8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 OR 15(d) of

The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported)

October 20, 2004

AMGEN INC.

(Exact name of registrant as specified in its charter)

Delaware	000-12477	95-3540776
(State or Other Jurisdiction of Incorporation)	(Commission File Number)	(IRS Employer Identification No.)

Amgen Inc. One Amgen Center Drive Thousand Oaks, CA	91320-1799
(Address of principal executive offices)	(Zip Code)

Registrant’s telephone number, including area code

805-447-1000

N/A

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

¨ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

¨ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

¨ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

¨ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 2.02. Results of Operations and Financial Condition

On October 20, 2004, Amgen Inc. (the “Company”) issued a press release announcing its results of operations and financial condition for the three and nine months ended September 30, 2004. The full text of the press release is set forth in Exhibit 99.1 attached hereto.

In its press release the Company included certain historical non-GAAP financial measures as defined in Regulation G promulgated by the Securities and Exchange Commission with respect to the three and nine months ended September 30, 2004 and September 30, 2003. The Company believes that its presentation of historical non-GAAP financial measures provides useful supplementary information to investors. These historical non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with U.S. Generally Accepted Accounting Principles (“GAAP”).

Three and nine months ended September 30, 2004

For the three and nine months ended September 30, 2004, the Company’s adjustments to GAAP financial measures relate to amounts associated with the Company’s acquisitions of Tularik, Inc. (“Tularik”) in August 2004 (the “Tularik Acquisition”) and Immunex Corporation (“Immunex”) in July 2002 (the “Immunex Acquisition”) and amounts associated with the Company’s share of the loss incurred relating to the settlement of a patent litigation between the Company and Genentech, Inc. (the “Genentech Settlement”).

For the three months ended September 30, 2004, the Company reported non-GAAP financial results for research and development (“R&D”) and selling, general and administrative (“SG&A”) expense. R&D and SG&A expense were each adjusted to exclude incremental compensation provided to certain Tularik employees for a limited period, principally related to non-cash compensation expense associated with stock options assumed in the acquisition and amounts payable primarily under the Tularik short-term retention plan for the applicable period. The Company believes that excluding such incremental compensation provides a supplemental measure that will facilitate comparisons between periods before, during and after such expenses are incurred. SG&A expense was further adjusted for this period to exclude the impact to the Company of its share of third party reimbursement received by Kirin Amgen, Inc. related to the Genentech Settlement. The Company believes that excluding the amounts related to the Genentech Settlement provides a supplemental measure that will facilitate comparisons between periods in which such items did not occur.

For the nine months ended September 30, 2004, the Company reported non-GAAP financial results for the following operating expenses: cost of sales, R&D and SG&A which were each adjusted to exclude incremental compensation payable to certain Immunex employees for a limited period, principally under the Immunex short-term retention plan for the applicable period. The Company believes that excluding such incremental compensation provides a supplemental measure that will facilitate comparisons between periods before, during and after such expenses are incurred. R&D and SG&A expense for the nine months ended September 30, 2004 were also adjusted to exclude the expenses related to the Tularik Acquisition identified above and for the reasons discussed above. Further, SG&A expense for this period was adjusted to exclude the impact to the Company of its share of third party reimbursement received by Kirin Amgen, Inc. related to the Genentech Settlement for the reasons discussed above.

For the three months and nine months ended September 30, 2004, the Company reported non-GAAP adjusted net income and adjusted earnings per share, excluding the foregoing operating expense amounts for the reasons discussed above, as well as excluding ongoing, non-cash amortization of acquired intangible assets associated with the Immunex Acquisition and the non-cash expense associated with writing off the acquired in-process research and development related to the Tularik Acquisition (the “Tularik IPR&D Write-off”). The Company believes that excluding the ongoing, non-cash amortization of intangible assets acquired in the Immunex Acquisition (primarily ENBREL^®) treats those assets as if the Company had developed them internally in the past, and thus provides a supplemental measure of profitability in which the Company’s acquired intellectual property is treated in a comparable manner to its internally developed intellectual property. The Company believes that excluding the Tularik IPR&D Write-off provides a supplemental measure that will facilitate comparisons between periods in which such item did not occur.

Three and nine months ended September 30, 2003

For the three and nine months ended September 30, 2003, the Company’s adjustments to GAAP financial measures relate to amounts associated with the Immunex Acquisition and the Genentech Settlement.

For the nine months ended September 30, 2003, the Company’s adjustments to GAAP financial measures also relate to amounts associated with the recovery of certain cost and expenses associated with the Company’s arbitration with Johnson & Johnson for breach of the license agreement with the Company (the “Cost Recovery”) and the Company’s cash contribution to the Amgen Foundation (the “Foundation Contribution”).

For the three and nine months ended September 30, 2003, the Company reported non-GAAP financial results for the following operating expenses: cost of sales, R&D, and SG&A, which were each adjusted to exclude incremental compensation payable to certain Immunex employees for a limited period, principally under the Immunex short-term retention plan for the applicable period. The Company believes that excluding such incremental compensation provides a supplemental measure that will facilitate comparisons between periods before, during and after such expenses are incurred. SG&A expense was further adjusted for this period to exclude the impact to the Company of its share of the loss incurred related to the Genentech Settlement. The Company believes that excluding the Genentech Settlement provides a supplemental measure that will facilitate comparisons between periods in which such item did not occur.

For the three months ended September 30, 2003, the Company reported non-GAAP adjusted net income and adjusted earnings per share, excluding the foregoing operating expense amounts for the reasons discussed above, as well as excluding ongoing, non-cash amortization of acquired intangible assets associated with the Immunex Acquisition. The Company believes that excluding the ongoing, non-cash amortization of intangible assets acquired in the Immunex Acquisition (primarily ENBREL^®) treats those assets as if the Company had developed them internally in the past, and thus provides a supplemental measure of profitability in which the Company’s acquired intellectual property is treated in a comparable manner to its internally developed intellectual property.

For the nine months ended September 30, 2003, the Company also reported non-GAAP adjusted net income and adjusted earnings per share, excluding all of the items identified above as being excluded in the three months ended September 30, 2003 for the reasons discussed above. The nine months ended September 30, 2003 also excludes the Cost Recovery and the Foundation Contribution. The Company believes that excluding the Cost Recovery and the Foundation Contribution provides a supplemental measure that will facilitate comparisons between periods in which such items did not occur.

The Company uses the foregoing non-GAAP financial measures in connection with its own budgeting and financial planning.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	AMGEN INC.
Date: October 26, 2004	By:	/s/ Richard Nanula
	Name:	Richard Nanula
	Title:	Executive Vice President and Chief Financial Officer

EXHIBIT INDEX

Exhibit Number	Document Description
99.1	Press release dated October 20, 2004

EX-99.1

Exhibit 99.1

	One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone (805) 447-4587 Fax (805) 499-3507 www.Amgen.com
News Release

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

THIRD QUARTER GAAP EARNINGS PER SHARE OF 18 CENTS INCLUDES A $554 MILLION ACQUIRED IN-PROCESS R&D CHARGE RELATED TO TULARIK ACQUISITION

Total Product Sales Grew 23 Percent in the Third Quarter Led by Aranesp^® and Enbrel^®

2004 Guidance Increased for Total Revenue and Adjusted Earnings Per Share

THOUSAND OAKS, Calif. (Oct 20, 2004) – Amgen Inc. (Nasdaq: AMGN), the world’s largest biotechnology company, today announced adjusted earnings per share of 64 cents for the third quarter of 2004 versus 53 cents for the third quarter of 2003, an increase of 21 percent. The company increased full-year guidance for adjusted earnings per share to a range of $2.38 to $2.43 from the previous range of $2.30 to $2.40. Total revenue guidance for 2004 was increased to a range of $10.3 to $10.6 billion from the previous range of $9.7 to $10.4 billion.

Adjusted earnings per share and adjusted net income for the three and nine months ended September 30, 2004 and 2003 exclude certain charges and expenses related to the acquisitions of Tularik, Inc. in the third quarter of 2004 and Immunex Corporation in 2002. These charges and certain other items are detailed on the reconciliation tables below.

Total revenue increased 23 percent to $2.7 billion in the third quarter of 2004 versus $2.2 billion in the comparable period in 2003. Adjusted net income was $839 million in the third quarter of 2004 versus $714 million in the third quarter of 2003, an increase of 18 percent.

On a reported basis and in accordance with U.S. generally accepted accounting principles (GAAP), Amgen reported earnings per share of 18 cents in the third quarter of 2004 versus 46 cents in the third quarter of 2003, a 61 percent decrease. GAAP net income for the third quarter 2004 was $236 million versus $612 million in the third quarter of 2003, a decrease of 61 percent. GAAP earnings per share and net income decreased primarily due to the write-off of acquired in-process research and development of $554 million related to the acquisition of Tularik, Inc.

- MORE -

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 2

“We had excellent growth during the third quarter, made clinical and regulatory progress, and gained a significant victory toward protecting our intellectual property,” said Kevin Sharer, Amgen’s chairman and chief executive officer. “We initiated large Phase 3 studies in postmenopausal osteoporosis and treatment-induced bone loss for AMG 162. The company received two significant regulatory approvals in the U.S. for ENBREL including approval for a convenient 50 mg/mL pre-filled syringe as well as approval to manufacture ENBREL in a Genentech facility, which will enhance our ability to meet growing demand for this key product. We also recently received an affirmation of our erythropoietin patents in a ruling from the U.S. District Court of Massachusetts. The court’s ruling, along with earlier decisions, confirms that all four of our patents on erythropoietin are valid, enforceable and infringed by Transkaryotic Therapies Inc. and Aventis Pharmaceuticals Inc.”

Product Sales Performance and Expenses

Third quarter total product sales increased 23 percent to $2.6 billion from $2.1 billion in the third quarter of 2003. This strong sales growth was primarily driven by sales of Aranesp^® (darbepoetin alfa) and ENBREL.

U.S. product sales were $2.1 billion, an increase of 20 percent versus the third quarter of last year. International sales were $419 million for the third quarter of 2004 versus $300 million for the same quarter last year, an increase of 40 percent. Excluding the impact of foreign exchange in the third quarter of 2004, international sales would have grown 31 percent.

Combined worldwide sales of EPOGEN^® (Epoetin alfa), Amgen’s anemia therapy for patients on dialysis, and Aranesp, its latest anemia product for the treatment of anemia associated with chronic renal failure and anemia due to chemotherapy, increased 21 percent to $1.3 billion during the third quarter of 2004 from $1.1 billion during the third quarter of 2003. The company now expects combined full-year 2004 EPOGEN and Aranesp sales in the range of $4.8 to $5.1 billion from the previous $4.6 to $5.1 billion range.

Sales of EPOGEN were $681 million for the third quarter of 2004, an increase of 9 percent over the same quarter last year. The company believes this growth was driven by increases in wholesaler inventory levels, and to a lesser extent, end-user customer demand. For the full-year, the company expects that EPOGEN sales will grow at a slightly higher rate than the underlying patient growth rate of approximately 4 percent.

Worldwide Aranesp sales increased 39 percent during the third quarter of 2004 to $608 million versus $438 million in the third quarter of last year. The company believes worldwide Aranesp sales were driven by demand and market share gains. U.S. sales were impacted by higher discounts associated with performance-based contracts.

- MORE -

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 3

Third quarter U.S. Aranesp sales were $374 million versus $284 million last year. International Aranesp sales were $234 million versus $154 million in the third quarter last year.

Combined worldwide sales of Neulasta and NEUPOGEN increased 14 percent to $752 million from $657 million in the third quarter last year. This increase was driven by worldwide Neulasta demand. The company has raised its guidance for full-year 2004 combined NEUPOGEN and Neulasta sales to a range of $2.8 to $3.1 billion from the previous $2.7 to $3.0 billion. Neulasta is Amgen’s once-per-cycle product for decreasing the risk of chemotherapy-related infections due to neutropenia, and NEUPOGEN is used to decrease the incidence of many types of chemotherapy-related infections.

Worldwide Neulasta sales increased 38 percent to $450 million in the third quarter of 2004, including $66 million of international sales. U.S. Neulasta sales increased 26 percent to $384 million in the third quarter versus $304 million for the third quarter of last year, reflecting an increase in demand. U.S. sales were impacted by higher discounts associated with performance-based contracts.

Worldwide NEUPOGEN sales were $302 million in the third quarter of 2004 versus $330 million in the prior year, a decrease of 8 percent due primarily to lower U.S. demand. Third quarter NEUPOGEN sales in the U.S. were $207 million versus $228 million in the third quarter of 2003, a decrease of 9 percent.

ENBREL, Amgen’s leading biologic for inflammation, had third quarter sales of $496 million, a 45 percent increase over third quarter 2003 sales of $342 million. This increase was driven by growing demand in the rheumatology and dermatology segments due to greater use of biologics. Full-year sales guidance for ENBREL was raised to the range of $1.8 to $1.9 billion from the previous range of $1.6 to $1.8 billion.

Operating Expenses on an adjusted basis in both periods were as follows:

• Cost of sales increased 33 percent to $447 million from $336 million in the third quarter of 2003 primarily due to increased sales volumes and product mix changes.

• In the third quarter of 2004, Research and Development (R&D) expenses rose 24 percent to $495 million versus $400 million in the third quarter of 2003. This increase was primarily due to additions of R&D personnel, including those from Tularik, Inc.

• Selling, general and administrative (SG&A) expenses increased 36 percent to $635 million in the third quarter of 2004 versus $468 million in the previous year. This increase was primarily due to higher staff-related expenses; a higher proportion of profit sharing with Wyeth because of ENBREL’s strong growth; and higher compensation expenses as a result of increased sales.

- MORE -

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 4

The third quarter adjusted tax rate of 27 percent was lower than the prior year due to increased benefit from our Puerto Rico manufacturing operations.

In the third quarter of 2004, share repurchases totaled $1.4 billion representing approximately 24 million shares. Capital expenditures in the third quarter were $298 million compared to $388 million for the same period a year ago. The company’s cash and marketable securities were $3.8 billion at the end of the quarter.

The company announced that it would provide financial guidance for 2005 in conjunction with its full-year 2004 business results toward the end of January 2005.

Product and Pipeline Highlights

Aranesp: Aranesp received regulatory approval in Europe for two new extended dosing regimens to help physicians and patients simplify anemia management; once-every-three-weeks in adult cancer patients with non-myeloid malignancies receiving chemotherapy and up to once-per-month for chronic kidney disease (CKD) patients not yet on dialysis.

ENBREL: The new 50 mg/mL pre-filled syringe of ENBREL was approved in the U.S. as the recommended dosing form for treatment in all approved adult indications. The new pre-filled syringe, available for patient use in the fourth quarter 2004, will eliminate the need to mix drug prior to injecting and allows most patients receiving ENBREL to take only one injection per week. ENBREL also received approval in the U.S. as the first and only biologic to be indicated to induce a Major Clinical Response in patients with rheumatoid arthritis. Additionally, the ENBREL label was expanded to include data that shows ENBREL inhibited the progression of joint damage for up to five years in the majority of patients.

Last week, the FDA approved the manufacture of ENBREL bulk drug substance by Genentech, Inc., expanding Amgen’s ability to satisfy the growing patient demand for this product.

Mimpara^®: The Committee for Medicinal Products for Human use (CHMP) of the European Medicines Agency (EMEA) issued a positive opinion for Mimpara (cinacalcet HCl) recommending the grant of marketing authorization in the European Union for the treatment of secondary hyperparathyroidism in end-stage renal disease patients on maintenance dialysis, and reduction of elevated calcium levels (hypercalcemia) in patients with parathyroid carcinoma.

AMG 162: Pivotal Phase 3 studies for AMG 162 in postmenopausal osteoporosis and treatment-induced bone loss were initiated during the quarter. Also, study results from a Phase 2, 12-month study investigating the safety and efficacy of AMG 162 in postmenopausal osteoporosis were presented recently at ASBMR, the American Society of Bone and Mineral Research.

- MORE -

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 5

For more product information or the full prescribing information, please refer to the Amgen Web site at www.amgen.com.

FORWARD-LOOKING STATEMENTS

This news release contains forward-looking statements that involve significant risks and uncertainties, including those discussed below and others that can be found in our Form 10-K for the year ended December 31, 2003, and in our periodic reports on Form 10-Q and Form 8-K. Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

No forward-looking statement can be guaranteed and actual results may differ materially from those we project. The Company’s results may be affected by our ability to successfully market both new and existing products domestically and internationally, sales growth of recently launched products, difficulties or delays in manufacturing our products, and regulatory developments (domestic or foreign) involving current and future products and manufacturing facilities. In addition, sales of our products are affected by reimbursement policies imposed by first party payors, including governments, private insurance plans and managed care providers, and may be affected by domestic and international trends toward managed care and healthcare cost containment as well as possible U.S. legislation affecting pharmaceutical pricing and reimbursement. Government regulations and reimbursement policies may affect the development, usage and pricing of our products. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We, or others could identify side effects or manufacturing problems with our products after they are on the market. In addition, we compete with other companies with respect to some of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate will be successful and become a commercial product. In addition, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors. Further, some raw materials, medical devices, and component parts for our products are supplied by sole first party suppliers.

About Amgen

Amgen is a global biotechnology company that discovers, develops, manufactures and markets important human therapeutics based on advances in cellular and molecular biology.

CONTACT:	Amgen, Thousand Oaks
	Christine Cassiano, 805/447-4587 (Media)
	Laura Biswas, 805/447-1060 (Investors)

# # #

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 6

Appendix I

Amgen Inc.

Condensed Consolidated Statements of Operations and

Reconciliation of GAAP Earnings to “Adjusted” Earnings

(In millions, except per share data)

(Unaudited)

	Three Months Ended September 30, 2004							Three Months Ended September 30, 2003
	GAAP		Adjustments			“Adjusted”		GAAP		Adjustments			“Adjusted”
Revenues:
Product sales	$	2,560	$	—		$	2,560	$	2,078	$	—		$	2,078
Other revenues		153		—			153		130		—			130
Total revenues		2,713		—			2,713		2,208		—			2,208
Operating expenses:
Cost of sales (excludes amortization of acquired intangible assets presented below)		447		—			447		340		(4)	(5)		336
Research and development		502		(7)	(1)		495		408		(8)	(5)		400
Selling, general and administrative		632		(8)	(1)		635		519		(4)	(5)		468
				11	(2)						(47)	(6)
Write-off of acquired in-process R&D		554		(554)	(3)		—		—		—			—
Amortization of intangible assets		84		(84)	(4)		—		84		(84)	(4)		—
Total operating expenses		2,219		(642)			1,577		1,351		(147)			1,204
Operating income		494		642			1,136		857		147			1,004
Interest and other income, net		15		—			15		9		—			9
Income before income taxes		509		642			1,151		866		147			1,013
Provision for income taxes		273		39	(9)		312		254		45	(9)		299
Net income	$	236	$	603		$	839	$	612	$	102		$	714
Earnings per share:
Basic	$	0.19				$	0.66	$	0.47				$	0.55
Diluted (10)	$	0.18				$	0.64	$	0.46				$	0.53
Shares used in calculation of earnings per share:
Basic		1,272					1,272		1,289					1,289
Diluted (10)		1,320					1,320		1,348					1,348

(1) - (10) See explanatory notes

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 7

Amgen Inc.

Condensed Consolidated Statements of Operations and

Reconciliation of GAAP Earnings to “Adjusted” Earnings

(In millions, except per share data)

(Unaudited)

	Nine Months Ended September 30, 2004							Nine Months Ended September 30, 2003
	GAAP		Adjustments			“Adjusted”		GAAP		Adjustments			“Adjusted”
Revenues:
Product sales	$	7,199	$	—		$	7,199	$	5,631	$	—		$	5,631
Other revenues		442		—			442		379		—			379
Total revenues		7,641		—			7,641		6,010		—			6,010
Operating expenses:
Cost of sales (excludes amortization of acquired intangible assets presented below)		1,255		(2)	(5)		1,253		952		(14)	(5)		938
Research and development		1,411		(7)	(1)		1,388		1,153		(26)	(5)		1,127
				(16)	(5)
Selling, general and administrative		1,740		(8)	(1)		1,735		1,341		(12)	(5)		1,282
				(8)	(5)						(47)	(6)
				11	(2)
Write-off of acquired in-process R&D		554		(554)	(3)		—		—		—			—
Amortization of intangible assets		252		(252)	(4)		—		252		(252)	(4)		—
Other items, net		—		—			—		(24)		74	(7)		—
											(50)	(8)
Total operating expenses		5,212		(836)			4,376		3,674		(327)			3,347
Operating income		2,429		836			3,265		2,336		327			2,663
Interest and other income, net		46		—			46		67		—			67
Income before income taxes		2,475		836			3,311		2,403		327			2,730
Provision for income taxes		801		111	(9)		912		690		115	(9)		805
Net income	$	1,674	$	725		$	2,399	$	1,713	$	212		$	1,925
Earnings per share:
Basic	$	1.32				$	1.88	$	1.33				$	1.49
Diluted (10)	$	1.28				$	1.83	$	1.28				$	1.44
Shares used in calculation of earnings per share:
Basic		1,273					1,273		1,289					1,289
Diluted (10)		1,323					1,323		1,348					1,348

(1) - (10) See explanatory notes

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 8

Amgen Inc.

Notes to Reconciliation of GAAP Earnings to “Adjusted” Earnings

(In millions, except per share data)

(Unaudited)

(1) To exclude the incremental compensation provided to certain Tularik, Inc. employees principally related to non-cash compensation expense associated with stock options assumed in connection with the acquisition and amounts payable under the Tularik, Inc. short-term retention plan. The total estimated remaining costs of such incremental compensation is approximately $40 million, pre-tax.

(2) To exclude the impact to the Company of its share of the third-party reimbursement received by Kirin-Amgen, Inc. (“KA”) related to the Genentech, Inc. (“Genentech”) legal settlement (see (6) below).

(3) To exclude the non-cash expense associated with writing off the acquired in-process research and development related to the Tularik, Inc. acquisition.

(4) To exclude the ongoing, non-cash amortization of acquired intangible assets, primarily ENBREL^®, related to the Immunex Corporation (“Immunex”) acquisition. The total annual non-cash charge is currently estimated to be approximately $340 million, pre-tax.

(5) To exclude the incremental compensation payable to certain Immunex employees principally under the Immunex short-term retention plan. All amounts have been incurred under this plan.

(6) To exclude the impact to the Company of a legal settlement paid to Genentech in connection with settling a patent litigation matter relating to the Company’s processes for producing NEUPOGEN^® and Neulasta^®. Pursuant to the terms of a license agreement between the Company and KA, an entity 50% owned by the Company, KA was obligated to indemnify the Company for the payment made to Genentech. The Company accounts for its ownership interest in KA under the equity method and, accordingly, recorded its share of such loss incurred by KA in “Selling, general and administrative.”

(7) To exclude a benefit for the recovery of costs and expenses associated with a legal award related to an arbitration proceeding with Johnson & Johnson.

(8) To exclude a cash contribution to the Amgen Foundation.

(9) To reflect the tax effect of the above adjustments, except for the write-off of acquired in-process R&D (see (3) above).

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 9

(10) The following tables present the computations for GAAP and “Adjusted” diluted earnings per share computed under the treasury stock and the “if-converted” methods:

	Three Months Ended September 30, 2004				Three Months Ended September 30, 2003
	GAAP		“Adjusted”		GAAP		“Adjusted”
Income (Numerator):
Net income for basic EPS	$	236	$	839	$	612	$	714
Adjustment for interest expense on Convertible Notes, net of tax		5		5		5		5
Net income for diluted EPS, after assumed conversion of Convertible Notes	$	241	$	844	$	617	$	719
Shares (Denominator):
Weighted-average shares for basic EPS		1,272		1,272		1,289		1,289
Effect of Dilutive Securities		13		13		24		24
Effect of Convertible Notes, after assumed conversion of Convertible Notes		35		35		35		35
Adjusted weighted-average shares for diluted EPS		1,320		1,320		1,348		1,348
Diluted earnings per share	$	0.18	$	0.64	$	0.46	$	0.53
	Nine Months Ended September 30, 2004				Nine Months Ended September 30, 2003
	GAAP		“Adjusted”		GAAP		“Adjusted”
Income (Numerator):
Net income for basic EPS	$	1,674	$	2,399	$	1,713	$	1,925
Adjustment for interest expense on Convertible Notes, net of tax		16		16		16		16
Net income for diluted EPS, after assumed conversion of Convertible Notes	$	1,690	$	2,415	$	1,729	$	1,941
Shares (Denominator):
Weighted-average shares for basic EPS		1,273		1,273		1,289		1,289
Effect of Dilutive Securities		15		15		24		24
Effect of Convertible Notes, after assumed conversion of Convertible Notes		35		35		35		35
Adjusted weighted-average shares for diluted EPS		1,323		1,323		1,348		1,348
Diluted earnings per share	$	1.28	$	1.83	$	1.28	$	1.44

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 10

Amgen Inc.

Product Sales Detail by Product and Geographic Region

(In millions)

(Unaudited)

	Three Months Ended September 30,				Nine Months Ended September 30,
	2004		2003		2004		2003
EPOGEN® - U.S	$	681	$	626	$	1,904	$	1,784
Aranesp® - U.S.		374		284		1,084		659
Aranesp® - International		234		154		684		382
Neulasta® - U.S.		384		304		1,082		848
Neulasta® - International		66		23		189		41
NEUPOGEN® - U.S.		207		228		574		655
NEUPOGEN® - International		95		102		292		290
ENBREL® - U.S.		477		329		1,282		887
ENBREL® - International		19		13		51		32
Other product sales - U.S.		18		7		40		31
Other product sales - International		5		8		17		22
Total product sales	$	2,560	$	2,078	$	7,199	$	5,631
U.S.	$	2,141	$	1,778	$	5,966	$	4,864
International		419		300		1,233		767
	$	2,560	$	2,078	$	7,199	$	5,631

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 11

Amgen Inc.

Condensed Consolidated Balance Sheets

(In millions)

(Unaudited)

	September 30, 2004			December 31, 2003
Assets
Current assets:
Cash and marketable securities	$	3,838		$	5,123
Trade receivables, net		1,413			1,008
Inventories		716			713
Other current assets		808			558
Total current assets		6,775			7,402
Property, plant, and equipment, net		4,549			3,799
Intangible assets, net		4,278			4,456
Goodwill		10,437			9,716
Other assets		772			804
Total assets	$	26,811		$	26,177
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable and accrued liabilities	$	2,287		$	2,204
Convertible notes		2,904	*		—
Total current liabilities		5,191			2,204
Deferred tax liabilities		1,484			1,462
Other non-current liabilities		128			42
Long-term debt		200			3,080	*
Stockholders’ equity		19,808			19,389
Total liabilities and stockholders’ equity	$	26,811		$	26,177
Shares outstanding		1,270			1,284

* Holders of the Convertible Notes may require the Company to purchase all or a portion of the notes on specific dates as early as March 1, 2005 at the original issuance price plus accrued original issue discount through the purchase date. Accordingly, as of September 30, 2004, the Convertible Notes have been reclassified from long-term debt to current liabilities.

AMGEN’S THIRD QUARTER 2004 ADJUSTED EARNINGS PER SHARE INCREASED 21 PERCENT TO 64 CENTS

Page 12

Amgen Inc.

Reconciliation of “Adjusted” Earnings Per Share Guidance to GAAP

Earnings Per Share Guidance for the Year Ended December 31, 2004

	2004
“Adjusted” earnings per share guidance	$	2.38 - $ 2.43
Known adjustments to arrive at GAAP earnings:
Amortization of acquired intangible assets (1)		(0.20	)
Immunex merger related incremental compensation (2)		(0.01	)
Tularik merger related incremental compensation (3)		(0.01	)
Third-party Genentech legal reimbursement (4)		0.01
Write-off of Tularik acquired in-process R&D (5)		(0.42	)
GAAP earnings per share guidance	$	1.75 - $1.80

(1) To exclude the ongoing, non-cash amortization of acquired intangible assets, primarily ENBREL^®, related to the Immunex acquisition. The total annual non-cash charge is currently estimated to be approximately $340 million, pre- tax.

(2) To exclude the incremental compensation payable to certain Immunex employees principally under the Immunex short-term retention plan.

(3) To exclude the incremental compensation provided to certain Tularik, Inc. employees principally related to non-cash compensation expense associated with stock options assumed in connection with the acquisition and amounts payable under the the Tularik, Inc. short-term retention plan.

(4) To exclude the impact to the Company of its share of the third-party reimbursement received by KA related to the Genentech legal settlement.

(5) To exclude the non-cash expense associated with writing off the acquired in-process research and development related to the Tularik, Inc. acquisition.