Revenues - Summary of Revenues (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenue from External Customer [Line Items]
Total revenues	$ 6,105	$ 6,238
Product sales
Revenue from External Customer [Line Items]
Total revenues	5,846	5,731
Product sales | U.S.
Revenue from External Customer [Line Items]
Total revenues	3,975	4,037
Product sales | ROW
Revenue from External Customer [Line Items]
Total revenues	1,871	1,694
Prolia
Revenue from External Customer [Line Items]
Total revenues	927	852
Prolia | U.S.
Revenue from External Customer [Line Items]
Total revenues	623	582
Prolia | ROW
Revenue from External Customer [Line Items]
Total revenues	304	270
ENBREL
Revenue from External Customer [Line Items]
Total revenues	579	862
ENBREL | U.S.
Revenue from External Customer [Line Items]
Total revenues	564	843
ENBREL | ROW
Revenue from External Customer [Line Items]
Total revenues	15	19
XGEVA
Revenue from External Customer [Line Items]
Total revenues	536	502
XGEVA | U.S.
Revenue from External Customer [Line Items]
Total revenues	384	368
XGEVA | ROW
Revenue from External Customer [Line Items]
Total revenues	152	134
Otezla
Revenue from External Customer [Line Items]
Total revenues	392	451
Otezla | U.S.
Revenue from External Customer [Line Items]
Total revenues	294	350
Otezla | ROW
Revenue from External Customer [Line Items]
Total revenues	98	101
Repatha
Revenue from External Customer [Line Items]
Total revenues	388	329
Repatha | U.S.
Revenue from External Customer [Line Items]
Total revenues	197	165
Repatha | ROW
Revenue from External Customer [Line Items]
Total revenues	191	164
Nplate
Revenue from External Customer [Line Items]
Total revenues	362	266
Nplate | U.S.
Revenue from External Customer [Line Items]
Total revenues	246	156
Nplate | ROW
Revenue from External Customer [Line Items]
Total revenues	116	110
KYPROLIS
Revenue from External Customer [Line Items]
Total revenues	358	287
KYPROLIS | U.S.
Revenue from External Customer [Line Items]
Total revenues	234	196
KYPROLIS | ROW
Revenue from External Customer [Line Items]
Total revenues	124	91
Aranesp
Revenue from External Customer [Line Items]
Total revenues	355	358
Aranesp | U.S.
Revenue from External Customer [Line Items]
Total revenues	115	137
Aranesp | ROW
Revenue from External Customer [Line Items]
Total revenues	240	221
EVENITY
Revenue from External Customer [Line Items]
Total revenues	254	170
EVENITY | U.S.
Revenue from External Customer [Line Items]
Total revenues	164	110
EVENITY | ROW
Revenue from External Customer [Line Items]
Total revenues	90	60
Other products
Revenue from External Customer [Line Items]
Total revenues	1,695	1,654
Other products | U.S.
Revenue from External Customer [Line Items]
Total revenues	1,154	1,130
Other products | ROW
Revenue from External Customer [Line Items]
Total revenues	541	524
Other revenues
Revenue from External Customer [Line Items]
Total revenues	$ 259	$ 507