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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Millions
9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities:    
Net income $ 3,994 $ 5,649
Depreciation, amortization and other 2,546 2,728
Deferred income taxes (264) (339)
Acquired in-process research and development 1,505 0
Other items, net 187 270
Changes in operating assets and liabilities, net of acquisitions:    
Trade receivables, net (269) (31)
Inventories (215) (316)
Other assets (373) 64
Accounts payable (260) (202)
Accrued income taxes, net (719) (301)
Long-term tax liabilities 102 110
Other liabilities 219 712
Net cash provided by operating activities 6,453 8,344
Cash flows from investing activities:    
Payments to Acquire Businesses, Net of Cash Acquired (1,639) 0
Purchases of marketable securities (8,901) (5,329)
Proceeds from sales of marketable securities 4,403 2,597
Proceeds from maturities of marketable securities 7,927 2,338
Purchases of property, plant and equipment (593) (435)
Purchases of equity method investments (154) (3,154)
Other (80) (34)
Net cash provided by (used in) investing activities 963 (4,017)
Cash flows from financing activities:    
Net proceeds from issuance of debt 4,946 8,914
Repayment of debt 0 (5,000)
Repurchases of common stock (3,532) (2,281)
Dividends paid (3,023) (2,823)
Other (104) (87)
Net cash used in financing activities (1,713) (1,277)
Increase in cash and cash equivalents 5,703 3,050
Cash and cash equivalents at beginning of period 6,266 6,037
Cash and cash equivalents at end of period $ 11,969 $ 9,087