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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001254316-05-000151.txt : 20051123
<SEC-HEADER>0001254316-05-000151.hdr.sgml : 20051123
<ACCEPTANCE-DATETIME>20051123192210
ACCESSION NUMBER:		0001254316-05-000151
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20051122
FILED AS OF DATE:		20051123
DATE AS OF CHANGE:		20051123

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DESMOND HELLMANN SUSAN D
		CENTRAL INDEX KEY:			0001214218

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-09813
		FILM NUMBER:		051226244

	MAIL ADDRESS:	
		STREET 1:		C/O GENENTECH INC
		STREET 2:		1 DNA WAY MS 49
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080-4990

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENENTECH INC
		CENTRAL INDEX KEY:			0000318771
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				942347624
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1 DNA WAY
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650-225-1000

	MAIL ADDRESS:	
		STREET 1:		1 DNA WAY
		STREET 2:		.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
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    <schemaVersion>X0202</schemaVersion>

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    <periodOfReport>2005-11-22</periodOfReport>

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        <issuerName>GENENTECH INC</issuerName>
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            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94080</rptOwnerZipCode>
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            <isOfficer>1</isOfficer>
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            <officerTitle>PRESIDENT,</officerTitle>
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            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>100</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2002-09-12</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2012-09-12</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>225000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This stock option vests over four years, with the first 25% of the shares vesting one year from the grant date and 75% of the shares vesting in equal monthly increments over the following three years.  This option may be immediately exercisable with the consent of Genentech.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Susan D. Desmond-Hellmann</signatureName>
        <signatureDate>2005-11-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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