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Shareholders' Equity (Tables)
12 Months Ended
Dec. 31, 2012
Shareholders’ Equity [Abstract]  
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
The number of remaining shares authorized to be issued under the various equity plans are as follows:
 
 
 2003 Equity Plan
 
 2009 Equity Plan
Shares Authorized for Issuance
 
2,500,000

 
33,950,000

Outstanding Stock Options
 
(1,390,300
)
 
(20,296,380
)
Exercised Stock Options
 
(92,500
)
 
(5,000
)
Restricted stock or equity grants issued under Equity Plans
 
(889,939
)
 
(4,606,482
)
Total common shares remaining to be issued under the Equity Plans
 
127,261

 
9,042,138

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
The following table summarizes the activity for stock options and warrants for the year ended December 31, 2012:
 
Stock Options
 
Warrants
 
Shares
 
Weighted Average Exercise Price
 
Shares
 
Weighted Average Exercise Price
Outstanding at December 31, 2010
13,032,214

 
$1.66
 
21,843,507

 
$2.62
 
 
 
 
 
 
 
 
Changes during the Year:
 
 
 
 
 
 
 
Granted
8,697,600

 
$1.50
 
15,993,947

 
$2.09
Exercised
(5,000
)
 
$1.42
 

 
Forfeited
(1,217,189
)
 
$1.96
 
(447,629
)
 
$6.18
Expired
(3,364,120
)
 
$1.82
 

 
Outstanding at December 31, 2011
17,143,505

 
$1.71
 
37,389,825

 
$2.35
 
 
 
 
 
 
 
 
Changes during the Year:
 
 
 
 
 
 
 
Granted
7,787,529

 
$0.50
 
31,082,615

 
$0.57
Exercised

 
 
(11,076,182
)
 
$0.60
Forfeited
(3,020,209
)
 
$1.66
 
(790,003
)
 
$2.17
Expired
(224,145
)
 
$1.88
 
(1,318,644
)
 
$4.60
Outstanding at December 31, 2012
21,686,680

 
$1.29
 
55,287,611

 
$1.57
 
 
 
 
 
 
 
 
The following table summarizes the components of share-based compensation expense for the years ended December 31, 2012 and 2011 (in thousands):
 
Year Ended December 31,
 
2012
 
2011
Cost of goods sold
$
195.0

 
$
96.9

Research and development
432.9

 
867.8

Selling, general and administrative
6,084.6

 
9,301.3

Total share-based compensation expense
$
6,712.5

 
$
10,266.0

 
 
 
 
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
During the years ended December 31, 2012 and 2011, the Company issued warrants for services as follows ($ in thousands, except share data):
 
 
Year Ended December 31,
  
 
2012
 
2011
Number of Common Stock Purchase Warrants Issued
 
419,690

 
670,000

Value of Common Stock Purchase Warrants Issued
 
$
172.2

 
$
495.1

Restricted Stock [Table Text Block]
During the years ended December 31, 2012 and 2011, the Company issued restricted stock for services as follows ($ in thousands, except share data):

 
 
Year Ended December 31,
  
 
2012
 
2011
Number of Restricted Stock Issued
 
2,295,533

 
3,467,451

Value of Restricted Stock Issued
 
$
1,325.1

 
$
3,580.6