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Business combinations (Details Textual) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2018
Dec. 31, 2017
Dec. 31, 1984
Business Acquisition [Line Items]      
Net gain on remeasurement $ 80    
Goodwill 14,771 $ 14,761  
Corporate Joint Venture [Member]      
Business Acquisition [Line Items]      
Cash paid $ 780    
Kirin-Amgen, Inc. (K-A) [Member]      
Business Acquisition [Line Items]      
Percentage of voting interests acquired 50.00%    
Ownership percentage   50.00% 50.00%
Carrying value of equity method investment   $ 570  
Kirin-Amgen, Inc. (K-A) [Member] | Kirin [Member]      
Business Acquisition [Line Items]      
Ownership percentage     50.00%
Kirin-Amgen, Inc. (K-A) [Member]      
Business Acquisition [Line Items]      
Percentage of voting interests acquired 50.00%    
Ownership interest in acquiree prior to acquisition (as a percent) 50.00%    
Cash paid $ 780    
Estimated fair values of contingent consideration obligations 45    
Fair value of assets acquired, cash 977    
Fair value of liabilities assumed, deferred tax liabilities 102    
Fair value of assets acquired and liabilities assumed, net other assets and liabilities 131    
Goodwill 6    
Kirin-Amgen, Inc. (K-A) [Member] | Licensing Rights [Member]      
Business Acquisition [Line Items]      
Fair value of assets acquired, licensing rights $ 470    
Weighted average period of amortization 4 years