8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C.  20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

                                                                           Date of Report (Date of earliest event reported): November 22, 2010 (November 18, 2010)

PEOPLES BANCORP INC.

(Exact name of Registrant as specified in its charter)

Ohio	0-16772	31-0987416
(State or other jurisdiction	(Commission File	(I.R.S. Employer
of incorporation)	Number)	Identification Number)

138 Putnam Street, PO Box 738
Marietta, Ohio	45750-0738
(Address of principal executive offices)	(Zip Code)

Registrant's telephone number, including area code: (740) 373-3155

Not applicable

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

  o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

  o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

  o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

  o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Index to Exhibits on Page 2

Item 5.02 – Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

(a)   Not applicable

(b)On November 18, 2010, Peoples Bancorp Inc. (“Peoples”) received a letter, dated November 18, 2010, from Joseph H. Wesel notifying Peoples that Mr. Wesel was retiring from the Boards of Directors of Peoples and Peoples Bank, National Association effective as of November 18, 2010.  Mr. Wesel, who has been a member of the Peoples Board of Directors since 1980, and the Board of Directors of its subsidiary, Peoples Bank, National Association, since 1974, cited his health as the basis for his decision. Mr. Wesel served in the class of directors whose terms will expire in 2011. A copy of Mr. Wesel’s letter is included as Exhibit 17 to this Current Report on Form 8-K.

(c)   through (f)    Not applicable.

Item 9.01 – Financial Statements and Exhibits

(a)   through (c) Not applicable

(d) Exhibits:

The following exhibit is being included with this Current Report on Form 8-K:

Exhibit No:   17   Description   Letter, dated November 18, 2010 and received by Peoples Bancorp Inc. on November 18, 2010, from Joseph H. Wesel as notice of retirement from Boards of Directors of Peoples Bancorp Inc. and Peoples Bank, National Association effective November 18, 2010.

[Remainder of page intentionally left blank; signature on following page.]

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

		PEOPLES BANCORP INC.
Date: November 22, 2010	By: /s/	DAVID L. MEAD
		David L. Mead
		President and Chief Executive Officer

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EX-17

EXHIBIT 17

 520 Fifth Street

        Marietta, OH 45750

       November 18, 2010

Mr. David L. Mead

President and Chief Executive Officer

Peoples Bancorp, Inc.

138 Putnam Street

Marietta, OH 45750

Dear Mr. Mead,

After long and heartfelt consideration, I have decided to retire from the Boards of Peoples Bank and Peoples Bancorp, Inc. I had hoped to serve for the remainder of my term, but most unfortunately, my health is preventing me from doing so.

I have enjoyed serving Peoples Bank for over 35 years, participating in the bank's growth from a small-town to a regional bank and I will sincerely miss being a part of future growth and success.

My decision to resign is based on the fact my physical health has simply deteriorated to the point that I can no longer effectively serve.

My resignation is effective immediately after today's meeting. Thank you.

 Sincerely,

 /s/ JOSEPH H. WESEL

Joseph H. Wesel