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Collaborations - Novartis AG (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenues $ 23,362 $ 23,747 $ 22,849
Other revenues [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenues 1,158 1,214 1,054
Collaborative Arrangement with Novartis AG [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Potential future milestone payment 100    
Collaborative Arrangement with Novartis AG [Member] | Other revenues [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenues   295  
Collaborative Arrangement with Novartis AG [Member] | Selling, general and administrative [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Cost paid   44  
Cost recoveries 187    
Collaborative Arrangement with Novartis AG [Member] | Research and development [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Cost recoveries     $ 124
Collaborative Arrangement with Novartis AG [Member] | Cost of sales [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Royalties due $ 115 $ 43