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Business combinations (Details Textual) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2018
Sep. 30, 2018
Dec. 31, 2017
Dec. 31, 1984
Business Acquisition [Line Items]        
Goodwill   $ 14,684 $ 14,761  
Kirin-Amgen, Inc. (K-A) [Member]        
Business Acquisition [Line Items]        
Percentage of voting interests acquired 50.00%      
Ownership percentage     50.00% 50.00%
Carrying value of equity method investment     $ 570  
Kirin-Amgen, Inc. (K-A) [Member] | Kirin [Member]        
Business Acquisition [Line Items]        
Ownership percentage       50.00%
Kirin-Amgen, Inc. (K-A) [Member]        
Business Acquisition [Line Items]        
Percentage of voting interests acquired 50.00%      
Ownership interest in acquiree prior to acquisition (as a percent) 50.00%      
Net gain on remeasurement $ 80      
Cash paid 780      
Estimated fair values of contingent consideration obligations 45      
Fair value of assets acquired, cash 977      
Fair value of liabilities assumed, deferred tax liabilities 102      
Fair value of assets acquired and liabilities assumed, net other assets and liabilities 131      
Goodwill 6      
Kirin-Amgen, Inc. (K-A) [Member] | Licensing Rights [Member]        
Business Acquisition [Line Items]        
Fair value of assets acquired, licensing rights $ 470      
Weighted average period of amortization 4 years