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Quarterly financial data (unaudited) (Details) - USD ($)
$ / shares in Units, $ in Millions
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Effect of Fourth Quarter Events [Line Items]                      
Product sales                 $ 23,362 $ 23,747 $ 22,849
Gross profit from product sales $ 4,628 $ 4,427 $ 4,562 $ 4,231 $ 4,905 $ 4,473 $ 4,655 $ 4,399      
Net income $ 1,703 $ 1,968 $ 2,179 $ 1,992 $ 1,928 $ 1,859 $ 2,296 $ 2,311 $ 7,842 $ 8,394 $ 1,979
Earnings per share:                      
Basic (in usd per share) $ 2.87 $ 3.29 $ 3.59 $ 3.20 $ 3.04 $ 2.88 $ 3.50 $ 3.27 $ 12.96 $ 12.70 $ 2.71
Diluted (in usd per share) $ 2.85 $ 3.27 $ 3.57 $ 3.18 $ 3.01 $ 2.86 $ 3.48 $ 3.25 $ 12.88 $ 12.62 $ 2.69
Product [Member]                      
Effect of Fourth Quarter Events [Line Items]                      
Product sales $ 5,881 $ 5,463 $ 5,574 $ 5,286 $ 6,001 $ 5,510 $ 5,679 $ 5,343 $ 22,204 $ 22,533 $ 21,795