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Business combinations (Aggregate Consideration Paid) (Details) - Kirin-Amgen, Inc. (K-A) [Member]
$ in Millions
3 Months Ended
Mar. 31, 2018
USD ($)
Business Acquisition [Line Items]  
Total cash paid to Kirin $ 780
Fair value of contingent consideration obligation 45
Loss on settlement of preexisting relationship (168)
Total consideration transferred to acquire K-A 657
Fair value of Amgen’s investment in K-A 825
Total acquisition date fair value $ 1,482