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Revenues (Tables)
9 Months Ended
Sep. 30, 2022
Revenue from Contract with Customer [Abstract]  
Disaggregation of revenue by product and by geographic area
Revenues were as follows (in millions):
Three months ended September 30,
20222021
U.S.ROWTotalU.S.ROWTotal
ENBREL$1,086 $20 $1,106 $1,263 $26 $1,289 
Prolia590 272 862 530 273 803 
Otezla529 98 627 495 114 609 
XGEVA363 132 495 372 145 517 
Aranesp128 230 358 149 247 396 
Repatha142 167 309 139 133 272 
KYPROLIS217 101 318 198 95 293 
Neulasta205 42 247 360 55 415 
Nplate162 126 288 156 117 273 
Other products(1)
1,044 583 1,627 896 557 1,453 
Total product sales(2)
$4,466 $1,771 6,237 $4,558 $1,762 6,320 
Other revenues415 386 
Total revenues$6,652 $6,706 
Nine months ended September 30,
20222021
U.S.ROWTotalU.S.ROWTotal
ENBREL$2,965 $54 $3,019 $3,270 $87 $3,357 
Prolia1,783 853 2,636 1,569 806 2,375 
Otezla1,366 306 1,672 1,284 335 1,619 
XGEVA1,122 408 1,530 1,061 412 1,473 
Aranesp397 676 1,073 409 709 1,118 
Repatha461 502 963 421 423 844 
KYPROLIS626 296 922 547 277 824 
Neulasta772 133 905 1,215 168 1,383 
Nplate474 364 838 404 341 745 
Other products(1)
2,983 1,708 4,691 2,655 1,633 4,288 
Total product sales(2)
$12,949 $5,300 18,249 $12,835 $5,191 18,026 
Other revenues1,235 1,107 
Total revenues$19,484 $19,133 
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(1)    Consists of product sales of our non-principal products, as well as our Gensenta and Bergamo subsidiaries.
(2)    Hedging gains and losses, which are included in product sales, were not material for the three and nine months ended September 30, 2022 and 2021.