Exchange Commission for interim financial information. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. In the opinion of management, the accompanying Consolidated Financial Statements of the Company and its subsidiaries, which are unaudited, include all normal and recurring adjustments considered necessary to present fairly the Company’s financial position as of March 31, 2014 and the results of its operations and its cash flows for the periods presented. The unaudited consolidated financial statements herein should be read together with the historical consolidated financial statements of the Company for the years ended December 31, 2013 and 2012 included in our Annual Report on Form 10-K for the year ended December 31, 2013. Operating results for the three months endedMarch 31, 2014 are not necessarily indicative of the results that may be expected for the year ending December 31, 2014.

Use of Estimates

The preparation of financial statements in conformity with generally accepted accounting principles in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements. Estimates also affect the reported amounts of revenues and expenses during the reporting period. Accordingly, actual results could differ from those estimates.

Reclassifications

Certain reclassifications have been made to the Consolidated Financial Statements and Notes to the Consolidated Financial Statements for the three months endedMarch 31, 2013 to conform to the presentation for the three months endedMarch 31, 2014.

Principles of Consolidation

The Consolidated Financial Statements include the accounts of NeoStem, Inc. and its wholly owned and partially owned subsidiaries and affiliates as listed below.

Entity	Percentage of Ownership	Location
NeoStem, Inc.	Parent  Company	United States of America
NeoStem Therapies, Inc.	100%	United States of America
Stem Cell Technologies, Inc.	100%	United States of America
Amorcyte, LLC	100%	United States of America
Progenitor Cell Therapy, LLC (PCT)	100%	United States of America
NeoStem Family Storage, LLC	100%	United States of America
Athelos Corporation (1)	90%	United States of America
PCT Allendale, LLC	100%	United States of America
NeoStem Oncology, LLC (2)	100%	United States of America

(1) Pursuant to the Stock Purchase Agreement signed in March 2011, our initial ownership in Athelos was 80.1%, and Becton Dickinson's ("BD") initial minority ownership was 19.9%. Per the Agreement, BD will be diluted based on new investment in Athelos by us (subject to certain anti-dilution provisions). As of March 31, 2014, BD's ownership interest in Athelos was decreased to 10.0%, and our ownership increased to 90.0%. As a result in the change in ownership, approximately $0.1 million was transferred from additional paid in capital to non-controlling interests.

(2) On May 8, 2014, NeoStem acquired CSC, now known as NeoStem Oncology, LLC (see Note 15, Subsequent Events). Accordingly, the accounts of NeoStem Oncology, LLC are not included in the Company's consolidated financial position as of March 31, 2014 and the results of its consolidated operations and cash flows for the three months endedMarch 31, 2014 and 2013.

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The Business (Details) (USD $)	0 Months Ended		3 Months Ended
	Jun. 18, 2012 segment	Jun. 19, 2012 segment	Mar. 31, 2014
The Company [Line Items]
Change in Ownership in Subsidiary			$ 0
Number of Reporting Segments	3	1
Noncontrolling Interest [Member]
The Company [Line Items]
Change in Ownership in Subsidiary			$ 86,617

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Goodwill and Other Intangible Assets Intangible Assets and Related Accumulated Amortization (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Dec. 31, 2013
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets, Gross	$ 15,769,000	$ 15,769,000
Finite-Lived Intangible Assets, Accumulated Amortization	(2,044,700)	(1,893,400)
Finite-Lived Intangible Assets, Net	13,724,300	13,875,600
Customer Lists [Member]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets, Gross	1,000,000	1,000,000
Finite-Lived Intangible Assets, Accumulated Amortization	(320,100)	(295,100)
Finite-Lived Intangible Assets, Net	679,900	704,900
Finite-Lived Intangible Assets, Useful Life	10 years
Manufacturing Technology [Member]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets, Gross	3,900,000	3,900,000
Finite-Lived Intangible Assets, Accumulated Amortization	(1,248,400)	(1,150,900)
Finite-Lived Intangible Assets, Net	2,651,600	2,749,100
Finite-Lived Intangible Assets, Useful Life	10 years
Trade Names [Member]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets, Gross	800,000	800,000
Finite-Lived Intangible Assets, Accumulated Amortization	(256,100)	(236,100)
Finite-Lived Intangible Assets, Net	543,900	563,900
Finite-Lived Intangible Assets, Useful Life	10 years
In Process R and D [Member]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets, Gross	9,400,000	9,400,000
Finite-Lived Intangible Assets, Accumulated Amortization	0	0
Finite-Lived Intangible Assets, Net	9,400,000	9,400,000
Finite Lived Intangible Assets, Useful Life [String]	Indefinite
VSEL Patent Rights [Member]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets, Gross	669,000	669,000
Finite-Lived Intangible Assets, Accumulated Amortization	(220,100)	(211,300)
Finite-Lived Intangible Assets, Net	$ 448,900	$ 457,700
Finite-Lived Intangible Assets, Useful Life	19 years

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Subsequent Events (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013	Dec. 31, 2013
Subsequent Event [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number	4,473,306
Common Stock, Par Value	$ 0.001		$ 0.001
Common Stock, Shares, Issued	28,593,410		27,196,537
Proceeds from exercise of warrants	$ 1,275,000	$ 105,881
Proceeds from Stock Options Exercised	71,360	0
Aegis Capital Purchase Agreement [Member]
Subsequent Event [Line Items]
Shares, Issued	800,000
Proceeds from Issuance of Common Stock Gross	$ 5,600,000

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Consolidated Balance Sheets (USD $)	Mar. 31, 2014	Dec. 31, 2013
Current Assets
Cash and cash equivalents	$ 41,359,652	$ 46,133,759
Accounts receivable, net of allowance for doubtful accounts of $390,118 and $391,829 at March 31, 2014 and December 31, 2013, respectively	1,887,558	1,860,835
Inventory	1,475,812	1,270,223
Prepaid expenses and other current assets	1,833,082	1,561,933
Total current assets	46,556,104	50,826,750
Property, plant and equipment, net	13,790,672	12,844,216
Goodwill	11,117,770	11,117,770
Intangible assets, net	13,724,314	13,875,617
Other assets	1,204,765	1,151,729
Assets, Total	86,393,625	89,816,082
Current Liabilities
Accounts payable	3,296,078	3,354,908
Accrued liabilities	2,381,625	4,018,026
Notes payable	836,219	381,097
Mortgages payable	216,005	213,112
Derivative Liabilities, Current	23,175	23,175
Unearned revenues	2,033,116	1,816,601
Total current liabilities	8,786,218	9,806,919
Long-term Liabilities
Deferred income taxes	4,426,635	4,379,226
Notes payable	870,864	531,164
Secured Long-term Debt, Noncurrent	2,967,948	3,023,609
Business Combination, Contingent Consideration, Liability	9,640,000	9,450,000
Other long-term liabilities	635,008	598,729
Total liabilities	27,326,673	27,789,647
Commitments and Contingencies
Stockholders' Equity
Preferred stock, authorized, 20,000,000 shares; Series B convertible redeemable preferred stock liquidation value, 1/100 share of common stock, $.01 par value; 825,000 shares designated; issued and outstanding, 10,000 shares at March 31, 2014 and December 31, 2013	100	100
Common stock, $.001 par value, authorized 500,000,000 shares; issued and outstanding, 28,593,410 and 27,196,537 shares, at March 31, 2014 and December 31, 2013, respectively	28,594	27,197
Additional paid-in capital	310,377,112	299,594,525
Treasury stock, at cost	(705,742)	(705,742)
Accumulated deficit	(250,055,662)	(236,373,605)
Total NeoStem, Inc. stockholders' equity	59,644,402	62,542,475
Noncontrolling interests	(577,450)	(516,040)
Total equity	59,066,952	62,026,435
Liabilities and Equity, Total	$ 86,393,625	$ 89,816,082

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Preferred Stock Convertible Redeemable Series E Preferred Stock (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013	Dec. 31, 2013
Class of Stock [Line Items]
Preferred stock, par value	$ 0.01		$ 0.01
Net proceeds from issuance of common stock	$ 5,630,625	$ 2,730,262
Preferred Stock, Shares Outstanding	10,000		10,000
Fair Value, Inputs, Level 3 [Member]
Class of Stock [Line Items]
Warrant Derivative Liabilities	$ 23,200		$ 23,200

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Consolidated Statements of Equity (USD $)	Total	Series B Preferred Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Treasury Stock [Member]	Total NeoStem, Inc. Shareholders' Equity [Member]	Noncontrolling Interest [Member]
Beginning Balance at Dec. 31, 2012	$ 32,820,159	$ 100	$ 16,375	$ 231,218,615	$ 0	$ (197,392,361)	$ (665,600)	$ 33,177,129	$ (356,970)
Beginning Balance (shares) at Dec. 31, 2012		10,000	16,375,365
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(8,864,329)					(8,800,575)		(8,800,575)	(63,754)
Share-based compensation (in shares)			177,492
Share-based compensation	2,218,530		178	2,218,352				2,218,530
Net proceeds from issuance of common stock (in shares)			454,254
Net proceeds from issuance of common stock	2,730,263		455	2,729,808				2,730,263
Proceeds from Stock Options Exercised	0
Proceeds from warrant exercise (in shares)			20,761
Proceeds from exercise of warrants	105,881		21	105,860				105,881
Warrant Inducements (in shares)			0
Warrant Inducements			0	(6,239)				(6,239)
Adjustments to Additional Paid in Capital, Warrant Issued	(6,239)
Ending Balance at Mar. 31, 2013	29,004,265	100	17,029	236,266,396	0	(206,192,936)	(665,600)	29,424,989	(420,724)
Ending Balance (shares) at Mar. 31, 2013		10,000	17,027,872
Beginning Balance at Dec. 31, 2013	62,026,435	100	27,197	299,594,525	0	(236,373,605)	(705,742)	62,542,475	(516,040)
Beginning Balance (shares) at Dec. 31, 2013		10,000	27,196,537
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(13,830,084)					(13,682,057)		(13,682,057)	(148,027)
Share-based compensation (in shares)			329,698
Share-based compensation	3,893,616		330	3,893,286			0	3,893,616
Net proceeds from issuance of common stock (in shares)			804,375
Net proceeds from issuance of common stock	5,630,625		804	5,629,821				5,630,625
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period			12,800
Proceeds from Stock Options Exercised	71,360		13	71,347				71,360
Proceeds from warrant exercise (in shares)			250,000
Proceeds from exercise of warrants	1,275,000		250	1,274,750				1,275,000
Change in Ownership in Subsidiary	0		0	(86,617)				(86,617)	86,617
Ending Balance at Mar. 31, 2014	$ 59,066,952	$ 100	$ 28,594	$ 310,377,112	$ 0	$ (250,055,662)	$ (705,742)	$ 59,644,402	$ (577,450)
Ending Balance (shares) at Mar. 31, 2014		10,000	28,593,410

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Cash and Cash Equivalents (Details) (USD $)	Mar. 31, 2014	Dec. 31, 2013
Cash and Cash Equivalents [Abstract]
Cash and cash equivalents	$ 41,359,652	$ 46,133,759
Cash, FDIC Insured Amount	$ 700,000	$ 800,000

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Subsequent Events

3 Months Ended

Mar. 31, 2014

Subsequent Events [Abstract]

Subsequent Events [Text Block]

Subsequent Events

California Stem Cell Acquisition

On May 8, 2014 (the “Closing”), NeoStem closed its acquisition (the “CSC Acquisition”) of CSC, pursuant to the terms of the Agreement and Plan of Merger, dated as of April 11, 2014 (the “Merger Agreement”), by and among NeoStem, CSC, NBS Acquisition Sub I, Inc., a Delaware corporation and a wholly-owned subsidiary of NeoStem (“Subco”), NBS Acquisition Sub II, LLC, a Delaware limited liability company and a wholly-owned subsidiary of NeoStem (“Subco II”), and Jason Livingston, solely in his capacity as CSC stockholder representative (together with his permitted successors, the “CSC Representative”).

Pursuant to the Merger Agreement, on the Closing Date, (1) Subco was merged with and into CSC (the “First Merger”) and (2) CSC was then merged with and into Subco II (the “Second Merger”, and collectively with the First Merger, the “Mergers”), with Subco II surviving the Mergers as a wholly-owned subsidiary of NeoStem. At Closing, Subco II changed its legal name to NeoStem Oncology, LLC.

CSC (which after the Mergers is known as NeoStem Oncology, LLC) is a biopharmaceutical company with deep expertise in stem cell biology that is engaged in the development of therapies using a patient’s own, i.e., autologous, cells. To date, CSC’s development efforts have been directed at immunotherapies for cancer, regenerative medicine for motor neuron replacement and dermatology. CSC’s most advanced program is an immunotherapy, Melapuldencel-T, which uses patients’ own tumor cells to maximize the ability of their immune system to identify and eliminate the cancer initiating cells that are capable of reconstituting or developing new tumors (i.e., “cancer stem cells” or “replicating cells”). The focus of that program is the treatment of metastatic melanoma. As a result of encouraging Phase 2 data, CSC expects to initiate a Phase 3 clinical trial later in 2014, for which it has received Special Protocol Assessment (“SPA”) and Fast Track designation, as well as Orphan Drug designation. CSC maintains corporate offices and research facilities in Irvine, California.

Aggregate Merger Consideration

Pursuant to the terms of the Merger Agreement, all shares of CSC common stock (“CSC Common Stock”) and CSC preferred stock (“CSC Preferred Stock”, and collectively with the CSC Common Stock, the “CSC Capital Stock”) outstanding immediately prior to the Closing, and all outstanding unexercised options to purchase CSC Common Stock (“CSC Options”) (treated as if a net exercise had occurred), were canceled and converted into the right to receive, in the aggregate (and giving effect to the liquidation preferences accorded to the CSC Preferred Stock):

(1) An aggregate of 5,329,593 shares of NeoStem common stock (subject to payment of cash in lieu of fractional shares) (the “Closing Merger Consideration”).

(2) If payable after the Closing, certain milestone payments in an amount of up to $90 million in the aggregate, payable in shares of NeoStem common stock or cash, in NeoStem’s sole discretion, in the event of the successful completion of certain milestone events in connection with the CSC business acquired by NeoStem (the “Milestone Payments”, and together with the Closing Merger Consideration, the “Merger Consideration”).

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Inventories (Details) (USD $)	Mar. 31, 2014	Dec. 31, 2013
Schedule of Inventory [Line Items]
Inventory	$ 1,475,812	$ 1,270,223
Multiple Stage Contracts [Member]
Schedule of Inventory [Line Items]
Deferred Revenue	$ 1,600,000	$ 1,500,000

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The Business (Tables)

3 Months Ended

Mar. 31, 2014

The Business [Abstract]

Subsidiary [Table Text Block]

.

Entity	Percentage of Ownership	Location
NeoStem, Inc.	Parent  Company	United States of America
NeoStem Therapies, Inc.	100%	United States of America
Stem Cell Technologies, Inc.	100%	United States of America
Amorcyte, LLC	100%	United States of America
Progenitor Cell Therapy, LLC (PCT)	100%	United States of America
NeoStem Family Storage, LLC	100%	United States of America
Athelos Corporation (1)	90%	United States of America
PCT Allendale, LLC	100%	United States of America
NeoStem Oncology, LLC (2)	100%	United States of America

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Consolidated Statements of Cash Flows (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Cash flows from operating activities:
Net loss	$ (13,830,084)	$ (8,864,329)
Adjustments to reconcile net loss to net cash used in operating activities:
Equity-based compensation expense	3,893,616	2,218,530
Depreciation and amortization	444,452	554,954
Changes in fair value of derivative liability	0	10,606
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability	190,000	0
Bad debt recovery	(1,711)	0
Deferred Income Taxes	47,409	0
Prepaid expenses and other current assets	(271,149)	(192,009)
Accounts receivable	(25,012)	167,444
Inventory	(205,589)	(428,549)
Unearned revenues	216,515	346,912
Other assets	(53,035)	(22,986)
Accounts payable, accrued expenses and other liabilities	(1,658,952)	(905,094)
Net cash used in operating activities	(11,253,540)	(7,135,733)
Cash flows from investing activities:
Acquisition of property and equipment	(1,239,606)	(53,571)
Net cash used in investing activities	(1,239,606)	(53,571)
Cash flows from financing activities:
Proceeds from Stock Options Exercised	71,360	0
Proceeds from exercise of warrants	1,275,000	105,881
Net proceeds from issuance of common stock	5,630,625	2,730,262
Repayment of mortgage loan	(52,768)	(43,446)
Proceeds from notes payable	958,014	0
Repayment of notes payable	(163,192)	(81,015)
Change in warrant liabilities	0	(6,239)
Net cash provided by financing activities	7,719,039	2,705,443
Net decrease in cash and cash equivalents	(4,774,107)	(4,483,861)
Cash and cash equivalents at beginning of period	46,133,759	13,737,452
Cash and cash equivalents at end of period	41,359,652	9,253,591
Cash and cash equivalents of continuing operations at end of period	41,359,652
Supplemental Disclosure of Cash Flow Information:
Interest	93,100	95,700
Taxes	$ 0	$ 0

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Consolidated Balance Sheets (Parentheticals) (USD $)	Mar. 31, 2014	Dec. 31, 2013
Preferred Stock, Shares Outstanding	10,000	10,000
Common Stock, Par Value	$ 0.001	$ 0.001
Accounts receivable trade, net of allowance for doubtful accounts	$ 390,118	$ 391,829
Preferred Stock, authorized	20,000,000	20,000,000
Common stock, outstanding	28,593,410	27,196,537
Common Stock, authorized	500,000,000	500,000,000
Common Stock, Shares, Issued	28,593,410	27,196,537
Preferred stock, shares designated	825,000	825,000
Preferred stock, issued	10,000	10,000
Preferred stock, Series B convertible redeemable preferred stock liquidation value, share of common stock	1	1
Preferred stock, par value	$ 0.01	$ 0.01

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Shareholders' Equity

3 Months Ended

Mar. 31, 2014

Shareholders’ Equity [Abstract]

Stockholders' Equity Note Disclosure [Text Block]

Shareholders' Equity

Reverse Stock Split

On June 28, 2013, pursuant to prior shareholder authorization, the Company’s board of directors unanimously approved a 1-for-10 reverse stock split of the Company’s common stock, which the Company effected on July 16, 2013. All share and per share amounts of common stock, options and warrants in the accompanying financial statements have been restated for all periods to give retroactive effect to the reverse stock split. The shares of common stock retained a par value of $0.001 per share. Accordingly, the stockholders’ deficit reflects the reverse stock split by reclassifying from “common stock” to “Additional paid-in capital” an amount equal to the par value of the decreased shares resulting from the reverse stock split.

Equity Issuances

In September 2011, the Company entered into a common stock purchase agreement (the “Initial Purchase Agreement”) with Aspire Capital Fund, LLC, an Illinois limited liability company (“Aspire Capital”), which provided that Aspire Capital was committed to purchase up to an aggregate of $20.0 million worth of shares of the Company’s common stock over the 24-month term. In August, 2012, the Initial Purchase Agreement was extended for an additional 24-month term through September 2015. During the three months endedMarch 31, 2014, the Company issued 0.8 million shares of Common Stock under the provisions the Initial Purchase Agreement with Aspire for gross proceeds of approximately $5.6 million. As of March 31, 2014, the full $20.0 million worth of shares of the Company's stock had been issued under the Initial Purchase Agreement.

In March 2014, the Company entered into a new common stock purchase agreement (the “Purchase Agreement”) with Aspire Capital, which provides that, subject to certain terms and conditions, Aspire Capital is committed to purchase up to an aggregate of $30.0 million worth of shares of the Company’s common stock over the 24-month term. At the Company’s discretion, it may present Aspire Capital with purchase notices from time to time to purchase the Company’s common stock, provided certain price and other requirements are met. The purchase price for the shares of stock was based upon one of two formulas set forth in the Purchase Agreement depending on the type of purchase notice the Company submits to Aspire Capital, and is based on market prices of the Company’s common stock (in the case of regular purchases) or a discount of 5% applied to volume weighted average prices (in the case of VWAP purchases), in each case as determined by parameters defined in the Purchase Agreement. As consideration for entering into the Purchase Agreement, we are obligated to issue 150,000 shares of our common stock to Aspire Capital (the “Commitment Shares”).

Option Exercises

During the three months ended ended March 31, 2014, option holders exercised an aggregate of 12,800 options at at exercise prices between of $5.20 and $6.20 per share for gross proceeds of approximately $0.1 million.

Warrant Exercises

During the three months ended ended March 31, 2014, warrant holders exercised an aggregate of 250,000 warrants at an exercise price of $5.10 per share for gross proceeds of approximately $1.3 million.

Stock Options and Warrants

The following table summarizes the activity for stock options and warrants for the three months endedMarch 31, 2014:

	Stock Options							Warrants
	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)		Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2013	2,932,191		$	11.19	6.8	$	1,658.1	4,898,266		$	16.50	2.6	$	1,811.0
Changes during the Period:
Granted	1,169,200		$	7.70				2,722		$	12.26
Exercised	(12,800	)	$	5.58				(250,000	)	$	5.10
Forfeited	(109,329	)	$	6.97				(100,108	)	$	70.00
Expired	(66,565	)	$	14.77				(59,852	)	$	57.76
Outstanding at March 31, 2014	3,912,697		$	10.22	7.4	$	1,896.7	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014 or expected to vest in the future	3,596,457		$	10.46	7.2	$	1,848.9	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014	2,520,755		$	11.50	6.5	$	1,600.9	4,473,306		$	15.42	2.3	$	1,661.5

During the three months endedMarch 31, 2014 and 2013, the Company issued warrants for services as follows ($ in thousands, except share data):

	Three Months Ended March 31,
	2014		2013
Number of Common Stock Purchase Warrants Issued	—		3,913
Value of Common Stock Purchase Warrants Issued	$	—	$	14.9

Restricted Stock

During the three months endedMarch 31, 2014 and 2013, the Company issued restricted stock for services as follows ($ in thousands, except share data):

	Three Months Ended March 31,
	2014		2013
Number of Restricted Stock Issued	329,698		177,492
Value of Restricted Stock Issued	$	2,511.7	$	1,127.9

The weighted average estimated fair value of restricted stock issued for services in the three months endedMarch 31, 2014 and 2013 was $7.62 and $6.35 per share, respectively. The fair value of the restricted stock was determined using the Company’s closing stock price on the date of issuance. The vesting terms of restricted stock issuances are generally within one year.

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Document and Entity Information Document (USD $)	3 Months Ended
	Mar. 31, 2014	May 08, 2014	Jun. 30, 2013
Document Information [Line Items]
Entity Registrant Name	NeoStem, Inc.
Entity Central Index Key	0000320017
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Document Type	10-Q
Document Period End Date	Mar. 31, 2014
Document Fiscal Year Focus	2014
Document Fiscal Period Focus	Q1
Amendment Flag	false
Entity Common Stock, Shares Outstanding		34,008,862
Entity Public Float			$ 92,300,000

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Share-Based Compensation (Notes)

3 Months Ended

Mar. 31, 2014

Share-based Compensation [Abstract]

Disclosure of Compensation Related Costs, Share-based Payments [Text Block]

Share-Based Compensation

Share-based Compensation

We utilize share-based compensation in the form of stock options, warrants and restricted stock.  The following table summarizes the components of share-based compensation expense for the three months endedMarch 31, 2014 and 2013 (in thousands):

	Three Months Ended March 31,
	2014		2013
Cost of goods sold	$	138.1	$	86.4
Research and development	476.8		217.4
Selling, general and administrative	3,278.7		1,914.7
Total share-based compensation expense	$	3,893.6	$	2,218.5

Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at March 31, 2014 were as follows (dollars in thousands):

	Stock Options		Warrants		Restricted Stock
Unrecognized compensation cost	$	6,490.0	$	46.2	$	208.2
Expected weighted-average period in years of compensation cost to be recognized	5.62		1.30		0.35

Total fair value of shares vested and the weighted average estimated fair values of shares granted for the three months endedMarch 31, 2014 and 2013 were as follows (dollars in thousands):

	Stock Options				Warrants
	Three Months Ended March 31,				Three Months Ended March 31,
	2014		2013		2014		2013
Total fair value of shares vested	$	1,927.4	$	1,305.0	$	8.7	$	43.8
Weighted average estimated fair value of shares granted	$	5.47	$	4.71	$	—	$	3.82

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Consolidated Statements of Operations (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Revenues	$ 4,055,575	$ 2,523,912
Cost of revenues	3,825,444	2,392,089
Research and development	4,759,083	3,161,326
Selling, general, and administrative	8,970,016	5,801,872
Total operating costs and expenses	17,554,543	11,355,287
Operating loss	(13,498,968)	(8,831,375)
Other income (expense):
Other income (expense), net	(189,551)	10,606
Interest expense	(94,156)	(43,560)
Nonoperating Income (Expense), Total	(283,707)	(32,954)
Loss before provision for income taxes and noncontrolling interests	(13,782,675)	(8,864,329)
Provision for income taxes	47,409	0
Net loss	(13,830,084)	(8,864,329)
Less - loss attributable to noncontrolling interests	(148,027)	(63,754)
Net Income (Loss) Available to Common Stockholders, Basic	(13,682,057)	(8,800,575)
Amounts Attributable to NeoStem, Inc. common stockholders:
Net Income (Loss) Available to Common Stockholders, Basic	$ (13,682,057)	$ (8,800,575)
NeoStem, Inc. common stockholders	$ (0.49)	$ (0.53)
Weighted average common shares outstanding	28,120,847	16,698,897

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Loss Per Share

3 Months Ended

Mar. 31, 2014

Loss Per Share [Abstract]

Loss Per Share [Text Block]

Loss Per Share

For the three months endedMarch 31, 2014 and 2013, the Company incurred net losses and therefore no common stock equivalents were utilized in the calculation of loss per share. At March 31, 2014 and 2013, the Company excluded the following potentially dilutive securities:

	March 31,
	2014	2013
Stock Options	3,912,697	2,631,181
Warrants	4,491,028	5,501,055
Restricted Shares	175,731	35,500

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Inventories

3 Months Ended

Mar. 31, 2014

Inventories [Abstract]

Inventory Disclosure [Text Block]

Inventories

Inventories, representing work in process for costs incurred on projects at PCT that have not been completed, were $1.5 million and $1.3 million as of March 31, 2014 and December 31, 2013, respectively. The Company also has deferred revenue of approximately $1.6 million and $1.5 million of advance billings received as of March 31, 2014 and December 31, 2013, respectively, related to these contracts.

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Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2014

Summary of Significant Accounting Policies [Abstract]

Receivables, Policy [Policy Text Block]

Accounts Receivable

Accounts receivable are carried at original invoice amount less an estimate made for doubtful accounts. The Company applies judgment in connection with establishing the allowance for doubtful accounts. Specifically, the Company analyzes the aging of accounts receivable balances, historical bad debts, customer concentration and credit-worthiness, current economic trends and changes in the Company’s customer payment terms. Significant changes in customer concentrations or payment terms, deterioration of customer credit-worthiness or weakening economic trends could have a significant impact on the collectability of the receivables and the Company’s operating results. If the financial condition of the Company’s customers were to deteriorate, resulting in an impairment of their ability to make payments, additional allowances may be required. Management regularly reviews the aging of receivables and changes in payment trends by its customers, and records a reserve when it believes collection of amounts due are at risk.

Goodwill and Intangible Assets, Policy [Policy Text Block]

Goodwill and Other Intangible Assets

Revenue Recognition, Policy [Policy Text Block]

Revenue Recognition

Clinical Services: The Company recognizes revenue for its (i) process development and (ii) clinical manufacturing services based on the terms of individual contracts.

Revenues associated with process development services generally contain multiple stages that do not have stand-alone values and are dependent upon one another, and are recognized as revenue on a completed contract basis. We recognize revenues when all of the following conditions are met:

• persuasive evidence of an arrangement exists;

• delivery has occurred or the services have been rendered;

• the fee is fixed or determinable; and

• collectability is probable.

The Company considers signed contracts as evidence of an arrangement. The Company assesses whether the fee is fixed or determinable based on the payment terms associated with the transaction and whether the payment terms are subject to refund or adjustment. The Company assesses cash collectability based on a number of factors, including past collection history with the client and the client's creditworthiness. If the Company determines that collectability is not reasonably assured, it defers revenue recognition until collectability becomes reasonably assured, which is generally upon receipt of the cash. The Company's arrangements are generally non-cancellable, though clients typically have the right to terminate their agreement for cause if the Company materially fails to perform.

Clinical manufacturing services are generally distinct arrangements whereby the Company is paid for time and materials or for fixed monthly amounts. Revenue is recognized when efforts are expended or contractual terms have been met.

Some client agreements include multiple elements, comprised of process development and clinical manufacturing services. The Company believes that process development and clinical manufacturing services each have stand-alone value because these services can be provided separately by other companies. In accordance with ASC Update No. 2009-13, “Revenue Recognition (Topic 605): Multiple-Deliverable Revenue Arrangements,” the Company (1) separates deliverables into separate units of accounting when deliverables are sold in a bundled arrangement and (2) allocates the arrangement's consideration to each unit in the arrangement based on its relative selling price. 

Clinical Services Reimbursements: The Company separately charges the customers for the expenses associated with certain consumable resources (reimbursable expenses) that are specified in each clinical services contract. On a monthly basis, the Company bills customers for reimbursable expenses and immediately recognizes these billings as revenue, as the revenue is deemed earned as reimbursable expenses are incurred. For the three months endedMarch 31, 2014 and 2013, clinical services reimbursements were $0.7 million and $0.4 million, respectively.

Processing and Storage Services: The Company recognizes revenue related to the collection and cryopreservation of cord blood and autologous adult stem cells when the cryopreservation process is completed which is approximately twenty-four hours after cells have been collected. Revenue related to advance payments of storage fees is recognized ratably over the period covered by the advance payments.

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Income Taxes

3 Months Ended

Mar. 31, 2014

Income Taxes [Abstract]

Stockholders' Equity Note Disclosure [Text Block]

Shareholders' Equity

Reverse Stock Split

On June 28, 2013, pursuant to prior shareholder authorization, the Company’s board of directors unanimously approved a 1-for-10 reverse stock split of the Company’s common stock, which the Company effected on July 16, 2013. All share and per share amounts of common stock, options and warrants in the accompanying financial statements have been restated for all periods to give retroactive effect to the reverse stock split. The shares of common stock retained a par value of $0.001 per share. Accordingly, the stockholders’ deficit reflects the reverse stock split by reclassifying from “common stock” to “Additional paid-in capital” an amount equal to the par value of the decreased shares resulting from the reverse stock split.

Equity Issuances

In September 2011, the Company entered into a common stock purchase agreement (the “Initial Purchase Agreement”) with Aspire Capital Fund, LLC, an Illinois limited liability company (“Aspire Capital”), which provided that Aspire Capital was committed to purchase up to an aggregate of $20.0 million worth of shares of the Company’s common stock over the 24-month term. In August, 2012, the Initial Purchase Agreement was extended for an additional 24-month term through September 2015. During the three months endedMarch 31, 2014, the Company issued 0.8 million shares of Common Stock under the provisions the Initial Purchase Agreement with Aspire for gross proceeds of approximately $5.6 million. As of March 31, 2014, the full $20.0 million worth of shares of the Company's stock had been issued under the Initial Purchase Agreement.

In March 2014, the Company entered into a new common stock purchase agreement (the “Purchase Agreement”) with Aspire Capital, which provides that, subject to certain terms and conditions, Aspire Capital is committed to purchase up to an aggregate of $30.0 million worth of shares of the Company’s common stock over the 24-month term. At the Company’s discretion, it may present Aspire Capital with purchase notices from time to time to purchase the Company’s common stock, provided certain price and other requirements are met. The purchase price for the shares of stock was based upon one of two formulas set forth in the Purchase Agreement depending on the type of purchase notice the Company submits to Aspire Capital, and is based on market prices of the Company’s common stock (in the case of regular purchases) or a discount of 5% applied to volume weighted average prices (in the case of VWAP purchases), in each case as determined by parameters defined in the Purchase Agreement. As consideration for entering into the Purchase Agreement, we are obligated to issue 150,000 shares of our common stock to Aspire Capital (the “Commitment Shares”).

Option Exercises

During the three months ended ended March 31, 2014, option holders exercised an aggregate of 12,800 options at at exercise prices between of $5.20 and $6.20 per share for gross proceeds of approximately $0.1 million.

Warrant Exercises

During the three months ended ended March 31, 2014, warrant holders exercised an aggregate of 250,000 warrants at an exercise price of $5.10 per share for gross proceeds of approximately $1.3 million.

Stock Options and Warrants

The following table summarizes the activity for stock options and warrants for the three months endedMarch 31, 2014:

	Stock Options							Warrants
	Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)		Shares		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)	Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2013	2,932,191		$	11.19	6.8	$	1,658.1	4,898,266		$	16.50	2.6	$	1,811.0
Changes during the Period:
Granted	1,169,200		$	7.70				2,722		$	12.26
Exercised	(12,800	)	$	5.58				(250,000	)	$	5.10
Forfeited	(109,329	)	$	6.97				(100,108	)	$	70.00
Expired	(66,565	)	$	14.77				(59,852	)	$	57.76
Outstanding at March 31, 2014	3,912,697		$	10.22	7.4	$	1,896.7	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014 or expected to vest in the future	3,596,457		$	10.46	7.2	$	1,848.9	4,491,028		$	15.39	2.4	$	1,661.5
Vested at March 31, 2014	2,520,755		$	11.50	6.5	$	1,600.9	4,473,306		$	15.42	2.3	$	1,661.5

During the three months endedMarch 31, 2014 and 2013, the Company issued warrants for services as follows ($ in thousands, except share data):

	Three Months Ended March 31,
	2014		2013
Number of Common Stock Purchase Warrants Issued	—		3,913
Value of Common Stock Purchase Warrants Issued	$	—	$	14.9

Restricted Stock

During the three months endedMarch 31, 2014 and 2013, the Company issued restricted stock for services as follows ($ in thousands, except share data):

	Three Months Ended March 31,
	2014		2013
Number of Restricted Stock Issued	329,698		177,492
Value of Restricted Stock Issued	$	2,511.7	$	1,127.9

The weighted average estimated fair value of restricted stock issued for services in the three months endedMarch 31, 2014 and 2013 was $7.62 and $6.35 per share, respectively. The fair value of the restricted stock was determined using the Company’s closing stock price on the date of issuance. The vesting terms of restricted stock issuances are generally within one year.

Income Tax Disclosure [Text Block]

Income Taxes

As of December 31, 2013, the Company had approximately $110.6 million of Federal NOLs available to offset future taxable income expiring from 2025 through 2033. In accordance with Section 382 of the Internal Revenue code, the usage of the Company’s NOLs could be limited in the event of a change in ownership. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the period when those temporary differences become deductible.  If a change of ownership did occur there would be an annual limitation on the usage of the Company’s losses which are available through 2033.

In assessing the realizability of deferred tax assets, including the net operating loss carryforwards ("NOLs"), the Company assesses the available positive and negative evidence to estimate if sufficient future taxable income will be generated to utilize its existing deferred tax assets.  Based on its assessment, the Company has provided a full valuation allowance against its net deferred tax assets as their future utilization remains uncertain at this time.

Deferred tax liabilities were $4.4 million and $4.4 million as of March 31, 2014 and December 31, 2013, and relate to the taxable temporary differences on the goodwill recognized in the PCT acquisition in 2011, and the in-process R&D intangible asset recognized in the Amorcyte acquisition in 2011. The taxable temporary difference associated with the goodwill, which is tax deductible and will be amortized over 15 years, will continue to increase the deferred tax liability balance over the amortization period, with an associated charge to the tax provision in each period. The deferred tax liabilities will only reverse when these indefinite-lived assets are sold, impaired, or reclassified from an indefinite-lived asset to a finite-lived asset.

As of March 31, 2014, management does not believe the Company has any material uncertain tax positions that would require it to measure and reflect the potential lack of sustainability of a position on audit in its financial statements. The Company will continue to evaluate its uncertain tax positions in future periods to determine if measurement and recognition in its financial statements is necessary. The Company does not believe there will be any material changes in its unrecognized tax positions over the next year.

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Accrued Liabilities

3 Months Ended

Mar. 31, 2014

Accrued Liabilities [Abstract]

Accounts Payable and Accrued Liabilities Disclosure [Text Block]

Accrued Liabilities

Accrued liabilities as of March 31, 2014 and December 31, 2013 were as follows (in thousands):

	March 31, 2014		December 31, 2013
Salaries, employee benefits and related taxes	$	846.4	$	2,325.8
Professional fees	775.4		544.8
License Fees	200.0		500.0
Other	559.8		647.4
	$	2,381.6	$	4,018.0

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Fair Value Measurements

3 Months Ended

Mar. 31, 2014

Fair Value Measurements [Abstract]

Fair Value Disclosures [Text Block]

Fair Value Measurements

Fair value of financial assets and liabilities that are being measured and reported are defined as the exchange price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants in the principal market at the measurement date (exit price). The Company is required to classify fair value measurements in one of the following categories:

Level 1 inputs are defined as quoted prices (unadjusted) in active markets for identical assets or liabilities that the reporting entity has the ability to access at the measurement date.

Level 2 inputs are defined as inputs other than quoted prices included within Level 1 that are observable for the assets or liabilities, either directly or indirectly.

Level 3 inputs are defined as unobservable inputs for the assets or liabilities. Financial assets and liabilities are classified based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement requires judgment, and may affect the valuation of the fair value of assets and liabilities and their placement within the fair value hierarchy levels.

The Company determined the fair value of the warrant derivative liabilities to be level 3 inputs. These inputs require material subjectivity because value is derived through the use of a lattice model that values the derivatives based on probability weighted discounted cash flows.

Contingent consideration was recognized on October 17, 2011 in connection with the Company's acquisition of Amorcyte. The contingent consideration obligations relates to earn out payments equal to 10% of the net sales of Amorcyte’s lead product candidate AMR-001 (in the event of and following the date of first commercial sale of AMR-001), provided that in the event NeoStem sublicenses AMR-001, the applicable earn out payment will be equal to 30% of any sublicensing fees, and provided further that NeoStem will be entitled to recover direct out-of-pocket clinical development costs not previously paid or reimbursed and any costs, expenses, liabilities and settlement amounts arising out of claims of patent infringement or otherwise challenging Amorcyte’s right to use intellectual property, by reducing any earn out payments due by 50% until such costs have been recouped in full (the “Earn Out Payments”).

The fair value of contingent consideration obligations is determined using Level 3 inputs, and is based on a discounted cash flow model using a probability-weighted income approach. The measurement is based upon unobservable inputs supported by little or no market activity based on our own assumptions and experience. We base the timing to complete the development and approval of this product on the current development stage of the product and the inherent difficulties and uncertainties in developing a product candidate, such as obtaining U.S. Food and Drug Administration (FDA) and other regulatory approvals. In determining the probability of regulatory approval and commercial success, we utilize data regarding similar milestone events from several sources, including industry studies and our own experience. These fair value measurements represent Level 3 measurements as they are based on significant inputs not observable in the market. Significant judgment is employed in determining the appropriateness of these assumptions as of the acquisition date and for each subsequent period. Accordingly, changes in assumptions could have a material impact on the amount of contingent consideration expense we record in any given period. Changes in the fair value of the contingent consideration obligations are recorded in our consolidated statement of operations. The contingent consideration fair value increased from $9.5 million as of December 31, 2013 to $9.6 million as of March 31, 2014. The change in estimated fair value is based the impact of the time progression through the Phase 2 clinical trial from December 31, 2013 to March 31, 2014.

The following table sets forth by level within the fair value hierarchy the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of March 31, 2014, and December 31, 2013 (in thousands):

	March 31, 2014
	Fair Value Measurements Using Fair Value Hierarchy
	Level 1		Level 2		Level 3
Warrant derivative liabilities	$	—	$	—	$	23.2
Acquisition-related contingent consideration	—		—		9,640.0

	December 31, 2013
	Fair Value Measurements Using Fair Value Hierarchy
	Level 1		Level 2		Level 3
Warrant derivative liabilities	$	—	$	—	$	23.2
Acquisition-related contingent consideration	—		—		9,450.0

For those financial instruments with significant Level 3 inputs, the following table summarizes the activity for the three months endedMarch 31, 2014 by type of instrument (in thousands):

	Three Months Ended
	March 31, 2014
	Warrants		Acquisition-Related Contingent Consideration
Beginning liability balance	$	23.2	$	9,450.0
Change in fair value recorded in earnings	—		190.0
Ending liability balance	$	23.2	$	9,640.0

Some of the Company’s financial instruments are not measured at fair value on a recurring basis, but are recorded at amounts that approximate fair value due to their liquid or short-term nature, such as cash and cash equivalents, accounts receivable, accounts payable. Our long-term debt and notes payable are carried at cost and approximate fair value due to their variable or fixed interest rates, which are consistent with the interest rates in the market.

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Goodwill and Other Intangible Assets

3 Months Ended

Mar. 31, 2014

Goodwill and Other Intangible Assets [Abstract]

Goodwill and Intangible Assets [Text Block]

Goodwill and Other Intangible Assets

The Company's goodwill was $11.1 million as of March 31, 2014 and December 31, 2013.

The Company's intangible assets and related accumulated amortization as of March 31, 2014 and December 31, 2013 consisted of the following (in thousands):

		March 31, 2014							December 31, 2013
	Useful Life	Gross		Accumulated Amortization			Net		Gross		Accumulated Amortization			Net
Customer list	10 years	$	1,000.0	$	(320.1	)	$	679.9	$	1,000.0	$	(295.1	)	$	704.9
Manufacturing technology	10 years	3,900.0		(1,248.4		)	2,651.6		3,900.0		(1,150.9		)	2,749.1
Tradename	10 years	800.0		(256.1		)	543.9		800.0		(236.1		)	563.9
In process R&D	Indefinite	9,400.0		—			9,400.0		9,400.0		—			9,400.0
VSEL patent rights	19 years	669.0		(220.1		)	448.9		669.0		(211.3		)	457.7
Total Intangible Assets		$	15,769.0	$	(2,044.7	)	$	13,724.3	$	15,769.0	$	(1,893.4	)	$	13,875.6

Total intangible amortization expense was classified in the operating expense categories for the periods included below as follows (in thousands):

	Three Months Ended March 31,
	2014		2013
Cost of revenue	$	79.2	$	97.5
Research and development	27.1		8.8
Selling, general and administrative	45.0		45.0
Total	$	151.3	$	151.3

Estimated intangible amortization expense on an annual basis for the succeeding five years is as follow (in thousands):

2014	$	453.9
2015	605.2
2016	605.2
2017	605.2
2018	605.2
Thereafter	10,849.6
	$	13,724.3

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Debt

3 Months Ended

Mar. 31, 2014

Debt [Abstract]

Debt Disclosure [Text Block]

Debt

Notes Payable

As of March 31, 2014 and December 31, 2013, the Company had notes payable of approximately $1.7 million and $0.9 million, respectively. The notes relate to certain insurance policies and equipment financings, require monthly payments, and mature within one to three years.

Mortgages Payable

In October 2007, PCT issued a note to borrow $3.1 million (the “First Mortgage”) in connection with its $3.8 million purchase of condominium units in an existing building in Allendale, New Jersey (the “Property”) that PCT uses as a laboratory and stem cell processing facility. The First Mortgage is payable in 239 consecutive monthly payments of principal and interest, based on a 20 year amortization schedule; and one final payment of all outstanding principal plus accrued interest then due. The current monthly installment is $20,766, which includes interest at an initial rate of 5.00%; the interest rate and monthly installments payments are subject to adjustment on October 1, 2017. On that date, upon prior written notice, the lender has the option to declare the entire outstanding principal balance, together with all outstanding interest, due and payable in full. The First Mortgage is secured by substantially all of the assets of PCT, including a first mortgage on the Property and assignment of an amount approximately equal to eighteen months debt service held in escrow. The Note matures on October 1, 2027 if not called by the lender on October 1, 2017. The First Mortgage had previously been subject to certain debt service coverage and total debt to tangible net worth financial covenant ratios measured semi-annually. The outstanding balance was approximately $2.4 million and 2.5 million at March 31, 2014 and December 31, 2013, respectively, of which $128,300 is payable within twelve months as of March 31, 2014.

In December 2010 PCT Allendale, a wholly-owned subsidiary of PCT, entered into a note for a second mortgage in the amount of $1 million (the "Second Mortgage") on the Allendale Property with TD Bank, N.A. The initial guarantors of the Second Mortgage were PCT, DomaniCell (a wholly-owned subsidiary of PCT, now known as NeoStem Family Storage, LLC), Regional Cancer Care Associates LLC and certain of its partners. The Second Mortgage had been subject to an annual financial covenant starting December 31, 2011. The Second Mortgage is for 124 months at a fixed rate of 6% for the first 64 months. The loan is callable for a certain period prior to the interest reset date. The outstanding balance was approximately $0.7 million and $0.8 million at March 31, 2014 and December 31, 2013, respectively, of which $87,700 is payable within twelve months as of March 31, 2014.

In December 2013, the Company modified both the First Mortgage and Second Mortgage with TD Bank, N.A., whereby (i) prior debt service coverage and total debt to tangible net worth financial covenant ratios were replaced with a minimum unencumbered liquidity covenant, and (ii) prior guarantors were released (see Note 13) and replaced with NeoStem, PCT, and NeoStem Family Storage. The Company is in compliance with the new minimum unencumbered liquidity covenant.

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Summary of Significant Accounting Policies (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Summary of Significant Accounting Policies [Abstract]
Clinical Services Reimbursement	$ 0.7	$ 0.4

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Income Taxes Net Operating Loss Carry Forward (Details) (USD $)	Mar. 31, 2014	Dec. 31, 2013
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards		$ 110,600,000
Deferred Tax Liabilities, Net, Noncurrent	$ 4,426,635	$ 4,379,226

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Commitments and Contingencies

3 Months Ended

Mar. 31, 2014

Commitments and Contingencies [Abstract]

Commitments and Contingencies [Text Block]

Commitments and Contingencies

Lease Commitments

The Company leases offices, of which certain have escalation clauses and renewal options, and also leases equipment under certain noncancelable operating leases that expire from time to time through 2018. In January 2014, the Company signed a new lease for additional space at its current executive offices at 420 Lexington Avenue, New York, NY 10170. The new lease is believed to provide sufficient space for the near future and shall extend through 2018. This property is used as the Company's corporate headquarters.

A summary of future minimum rental payments required under operating leases that have initial or remaining terms in excess of one year as of March 31, 2014 are as follows (in thousands):  

Years ended	Operating Leases
2014	$	763.0
2015	840.4
2016	682.3
2017	386.9
2018	5.9
Total minimum lease payments	$	2,678.5

Expense incurred under operating leases was approximately $0.2 million and $0.3 million for the three months endedMarch 31, 2014 and 2013, respectively.

Contingencies

Under license agreements with third parties the Company is typically required to pay maintenance fees, make milestone payments and/or pay other fees and expenses and pay royalties upon commercialization of products. The Company also sponsors research at various academic institutions, which research agreements generally provide us with an option to license new technology discovered during the course of the sponsored research.

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Fair Value Measurements (Tables)

3 Months Ended

Mar. 31, 2014

Fair Value Measurements [Abstract]

Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]

For those financial instruments with significant Level 3 inputs, the following table summarizes the activity for the three months endedMarch 31, 2014 by type of instrument (in thousands):

	Three Months Ended
	March 31, 2014
	Warrants		Acquisition-Related Contingent Consideration
Beginning liability balance	$	23.2	$	9,450.0
Change in fair value recorded in earnings	—		190.0
Ending liability balance	$	23.2	$	9,640.0

Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis, Valuation Techniques [Table Text Block]

The following table sets forth by level within the fair value hierarchy the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of March 31, 2014, and December 31, 2013 (in thousands):

	March 31, 2014
	Fair Value Measurements Using Fair Value Hierarchy
	Level 1		Level 2		Level 3
Warrant derivative liabilities	$	—	$	—	$	23.2
Acquisition-related contingent consideration	—		—		9,640.0

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Shareholders' Equity Restricted Stock (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Stock Issued During Period, Shares, Restricted Stock Award, Gross	329,698	177,492
Stock Issued During Period, Value, Restricted Stock Award, Gross	$ 2,511,700	$ 1,127,900
weighted average estimated fair value of restricted stock	$ 7.62	$ 6.35

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Goodwill and Other Intangible Assets Intangible Amortization Expense (Details) (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	$ 151,300	$ 151,300
Cost of revenue
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	79,200	97,500
Research and development
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	27,100	8,800
Selling, general and administrative
Finite-Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	$ 45,000	$ 45,000

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Consolidated Statements of Comprehensive Loss (USD $)	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Net loss	$ (13,830,084)	$ (8,864,329)
Total other comprehensive (loss) income	0	0
Comprehensive loss	(13,830,084)	(8,864,329)
Comprehensive loss attributable to noncontrolling interests	(148,027)	(63,754)
Comprehensive net loss attributable to NeoStem, Inc. common stockholders	$ (13,682,057)	$ (8,800,575)

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Cash and Cash Equivalents

3 Months Ended

Mar. 31, 2014

Cash and Cash Equivalents [Abstract]

Cash and Cash Equivalents [Text Block]

Cash and Cash Equivalents

As of March 31, 2014 and December 31, 2013, the Company had cash and cash equivalents of approximately $41.4 million and $46.1 million, respectively, including bank deposits of approximately $0.7 million and $0.8 million, respectively, covered by the Federal Deposit Insurance Corporation.

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Goodwill and Other Intangible Assets (Tables)

3 Months Ended

Mar. 31, 2014

Goodwill and Other Intangible Assets [Abstract]

Schedule of Finite-Lived Intangible Assets by Major Class [Table Text Block]

The Company's intangible assets and related accumulated amortization as of March 31, 2014 and December 31, 2013 consisted of the following (in thousands):

		March 31, 2014							December 31, 2013
	Useful Life	Gross		Accumulated Amortization			Net		Gross		Accumulated Amortization			Net
Customer list	10 years	$	1,000.0	$	(320.1	)	$	679.9	$	1,000.0	$	(295.1	)	$	704.9
Manufacturing technology	10 years	3,900.0		(1,248.4		)	2,651.6		3,900.0		(1,150.9		)	2,749.1
Tradename	10 years	800.0		(256.1		)	543.9		800.0		(236.1		)	563.9
In process R&D	Indefinite	9,400.0		—			9,400.0		9,400.0		—			9,400.0
VSEL patent rights	19 years	669.0		(220.1		)	448.9		669.0		(211.3		)	457.7
Total Intangible Assets		$	15,769.0	$	(2,044.7	)	$	13,724.3	$	15,769.0	$	(1,893.4	)	$	13,875.6

Schedule of Amortization Expense [Table Text Block]

Total intangible amortization expense was classified in the operating expense categories for the periods included below as follows (in thousands):

	Three Months Ended March 31,
	2014		2013
Cost of revenue	$	79.2	$	97.5
Research and development	27.1		8.8
Selling, general and administrative	45.0		45.0
Total	$	151.3	$	151.3

Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]

Estimated intangible amortization expense on an annual basis for the succeeding five years is as follow (in thousands):

2014	$	453.9
2015	605.2
2016	605.2
2017	605.2
2018	605.2
Thereafter	10,849.6
	$	13,724.3

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Fair Value Measurements Fair value hierarchy the Company’s financial assets and liabilities (Details) (USD $)	Mar. 31, 2014	Dec. 31, 2013
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability	$ 9,640,000	$ 9,450,000
Fair Value, Inputs, Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant Derivative Liabilities	0	0
Contingent Consideration Classified As Equity Fair Value Disclosure	0	0
Fair Value, Inputs, Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant Derivative Liabilities	0	0
Contingent Consideration Classified As Equity Fair Value Disclosure	0	0
Fair Value, Inputs, Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant Derivative Liabilities	23,200	23,200
Contingent Consideration Classified As Equity Fair Value Disclosure	$ 9,640,000	$ 9,450,000

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Related Party Transactions

3 Months Ended

Mar. 31, 2014

Related Party Transactions [Abstract]

Related Party Transactions [Text Block]

Related Party Transactions

In December 2013, the Company modified both the First Mortgage and Second Mortgage with TD Bank, N.A. (see Note 9). Pursuant to the Loan Modifications, Andrew L. Pecora, M.D., Regional Cancer Care Associates LLC (Dr. Pecora’s medical practice), and certain partners in such practice, have been released as guarantors of the Second Mortgage Loan, and NeoStem has become a guarantor of the Loans pursuant to a Guaranty of Payment delivered by NeoStem to the Lender. Dr. Pecora, currently serves as a NeoStem director, NeoStem’s Chief Visionary Officer, PCT’s Chief Medical Officer and Amorcyte’s Chief Scientific Officer.