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Revenues (Tables)
6 Months Ended
Jun. 30, 2021
Revenue from Contract with Customer [Abstract]  
Disaggregation of revenue by product and by geographic area
Revenues were as follows (in millions):
Three months ended June 30,
20212020
U.S.ROWTotalU.S.ROWTotal
Enbrel® (etanercept)
$1,113 $31 $1,144 $1,213 $33 $1,246 
Prolia® (denosumab)
538 276 814 441 218 659 
Otezla® (apremilast)
423 111 534 464 97 561 
Neulasta® (pegfilgrastim)
434 52 486 520 73 593 
XGEVA® (denosumab)
355 133 488 318 117 435 
Aranesp® (darbepoetin alfa)
135 232 367 156 231 387 
Repatha® (evolocumab)
143 143 286 115 85 200 
KYPROLIS® (carfilzomib)
190 90 280 167 86 253 
Other products1,043 672 1,715 1,034 540 1,574 
Total product sales(1)
$4,374 $1,740 6,114 $4,428 $1,480 5,908 
Other revenues412 298 
Total revenues$6,526 $6,206 
Six months ended June 30,
20212020
U.S.ROWTotalU.S.ROWTotal
ENBREL$2,007 $61 $2,068 $2,330 $69 $2,399 
Prolia®
1,039 533 1,572 863 450 1,313 
Otezla®
789 221 1,010 841 199 1,040 
Neulasta®
855 113 968 1,054 148 1,202 
XGEVA®
689 267 956 673 243 916 
Aranesp®
260 462 722 331 478 809 
Repatha®
282 290 572 239 190 429 
KYPROLIS®
349 182 531 354 179 533 
Other products2,007 1,300 3,307 2,022 1,139 3,161 
Total product sales(1)
$8,277 $3,429 11,706 $8,707 $3,095 11,802 
Other revenues721 565 
Total revenues$12,427 $12,367 
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(1)    Hedging gains and losses, which are included in product sales, were not material for the three and six months ended June 30, 2021 and 2020.