Revenues (Details) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2022 USD ($)	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($) segment	Sep. 30, 2021 USD ($)
Revenue from Contract with Customer [Abstract]
Number of operating segments | segment			1
Revenue from External Customer [Line Items]
Total revenues	$ 6,652	$ 6,706	$ 19,484	$ 19,133
Product sales
Revenue from External Customer [Line Items]
Total revenues	6,237	6,320	18,249	18,026
Product sales | U.S.
Revenue from External Customer [Line Items]
Total revenues	4,466	4,558	12,949	12,835
Product sales | ROW
Revenue from External Customer [Line Items]
Total revenues	1,771	1,762	5,300	5,191
ENBREL
Revenue from External Customer [Line Items]
Total revenues	1,106	1,289	3,019	3,357
ENBREL | U.S.
Revenue from External Customer [Line Items]
Total revenues	1,086	1,263	2,965	3,270
ENBREL | ROW
Revenue from External Customer [Line Items]
Total revenues	20	26	54	87
Prolia
Revenue from External Customer [Line Items]
Total revenues	862	803	2,636	2,375
Prolia | U.S.
Revenue from External Customer [Line Items]
Total revenues	590	530	1,783	1,569
Prolia | ROW
Revenue from External Customer [Line Items]
Total revenues	272	273	853	806
Otezla
Revenue from External Customer [Line Items]
Total revenues	627	609	1,672	1,619
Otezla | U.S.
Revenue from External Customer [Line Items]
Total revenues	529	495	1,366	1,284
Otezla | ROW
Revenue from External Customer [Line Items]
Total revenues	98	114	306	335
XGEVA
Revenue from External Customer [Line Items]
Total revenues	495	517	1,530	1,473
XGEVA | U.S.
Revenue from External Customer [Line Items]
Total revenues	363	372	1,122	1,061
XGEVA | ROW
Revenue from External Customer [Line Items]
Total revenues	132	145	408	412
Aranesp
Revenue from External Customer [Line Items]
Total revenues	358	396	1,073	1,118
Aranesp | U.S.
Revenue from External Customer [Line Items]
Total revenues	128	149	397	409
Aranesp | ROW
Revenue from External Customer [Line Items]
Total revenues	230	247	676	709
Repatha
Revenue from External Customer [Line Items]
Total revenues	309	272	963	844
Repatha | U.S.
Revenue from External Customer [Line Items]
Total revenues	142	139	461	421
Repatha | ROW
Revenue from External Customer [Line Items]
Total revenues	167	133	502	423
KYPROLIS
Revenue from External Customer [Line Items]
Total revenues	318	293	922	824
KYPROLIS | U.S.
Revenue from External Customer [Line Items]
Total revenues	217	198	626	547
KYPROLIS | ROW
Revenue from External Customer [Line Items]
Total revenues	101	95	296	277
Neulasta
Revenue from External Customer [Line Items]
Total revenues	247	415	905	1,383
Neulasta | U.S.
Revenue from External Customer [Line Items]
Total revenues	205	360	772	1,215
Neulasta | ROW
Revenue from External Customer [Line Items]
Total revenues	42	55	133	168
Nplate
Revenue from External Customer [Line Items]
Total revenues	288	273	838	745
Nplate | U.S.
Revenue from External Customer [Line Items]
Total revenues	162	156	474	404
Nplate | ROW
Revenue from External Customer [Line Items]
Total revenues	126	117	364	341
Other products
Revenue from External Customer [Line Items]
Total revenues	1,627	1,453	4,691	4,288
Other products | U.S.
Revenue from External Customer [Line Items]
Total revenues	1,044	896	2,983	2,655
Other products | ROW
Revenue from External Customer [Line Items]
Total revenues	583	557	1,708	1,633
Other revenues
Revenue from External Customer [Line Items]
Total revenues	$ 415	$ 386	$ 1,235	$ 1,107