Revenues - Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Disaggregation of Revenue [Line Items]
Total revenues	$ 28,190	$ 26,323	$ 25,979
U.S.
Disaggregation of Revenue [Line Items]
Total revenues	19,806	18,595	18,194
ROW
Disaggregation of Revenue [Line Items]
Total revenues	8,384	7,728	7,785
Prolia
Disaggregation of Revenue [Line Items]
Total revenues	4,048	3,628	3,248
Prolia | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	2,733	2,465	2,150
Prolia | ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,315	1,163	1,098
ENBREL
Disaggregation of Revenue [Line Items]
Total revenues	3,697	4,117	4,465
ENBREL | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	3,650	4,044	4,352
ENBREL | ROW
Disaggregation of Revenue [Line Items]
Total revenues	47	73	113
Otezla
Disaggregation of Revenue [Line Items]
Total revenues	2,188	2,288	2,249
Otezla | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,777	1,886	1,804
Otezla | ROW
Disaggregation of Revenue [Line Items]
Total revenues	411	402	445
XGEVA
Disaggregation of Revenue [Line Items]
Total revenues	2,112	2,014	2,018
XGEVA | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,527	1,480	1,434
XGEVA | ROW
Disaggregation of Revenue [Line Items]
Total revenues	585	534	584
Repatha
Disaggregation of Revenue [Line Items]
Total revenues	1,635	1,296	1,117
Repatha | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	793	608	557
Repatha | ROW
Disaggregation of Revenue [Line Items]
Total revenues	842	688	560
Nplate
Disaggregation of Revenue [Line Items]
Total revenues	1,477	1,307	1,027
Nplate | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	996	848	566
Nplate | ROW
Disaggregation of Revenue [Line Items]
Total revenues	481	459	461
KYPROLIS
Disaggregation of Revenue [Line Items]
Total revenues	1,403	1,247	1,108
KYPROLIS | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	921	850	736
KYPROLIS | ROW
Disaggregation of Revenue [Line Items]
Total revenues	482	397	372
Aranesp
Disaggregation of Revenue [Line Items]
Total revenues	1,362	1,421	1,480
Aranesp | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	452	521	537
Aranesp | ROW
Disaggregation of Revenue [Line Items]
Total revenues	910	900	943
EVENITY
Disaggregation of Revenue [Line Items]
Total revenues	1,160	787	530
EVENITY | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	809	533	331
EVENITY | ROW
Disaggregation of Revenue [Line Items]
Total revenues	351	254	199
Vectibix
Disaggregation of Revenue [Line Items]
Total revenues	984	893	873
Vectibix | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	461	396	347
Vectibix | ROW
Disaggregation of Revenue [Line Items]
Total revenues	523	497	526
BLINCYTO
Disaggregation of Revenue [Line Items]
Total revenues	861	583	472
BLINCYTO | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	566	336	278
BLINCYTO | ROW
Disaggregation of Revenue [Line Items]
Total revenues	295	247	194
TEPEZZA
Disaggregation of Revenue [Line Items]
Total revenues	448	0	0
TEPEZZA | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	441	0	0
TEPEZZA | ROW
Disaggregation of Revenue [Line Items]
Total revenues	7	0	0
KRYSTEXXA
Disaggregation of Revenue [Line Items]
Total revenues	272	0	0
KRYSTEXXA | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	272	0	0
KRYSTEXXA | ROW
Disaggregation of Revenue [Line Items]
Total revenues	0	0	0
Other products
Disaggregation of Revenue [Line Items]
Total revenues	5,263	5,220	5,710
Other products | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	3,874	3,776	4,194
Other products | ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,389	1,444	1,516
Total product sales
Disaggregation of Revenue [Line Items]
Total revenues	26,910	24,801	24,297
Total product sales | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	19,272	17,743	17,286
Total product sales | ROW
Disaggregation of Revenue [Line Items]
Total revenues	7,638	7,058	7,011
Other revenues
Disaggregation of Revenue [Line Items]
Total revenues	1,280	1,522	1,682
Other revenues | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	534	852	908
Other revenues | ROW
Disaggregation of Revenue [Line Items]
Total revenues	$ 746	$ 670	$ 774