Revenues - Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Revenue from External Customer [Line Items]
Total revenues	$ 7,447	$ 6,105
Product sales
Revenue from External Customer [Line Items]
Total revenues	7,118	5,846
Product sales | U.S.
Revenue from External Customer [Line Items]
Total revenues	4,973	3,975
Product sales | ROW
Revenue from External Customer [Line Items]
Total revenues	2,145	1,871
Prolia
Revenue from External Customer [Line Items]
Total revenues	999	927
Prolia | U.S.
Revenue from External Customer [Line Items]
Total revenues	657	623
Prolia | ROW
Revenue from External Customer [Line Items]
Total revenues	342	304
ENBREL
Revenue from External Customer [Line Items]
Total revenues	567	579
ENBREL | U.S.
Revenue from External Customer [Line Items]
Total revenues	561	564
ENBREL | ROW
Revenue from External Customer [Line Items]
Total revenues	6	15
XGEVA
Revenue from External Customer [Line Items]
Total revenues	561	536
XGEVA | U.S.
Revenue from External Customer [Line Items]
Total revenues	366	384
XGEVA | ROW
Revenue from External Customer [Line Items]
Total revenues	195	152
Repatha
Revenue from External Customer [Line Items]
Total revenues	517	388
Repatha | U.S.
Revenue from External Customer [Line Items]
Total revenues	273	197
Repatha | ROW
Revenue from External Customer [Line Items]
Total revenues	244	191
TEPEZZA
Revenue from External Customer [Line Items]
Total revenues	424	0
TEPEZZA | U.S.
Revenue from External Customer [Line Items]
Total revenues	419	0
TEPEZZA | ROW
Revenue from External Customer [Line Items]
Total revenues	5	0
Otezla
Revenue from External Customer [Line Items]
Total revenues	394	392
Otezla | U.S.
Revenue from External Customer [Line Items]
Total revenues	293	294
Otezla | ROW
Revenue from External Customer [Line Items]
Total revenues	101	98
KYPROLIS
Revenue from External Customer [Line Items]
Total revenues	376	358
KYPROLIS | U.S.
Revenue from External Customer [Line Items]
Total revenues	234	234
KYPROLIS | ROW
Revenue from External Customer [Line Items]
Total revenues	142	124
Aranesp
Revenue from External Customer [Line Items]
Total revenues	349	355
Aranesp | U.S.
Revenue from External Customer [Line Items]
Total revenues	100	115
Aranesp | ROW
Revenue from External Customer [Line Items]
Total revenues	249	240
EVENITY
Revenue from External Customer [Line Items]
Total revenues	342	254
EVENITY | U.S.
Revenue from External Customer [Line Items]
Total revenues	236	164
EVENITY | ROW
Revenue from External Customer [Line Items]
Total revenues	106	90
Nplate
Revenue from External Customer [Line Items]
Total revenues	317	362
Nplate | U.S.
Revenue from External Customer [Line Items]
Total revenues	190	246
Nplate | ROW
Revenue from External Customer [Line Items]
Total revenues	127	116
Vectibix
Revenue from External Customer [Line Items]
Total revenues	247	233
Vectibix | U.S.
Revenue from External Customer [Line Items]
Total revenues	120	111
Vectibix | ROW
Revenue from External Customer [Line Items]
Total revenues	127	122
BLINCYTO
Revenue from External Customer [Line Items]
Total revenues	244	194
BLINCYTO | U.S.
Revenue from External Customer [Line Items]
Total revenues	153	126
BLINCYTO | ROW
Revenue from External Customer [Line Items]
Total revenues	91	68
KRYSTEXXA
Revenue from External Customer [Line Items]
Total revenues	235	0
KRYSTEXXA | U.S.
Revenue from External Customer [Line Items]
Total revenues	235	0
KRYSTEXXA | ROW
Revenue from External Customer [Line Items]
Total revenues	0	0
TEZSPIRE
Revenue from External Customer [Line Items]
Total revenues	173	96
TEZSPIRE | U.S.
Revenue from External Customer [Line Items]
Total revenues	173	96
TEZSPIRE | ROW
Revenue from External Customer [Line Items]
Total revenues	0	0
Other products
Revenue from External Customer [Line Items]
Total revenues	1,373	1,172
Other products | U.S.
Revenue from External Customer [Line Items]
Total revenues	963	821
Other products | ROW
Revenue from External Customer [Line Items]
Total revenues	410	351
Other revenues
Revenue from External Customer [Line Items]
Total revenues	$ 329	$ 259