0000318154-22-000005.txt : 20220207 0000318154-22-000005.hdr.sgml : 20220207 20220207161656 ACCESSION NUMBER: 0000318154-22-000005 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 15 CONFORMED PERIOD OF REPORT: 20220207 ITEM INFORMATION: Results of Operations and Financial Condition ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20220207 DATE AS OF CHANGE: 20220207 FILER: COMPANY DATA: COMPANY CONFORMED NAME: AMGEN INC CENTRAL INDEX KEY: 0000318154 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 953540776 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 001-37702 FILM NUMBER: 22597564 BUSINESS ADDRESS: STREET 1: ONE AMGEN CENTER DRIVE CITY: THOUSAND OAKS STATE: CA ZIP: 91320 BUSINESS PHONE: (805)447-1000 MAIL ADDRESS: STREET 1: ONE AMGEN CENTER DRIVE CITY: THOUSAND OAKS STATE: CA ZIP: 91320 FORMER COMPANY: FORMER CONFORMED NAME: AMGEN DATE OF NAME CHANGE: 19870305 8-K 1 amgn-20220207.htm 8-K amgn-20220207
0000318154false00003181542022-02-072022-02-070000318154exch:XNGSus-gaap:CommonStockMember2022-02-072022-02-070000318154exch:XNGSamgn:A2.00SeniorNotesDue2026Member2022-02-072022-02-07

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
  
FORM 8-K
  
CURRENT REPORT
Pursuant to Section 13 OR 15(d) of
The Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
February 7, 2022
 
Amgen Inc.
(Exact name of registrant as specified in its charter)
  
Delaware 001-37702 95-3540776
(State or other jurisdiction
of incorporation)		 (Commission
File Number)		 (IRS Employer
Identification No.)
One Amgen Center Drive 
Thousand Oaks
California91320-1799
(Address of principal executive offices) (Zip Code)
Registrant’s telephone number, including area code
(805) 447-1000

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
☐Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐Pre-commencement communication pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐Pre-commencement communication pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading Symbol(s)Name of each exchange on which registered
Common stock, $0.0001 par valueAMGNThe Nasdaq Stock Market LLC
2.000% Senior Notes due 2026AMGN26The Nasdaq Stock Market LLC
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐


Item 2.02 Results of Operations and Financial Condition.
On February 7, 2022, Amgen Inc. (the Company) issued a press release announcing its unaudited results of operations for the three months and year ended December 31, 2021, and its unaudited financial position as of December 31, 2021. The full text of the press release is furnished as Exhibit 99.1 hereto.
In its press release the Company included certain non-U.S. Generally Accepted Accounting Principles (GAAP) financial measures as defined in Regulation G promulgated by the Securities and Exchange Commission. The non-GAAP financial measures included in the press release are non-GAAP earnings per share, non-GAAP operating income, non-GAAP operating margin, non-GAAP tax rate, non-GAAP net income, non-GAAP operating expenses and sub-components of non-GAAP operating expenses such as non-GAAP cost of sales, non-GAAP research and development (R&D) expenses and non-GAAP selling, general and administrative expenses. Reconciliations for such non-GAAP financial measures to the most directly comparable GAAP financial measures are included in the press release. The Company also included Free Cash Flow (FCF), which is computed by subtracting capital expenditures from operating cash flow, each as determined in accordance with GAAP.
The Company believes that this presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. The Company uses certain non-GAAP financial measures to enhance an investor’s overall understanding of the financial performance and prospects for the future of the Company’s ongoing business activities by facilitating comparisons of results of ongoing business operations among current, past and future periods. The Company believes that FCF provides a further measure of the Company’s liquidity. The Company uses non-GAAP financial measures in connection with its own budgeting and financial planning internally to evaluate the performance of the business, including to allocate resources and to evaluate results relative to incentive compensation targets. The non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP.
The following is a summary of the costs and other items excluded from the most directly comparable GAAP financial measures to calculate non-GAAP financial measures:
•Acquisition-related expenses: Acquisition-related charges are primarily associated with intangible assets acquired in connection with business acquisitions. Such charges include amortization of developed-product-technology rights, licensing rights, R&D technology rights, and marketing-related rights, as well as impairments of in-process R&D assets. Charges for purchased intangible assets are significantly impacted by the timing and magnitude of the Company’s acquisitions and potential product approvals as they relate to in-process R&D projects acquired. Accordingly, these charges may vary in amount from period to period. The Company excludes these charges for purposes of calculating the non-GAAP financial measures presented to facilitate a more meaningful evaluation of the Company’s current operating performance and comparisons to past operating performance. The Company believes that excluding the noncash charges related to those intangible assets acquired in business acquisitions treats those assets as if the Company had developed them internally in the past and, thus, provides a supplemental measure of profitability in which the Company’s acquired intellectual property is treated in a comparable manner to its internally-developed-intellectual property.
•Licensing-related expenses: Licensing-related charges primarily related to an upfront payment made in connection with the entry into a license and collaboration agreement. Charges from such agreements are significantly impacted by the timing and magnitude of these arrangements and potential regulatory related events and milestones as they relate to in-process R&D projects. Accordingly, these charges may vary in amount from period to period. The Company excludes these charges for purposes of calculating the non-GAAP financial measures presented to facilitate a more meaningful evaluation of the Company’s current operating performance and comparisons to past operating performance.
•Net charges pursuant to the Company’s costs savings initiatives: Costs from cost savings initiatives are primarily related to facilities charges, including accelerated depreciation, and severance and benefits for employees terminated pursuant to our transformation and process improvement efforts. Costs from such initiatives are inconsistent in amount and are significantly impacted by the timing and nature of these events. Therefore, although the Company may incur these types of expenses in the future, it believes that eliminating these charges for purposes of calculating the non-GAAP financial measures provides a supplemental evaluation of the Company’s current operating performance and facilitates comparisons to past operating performance.
•Other items: The Company adjusts GAAP financial results for certain income and expenses (or gains and losses). These adjustments include certain items from investment transactions, including amortization and impairments from the basis difference that arises from certain equity method investments and certain gains and losses on our investments in equity securities that are recorded to other income and expense. Further, the Company also adjusts GAAP financial results for certain items associated with judgments and/or settlements for legal proceedings discussed in our filings. The Company excludes these items for the purpose of calculating the non-GAAP financial measures presented because the Company believes these items are outside the ordinary course of business. The Company believes eliminating these items provides a supplemental evaluation of the Company’s current operating performance and facilitates comparisons to past operating


performance.
•The tax effect of the adjustments between GAAP and non-GAAP results take into account the tax treatment and related tax rate(s) that apply to each adjustment in the applicable tax jurisdiction(s). Generally, this results in a tax impact at the U.S. marginal tax rate for certain adjustments, including the majority of amortization of intangible assets, whereas the tax impact of other adjustments, including expenses related to cost savings initiatives, depends on whether the amounts are deductible in the respective tax jurisdictions and the applicable tax rate(s) in those jurisdictions.
The press release also contains a discussion of the additional purposes for which the Company’s management uses these non-GAAP financial measures, including, effective January 1, 2021, we began to exclude the gains and losses on our investments in equity securities from our non-GAAP measures that are recorded to other income and expense. This exclusion does not apply to our share of the earnings and losses of our strategic investments in corporations accounted for under the equity method of accounting, such as our investment in BeiGene. The Company began excluding gains and losses from equity investments for the purpose of calculating the non-GAAP financial measures presented because the Company believes the results of such gains and losses are not representative of our normal business operations. We made this change in 2021 because, as we have increased our investments in these companies, we recognized that the resulting variability can impede comparability between periods of our financial performance for our ongoing business operations. For comparability of results to the prior year, non-GAAP net income and non-GAAP EPS amounts for 2020 have also been revised to reflect this update to our non-GAAP policy.
This information and the information contained in the press release shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section. The information in Item 2.02 of this Current Report is not incorporated by reference into any filings of the Company made under the Securities Act of 1933, as amended, whether made before or after the date of this Current Report, regardless of any general incorporation language in the filing unless specifically stated so therein.



Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.
  
99.1 
104 Cover Page Interactive Data File (embedded within the Inline XBRL document).



SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
 
    
 AMGEN INC.
  
Date:February 7, 2022By: /s/ Peter H. Griffith
 Name: Peter H. Griffith
 Title: Executive Vice President and Chief Financial Officer

 EX-99.1 2 amgenq42021earningsrelease.htm EX-99.1 Document
Exhibit 99.1
amgenlogoa14.jpg
News Release

One Amgen Center Drive
Thousand Oaks, CA 91320-1799
Telephone 805-447-1000
www.amgen.com


AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
THOUSAND OAKS, Calif. (February 7, 2022) - Amgen (NASDAQ:AMGN) today announced financial results for the fourth quarter and full year 2021 versus comparable periods in 2020. Key results include:
•For the fourth quarter, total revenues increased 3% to $6.8 billion in comparison to the fourth quarter of 2020, driven by increased Other Revenue from the Eli Lilly and Company (Lilly) COVID-19 manufacturing collaboration. Product sales decreased 1% globally for the fourth quarter.
◦Volumes grew double-digits for a number of products including Prolia® (denosumab), MVASI® (bevacizumab-awwb), Repatha® (evolocumab) and EVENITY® (romosozumab-aqqg).
•For the full year, total revenues increased 2% to $26.0 billion driven by increased Other Revenue from the Lilly collaboration. Product sales for the full year were flat versus 2020 with 7% growth in unit volumes offset by a 7% decline in net selling price.
•GAAP earnings per share (EPS) increased 22% to $3.36 in the fourth quarter driven by increased revenues and lower weighted average shares outstanding. For the full year, GAAP EPS decreased 16% to $10.28 primarily driven by the write-off of $1.5 billion in acquired in-process research & development (acquired IPR&D) associated with our acquisition of Five Prime Therapeutics, partially offset by increased revenues.
◦For the fourth quarter, GAAP operating income increased 15% to $2.3 billion, and GAAP operating margin increased 5.0 percentage points to 36.7%. For the full year, GAAP operating income decreased 16% to $7.6 billion and GAAP operating margin decreased 6.3 percentage points to 31.4%, primarily driven by the acquisition of Five Prime Therapeutics.
•Non-GAAP EPS increased 26% in the fourth quarter to $4.36, and increased 6% to $17.10 for the full year, driven by increased revenues, decreased other expense and the impact of fewer weighted average shares outstanding. Full year non-GAAP EPS was partially offset by higher operating expenses.
◦For the fourth quarter, non-GAAP operating income increased 10% to $3.0 billion, and non-GAAP operating margin increased 4.7 percentage points to 47.8%. For the full year, non-GAAP operating income increased 1.0% to $12.4 billion and non-GAAP operating margin increased 0.2 percentage points to 51.1%.
•The Company generated $8.4 billion of free cash flow for the full year versus $9.9 billion in 2020. The decrease in 2021 was primarily driven by the monetization of interest rate swaps that occurred in 2020 and the timing of payments for sales incentives and discounts, as well as increased capital expenditures in 2021.




AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 2
"We realized strong volume growth for many of our key products during last year," said Robert A. Bradway, chairman and chief executive officer. "These products, combined with our many pipeline opportunities, position us well for long-term growth.”

$Millions, except EPS, dividends paid per share and percentagesQ4 ’21Q4 ’20YOY ΔFY ’21FY ’20YOY Δ
Total Revenues$6,846 $6,634 3%$25,979 $25,424 2%
GAAP Operating Income$2,304 $2,008 15%$7,639 $9,139 (16%)
GAAP Net Income$1,899 $1,615 18%$5,893 $7,264 (19%)
GAAP EPS$3.36 $2.76 22%$10.28 $12.31 (16%)
Non-GAAP Operating Income$2,997 $2,728 10%$12,424 $12,334 1%
Non-GAAP Net Income$2,461 $2,022 22%$9,797 $9,479 3%
Non-GAAP EPS$4.36 $3.46 26%$17.10 $16.07 6%
Dividends Paid Per Share$1.76 $1.60 10%$7.04 $6.40 10%

References in this release to “non-GAAP” measures, measures presented “on a non-GAAP basis” and to “free cash flow” (computed by subtracting capital expenditures from operating cash flow) refer to non-GAAP financial measures. Adjustments to the most directly comparable GAAP financial measures and other items are presented on the attached reconciliations. For comparability of results to the prior year, non-GAAP net income and non-GAAP EPS amounts for 2020 have been revised to reflect the update to our non-GAAP policy that excludes gains and losses on certain equity investments. Refer to Non-GAAP Financial Measures below for further discussion.

Product Sales Performance
Total product sales decreased 1% for the fourth quarter of 2021 versus the fourth quarter of 2020. Unit volumes grew 7% but were more than offset by lower net selling price and lower inventory levels. Product sales for the full year were flat versus 2020 with 7% growth in unit volumes offset by a 7% decline in net selling price. Full-year product sales in the U.S. declined 4%, with unit volumes increasing by 3% and net selling price declining by 6%. Full-year product sales outside the U.S. grew 12%, including 36% sales growth in the Asia-Pacific region.
During 2021 there has been a gradual recovery from the COVID-19 pandemic, with patient visits and diagnosis rates approaching pre-pandemic levels by early in the fourth quarter. Late in the year, the Omicron variant began to impact the healthcare sector. As a result, we have seen some shift back to virtual engagement by our field staff, delayed healthcare procedures, and variability in demand patterns.

General Medicine
•Prolia sales increased 17% year-over-year for the fourth quarter and 18% for the full year. Prolia unit volumes grew 17% for the quarter and 15% for the full year driven by a year-over-year increase in both new and repeat patients. As of the fourth quarter of 2021, osteoporosis diagnosis levels are largely back to pre-COVID levels; however, there has been some volatility with the recent Omicron surge which could impact sales in 2022.
•EVENITY sales increased 59% year-over-year for the fourth quarter and 51% for the full year. EVENITY unit volumes grew 57% for the quarter and 46% for the full year.




AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 3
•Repatha sales increased 8% year-over-year for the fourth quarter and 26% for the full year. Volume growth of 35% for the quarter and 40% for the full year was partially offset by lower net selling price, most significantly as a result of the increase in Medicare Part D patients receiving Repatha who entered the coverage gap, also known as the “doughnut hole.” For 2021, Repatha remained the global proprotein convertase subtilisin/kexin type 9 (PCSK9) segment leader, with more than 1 million patients treated since launch.
•Aimovig® (erenumab-aooe) sales decreased 13% year-over-year for the fourth quarter and 16% for the full year. Volume growth of 9% for the quarter and 12% for the full year was more than offset by lower net selling price. We recently published data from the HER-MES study, in which Aimovig showed superior tolerability and efficacy against topiramate and provided a significant reduction in monthly migraine days.

Inflammation
•Otezla® (apremilast) sales increased 2% year-over-year for both the fourth quarter and full year, with 8% volume growth over both periods being partially offset by lower net selling price and lower inventory levels. In the U.S., Otezla continued to maintain first-line share leadership in psoriasis for the fourth quarter of 2021. During the fourth quarter, the U.S. Food and Drug Administration (FDA) approved Otezla for the treatment of adult patients with plaque psoriasis across all severities. This expanded indication will extend Otezla’s reach to an additional 1.5 million patients with mild-to-moderate psoriasis that can benefit from a systemic oral therapy.
•Enbrel® (etanercept) sales decreased 13% year-over-year for the fourth quarter and 11% for the full year, driven by declines in net selling price, unit volume and inventory levels. Year-over-year volume declined 1% in the fourth quarter, representing the third consecutive quarter of slowing volume declines. On a full year basis, Enbrel benefited from $254 million of favorable adjustments to estimated sales deductions. For 2022, we expect Enbrel's net selling price to decline.
We expect Otezla and Enbrel to follow the historical pattern of lower sales in the first quarter relative to subsequent quarters due to the impact of benefit plan changes, insurance reverification and increased co-pay expenses as U.S. patients work through deductibles.
•AMGEVITA™ (adalimumab) sales increased 12% year-over-year for the fourth quarter, driven by 24% volume growth, and 33% for the full year, driven by 45% volume growth. Volume growth in both periods was partially offset by lower net selling price. In 2021, AMGEVITA continued to be the most prescribed adalimumab biosimilar in Europe.

Hematology-Oncology
•LUMAKRAS®/LUMYKRAS® (sotorasib) generated $45 million of sales for the fourth quarter and $90 million for the full year. In the U.S., LUMAKRAS has been prescribed to approximately 2,000 patients by over 1,000 physicians in both academic and community settings. The large majority of the top clinical laboratories in the U.S. are now routinely reflecting KRAS G12C as an actionable mutation, and approximately 75% of patients with NSCLC are now being tested by their oncologists at diagnosis for the KRAS G12C mutation. LUMAKRAS has strong payer coverage in the U.S., with 90% of patients having formulary access. Outside the U.S., LUMYKRAS is currently approved in 35 countries and we are leveraging early access programs where available to enable patients in need to receive treatment without delay.
•KYPROLIS® (carfilzomib) sales increased 4% year-over-year for the fourth quarter and full year, driven by 3% and 4% volume growth, respectively.



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 4
•XGEVA® (denosumab) sales increased 9% year-over-year for the fourth quarter and 6% for the full year, driven by 9% volume growth in both periods, partially offset by lower net selling price. In addition, XGEVA benefited from favorable changes to estimated sales deductions in the fourth quarter.
•Vectibix® (panitumumab) sales increased 10% year-over-year for the fourth quarter, driven by volume growth, and 8% for the full year, driven by volume growth. Vectibix remains the anti-EGFR antibody of choice in all lines of colorectal cancer therapy. In the fourth quarter, volume growth benefited from shipments to Takeda, our partner in Japan.
•Nplate® (romiplostim) sales increased 24% year-over-year for the fourth quarter, primarily driven by 17% volume growth, and 21% for the full year, primarily driven by 15% volume growth.
•BLINCYTO® (blinatumomab) sales increased 28% year-over-year for the fourth quarter, driven by volume growth, and 25% for the full year, driven by volume growth.
•MVASI sales increased 9% year-over-year for the fourth quarter, driven by 36% volume growth, and 46% for the full year, driven by 78% volume growth. Volume growth in both periods was partially offset by lower net selling price. In the U.S., MVASI continues to hold leading volume share with 49% of the bevacizumab segment in the quarter. Going forward, we expect that continued worldwide volume growth will be more than offset by declines in net selling price driven by increased competition and Average Selling Price (ASP) erosion.
•KANJINTI® (trastuzumab-anns) sales decreased 12% year-over-year for the fourth quarter, driven by declines in net selling price and volume, partially offset by favorable changes to estimated sales deductions. Sales increased 1% for the full year, driven by 36% volume growth, largely offset by lower net selling price. In the U.S., KANJINTI continues to hold leading volume share with 41% of the trastuzumab segment for the fourth quarter. Going forward, we expect volume declines and continued net selling price deterioration driven by increased competition and ASP erosion.
Established Products
•Total sales of our established products, which include Neulasta® (pegfilgrastim), NEUPOGEN® (filgrastim), EPOGEN® (epoetin alfa), Aranesp® (darbepotein alfa), Parsabiv® (etelcalcetide), and Sensipar®/Mimpara™ (cinacalcet), decreased 27% year-over-year for the fourth quarter and decreased 25% for the full year, primarily driven by volume declines and lower net selling price. In the fourth quarter, the published Average Selling Price for Neulasta in the U.S. declined 38% year-over-year and 10% quarter-over-quarter. Going forward, we expect additional net price and volume erosion across this portfolio of products.



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 5
Product Sales Detail by Product and Geographic Region
$Millions, except percentagesQ4 ’21Q4 ’20YOY Δ
USROWTOTALTOTALTOTAL
Prolia®
$581 $292 $873 $749 17%
EVENITY®
101 42 143 90 59%
Repatha®
136 137 273 253 8%
Aimovig®
88 2 90 104 (13%)
Otezla®
520 110 630 617 2%
Enbrel® 
1,082 26 1,108 1,272 (13%)
AMGEVITA™
— 115 115 103 12%
LUMAKRAS®/LUMYKRAS®
40 5 45 — *
KYPROLIS®
189 95 284 272 4%
XGEVA®
373 172 545 502 9%
Vectibix®
92 151 243 221 10%
Nplate®
162 120 282 227 24%
BLINCYTO®
77 55 132 103 28%
MVASI®
209 95 304 280 9%
KANJINTI®
125 14 139 158 (12%)
Neulasta®
299 52 351 536 (35%)
NEUPOGEN®
15 16 31 46 (33%)
EPOGEN®
128 — 128 133 (4%)
Aranesp®
128 234 362 375 (3%)
Parsabiv®
43 26 69 172 (60%)
Sensipar®/Mimpara™
2 16 18 45 (60%)
Other products**61 45 106 76 39%
Total product sales$4,451 $1,820 $6,271 $6,334 (1%)
* Change in excess of 100%
** Other products includes Corlanor®, GENSENTA, IMLYGIC®, AVSOLA®, Bergamo, and RIABNI™



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 6
$Millions, except percentagesFY ’21FY ’20YOY Δ
USROWTOTALTOTALTOTAL
Prolia®
$2,150 $1,098 $3,248 $2,763 18%
EVENITY®
331 199 530 350 51%
Repatha®
557 560 1,117 887 26%
Aimovig®
313 4 317 378 (16%)
Otezla®
1,804 445 2,249 2,195 2%
Enbrel® 
4,352 113 4,465 4,996 (11%)
AMGEVITA™
— 439 439 331 33%
LUMAKRAS®/LUMYKRAS®
82 8 90 — *
KYPROLIS®
736 372 1,108 1,065 4%
XGEVA®
1,434 584 2,018 1,899 6%
Vectibix®
347 526 873 811 8%
Nplate®
566 461 1,027 850 21%
BLINCYTO®
278 194 472 379 25%
MVASI®
826 340 1,166 798 46%
KANJINTI®
479 93 572 567 1%
Neulasta®
1,514 220 1,734 2,293 (24%)
NEUPOGEN®
101 67 168 225 (25%)
EPOGEN®
521 — 521 598 (13%)
Aranesp®
537 943 1,480 1,568 (6%)
Parsabiv®
150 130 280 716 (61%)
Sensipar®/Mimpara™
6 78 84 288 (71%)
Other products**202 137 339 283 20%
Total product sales$17,286 $7,011 $24,297 $24,240 —%
* Change in excess of 100%
** Other products includes Corlanor®, GENSENTA, IMLYGIC®, AVSOLA®, Bergamo, and RIABNI™




AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 7
Operating Expense, Operating Margin and Tax Rate Analysis
On a GAAP basis:
•Total Operating Expenses decreased 2% year-over-year for the fourth quarter. For the full year, Total Operating Expenses increased 13% primarily driven by the acquisition of Five Prime Therapeutics. Cost of Sales margin increased 2.2 percentage points in the fourth quarter primarily driven by product mix, including COVID-19 antibody shipments to Lilly and profit share. The impact of these product mix changes was partially offset by lower manufacturing cost. For the full year, Cost of Sales margin increased 1.2 percentage points, primarily driven by product mix, including COVID-19 antibody shipments to Lilly, profit share and royalties, partially offset by lower amortization expense from acquisition-related assets and lower manufacturing cost. Research & Development (R&D) expenses increased 10% in the fourth quarter primarily due to higher research and early pipeline spend related to recent business development activities for Generate Biomedicines and Arrakis Therapeutics. For the full year, R&D expenses increased 15% driven by a licensing-related expense from our collaboration with Kyowa Kirin Co. and higher spend in research and early pipeline, including other business development activities. Acquired IPR&D expenses in 2021 were driven by the Five Prime Therapeutics acquisition. Selling, General & Administrative (SG&A) expenses decreased 20% in the fourth quarter driven by lower spend for marketed products. For the full year, SG&A expenses decreased 6% driven by lower spend for marketed products and lower general and administrative expenses.
•Operating Margin as a percentage of product sales increased 5.0 percentage points in the fourth quarter to 36.7%, and decreased 6.3 percentage points for the full year to 31.4%.
•Tax Rate decreased 3.1 percentage points in the fourth quarter and increased 1.4 percentage points for the full year. The fourth quarter tax rate decrease is primarily driven by current year favorable items and change in earnings mix partially offset by the non-deductible IPR&D expense arising from the acquisition of Five Prime Therapeutics. The full year tax rate increase is primarily driven by the non-deductible IPR&D expense arising from the acquisition of Five Prime Therapeutics partially offset by earnings mix and adjustments to prior year tax liabilities.

On a non-GAAP basis:
•Total Operating Expenses decreased 1% in the fourth quarter and increased 4% for the full year. Cost of Sales margin increased 2.4 percentage points in the fourth quarter primarily due to product mix, including COVID-19 antibody shipments to Lilly and profit share, partially offset by lower manufacturing cost. For the full year, Cost of Sales margin increased 2.5 percentage points primarily due to product mix, including COVID-19 antibody shipments to Lilly, profit share and royalties, partially offset by lower manufacturing cost. R&D expenses increased 11% in the fourth quarter primarily due to higher research and early pipeline spend related to recent business development activities for Generate Biomedicines and Arrakis Therapeutics. For the full year, R&D expenses increased 5% driven by higher spend in research and early pipeline, including business development activities. SG&A expenses decreased 19% in the fourth quarter driven by lower spend for marketed products. For the full year, SG&A expenses decreased 7% driven by lower spend for marketed products and lower general and administrative expenses.
•Operating Margin as a percentage of product sales increased 4.7 percentage points in the fourth quarter to 47.8%, and increased 0.2 percentage points to 51.1% for the full year.
•Tax Rate decreased 3.0 percentage points in the fourth quarter and decreased 0.7 percentage points for the full year. The fourth quarter tax rate decrease was primarily driven by net favorable items partially offset by a change in earnings mix. The full year tax rate decrease is primarily driven by net favorable items.




AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 8
$Millions, except percentagesGAAPNon-GAAP
Q4 ’21Q4 ’20YOY ΔQ4 ’21Q4 ’20YOY Δ
Cost of Sales$1,718 $1,597 8%$1,096 $959 14%
% of product sales27.4 %25.2 %2.2 pts.17.5 %15.1 %2.4 pts.
Research & Development$1,348 $1,229 10%$1,319 $1,185 11%
% of product sales21.5 %19.4 %2.1 pts.21.0 %18.7 %2.3 pts.
Selling, General & Administrative$1,425 $1,773 (20%)$1,434 $1,762 (19%)
% of product sales22.7 %28.0 %(5.3) pts.22.9 %27.8 %(4.9) pts.
Other$51 $27 89%$— $— NM
Total Operating Expenses$4,542 $4,626 (2%)$3,849 $3,906 (1%)
Operating Margin
operating income as % of product sales36.7 %31.7 %5.0 pts.47.8 %43.1 %4.7 pts.
Tax Rate10.9 %14.0 %(3.1) pts. 11.6 %14.6 %(3.0) pts.
pts: percentage points
NM: not meaningful
$Millions, except percentagesGAAPNon-GAAP
FY ’21FY ’20YOY ΔFY ’21FY ’20YOY Δ
Cost of Sales$6,454 $6,159 5%$3,994 $3,362 19%
% of product sales26.6 %25.4 %1.2 pts.16.4 %13.9 %2.5 pts.
Research & Development$4,819 $4,207 15%$4,296 $4,085 5%
% of product sales19.8 %17.4 %2.4 pts.17.7 %16.9 %0.8 pts.
Acquired IPR&D$1,505 $— NM$— $— NM
% of product sales6.2 %— %NM— %— %NM
Selling, General & Administrative$5,368 $5,730 (6%)$5,265 $5,643 (7%)
% of product sales22.1 %23.6 %(1.5) pts.21.7 %23.3 %(1.6) pts.
Other$194 $189 3%$— $— NM
Total Operating Expenses$18,340 $16,285 13%$13,555 $13,090 4%
Operating Margin
operating income as % of product sales31.4 %37.7 %(6.3) pts.51.1 %50.9 %0.2 pts.
Tax Rate12.1 %10.7 %1.4 pts. 12.8 %13.5 %(0.7) pts.
pts: percentage points
NM: not meaningful


Cash Flow and Balance Sheet
•The Company generated $2.5 billion of free cash flow in the fourth quarter of 2021 versus $2.0 billion in the fourth quarter of 2020, driven by the timing of tax payments in the fourth quarter of 2020 and higher net income, partially offset by increased capital expenditures. The Company generated $8.4 billion of free cash flow for the full year 2021 versus $9.9 billion in 2020.
•The Company’s fourth quarter 2021 dividend of $1.76 per share was declared on October 21, 2021, and was paid on December 8, 2021, to all stockholders of record as of November 16, 2021, representing a 10% increase from 2020.



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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•During the fourth quarter, the Company repurchased 6.9 million shares of common stock at a total cost of $1.5 billion. For the full year, the Company repurchased 21.7 million of common stock at a total cost of $5.0 billion.
•Cash and investments totaled $8.0 billion and debt outstanding totaled $33.3 billion as of December 31, 2021.
$Billions, except sharesQ4 ’21Q4 ’20YOY ΔFY '21FY '20YOY Δ
Operating Cash Flow$2.8 $2.2 $0.7 $9.3 $10.5 $(1.2)
Capital Expenditures$0.3 $0.2 $0.1 $0.9 $0.6 $0.3 
Free Cash Flow$2.5 $2.0 $0.5 $8.4 $9.9 $(1.5)
Dividends Paid$1.0 $0.9 $0.1 $4.0 $3.8 $0.3 
Share Repurchases$1.5 $1.2 $0.2 $5.0 $3.5 $1.5 
Average Diluted Shares (millions)565 585 (20)573 590 (17)
Note: Numbers may not add due to rounding
$Billions12/31/2112/31/20YOY Δ
Cash and Investments$8.0 $10.6 $(2.6)
Debt Outstanding$33.3 $33.0 $0.3 
Note: Numbers may not add due to rounding





AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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Fourth Quarter Product and Pipeline Update
The Company provided the following updates on selected transactions, product and pipeline programs:

Recent business development transactions further strengthen Amgen’s Research capabilities

•In January 2022, Amgen and Generate Biomedicines announced a research collaboration agreement to discover and create protein therapeutics for five clinical targets across several therapeutic areas and multiple modalities. Combining Amgen’s biologics drug discovery expertise with the power of Generate Biomedicines Artificial Intelligence (AI) platform provides the opportunity to further facilitate multispecific drug design by shaving time off discovery timelines and generating potential lead molecules that have predictable manufacturability and clinical behavior.
•In January 2022, Amgen and Arrakis Therapeutics announced a research collaboration focused on the discovery and development of RNA degrader therapeutics against a range of difficult-to-drug targets in multiple therapeutic areas. This new class of "targeted RNA degraders" consists of small molecule drugs that selectively destroy RNAs encoding disease-causing proteins by inducing their proximity to nucleases. This collaboration further enhances Amgen’s induced proximity platform by significantly broadening the possibilities of addressing difficult protein targets considered undruggable because they may not have binding sites needed for conventional medicines.
•In February 2022, Amgen and Plexium announced a research collaboration and license agreement to identify novel targeted protein degradation therapeutics toward historically challenging drug targets. The multi-year collaboration supports the discovery of novel molecular glue therapeutics leveraging insights from Amgen's expertise in developing multispecific molecules. This collaboration further strengthens the Company's multispecific drug development capabilities providing the potential to tackle some of the most challenging protein targets.

LUMAKRAS/LUMYKRAS
•In January 2022, the European Commission granted conditional marketing authorization for LUMYKRAS, for the treatment of adults with advanced non-small cell lung cancer (NSCLC) with KRAS G12C mutation and who have progressed after at least one prior line of systemic therapy.
•In January 2022, the Japan Ministry of Health, Labour and Welfare approved LUMAKRAS for the treatment of KRAS G12C-mutated positive, unresectable, advanced and/or recurrent NSCLC that has progressed after systemic anticancer therapy.
•In December 2021, conditional marketing authorization was granted in Switzerland for LUMYKRAS. Regulatory reviews continue in other jurisdictions.
•A Phase 3 study of LUMAKRAS in combination with Vectibix in third-line colorectal cancer was initiated in Q4 2021.
•Initial data from cohorts exploring LUMAKRAS in combination with the anti-programmed cell death 1 (PD-1) antibody pembrolizumab are expected to be presented in H1 2022.
•Initial data from cohorts exploring LUMAKRAS in combination with the Src homology-2 domain-containing protein tyrosine phosphatase-2 (SHP2) inhibitor RMC-4630 from Revolution Medicines are expected to be presented in H2 2022.
•Top-line results from the event-driven, confirmatory Phase 3 study comparing LUMAKRAS to docetaxel in patients with KRAS G12C-mutated advanced NSCLC are expected in H2 2022.
•A Phase 2 study in first-line patients with KRAS G12C-mutated NSCLC whose tumors express serine/threonine kinase 11 (STK11) mutations and/or less than 1% programmed death-ligand 1 continues to enroll.



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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•Top-line results from the Phase 2 monotherapy study in patients with KRAS G12C-mutated solid tumors other than NSCLC and CRC are expected in H1 2022.
•Amgen and BridgeBio Pharma entered into a non-exclusive clinical collaboration and supply agreement, covering a Phase 1/2 study sponsored by BridgeBio, evaluating the combination of LUMAKRAS with BBP-398 (BridgeBio’s SHP2 inhibitor) in advanced solid tumors expressing the KRAS G12C mutation, with Amgen providing global supply of LUMAKRAS.
•A presentation titled: “First data for sotorasib in patients with pancreatic cancer with KRAS p.G12C mutation: A phase I/II study evaluating efficacy and safety” is scheduled for the American Society of Clinical Oncology monthly plenary series on February 15th, 2022.

KYPROLIS
•In December 2021, the FDA approved the expansion of the KYPROLIS U.S. prescribing information to include its use in combination with DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) and dexamethasone for patients with multiple myeloma at first or subsequent relapse.

Bemarituzumab
•A Phase 3 study (FORTITUDE-101) of bemarituzumab, a fibroblast growth factor receptor 2b (FGFR2b) antibody, or placebo plus chemotherapy in gastric cancers with FGFR2b overexpression is open for enrollment.
•A Phase 1b/3 study (FORTITUDE-102) of bemarituzumab plus chemotherapy and nivolumab versus chemotherapy and nivolumab in gastric cancers with FGFR2b overexpression is open for enrollment.
•A Phase 1b study (FORTITUDE-201) of bemarituzumab for the treatment of squamous NSCLC is expected to initiate in Q1 2022.
•Planning is underway for signal-seeking studies in other solid tumors.

Tarlatamab (AMG 757)
•A potentially pivotal Phase 2 study for tarlatamab, an HLE BiTE molecule targeting delta-like ligand 3 (DLL3), was initiated in patients with relapsed/refractory small cell lung cancer (SCLC) after two or more prior lines of treatment.
•A Phase 1b study of tarlatamab continues to enroll patients with neuroendocrine prostate cancer.
•A Phase 1b study of tarlatamab in combination with AMG 404 continues to enroll patients with SCLC.

Acapatamab (AMG 160)
•Data continue to mature in a dose-expansion cohort of acapatamab, a half-life extended (HLE) BiTE® molecule targeting prostate-specific membrane antigen (PSMA) for the treatment of patients with metastatic castrate-resistant prostate cancer (mCRPC). Enrollment of acapatamab is ongoing in cohorts to explore outpatient administration. Decision-enabling data are expected in H1 2022.
•A master protocol evaluating combinations with acapatamab continues to enroll patients with earlier-line mCRPC.

AMG 340 (formerly TNB-585)
•A Phase 1 dose-escalation study of AMG 340, a bispecific T-cell engager targeting PSMA, is enrolling patients with mCRPC; decision enabling data are expected in mid-2022.




AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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AMG 509
•A Phase 1 study of AMG 509, a six-transmembrane epithelial antigen of prostate 1 (STEAP1) targeting bi-specific molecule evaluating safety, tolerability, pharmacokinetics, and efficacy in subjects with mCRPC, continues to enroll patients.

Pavurutamab (AMG 701)
•A Phase 1b study of pavurutamab an HLE BiTE molecule targeting B-cell maturation antigen (BCMA) has started enrollment in patients with relapsed / refractory multiple myeloma.

AMG 193
•A Phase 1/1b/2 study of AMG 193, a novel small molecule methylthioadenosine (MTA) cooperative protein arginine methyltransferase 5 (PRMT5) molecular glue, was initiated as a monotherapy for patients with advanced solid tumors.

TEZSPIRE™ (tezepelumab)
•Following a priority review by the FDA, TEZSPIRE was approved early in December 2021 for the add-on maintenance treatment of adult and pediatric patients aged 12 years and older with severe asthma. Regulatory reviews are underway in the EU, Japan, and other jurisdictions.
•A Phase 3 study continues to enroll patients with chronic rhinosinusitis with nasal polyps.
•Planning is underway for a Phase 3 study in patients with eosinophilic esophagitis.
•A Phase 2b study continues to enroll patients with chronic spontaneous urticaria.
•A Phase 2 study continues to enroll patients with chronic obstructive pulmonary disease.

Otezla
•In December 2021, Otezla was approved by the FDA for the treatment of adult patients with plaque psoriasis who are candidates for phototherapy or systemic therapy. With this expanded indication, Otezla is now the first and only oral treatment approved in adult patients with plaque psoriasis regardless of severity.
•In December 2021, the Company announced positive top-line results from the DISCREET trial, a Phase 3, multicenter, randomized, placebo-controlled, double-blind study to assess the efficacy of Otezla in adults with moderate to severe genital psoriasis and moderate to severe plaque psoriasis. The study met all primary and secondary endpoints at week 16 and will continue through week 32.
•Phase 3 study initiation for the treatment of Japanese patients with palmoplantar pustulosis is expected in H1 2022.

AMG 451 / KHK4083
•The Company is planning to conduct a comprehensive Phase 3 program in atopic dermatitis with AMG 451, a monoclonal antibody that inhibits OX-40 resulting in the partial depletion of activated T-cells and the inhibition of T-cell activation cascade; study initiation is anticipated in mid-2022.

Efavaleukin alfa (AMG 592)1
•A Phase 2b study of efavaleukin alfa, an interleukin-2 (IL-2) mutein Fc fusion protein, continues to enroll patients with SLE.
•In November 2021, data from a Phase 1b study in patients with SLE were presented at the American College of Rheumatology Convergence. The multiple ascending dose Phase 1b study demonstrated robust and prolonged dose-dependent Treg expansion, with minimal changes in other IL-2-responsive cells.



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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•A Phase 2 study of efavaleukin alfa in patients with ulcerative colitis continues to enroll.

Rozibafusp alfa (AMG 570)
•A Phase 2b study of rozibafusp alfa, a first-in-class bispecific antibody-peptide conjugate
designed to uniquely disrupt T-cell and B-cell activity through a dual blockade of inducible T-cell costimulatory ligand (ICOSL) and B-cell activating factor (BAFF), continues to enroll patients with systemic lupus erythematosus (SLE).

Ordesekimab (AMG 714 / PRV-015)
•A Phase 2b study of AMG 714, a monoclonal antibody that binds interleukin-15, continues to enroll patients with non-responsive celiac disease. Top-line results from this study are expected by the end of 2023.

AMG 104 / AZD8630
•AMG 104 / AZD8630, a human anti-TSLP antibody fragment for inhaled delivery, initiated a Phase 1 study to assess safety, tolerability and pharmacokinetics.
•In November 2021, Amgen and AstraZeneca agreed to include AMG 104 / AZD8630 in the existing collaboration agreement between the parties. AMG 104 / AZD8630 becomes part of the collaboration with the companies sharing both costs and income, with no inventor royalty. AstraZeneca will be the development/regulatory lead, manufacturing lead, and commercial lead. AstraZeneca and Amgen will jointly commercialize AMG 104 / AZD8630 in North America, and AstraZeneca will distribute the product and book sales globally, including for the U.S. For commercialization in the U.S., Amgen will be responsible for commercial negotiations and contracting (including to payer, pharmacy, pharmacy support services), rebate processing and U.S. government price reporting.

Repatha
•In November 2021 the European Commission granted marketing authorization for Repatha for the treatment of pediatric patients aged 10 years and older with heterozygous familial hypercholesterolemia, and the expansion of treatment for pediatric homozygous familial hypercholesterolemia patients aged 10 years and older.
•A Phase 3 cardiovascular outcomes study (VESALIUS-CV) completed enrollment of patients at high cardiovascular risk without prior myocardial infarction or stroke. Top-line data are expected in 2025.

Olpasiran (AMG 890)
•Top-line results from a Phase 2 study of olpasiran, a lipoprotein(a) (Lp(a)) small interfering RNA molecule, in 290 subjects with elevated Lp(a), are expected in H1 2022. Publication of results is expected in H2 2022.

Biosimilars
•A Phase 3 study of ABP 938, an investigational biosimilar to EYLEA® (aflibercept) is on track with data expected in 2022.
•Phase 3 studies of ABP 654, an investigational biosimilar to STELARA® (ustekinumab), and ABP 959, an investigational biosimilar to SOLIRIS® (eculizumab), are on track, with data expected in 2022.
•A Phase 3 study to support an interchangeability designation in the U.S. for ABP 654 is ongoing.
•A Phase 3 study to support an interchangeability designation in the U.S. for AMJEVITA™ (adalimumab-atto) is enrolling patients.



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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Amgenpipeline.com
•A listing of additional ongoing clinical programs can be found at Amgenpipeline.com

Amgen Business Review
On Tuesday, Feb. 8, 2022, from 8:00 a.m. to approximately 12:00 p.m. ET, Amgen will host a virtual Business Review to share its growth strategy through 2030 and beyond. Members of Amgen’s senior leadership team will discuss plans to grow the many innovative medicines and biosimilars in the Company’s currently marketed portfolio; to advance numerous potential new medicines through its pipeline; and to capitalize on advances in science and technology to build a set of differentiated discovery research capabilities. Additionally, the Company will provide financial guidance for 2022 and longer-term financial guidance through the end of the decade.

Financial analysts, investors, members of the news media and the general public may access the business review and other webcasts and presentations regarding developments in Amgen's business given at investor and medical conferences via www.amgen.com under the Investors tab. Information regarding presentation times, webcast availability and webcast links are noted on Amgen's Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event.

At the conclusion of the meeting, Amgen will issue a press release reviewing the content of the meeting that provided a comprehensive overview of the Company’s strategy, commercial operations, pipeline, research and development capabilities.

TEZSPIRE and AMG 104 / AZD8630 are being developed in collaboration with AstraZeneca
AMG 451 (also known as KHK4083) is being developed in collaboration with Kyowa Kirin
AMG 714 (also known as PRV-015) is being developed in collaboration with Provention Bio
AMG 509 is being developed in collaboration with Xencor
DARZALEX FASPRO® and STELARA® are registered trademarks of Janssen Pharmaceutica NV
EYLEA® is a registered trademark of Regeneron Pharmaceuticals, Inc.
SOLIRIS® is a registered trademark of Alexion Pharmaceuticals, Inc.
1 A phase 1b study of AMG 592 for chronic graft vs. host disease has stopped enrollment and will be discontinued.






AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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Non-GAAP Financial Measures
In this news release, management has presented its operating results for the fourth quarters and full years of 2021 and 2020, in accordance with U.S. Generally Accepted Accounting Principles (GAAP) and on a non-GAAP basis. These non-GAAP financial measures are computed by excluding certain items related to acquisitions, restructuring and certain other items from the related GAAP financial measures. Reconciliations for these non-GAAP financial measures to the most directly comparable GAAP financial measures are included in the news release. Management has also presented Free Cash Flow (FCF), which is a non-GAAP financial measure, for the fourth quarters and full years of 2021 and 2020. FCF is computed by subtracting capital expenditures from operating cash flow, each as determined in accordance with GAAP.
The Company believes that its presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. The Company uses certain non-GAAP financial measures to enhance an investor’s overall understanding of the financial performance and prospects for the future of the Company’s ongoing business activities by facilitating comparisons of results of ongoing business operations among current, past and future periods. The Company believes that FCF provides a further measure of the Company’s liquidity.
Beginning January 1, 2021, we began to exclude the gains and losses on our investments in equity securities from our non-GAAP measures that are recorded to Other income (expense). This exclusion will not apply to our share of the earnings and losses of our strategic investments in corporations accounted for under the equity method of accounting, such as our investment in BeiGene. The Company will be excluding gains and losses from equity investments for the purpose of calculating the non-GAAP financial measures presented because the Company believes the results of such gains and losses are not representative of our normal business operations. We are making this change beginning in 2021 because, as we have increased our investments in these companies, we recognized that the resulting variability can impede comparability between periods of our financial performance for our ongoing business operations. For comparability of results to the prior year, non-GAAP net income and non-GAAP EPS amounts for 2020 have been revised to reflect the update to our non-GAAP policy that excludes gains and losses on certain equity investments.
The Company uses the non-GAAP financial measures set forth in the news release in connection with its own budgeting and financial planning internally to evaluate the performance of the business, including to allocate resources and to evaluate results relative to incentive compensation targets. The non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP.
About Amgen
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.
Forward-Looking Statements

This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd., Kyowa-Kirin Co., Ltd., Generate Biomedicines, Inc., Arrakis Therapeutics, Inc., Plexium, Inc., or any collaboration to manufacture therapeutic antibodies against COVID-19), the performance of Otezla® (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), the Five Prime Therapeutics, Inc. acquisition, or the Teneobio, Inc. acquisition, as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems such as the ongoing COVID-19 pandemic on our business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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business and results of operations. Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. A breakdown, cyberattack or information security breach could compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Global economic conditions may magnify certain risks that affect our business. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all.


###

CONTACT: Amgen, Thousand Oaks
Megan Fox, 805-447-1423 (media)
Arvind Sood, 805-447-1060 (investors)



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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Amgen Inc.
Consolidated Statements of Income - GAAP
(In millions, except per-share data)
(Unaudited)
 
 Three months ended
December 31,		Twelve months ended
December 31,
 2021202020212020
Revenues:
Product sales$6,271 $6,334 $24,297 $24,240 
Other revenues575 300 1,682 1,184 
Total revenues6,846 6,634 25,979 25,424 
Operating expenses:
Cost of sales
1,718 1,597 6,454 6,159 
Research and development1,348 1,229 4,819 4,207 
Acquired in-process research and development— — 1,505 — 
Selling, general and administrative1,425 1,773 5,368 5,730 
Other51 27 194 189 
Total operating expenses4,542 4,626 18,340 16,285 
Operating income2,304 2,008 7,639 9,139 
Other income (expense):
Interest expense, net(335)(318)(1,197)(1,262)
Other income, net162 187 259 256 
Income before income taxes2,131 1,877 6,701 8,133 
Provision for income taxes232 262 808 869 
Net income$1,899 $1,615 $5,893 $7,264 
Earnings per share:
Basic$3.38 $2.78 $10.34 $12.40 
Diluted$3.36 $2.76 $10.28 $12.31 
Weighted-average shares used in calculation of earnings per share:
Basic562 581 570 586 
Diluted565 585 573 590 



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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Amgen Inc.
Consolidated Balance Sheets - GAAP
(In millions)

December 31,December 31,
20212020
(Unaudited)
Assets
Current assets:
Cash, cash equivalents and marketable securities$8,037 $10,647 
Trade receivables, net4,895 4,525 
Inventories4,086 3,893 
Other current assets2,367 2,079 
Total current assets19,385 21,144 
Property, plant and equipment, net5,184 4,889 
Intangible assets, net15,182 16,587 
Goodwill14,890 14,689 
Other noncurrent assets6,524 5,639 
Total assets$61,165 $62,948 
Liabilities and Stockholders' Equity
Current liabilities:
Accounts payable and accrued liabilities$12,097 $11,562 
Current portion of long-term debt87 91 
Total current liabilities12,184 11,653 
Long-term debt33,222 32,895 
Long-term tax liabilities6,594 6,968 
Other noncurrent liabilities2,465 2,023 
Total stockholders’ equity6,700 9,409 
Total liabilities and stockholders’ equity$61,165 $62,948 
Shares outstanding558 578 



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
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Amgen Inc.
GAAP to Non-GAAP Reconciliations
(Dollars in millions)
(Unaudited)
Three months ended
December 31,		Twelve months ended
December 31,
20212020*20212020*
GAAP cost of sales$1,718 $1,597 $6,454 $6,159 
Adjustments to cost of sales:
Acquisition-related expenses (a)(616)(638)(2,443)(2,797)
Other(6)— (17)— 
Total adjustments to cost of sales(622)(638)(2,460)(2,797)
Non-GAAP cost of sales$1,096 $959 $3,994 $3,362 
GAAP cost of sales as a percentage of product sales27.4 %25.2 %26.6 %25.4 %
Acquisition-related expenses (a)(9.8)(10.1)(10.1)(11.5)
Other(0.1)0.0 (0.1)0.0 
Non-GAAP cost of sales as a percentage of product sales17.5 %15.1 %16.4 %13.9 %
GAAP research and development expenses$1,348 $1,229 $4,819 $4,207 
Adjustments to research and development expenses:
Licensing- and acquisition-related expenses (b)(29)(43)(523)(120)
Certain net charges pursuant to our cost savings initiatives— (1)— (2)
Total adjustments to research and development expenses(29)(44)(523)(122)
Non-GAAP research and development expenses$1,319 $1,185 $4,296 $4,085 
GAAP research and development expenses as a percentage of product sales21.5 %19.4 %19.8 %17.4 %
Licensing- and acquisition-related expenses (b)(0.5)(0.7)(2.1)(0.5)
Certain net charges pursuant to our cost savings initiatives0.0 0.0 0.0 0.0 
Non-GAAP research and development expenses as a percentage of product sales21.0 %18.7 %17.7 %16.9 %
GAAP acquired IPR&D$— $— $1,505 $— 
Adjustments to acquired IPR&D:
Five Prime acquisition IPR&D expense— — (1,505)— 
Non-GAAP acquired IPR&D$— $— $— $— 
GAAP acquired IPR&D expenses as a percentage of product sales— %— %6.2 %— %
Five Prime acquisition IPR&D expense0.0 0.0 (6.2)0.0 
Non-GAAP acquired IPR&D expenses as a percentage of product sales— %— %— %— %
GAAP selling, general and administrative expenses$1,425 $1,773 $5,368 $5,730 
Adjustments to selling, general and administrative expenses:
Acquisition-related expenses (a)(20)(11)(87)(85)
Other29 — (16)(2)
Total adjustments to selling, general and administrative expenses9 (11)(103)(87)
Non-GAAP selling, general and administrative expenses$1,434 $1,762 $5,265 $5,643 
GAAP selling, general and administrative expenses as a percentage of product sales22.7 %28.0 %22.1 %23.6 %
Acquisition-related expenses (a)(0.3)(0.2)(0.4)(0.3)
Other0.5 0.0 0.0 0.0 
Non-GAAP selling, general and administrative expenses as a percentage of product sales22.9 %27.8 %21.7 %23.3 %
GAAP operating expenses$4,542 $4,626 $18,340 $16,285 
Adjustments to operating expenses:
Adjustments to cost of sales(622)(638)(2,460)(2,797)
Adjustments to research and development expenses(29)(44)(523)(122)
Adjustments to acquired IPR&D— — (1,505)— 
Adjustments to selling, general and administrative expenses9 (11)(103)(87)
Certain charges pursuant to our cost savings initiatives(1)1 (130)5 
Certain other expenses (c)(50)(28)(64)(194)
Total adjustments to operating expenses(693)(720)(4,785)(3,195)
Non-GAAP operating expenses$3,849 $3,906 $13,555 $13,090 



AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 21
Three months ended
December 31,		Twelve months ended
December 31,
20212020*20212020*
GAAP operating income$2,304 $2,008 $7,639 $9,139 
Adjustments to operating expenses693 720 4,785 3,195 
Non-GAAP operating income$2,997 $2,728 $12,424 $12,334 
GAAP operating income as a percentage of product sales36.7 %31.7 %31.4 %37.7 %
Adjustments to cost of sales9.9 10.1 10.2 11.5 
Adjustments to research and development expenses0.5 0.7 2.1 0.5 
Acquired IPR&D0.0 0.0 6.2 0.0 
Adjustments to selling, general and administrative expenses(0.2)0.2 0.4 0.4 
Certain charges pursuant to our cost savings initiatives0.0 0.0 0.5 0.0 
Certain other expenses (c)0.9 0.4 0.3 0.8 
Non-GAAP operating income as a percentage of product sales47.8 %43.1 %51.1 %50.9 %
GAAP other income, net$162 $187 $259 $256 
Adjustments to other income (expense), net:
Equity method investment basis difference amortization45 37 173 109 
Net gains from equity investments(86)(265)(421)(404)
Gain from legal judgment proceeds— — — (72)
Total adjustments to other income (expense), net(41)(228)(248)(367)
Non-GAAP other income (expense), net$121 $(41)$11 (111)
GAAP income before income taxes$2,131 $1,877 $6,701 $8,133 
Adjustments to income before income taxes:
Adjustments to operating expenses693 720 4,785 3,195 
Adjustments to other income, net(41)(228)(248)(367)
Total adjustments to income before income taxes652 492 4,537 2,828 
Non-GAAP income before income taxes$2,783 $2,369 $11,238 $10,961 
GAAP provision for income taxes$232 $262 $808 $869 
Adjustments to provision for income taxes:
Income tax effect of the above adjustments (d) 104 81 630 546 
Other income tax adjustments (e)(14)4 3 67 
Total adjustments to provision for income taxes90 85 633 613 
Non-GAAP provision for income taxes$322 $347 $1,441 $1,482 
GAAP tax as a percentage of income before taxes10.9 %14.0 %12.1 %10.7 %
Adjustments to provision for income taxes:
Income tax effect of the above adjustments (d) 1.2 0.5 0.7 2.2 
Other income tax adjustments (e)(0.5)0.1 0.0 0.6 
Total adjustments to provision for income taxes0.7 0.6 0.7 2.8 
Non-GAAP tax as a percentage of income before taxes11.6 %14.6 %12.8 %13.5 %
GAAP net income$1,899 $1,615 $5,893 $7,264 
Adjustments to net income:
Adjustments to income before income taxes, net of the income tax effect548 411 3,907 2,282 
Other income tax adjustments (e)14 (4)(3)(67)
Total adjustments to net income562 407 3,904 2,215 
Non-GAAP net income$2,461 $2,022 $9,797 $9,479 
Note: Numbers may not add due to rounding




AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 22
Amgen Inc.
GAAP to Non-GAAP Reconciliations
(In millions, except per-share data)
(Unaudited)

The following table presents the computations for GAAP and non-GAAP diluted earnings per share:

Three months ended
December 31, 2021		Three months ended
December 31, 2020*
GAAPNon-GAAPGAAPNon-GAAP
Net income$1,899 $2,461 $1,615 $2,022 
Weighted-average shares for diluted EPS565 565 585 585 
Diluted EPS$3.36 $4.36 $2.76 $3.46 
Twelve months ended
December 31, 2021		Twelve months ended
December 31, 2020*
GAAPNon-GAAPGAAPNon-GAAP
Net income$5,893 $9,797 $7,264 $9,479 
Weighted-average shares for diluted EPS573 573 590 590 
Diluted EPS$10.28 $17.10 $12.31 $16.07 

*Effective January 2021, we began to exclude the gains and losses on our investments in equity securities from our non-GAAP measures that are recorded to Other income, net pursuant to an update to our non-GAAP policy. For comparability of results to the prior year, non-GAAP Other income, net, non-GAAP Net income and non-GAAP EPS amounts for 2020 have been revised to reflect the update to our non-GAAP policy.

(a)The adjustments related primarily to noncash amortization of intangible assets from business acquisitions.
(b)The adjustments for the three months ended December 31, 2021, related primarily to noncash amortization of intangible assets from business acquisitions. The adjustments for the twelve months ended December 31, 2021, related primarily to licensing-related expense from the upfront payment to Kyowa Kirin Co., Ltd. and noncash amortization of intangible assets from business acquisitions. The adjustments for the three and twelve months ended December 31, 2020, related primarily to noncash amortization of intangible assets from business acquisitions.
(c)For the three and twelve months ended December 31, 2021 and 2020, the adjustments related primarily to legal matters.
(d)The tax effect of the adjustments between our GAAP and non-GAAP results takes into account the tax treatment and related tax rate(s) that apply to each adjustment in the applicable tax jurisdiction(s). Generally, this results in a tax impact at the U.S. marginal tax rate for certain adjustments, including the majority of amortization of intangible assets, whereas the tax impact of other adjustments, including restructuring initiatives, depends on whether the amounts are deductible in the respective tax jurisdictions and the applicable tax rate(s) in those jurisdictions. Acquired IPR&D expense from the Five Prime acquisition was not tax deductible. Due to these factors, the effective tax rates for the adjustments to our GAAP income before income taxes, for the three and twelve months ended December 31, 2021, were 16.0% and 13.9%, compared to 16.5% and 19.3% for the corresponding periods of the prior year.
(e)The adjustments related to certain acquisition items, prior period and other items excluded from GAAP earnings.







AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS
Page 23
Amgen Inc.
Reconciliations of Cash Flows
(In millions)
(Unaudited)


Three months ended
December 31,		Twelve months ended
December 31,
2021202020212020
Net cash provided by operating activities$2,808 $2,153 $9,261 $10,497 
Net cash (used in) provided by investing activities(230)(1,384)733 (5,401)
Net cash used in financing activities(6,558)(3,590)(8,271)(4,867)
(Decrease) increase in cash and cash equivalents(3,980)(2,821)1,723 229 
Cash and cash equivalents at beginning of period11,969 9,087 6,266 6,037 
Cash and cash equivalents at end of period$7,989 $6,266 $7,989 $6,266 
Three months ended
December 31,		Twelve months ended
December 31,
2021202020212020
Net cash provided by operating activities$2,808 $2,153 $9,261 $10,497 
Capital expenditures(287)(173)(880)(608)
Free cash flow$2,521 $1,980 $8,381 $9,889 


Reconciliation of 2020 Non-GAAP Financial Information As Reported to Updated Non-GAAP Policy
2020 Non-GAAP Financial Results - Excluding gains and losses from equity investments
(Unaudited)

Effective January 2021, we began to exclude the gains and losses on our investments in equity securities from our non-GAAP measures that are recorded to Other income, net pursuant to an update to our non-GAAP policy. This policy update excludes our share of the earnings and losses of our strategic investments in corporations accounted for under the equity method of accounting, such as our investment in BeiGene. This updated non-GAAP policy is the basis for our comparisons starting in 2021. The reconciliations below show the effects of the application of the new policy as if it had been adopted at the beginning of 2020.

$Millions, except EPSQ1 ’20Q2 ’20Q3 ’20Q4 ’20FY ’20
Net income (as reported)$2,476$2,518$2,572$2,229$9,795
Equity securities losses (gains)39(44)(134)(265)(404)
Tax impact(9)10295888
Net income (adjusted)$2,506$2,484$2,467$2,022$9,479
Diluted shares594592589585590
Diluted EPS (as reported)$4.17$4.25$4.37$3.81$16.60
Diluted EPS (adjusted)$4.22$4.20$4.19$3.46$16.07

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Cover Page Document
Feb. 07, 2022
Entity Information [Line Items]  
Entity Central Index Key 0000318154
Amendment Flag false
Pre-commencement Issuer Tender Offer false
Pre-commencement Tender Offer false
Soliciting Material false
Written Communications false
Entity Incorporation, State or Country Code DE
Document Type 8-K
Document Period End Date Feb. 07, 2022
Entity Registrant Name Amgen Inc.
Entity File Number 001-37702
Entity Tax Identification Number 95-3540776
Entity Address, Address Line One One Amgen Center Drive
Entity Address, City or Town Thousand Oaks
Entity Address, State or Province CA
Entity Address, Postal Zip Code 91320-1799
City Area Code 805
Local Phone Number 447-1000
Entity Emerging Growth Company false
NASDAQ/NGS (GLOBAL SELECT MARKET) [Member] | Common Stock [Member]  
Entity Information [Line Items]  
Security Exchange Name NASDAQ
Trading Symbol AMGN
Title of 12(b) Security Common stock, $0.0001 par value
NASDAQ/NGS (GLOBAL SELECT MARKET) [Member] | 2.00% Senior Notes Due 2026 [Member]  
Entity Information [Line Items]  
Security Exchange Name NASDAQ
Trading Symbol AMGN26
Title of 12(b) Security 2.000% Senior Notes due 2026
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