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Fair value measurement - Narrative (Details) - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2015
Dec. 31, 2011
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
Length of time hedged in foreign currency contracts 3 years        
Aggregate fair value of long-term debt, including current portion $ 33,700,000,000 $ 35,000,000,000.0      
Carrying value of long-term debt, including current portion $ 29,903,000,000 33,929,000,000      
Other operating income (expense) [Member] | IPR&D [Member]          
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
IPR&D impairment charge   $ 330,000,000      
Other operating income (expense) [Member] | AMG 899 [Member] | IPR&D [Member]          
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
IPR&D impairment charge     $ 400,000,000    
Dezima [Member]          
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
Maximum additional consideration due contingent on certain milestones       $ 1,250,000,000  
Estimated fair values of contingent consideration obligations     110,000,000 $ 110,000,000  
Dezima [Member] | AMG 899 [Member]          
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
Estimated fair values of contingent consideration obligations     0    
Dezima [Member] | Other operating income (expense) [Member] | AMG 899 [Member]          
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
Estimated fair values of contingent consideration obligations     $ 116,000,000    
Biovex [Member]          
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
Additional contingent consideration upon achievement of milestones         $ 325,000,000
Other government-related and corporate debt securities [Member]          
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]          
Investment maturity period 3 years