Exhibit 12.1

AMGEN INC.

COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES

(Dollars in millions)

	Nine Months Ended September 30,			Year Ended December 31,
	2016			2015			2014			2013			2012			2011
Computation of Earnings:
Income before taxes	$	6,880		$	7,978		$	5,585		$	5,265		$	5,009		$	4,150
Net interest expense		932			1,095			1,071			1,022			1,053			610
Interest portion of operating lease expense		33			45			47			47			45			49
Equity in (earnings) losses of 50%-or-less owned companies accounted for under the equity method		(54	)		(65	)		(30	)		6			24			(47	)
Earnings	$	7,791		$	9,053		$	6,673		$	6,340		$	6,131		$	4,762
Computation of Fixed Charges:
Net interest expense	$	932		$	1,095		$	1,071		$	1,022		$	1,053		$	610
Capitalized interest		11			12			18			18			26			22
Interest portion of operating lease expense		33			45			47			47			45			49
Fixed Charges	$	976		$	1,152		$	1,136		$	1,087		$	1,124		$	681
Ratio of Earnings to Fixed Charges:		8.0	x		7.9	x		5.9	x		5.8	x		5.5	x		7.0	x

These computations include Amgen and its consolidated subsidiaries. For these ratios, “earnings” is computed by adding income before income taxes and fixed charges (excluding capitalized interest), excluding our share of income/losses in equity method affiliates and including distributions from our affiliate, Kirin-Amgen, Inc. Fixed charges consist of (i) interest expense, which includes amortized premiums, discounts and capitalized expenses related to indebtedness, (ii) capitalized interest, (iii) a reasonable approximation of the interest factor deemed to be included in rental expense and (iv) preference security dividend requirements of consolidated subsidiaries, which were not material. Fixed charges exclude any interest related to unrecognized tax benefits, which is included in the provision for income taxes in our Consolidated Statements of Income.